{"id":"https://openalex.org/W7215101147","doi":"https://doi.org/10.1186/s12916-026-05235-7","title":"Neuropsychiatric outcomes after montelukast versus inhaled corticosteroids in pediatric asthma: a pooled birth cohort study","display_name":"Neuropsychiatric outcomes after montelukast versus inhaled corticosteroids in pediatric asthma: a pooled birth cohort study","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7215101147","doi":"https://doi.org/10.1186/s12916-026-05235-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/42823762","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13632352"},"language":"en","primary_location":{"id":"doi:10.1186/s12916-026-05235-7","doi":"https://doi.org/10.1186/s12916-026-05235-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12916-026-05235-7","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12916-026-05235-7.pdf","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12916-026-05235-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5153856530","display_name":"Xue-Feng Jiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2802351361","display_name":"Centre Hospitalier Universitaire Sainte-Justine","ror":"https://ror.org/01gv74p78","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I2802351361","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]},{"id":"https://openalex.org/I4405268511","display_name":"CHU Sainte-Justine Research Center","ror":"https://ror.org/016e4fa89","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4405268511"]}],"countries":["CA","CN"],"is_corresponding":false,"raw_author_name":"Xue-Feng Jiao","raw_affiliation_strings":["Children's Medicine Key Laboratory of Sichuan Province, Chengdu, China","Department of Pharmacy/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China","Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China","Research Center, CHU Sainte-Justine, Montreal, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medicine Key Laboratory of Sichuan Province, Chengdu, China","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacy/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089228"]},{"raw_affiliation_string":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Research Center, CHU Sainte-Justine, Montreal, QC, Canada","institution_ids":["https://openalex.org/I2802351361","https://openalex.org/I4405268511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065533338","display_name":"Francine Monique Ducharme","orcid":"https://orcid.org/0000-0001-5096-0614","observed_orcids":["https://orcid.org/0000-0001-5096-0614"]},"institutions":[{"id":"https://openalex.org/I2802351361","display_name":"Centre Hospitalier Universitaire Sainte-Justine","ror":"https://ror.org/01gv74p78","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I2802351361","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Francine M Ducharme","raw_affiliation_strings":["Clinical Research and Knowledge Transfer Unit on Childhood Asthma, CHU Sainte-Justine, Montreal, QC, Canada","Department of Pediatrics, Faculty of Medicine, University of Montreal, Sainte-Justine Hospital, Montreal, QC, Canada","Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research and Knowledge Transfer Unit on Childhood Asthma, CHU Sainte-Justine, Montreal, QC, Canada","institution_ids":["https://openalex.org/I2802351361"]},{"raw_affiliation_string":"Department of Pediatrics, Faculty of Medicine, University of Montreal, Sainte-Justine Hospital, Montreal, QC, Canada","institution_ids":["https://openalex.org/I2802351361","https://openalex.org/I70931966"]},{"raw_affiliation_string":"Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, QC, Canada","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048073572","display_name":"Lisiane Freitas Leal","orcid":"https://orcid.org/0000-0002-4151-8960","observed_orcids":["https://orcid.org/0000-0002-4151-8960"]},"institutions":[{"id":"https://openalex.org/I2802351361","display_name":"Centre Hospitalier Universitaire Sainte-Justine","ror":"https://ror.org/01gv74p78","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I2802351361","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405268511","display_name":"CHU Sainte-Justine Research Center","ror":"https://ror.org/016e4fa89","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4405268511"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lisiane Freitas Leal","raw_affiliation_strings":["Research Center, CHU Sainte-Justine, Montreal, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center, CHU Sainte-Justine, Montreal, QC, Canada","institution_ids":["https://openalex.org/I2802351361","https://openalex.org/I4405268511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072657794","display_name":"Cristina Longo","orcid":"https://orcid.org/0000-0001-5666-0372","observed_orcids":["https://orcid.org/0000-0001-5666-0372"]},"institutions":[{"id":"https://openalex.org/I2802351361","display_name":"Centre Hospitalier Universitaire Sainte-Justine","ror":"https://ror.org/01gv74p78","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I2802351361","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405268511","display_name":"CHU Sainte-Justine Research Center","ror":"https://ror.org/016e4fa89","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4405268511"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Cristina Longo","raw_affiliation_strings":["Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada","Research Center, CHU Sainte-Justine, Montreal, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Research Center, CHU Sainte-Justine, Montreal, QC, Canada","institution_ids":["https://openalex.org/I2802351361","https://openalex.org/I4405268511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108232554","display_name":"Odile Sheehy","orcid":"https://orcid.org/0000-0002-6784-2080","observed_orcids":["https://orcid.org/0000-0002-6784-2080"]},"institutions":[{"id":"https://openalex.org/I2802351361","display_name":"Centre Hospitalier Universitaire Sainte-Justine","ror":"https://ror.org/01gv74p78","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I2802351361","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405268511","display_name":"CHU Sainte-Justine Research Center","ror":"https://ror.org/016e4fa89","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4405268511"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Odile Sheehy","raw_affiliation_strings":["Research Center, CHU Sainte-Justine, Montreal, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center, CHU Sainte-Justine, Montreal, QC, Canada","institution_ids":["https://openalex.org/I2802351361","https://openalex.org/I4405268511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029552809","display_name":"Florentia Kaguelidou","orcid":"https://orcid.org/0000-0002-7842-5602","observed_orcids":["https://orcid.org/0000-0002-7842-5602"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210126712","display_name":"H\u00f4pital Robert-Debr\u00e9","ror":"https://ror.org/02dcqy320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210126712"]},{"id":"https://openalex.org/I4403386629","display_name":"Centre d'Investigation Clinique Robert Debr\u00e9","ror":"https://ror.org/03s5x2j36","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4403386629"]},{"id":"https://openalex.org/I4403386667","display_name":"Pharmacologie et \u00e9valuation th\u00e9rapeutiques chez l'enfant et la femme enceinte","ror":"https://ror.org/00ghmzn75","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4403386667"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Florentia Kaguelidou","raw_affiliation_strings":["Center of Clinical Investigations, APHP.Nord, INSERM CIC1426, Robert Debr\u00e9 University Hospital, Paris, France","Paris Cit\u00e9 University, UMR-S 1343 Perinatal and Pediatric Pharmacology and Therapeutic Assessment, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Clinical Investigations, APHP.Nord, INSERM CIC1426, Robert Debr\u00e9 University Hospital, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210126712","https://openalex.org/I4403386629"]},{"raw_affiliation_string":"Paris Cit\u00e9 University, UMR-S 1343 Perinatal and Pediatric Pharmacology and Therapeutic Assessment, Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4403386667"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006777946","display_name":"Anick B\u00e9rard","orcid":"https://orcid.org/0000-0001-7535-5517","observed_orcids":["https://orcid.org/0000-0001-7535-5517","https://orcid.org/0000-0003-4391-5166"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I2802351361","display_name":"Centre Hospitalier Universitaire Sainte-Justine","ror":"https://ror.org/01gv74p78","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I2802351361","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405268511","display_name":"CHU Sainte-Justine Research Center","ror":"https://ror.org/016e4fa89","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4405268511"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA","FR"],"is_corresponding":true,"raw_author_name":"Anick B\u00e9rard","raw_affiliation_strings":["Faculty of Medicine, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France. anick.berard@umontreal.ca","Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada. anick.berard@umontreal.ca","Research Center, CHU Sainte-Justine, Montreal, QC, Canada. anick.berard@umontreal.ca"],"raw_orcid":"https://orcid.org/0000-0001-7535-5517","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France. anick.berard@umontreal.ca","institution_ids":["https://openalex.org/I100532134"]},{"raw_affiliation_string":"Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada. anick.berard@umontreal.ca","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Research Center, CHU Sainte-Justine, Montreal, QC, Canada. anick.berard@umontreal.ca","institution_ids":["https://openalex.org/I2802351361","https://openalex.org/I4405268511"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5006777946"],"corresponding_institution_ids":["https://openalex.org/I100532134","https://openalex.org/I2802351361","https://openalex.org/I4405268511","https://openalex.org/I70931966"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73009959,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/montelukast","display_name":"montelukast","score":0.9980000257492065},{"id":"https://openalex.org/keywords/inhaled-corticosteroids","display_name":"inhaled corticosteroids","score":0.9779999852180481},{"id":"https://openalex.org/keywords/childhood-asthma","display_name":"childhood asthma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neuropsychiatric-side-effects","display_name":"neuropsychiatric adverse effects","score":0.9739999771118164},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.9850000143051147},{"id":"https://openalex.org/keywords/oppositional-defiant-disorder","display_name":"oppositional defiant disorder","score":0.8740000128746033},{"id":"https://openalex.org/keywords/conduct-disorder","display_name":"conduct disorder","score":0.9760000109672546},{"id":"https://openalex.org/keywords/sleep-disturbance","display_name":"sleep disorders","score":0.9649999737739563},{"id":"https://openalex.org/keywords/mood-disorders","display_name":"mood disorders","score":0.9779999852180481},{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.9959999918937683},{"id":"https://openalex.org/keywords/asthma-controller-therapy","display_name":"asthma controller therapy","score":0.8299999833106995},{"id":"https://openalex.org/keywords/birth-cohort-studies","display_name":"birth cohort studies","score":0.4690000116825104},{"id":"https://openalex.org/keywords/oral-corticosteroids","display_name":"oral corticosteroids","score":0.7300000190734863},{"id":"https://openalex.org/keywords/pediatric-drug-safety","display_name":"drug safety in children","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9854999780654907},{"id":"https://openalex.org/C2776322731","wikidata":"https://www.wikidata.org/wiki/Q417767","display_name":"Montelukast","level":3,"score":0.7080000042915344},{"id":"https://openalex.org/C2991922776","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Inhaled corticosteroids","level":3,"score":0.669700026512146},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.5656999945640564},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5611000061035156},{"id":"https://openalex.org/C3017906399","wikidata":"https://www.wikidata.org/wiki/Q48973845","display_name":"Pooled analysis","level":3,"score":0.3959999978542328},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.38519999384880066},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3736000061035156},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.3528999984264374},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3425000011920929},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.3179999887943268},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.31790000200271606},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.31200000643730164},{"id":"https://openalex.org/C2776344615","wikidata":"https://www.wikidata.org/wiki/Q625506","display_name":"Premature birth","level":4,"score":0.30959999561309814},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.30790001153945923},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2980000078678131},{"id":"https://openalex.org/C3018709324","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Population based study","level":3,"score":0.29019999504089355},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.2825999855995178},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.27469998598098755},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.26570001244544983}],"mesh":[{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000089822","descriptor_name":"Birth Cohort","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000096865","descriptor_name":"Oppositional Defiant Disorder","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000096865","descriptor_name":"Oppositional Defiant Disorder","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001289","descriptor_name":"Attention Deficit Disorder with Hyperactivity","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001289","descriptor_name":"Attention Deficit Disorder with Hyperactivity","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003521","descriptor_name":"Cyclopropanes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012893","descriptor_name":"Sleep Wake Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012893","descriptor_name":"Sleep Wake Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D013440","descriptor_name":"Sulfides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018927","descriptor_name":"Anti-Asthmatic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018927","descriptor_name":"Anti-Asthmatic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018927","descriptor_name":"Anti-Asthmatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019955","descriptor_name":"Conduct Disorder","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D019955","descriptor_name":"Conduct Disorder","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D019964","descriptor_name":"Mood Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12916-026-05235-7","doi":"https://doi.org/10.1186/s12916-026-05235-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12916-026-05235-7","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12916-026-05235-7.pdf","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13632352","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13632352/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13632352/pdf/12916_2026_Article_5235.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Med","raw_type":"Text"},{"id":"pmid:42823762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42823762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a60690ac3563481e8ab8721a1609e5e0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a60690ac3563481e8ab8721a1609e5e0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medicine, Vol 24, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12916-026-05235-7","doi":"https://doi.org/10.1186/s12916-026-05235-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12916-026-05235-7","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12916-026-05235-7.pdf","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334618","display_name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","ror":"https://ror.org/02eqrsj93"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7215101147.pdf","grobid_xml":"https://content.openalex.org/works/W7215101147.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1728739831","https://openalex.org/W1889406081","https://openalex.org/W1943198688","https://openalex.org/W1981254809","https://openalex.org/W1982191652","https://openalex.org/W2015865975","https://openalex.org/W2026942296","https://openalex.org/W2077955726","https://openalex.org/W2106920343","https://openalex.org/W2153149205","https://openalex.org/W2157029647","https://openalex.org/W2259003101","https://openalex.org/W2310901737","https://openalex.org/W2345609563","https://openalex.org/W2534334947","https://openalex.org/W2590500201","https://openalex.org/W2769778858","https://openalex.org/W2885969928","https://openalex.org/W2900963908","https://openalex.org/W2921495327","https://openalex.org/W2956862886","https://openalex.org/W3010541908","https://openalex.org/W3011771863","https://openalex.org/W3096643386","https://openalex.org/W3117052388","https://openalex.org/W3119534583","https://openalex.org/W3131215500","https://openalex.org/W3131243367","https://openalex.org/W3148822462","https://openalex.org/W3154172296","https://openalex.org/W3157326139","https://openalex.org/W3165524418","https://openalex.org/W3188914669","https://openalex.org/W3199209686","https://openalex.org/W3202426405","https://openalex.org/W4205748115","https://openalex.org/W4205760625","https://openalex.org/W4211155347","https://openalex.org/W4226409348","https://openalex.org/W4280620036","https://openalex.org/W4282927966","https://openalex.org/W4303985854","https://openalex.org/W4309728383","https://openalex.org/W4309818166","https://openalex.org/W4321487670","https://openalex.org/W4372286491","https://openalex.org/W4381615988","https://openalex.org/W4385680744","https://openalex.org/W4386227114","https://openalex.org/W4386765458","https://openalex.org/W4387296223","https://openalex.org/W4387458237","https://openalex.org/W4390205553","https://openalex.org/W4392974489","https://openalex.org/W4401053493","https://openalex.org/W4401522185","https://openalex.org/W4404635301","https://openalex.org/W4405523367","https://openalex.org/W4406467302","https://openalex.org/W4406666899","https://openalex.org/W4406882284","https://openalex.org/W4408230053","https://openalex.org/W4408966361","https://openalex.org/W4408995655","https://openalex.org/W4410904602","https://openalex.org/W4411462851","https://openalex.org/W4412952281","https://openalex.org/W4415658824","https://openalex.org/W4416928965","https://openalex.org/W4417304245","https://openalex.org/W4417449330","https://openalex.org/W7124908083","https://openalex.org/W7162084123"],"related_works":["https://openalex.org/W4404635301","https://openalex.org/W4388190053","https://openalex.org/W2913533113","https://openalex.org/W1782812324","https://openalex.org/W2906371980","https://openalex.org/W7171220010","https://openalex.org/W2924714191","https://openalex.org/W2029100321","https://openalex.org/W2749797813","https://openalex.org/W7113257308"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,96],"evidence":[2],"regarding":[3,240],"montelukast\u2011associated":[4],"neuropsychiatric":[5,31],"adverse":[6],"events":[7,32],"in":[8,33,134,163,170,184,191,260,269],"children":[9,34,65,158,179,270,300],"with":[10,35,72,161,182,202,253,290,303,310,326,340],"asthma":[11,78,84,266],"is":[12,308,338],"controversial":[13],"and":[14,27,55,81,102,114,117,168,189,218,221,235,263,268,315,318],"inconclusive.":[15],"We":[16,38,63,120],"sought":[17],"to":[18,68,130,145,231,282,292,322,348],"further":[19],"examine":[20],"the":[21,28,47,53,56,73,132,164,171,185,192,244,261],"association":[22],"between":[23],"use":[24,247,305,335],"of":[25,30,43,77,197,205,248,257,306,313,336,344],"montelukast":[26,89,165,186,198,249,307,337],"risk":[29,256,343],"asthma.":[36],"METHODS:":[37],"conducted":[39],"a":[40],"pooled":[41],"analysis":[42],"two":[44],"birth":[45,80,136],"cohorts:":[46],"AMerican":[48],"PREGNANcy-Mother-Child":[49],"CohorT":[50],"(AM-PREGNANT)":[51],"from":[52,61],"US,":[54],"Quebec":[57],"Pregnancy":[58],"Cohort":[59],"(QPC)":[60],"Canada.":[62],"included":[64,109],"aged":[66],"1":[67],"<":[69],"18":[70],"years":[71],"first":[74],"incident":[75],"diagnosis":[76],"after":[79],"whose":[82],"initial":[83],"controller":[85],"therapy":[86],"was":[87,143,151,199,250],"either":[88],"monotherapy":[90,166,173,187,194],"or":[91,295,332],"inhaled":[92],"corticosteroids":[93,276],"(ICS)":[94],"monotherapy.":[95],"primary":[97],"outcomes":[98,108],"were":[99,159,180,285],"sleep":[100,241,258,345],"disorders":[101,223,259,294,320,346],"attention-deficit/hyperactivity":[103],"disorder":[104],"(ADHD),":[105],"while":[106],"secondary":[107],"mood":[110,293],"disorders,":[111,113],"anxiety":[112,296],"oppositional":[115,219,316],"defiant":[116,220,317],"conduct":[118,222,319],"disorders.":[119,242,297],"used":[121,144,274],"Cox":[122],"proportional":[123],"hazards":[124],"regressions,":[125],"adjusting":[126],"for":[127],"potential":[128],"confounders,":[129],"quantify":[131],"associations":[133],"each":[135],"cohort":[137],"independently.":[138],"A":[139],"random":[140],"effects":[141],"Meta-analysis":[142],"pool":[146],"outcome-specific":[147],"results":[148],"if":[149],"heterogeneity":[150],"acceptable.":[152],"RESULTS:":[153],"In":[154,175,243],"AM-PREGNANT,":[155],"85,322":[156],"asthmatic":[157,178],"included,":[160,181],"21,534":[162],"group":[167,188],"63,788":[169],"ICS":[172,193],"group.":[174,195],"QPC,":[176],"11,854":[177],"373":[183],"11,481":[190],"Use":[196],"significantly":[200,251],"associated":[201,252,309,339],"increased":[203,255,311,342],"risks":[204,312],"ADHD":[206,314],"(pooled":[207],"adjusted":[208],"hazard":[209],"ration":[210],"[HR],":[211],"1.40;":[212],"95%":[213,227],"confidence":[214],"interval":[215],"[CI],":[216],"1.19-1.66)":[217],"(adjusted":[224],"HR,":[225],"1.43;":[226],"CI,":[228],"1.13-1.82)":[229],"compared":[230,281,321,347],"ICS;":[232,323],"however,":[233],"AM-PREGNANT":[234],"QPC":[236],"yielded":[237],"inconsistent":[238],"findings":[239],"subgroup":[245,267],"analyses,":[246],"an":[254,341],"controlled":[262,265],"partly":[264,330],"who":[271],"had":[272],"not":[273],"oral":[275],"during":[277],"follow-up":[278],"time":[279],"when":[280],"ICS.":[283,349],"There":[284],"no":[286],"significant":[287],"between-group":[288],"differences":[289],"regards":[291],"CONCLUSIONS:":[298],"Among":[299],"newly":[301,327],"diagnosed":[302,328],"asthma,":[304,334],"among":[324],"those":[325],"controlled,":[329,331],"non-severe":[333]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-02T00:00:00"}
