{"id":"https://openalex.org/W7215099208","doi":"https://doi.org/10.1038/s41598-026-69139-5","title":"Skin carotenoid levels are associated with blood amyloid-beta 42/40 ratios in healthy individuals under 60 years of age","display_name":"Skin carotenoid levels are associated with blood amyloid-beta 42/40 ratios in healthy individuals under 60 years of age","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7215099208","doi":"https://doi.org/10.1038/s41598-026-69139-5"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-69139-5","doi":"https://doi.org/10.1038/s41598-026-69139-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-69139-5","pdf_url":"https://www.nature.com/articles/s41598-026-69139-5_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-69139-5_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068646135","display_name":"T. Yamauchi","orcid":"https://orcid.org/0009-0006-9060-2604","observed_orcids":["https://orcid.org/0009-0006-9060-2604"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]},{"id":"https://openalex.org/I4405265586","display_name":"Kagome Co., Ltd. (Japan)","ror":"https://ror.org/057c9m085","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265586"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshitaka Yamauchi","raw_affiliation_strings":["Department of Medical Data Intelligence, Research Center for Health-Medical Data Science, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan","Diet & Well-being Research Institute, KAGOME CO., LTD., Nasushiobara, Japan"],"raw_orcid":"https://orcid.org/0009-0006-9060-2604","affiliations":[{"raw_affiliation_string":"Department of Medical Data Intelligence, Research Center for Health-Medical Data Science, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]},{"raw_affiliation_string":"Diet & Well-being Research Institute, KAGOME CO., LTD., Nasushiobara, Japan","institution_ids":["https://openalex.org/I4405265586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072004492","display_name":"Naoko Waki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405265586","display_name":"Kagome Co., Ltd. (Japan)","ror":"https://ror.org/057c9m085","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265586"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoko Waki","raw_affiliation_strings":["Diet & Well-being Research Institute, KAGOME CO., LTD., Nasushiobara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diet & Well-being Research Institute, KAGOME CO., LTD., Nasushiobara, Japan","institution_ids":["https://openalex.org/I4405265586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154088654","display_name":"Shigenori Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405265586","display_name":"Kagome Co., Ltd. (Japan)","ror":"https://ror.org/057c9m085","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265586"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigenori Suzuki","raw_affiliation_strings":["Diet & Well-being Research Institute, KAGOME CO., LTD., Nasushiobara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diet & Well-being Research Institute, KAGOME CO., LTD., Nasushiobara, Japan","institution_ids":["https://openalex.org/I4405265586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104219565","display_name":"Shun Murakami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I54594937","display_name":"Sysmex (Japan)","ror":"https://ror.org/00gfstq19","country_code":"JP","type":"company","lineage":["https://openalex.org/I54594937"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shun Murakami","raw_affiliation_strings":["Central Research Laboratories, Sysmex Corporation, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratories, Sysmex Corporation, Kobe, Japan","institution_ids":["https://openalex.org/I54594937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053701790","display_name":"Kengo Ishiki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I54594937","display_name":"Sysmex (Japan)","ror":"https://ror.org/00gfstq19","country_code":"JP","type":"company","lineage":["https://openalex.org/I54594937"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kengo Ishiki","raw_affiliation_strings":["Central Research Laboratories, Sysmex Corporation, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratories, Sysmex Corporation, Kobe, Japan","institution_ids":["https://openalex.org/I54594937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067379475","display_name":"Kazuto Yamashita","orcid":"https://orcid.org/0000-0002-9793-0751","observed_orcids":["https://orcid.org/0000-0002-9793-0751"]},"institutions":[{"id":"https://openalex.org/I54594937","display_name":"Sysmex (Japan)","ror":"https://ror.org/00gfstq19","country_code":"JP","type":"company","lineage":["https://openalex.org/I54594937"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuto Yamashita","raw_affiliation_strings":["Central Research Laboratories, Sysmex Corporation, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratories, Sysmex Corporation, Kobe, Japan","institution_ids":["https://openalex.org/I54594937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077753827","display_name":"Masahiro Miura","orcid":"https://orcid.org/0000-0003-3172-4944","observed_orcids":["https://orcid.org/0000-0003-3172-4944"]},"institutions":[{"id":"https://openalex.org/I54594937","display_name":"Sysmex (Japan)","ror":"https://ror.org/00gfstq19","country_code":"JP","type":"company","lineage":["https://openalex.org/I54594937"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Miura","raw_affiliation_strings":["Central Research Laboratories, Sysmex Corporation, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratories, Sysmex Corporation, Kobe, Japan","institution_ids":["https://openalex.org/I54594937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004361618","display_name":"Jun Sato","orcid":"https://orcid.org/0000-0001-9249-6522","observed_orcids":["https://orcid.org/0000-0001-9249-6522"]},"institutions":[{"id":"https://openalex.org/I54594937","display_name":"Sysmex (Japan)","ror":"https://ror.org/00gfstq19","country_code":"JP","type":"company","lineage":["https://openalex.org/I54594937"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Sato","raw_affiliation_strings":["Strategic Technology Planning, Technology Strategy, Sysmex Corporation, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Strategic Technology Planning, Technology Strategy, Sysmex Corporation, Kobe, Japan","institution_ids":["https://openalex.org/I54594937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103091662","display_name":"Toshiyuki Sato","orcid":"https://orcid.org/0000-0002-4515-4201","observed_orcids":["https://orcid.org/0000-0002-4515-4201","https://orcid.org/0009-0009-5460-2625"]},"institutions":[{"id":"https://openalex.org/I54594937","display_name":"Sysmex (Japan)","ror":"https://ror.org/00gfstq19","country_code":"JP","type":"company","lineage":["https://openalex.org/I54594937"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Sato","raw_affiliation_strings":["Central Research Laboratories, Sysmex Corporation, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratories, Sysmex Corporation, Kobe, Japan","institution_ids":["https://openalex.org/I54594937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002456826","display_name":"Tatsuya Mikami","orcid":"https://orcid.org/0000-0002-6657-6446","observed_orcids":["https://orcid.org/0000-0002-6657-6446"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuya Mikami","raw_affiliation_strings":["Department of Preemptive Medicine, Innovation Center for Health Promotion, Hirosaki University Graduate School of Medicine, Hirosaki, Japan","Department of Vegetable Life Science, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preemptive Medicine, Innovation Center for Health Promotion, Hirosaki University Graduate School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]},{"raw_affiliation_string":"Department of Vegetable Life Science, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044155553","display_name":"Koichi Murashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Murashita","raw_affiliation_strings":["Department of Vegetable Life Science, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan","Research Institute of Health Innovation, Hirosaki University, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vegetable Life Science, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]},{"raw_affiliation_string":"Research Institute of Health Innovation, Hirosaki University, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041484422","display_name":"Shigeyuki Nakaji","orcid":"https://orcid.org/0000-0002-4190-5151","observed_orcids":["https://orcid.org/0000-0002-4190-5151"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeyuki Nakaji","raw_affiliation_strings":["Department of Preemptive Medicine, Innovation Center for Health Promotion, Hirosaki University Graduate School of Medicine, Hirosaki, Japan","Department of Vegetable Life Science, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preemptive Medicine, Innovation Center for Health Promotion, Hirosaki University Graduate School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]},{"raw_affiliation_string":"Department of Vegetable Life Science, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088441205","display_name":"Yoshinori Tamada","orcid":"https://orcid.org/0000-0003-3483-9712","observed_orcids":["https://orcid.org/0000-0003-3483-9712"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinori Tamada","raw_affiliation_strings":["Department of Medical Data Intelligence, Research Center for Health-Medical Data Science, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan","Department of Vegetable Life Science, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Data Intelligence, Research Center for Health-Medical Data Science, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]},{"raw_affiliation_string":"Department of Vegetable Life Science, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5154014266","display_name":"Ken Itoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Itoh","raw_affiliation_strings":["Department of Stress Response Science, Biomedical Research Center, Hirosaki University Graduate School of Medicine, Hirosaki, Japan","Department of Vegetable Life Science, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stress Response Science, Biomedical Research Center, Hirosaki University Graduate School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]},{"raw_affiliation_string":"Department of Vegetable Life Science, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5068646135"],"corresponding_institution_ids":["https://openalex.org/I146516829","https://openalex.org/I4405265586"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72331577,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.1023000031709671,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carotenoids","display_name":"carotenoids","score":0.8700000047683716},{"id":"https://openalex.org/keywords/amyloid-beta-42-40-ratio","display_name":"amyloid-beta 42/40 ratio","score":0.9470000267028809},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9620000123977661},{"id":"https://openalex.org/keywords/amyloid-beta-aggregation","display_name":"amyloid-beta aggregation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/lutein","display_name":"lutein","score":0.949999988079071},{"id":"https://openalex.org/keywords/alpha-carotene","display_name":"alpha-carotene","score":0.996999979019165},{"id":"https://openalex.org/keywords/dementia-biomarkers","display_name":"dementia biomarkers","score":0.7269999980926514},{"id":"https://openalex.org/keywords/healthy-young-adults","display_name":"healthy young adults","score":0.5070000290870667},{"id":"https://openalex.org/keywords/iwaki-health-promotion-project","display_name":"Iwaki Health Promotion Project","score":0.9169999957084656}],"concepts":[{"id":"https://openalex.org/C28781525","wikidata":"https://www.wikidata.org/wiki/Q191907","display_name":"Carotenoid","level":2,"score":0.9221000075340271},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.7508000135421753},{"id":"https://openalex.org/C2778411929","wikidata":"https://www.wikidata.org/wiki/Q422067","display_name":"Lutein","level":3,"score":0.6675999760627747},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5450000166893005},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41760000586509705},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.41749998927116394},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4065999984741211},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39469999074935913},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.34549999237060547},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3418999910354614},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.3391000032424927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33880001306533813},{"id":"https://openalex.org/C1621761","wikidata":"https://www.wikidata.org/wiki/Q7997549","display_name":"Whole blood","level":2,"score":0.3212999999523163},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.30869999527931213},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3084999918937683},{"id":"https://openalex.org/C170853661","wikidata":"https://www.wikidata.org/wiki/Q193788","display_name":"Sunlight","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.27399998903274536},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.2502000033855438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41598-026-69139-5","doi":"https://doi.org/10.1038/s41598-026-69139-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-69139-5","pdf_url":"https://www.nature.com/articles/s41598-026-69139-5_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-69139-5","doi":"https://doi.org/10.1038/s41598-026-69139-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-69139-5","pdf_url":"https://www.nature.com/articles/s41598-026-69139-5_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320317814","display_name":"Sysmex Corporation","ror":"https://ror.org/00gfstq19"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7215099208.pdf","grobid_xml":"https://content.openalex.org/works/W7215099208.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W4220771887","https://openalex.org/W4400475681","https://openalex.org/W4411122023"],"related_works":["https://openalex.org/W2182022980","https://openalex.org/W308892131","https://openalex.org/W3172684630","https://openalex.org/W2914291829","https://openalex.org/W3098520781","https://openalex.org/W2021041444","https://openalex.org/W7170647930","https://openalex.org/W1951537847","https://openalex.org/W4362506322","https://openalex.org/W2064156568"],"abstract_inverted_index":{"Dementia":[0],"prevalence":[1],"is":[2,17],"increasing":[3],"worldwide,":[4],"with":[5,168,179],"Alzheimer\u2019s":[6],"disease":[7],"(AD)":[8],"being":[9],"the":[10,71,112,127,139,144,158],"most":[11],"common":[12],"type.":[13],"Amyloid-beta":[14],"(A\u03b2)":[15],"aggregation":[16,34],"an":[18],"early":[19],"pathological":[20],"event":[21],"in":[22,29,77,101,111,126,147,184],"AD.":[23],"Although":[24],"carotenoids":[25,160],"have":[26,60],"been":[27],"shown":[28],"vitro":[30],"to":[31,143],"inhibit":[32],"A\u03b2":[33,182],"through":[35],"antioxidant":[36],"and":[37,55,86,88,97,163],"anti-inflammatory":[38],"effects,":[39],"human":[40],"evidence":[41],"remains":[42],"limited.":[43],"Recently,":[44],"blood-based":[45],"biomarkers":[46,91],"such":[47],"as":[48],"A\u03b242/40":[49,122,148,169],"ratios,":[50],"phosphorylated":[51],"tau":[52],"(p-tau181,":[53],"p-tau217),":[54],"neurofilament":[56],"light":[57],"chain":[58],"(NfL)":[59],"enabled":[61],"assessment":[62],"of":[63,115,138,155],"AD-related":[64,90],"pathology.":[65],"We":[66],"analyzed":[67],"770":[68],"participants":[69,106],"from":[70],"2024":[72],"Iwaki":[73],"Health":[74],"Promotion":[75],"Project":[76],"Japan.":[78],"The":[79,136],"associations":[80],"between":[81],"circulating":[82,174],"carotenoid":[83,117,175],"levels":[84,118,176],"(skin":[85],"blood)":[87],"blood":[89,159],"were":[92,165,177],"examined":[93],"using":[94],"adjusted":[95],"linear":[96],"nonlinear":[98],"regression":[99],"models":[100],"a":[102],"cross-sectional":[103,145],"design.":[104],"Among":[105,157],"under":[107,186],"60":[108,187],"years,":[109],"those":[110,125],"highest":[113],"quartile":[114,129],"skin":[116],"had":[119],"significantly":[120],"higher":[121,173],"ratios":[123],"than":[124],"lowest":[128],"(\u03b2":[130],"=":[131],"0.0024,":[132],"95%":[133],"CI:":[134],"0.0003\u20130.0046).":[135],"magnitude":[137],"association":[140],"was":[141],"comparable":[142],"difference":[146],"ratio":[149],"observed":[150],"across":[151],"approximately":[152],"4\u20138":[153],"years":[154],"age.":[156],"measured,":[161],"lutein":[162],"\u03b1-carotene":[164],"positively":[166],"associated":[167,178],"ratios.":[170],"In":[171],"summary,":[172],"more":[180],"favorable":[181],"profiles":[183],"individuals":[185],"years.":[188]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-02T00:00:00"}