{"id":"https://openalex.org/W7215100612","doi":"https://doi.org/10.64898/2026.09.29.755342","title":"Neocortical Feedback Biases Hippocampal Reactivation Toward Unconsolidated Memories in a Predictive-Coding Model of Systems Consolidation","display_name":"Neocortical Feedback Biases Hippocampal Reactivation Toward Unconsolidated Memories in a Predictive-Coding Model of Systems Consolidation","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7215100612","doi":"https://doi.org/10.64898/2026.09.29.755342"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.29.755342","doi":"https://doi.org/10.64898/2026.09.29.755342","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.29.755342","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.29.755342.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.29.755342.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040385511","display_name":"Paul Saighi","orcid":"https://orcid.org/0000-0001-9055-2762","observed_orcids":["https://orcid.org/0000-0001-9055-2762"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4387154659","display_name":"Centre Neurosciences int\u00e9gratives et Cognition","ror":"https://ror.org/02fgakj19","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4387154659"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Saighi Paul","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, CNRS, Integrative Neuroscience and Cognition Center (INCC), 75006, Paris, France"],"raw_orcid":"https://orcid.org/0000-0001-9055-2762","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, CNRS, Integrative Neuroscience and Cognition Center (INCC), 75006, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4387154659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040385511"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4387154659"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10918","display_name":"Memory Processes and Influences","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-consolidation","display_name":"systems consolidation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/hippocampal-reactivation","display_name":"hippocampal reactivation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/memory-replay","display_name":"memory replay","score":0.8960000276565552},{"id":"https://openalex.org/keywords/predictive-coding","display_name":"predictive coding","score":0.8500000238418579},{"id":"https://openalex.org/keywords/memory-transfer","display_name":"memory transfer","score":0.5490000247955322},{"id":"https://openalex.org/keywords/free-energy","display_name":"free energy","score":0.515999972820282},{"id":"https://openalex.org/keywords/prediction-error","display_name":"prediction error","score":0.5360000133514404},{"id":"https://openalex.org/keywords/associative-memory-networks","display_name":"associative memory networks","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7311000227928162},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7087000012397766},{"id":"https://openalex.org/C2777222312","wikidata":"https://www.wikidata.org/wiki/Q726562","display_name":"Neocortex","level":2,"score":0.7038000226020813},{"id":"https://openalex.org/C48455012","wikidata":"https://www.wikidata.org/wiki/Q2892593","display_name":"Memory consolidation","level":3,"score":0.6182000041007996},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5376999974250793},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45239999890327454},{"id":"https://openalex.org/C53442348","wikidata":"https://www.wikidata.org/wiki/Q745101","display_name":"Content-addressable memory","level":3,"score":0.44279998540878296},{"id":"https://openalex.org/C21963081","wikidata":"https://www.wikidata.org/wiki/Q11337567","display_name":"Working memory","level":3,"score":0.43529999256134033},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.41659998893737793},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36309999227523804},{"id":"https://openalex.org/C88576662","wikidata":"https://www.wikidata.org/wiki/Q18646","display_name":"Episodic memory","level":3,"score":0.3294000029563904},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.3140000104904175},{"id":"https://openalex.org/C103539492","wikidata":"https://www.wikidata.org/wiki/Q18648","display_name":"Neuroanatomy of memory","level":5,"score":0.3102000057697296},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.30469998717308044},{"id":"https://openalex.org/C159423971","wikidata":"https://www.wikidata.org/wiki/Q177251","display_name":"Associative property","level":2,"score":0.3034000098705292},{"id":"https://openalex.org/C187782996","wikidata":"https://www.wikidata.org/wiki/Q9390548","display_name":"Neural ensemble","level":2,"score":0.29159998893737793},{"id":"https://openalex.org/C24590219","wikidata":"https://www.wikidata.org/wiki/Q18601","display_name":"Long-term memory","level":3,"score":0.26600000262260437},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.2606000006198883},{"id":"https://openalex.org/C3832189","wikidata":"https://www.wikidata.org/wiki/Q8588916","display_name":"Models of neural computation","level":3,"score":0.2549000084400177}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.29.755342","doi":"https://doi.org/10.64898/2026.09.29.755342","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.29.755342","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.29.755342.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.29.755342","doi":"https://doi.org/10.64898/2026.09.29.755342","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.29.755342","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.29.755342.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7215100612.pdf","grobid_xml":"https://content.openalex.org/works/W7215100612.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1980576528","https://openalex.org/W1980940513","https://openalex.org/W1988013646","https://openalex.org/W1994475466","https://openalex.org/W1997226120","https://openalex.org/W2017814058","https://openalex.org/W2047057213","https://openalex.org/W2047999252","https://openalex.org/W2062240599","https://openalex.org/W2071290167","https://openalex.org/W2075312701","https://openalex.org/W2076327464","https://openalex.org/W2092284040","https://openalex.org/W2101967150","https://openalex.org/W2112246162","https://openalex.org/W2112823205","https://openalex.org/W2120574801","https://openalex.org/W2127958135","https://openalex.org/W2127968061","https://openalex.org/W2128084896","https://openalex.org/W2131352719","https://openalex.org/W2134460774","https://openalex.org/W2168101731","https://openalex.org/W2182128059","https://openalex.org/W2201581102","https://openalex.org/W2237059274","https://openalex.org/W2406558043","https://openalex.org/W2510739097","https://openalex.org/W2604988916","https://openalex.org/W2617647752","https://openalex.org/W2745165449","https://openalex.org/W2903812730","https://openalex.org/W2922284438","https://openalex.org/W2950552440","https://openalex.org/W2950770251","https://openalex.org/W2952504784","https://openalex.org/W2970568021","https://openalex.org/W3093704180","https://openalex.org/W3132033538","https://openalex.org/W3178029257","https://openalex.org/W3206314049","https://openalex.org/W4210673222","https://openalex.org/W4225248781","https://openalex.org/W4247532959","https://openalex.org/W4299286143","https://openalex.org/W4307342067","https://openalex.org/W4312181332","https://openalex.org/W4324129500","https://openalex.org/W4360820043","https://openalex.org/W4365483405","https://openalex.org/W4383823266","https://openalex.org/W4384922492","https://openalex.org/W4388971894","https://openalex.org/W4389506948","https://openalex.org/W4391027709","https://openalex.org/W4399287105"],"related_works":["https://openalex.org/W2948630462","https://openalex.org/W2909218809","https://openalex.org/W7167316205","https://openalex.org/W4381611524","https://openalex.org/W2329712532","https://openalex.org/W4307342067","https://openalex.org/W2969512327","https://openalex.org/W2125938763","https://openalex.org/W2972988718","https://openalex.org/W93980065"],"abstract_inverted_index":{"Abstract":[0],"During":[1],"sleep":[2],"and":[3,44,90,96,110,147,169,280],"quiet":[4],"wakefulness,":[5],"the":[6,31,48,73,80,94,170,222,245,253],"brain":[7],"spontaneously":[8],"revisits":[9],"neural":[10,143],"activity":[11,183,193,209],"patterns":[12,284],"associated":[13],"with":[14,158,277],"previous":[15],"experience,":[16],"a":[17,176,294],"phenomenon":[18],"known":[19],"as":[20,59,151],"reactivation,":[21],"or":[22,62],"replay.":[23],"Reactivation":[24],"is":[25,52],"thought":[26],"to":[27,108,244,304],"support":[28,199,305],"systems":[29,312],"consolidation,":[30],"process":[32],"by":[33,127,162],"which":[34,181,197,298],"memory":[35,56,84,140,156,258,267,309],"retrieval":[36],"becomes":[37],"progressively":[38],"more":[39],"dependent":[40,46],"on":[41,47,238,264],"neocortical":[42,111,185,188,198,214,234,254,299],"circuits":[43,112],"less":[45],"hippocampus.":[49],"Importantly,":[50],"reactivation":[51,82,303],"not":[53],"indiscriminate:":[54],"some":[55],"traces,":[57,85],"such":[58],"newly":[60],"acquired":[61],"weakly":[63],"learned":[64],"ones,":[65],"are":[66,149],"preferentially":[67],"reactivated.":[68],"These":[69],"observations":[70],"have":[71,103],"motivated":[72,161],"development":[74],"of":[75,83,125,212,308],"computational":[76],"models":[77,102],"accounting":[78],"for":[79,88,196,272],"spontaneous":[81,239],"their":[86,91,278],"prioritisation":[87,219],"replay,":[89],"transfer":[92,138,307],"between":[93,142,165],"hippocampus":[95,146],"neocortex.":[97],"In":[98,231],"parallel,":[99],"predictive-coding":[100],"(PC)":[101],"shown":[104],"how":[105,129],"computations":[106],"attributed":[107],"hippocampal":[109,166,182,192,208,240,302],"can":[113,137],"arise":[114],"from":[115,221,227],"local":[116],"prediction-error":[117],"dynamics.":[118],"Here,":[119],"we":[120,250],"connect":[121],"these":[122,291],"two":[123,152],"lines":[124],"work":[126],"showing":[128],"autonomous":[130],"intrinsic":[131],"dynamics":[132],"in":[133,180,297],"coupled":[134,153],"PC":[135,154,295],"networks":[136],"stored":[139],"content":[141,195,259,310],"systems.":[144],"The":[145],"neocortex":[148],"modelled":[150],"associative":[155],"networks,":[157],"asymmetric":[159],"coupling":[160,174],"reported":[163],"interactions":[164],"area":[167],"CA1":[168],"prefrontal":[171],"cortex.":[172],"This":[173,269],"establishes":[175],"closed-loop":[177],"hippocampal-neocortical":[178],"dialogue":[179,223],"drives":[184],"learning,":[186],"while":[187],"feedback":[189,206,300],"biases":[190],"subsequent":[191],"toward":[194,210],"remains":[200],"weak.":[201],"We":[202],"prove":[203],"that":[204,218,252],"this":[205],"steers":[207],"states":[211],"higher":[213],"free":[215],"energy,":[216],"so":[217],"emerges":[220],"itself":[224],"rather":[225],"than":[226,261],"an":[228],"explicit":[229],"scheduler.":[230],"our":[232],"model,":[233],"learning":[235],"relies":[236],"exclusively":[237],"activity,":[241],"without":[242],"access":[243],"initial":[246],"training":[247,263],"corpus.":[248],"Nevertheless,":[249],"show":[251],"network":[255],"acquires":[256],"correlated":[257,274],"faster":[260],"direct":[262],"randomly":[265],"sampled":[266],"patterns.":[268],"advantage":[270],"appeared":[271],"sufficiently":[273],"patterns,":[275],"grew":[276],"correlation,":[279],"persisted":[281],"when":[282],"new":[283],"were":[285],"incrementally":[286],"added":[287],"during":[288,311],"transfer.":[289],"Together,":[290],"results":[292],"provide":[293],"account":[296],"organises":[301],"efficient":[306],"consolidation.":[313]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-02T00:00:00"}
