{"id":"https://openalex.org/W7215073740","doi":"https://doi.org/10.2174/0118715265468377260910101619","title":"Chemical Composition, Antibacterial and Antioxidant Properties, and Molecular Docking of Major Compounds from Ocimum lamiifolium Leaves: A Common Home-Remedy Plant in Ethiopia","display_name":"Chemical Composition, Antibacterial and Antioxidant Properties, and Molecular Docking of Major Compounds from Ocimum lamiifolium Leaves: A Common Home-Remedy Plant in Ethiopia","publication_year":2026,"publication_date":"2026-09-28","ids":{"openalex":"https://openalex.org/W7215073740","doi":"https://doi.org/10.2174/0118715265468377260910101619","pmid":"https://pubmed.ncbi.nlm.nih.gov/42816990"},"language":"en","primary_location":{"id":"doi:10.2174/0118715265468377260910101619","doi":"https://doi.org/10.2174/0118715265468377260910101619","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0118715265468377260910101619","pdf_url":null,"source":{"id":"https://openalex.org/S2765027702","display_name":"Infectious Disorders - Drug Targets","issn_l":"1871-5265","issn":["1871-5265","2212-3989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infectious Disorders - Drug Targets","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100497964","display_name":"shewarega habtamu haile","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I865572129","display_name":"Adama Science and Technology University","ror":"https://ror.org/02ccba128","country_code":"ET","type":"education","lineage":["https://openalex.org/I865572129"]}],"countries":["ET"],"is_corresponding":false,"raw_author_name":"Shewarega Habtamu Haile","raw_affiliation_strings":["Department of Chemical Engineering, Adama Science and Technology University, Adama, Ethiopia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Adama Science and Technology University, Adama, Ethiopia","institution_ids":["https://openalex.org/I865572129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065507900","display_name":"Melakuu Tesfaye Alemea","orcid":"https://orcid.org/0000-0002-8466-9566","observed_orcids":["https://orcid.org/0000-0002-8466-9566"]},"institutions":[{"id":"https://openalex.org/I865572129","display_name":"Adama Science and Technology University","ror":"https://ror.org/02ccba128","country_code":"ET","type":"education","lineage":["https://openalex.org/I865572129"]}],"countries":["ET"],"is_corresponding":false,"raw_author_name":"Melakuu Tesfaye Alemea","raw_affiliation_strings":["Department of Chemical Engineering, Adama Science and Technology University, Adama, Ethiopia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Adama Science and Technology University, Adama, Ethiopia","institution_ids":["https://openalex.org/I865572129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040392358","display_name":"Tekalign Begna","orcid":"https://orcid.org/0000-0002-0401-6638","observed_orcids":["https://orcid.org/0000-0002-0401-6638"]},"institutions":[{"id":"https://openalex.org/I113018520","display_name":"Gyeongkuk National University","ror":"https://ror.org/04wd10e19","country_code":"KR","type":"education","lineage":["https://openalex.org/I113018520"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tekalign Begna","raw_affiliation_strings":["Agricultural Science and Technology Research Institute, Andong National University, South Korea","Department of Plant Medicals, Andong National University, Andong GB 36729, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agricultural Science and Technology Research Institute, Andong National University, South Korea","institution_ids":["https://openalex.org/I113018520"]},{"raw_affiliation_string":"Department of Plant Medicals, Andong National University, Andong GB 36729, South Korea","institution_ids":["https://openalex.org/I113018520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154085537","display_name":"Chuleui Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113018520","display_name":"Gyeongkuk National University","ror":"https://ror.org/04wd10e19","country_code":"KR","type":"education","lineage":["https://openalex.org/I113018520"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chuleui Jung","raw_affiliation_strings":["Agricultural Science and Technology Research Institute, Andong National University, South Korea","Department of Plant Medicals, Andong National University, Andong GB 36729, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agricultural Science and Technology Research Institute, Andong National University, South Korea","institution_ids":["https://openalex.org/I113018520"]},{"raw_affiliation_string":"Department of Plant Medicals, Andong National University, Andong GB 36729, South Korea","institution_ids":["https://openalex.org/I113018520"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045508655","display_name":"Aman Dekebo","orcid":"https://orcid.org/0000-0003-4767-606X","observed_orcids":["https://orcid.org/0000-0003-4767-606X"]},"institutions":[{"id":"https://openalex.org/I113018520","display_name":"Gyeongkuk National University","ror":"https://ror.org/04wd10e19","country_code":"KR","type":"education","lineage":["https://openalex.org/I113018520"]},{"id":"https://openalex.org/I865572129","display_name":"Adama Science and Technology University","ror":"https://ror.org/02ccba128","country_code":"ET","type":"education","lineage":["https://openalex.org/I865572129"]}],"countries":["ET","KR"],"is_corresponding":true,"raw_author_name":"Aman Dekebo","raw_affiliation_strings":["Department of Applied Chemistry, Adama Science and Technology University, Adama, Ethiopia","Department of Plant Medicals, Andong National University, Andong GB 36729, South Korea"],"raw_orcid":"https://orcid.org/0000-0003-4767-606X","affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, Adama Science and Technology University, Adama, Ethiopia","institution_ids":["https://openalex.org/I865572129"]},{"raw_affiliation_string":"Department of Plant Medicals, Andong National University, Andong GB 36729, South Korea","institution_ids":["https://openalex.org/I113018520"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045508655"],"corresponding_institution_ids":["https://openalex.org/I113018520","https://openalex.org/I865572129"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ocimum-lamiifolium","display_name":"Ocimum lamiifolium","score":1.0},{"id":"https://openalex.org/keywords/essential-oils","display_name":"essential oils","score":0.7020000219345093},{"id":"https://openalex.org/keywords/leaf-extract","display_name":"leaf extract","score":0.6600000262260437},{"id":"https://openalex.org/keywords/chemical-composition","display_name":"chemical composition","score":0.8190000057220459},{"id":"https://openalex.org/keywords/monoterpenoids","display_name":"monoterpenoids","score":0.9049999713897705},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8059999942779541},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.9670000076293945},{"id":"https://openalex.org/keywords/delta-cadinene","display_name":"\u03b4-cadinene","score":0.9309999942779541},{"id":"https://openalex.org/keywords/dna-gyrase-inhibitors","display_name":"DNA gyrase inhibitors","score":0.8569999933242798},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8069999814033508},{"id":"https://openalex.org/keywords/lamiaceae","display_name":"Lamiaceae","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7960000038146973},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7186999917030334},{"id":"https://openalex.org/C2779342943","wikidata":"https://www.wikidata.org/wiki/Q148818","display_name":"Ocimum","level":2,"score":0.5899999737739563},{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.5295000076293945},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5087000131607056},{"id":"https://openalex.org/C74940592","wikidata":"https://www.wikidata.org/wiki/Q6723254","display_name":"Maceration (sewage)","level":2,"score":0.48019999265670776},{"id":"https://openalex.org/C2777278459","wikidata":"https://www.wikidata.org/wiki/Q170885","display_name":"Essential oil","level":2,"score":0.4359999895095825},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.39340001344680786},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.36649999022483826},{"id":"https://openalex.org/C2778609962","wikidata":"https://www.wikidata.org/wiki/Q424567","display_name":"Apigenin","level":4,"score":0.35679998993873596},{"id":"https://openalex.org/C2777728882","wikidata":"https://www.wikidata.org/wiki/Q407142","display_name":"Phenols","level":2,"score":0.34310001134872437},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.33309999108314514},{"id":"https://openalex.org/C2780470866","wikidata":"https://www.wikidata.org/wiki/Q423357","display_name":"Eugenol","level":2,"score":0.32499998807907104},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3181000053882599},{"id":"https://openalex.org/C44937612","wikidata":"https://www.wikidata.org/wiki/Q212364","display_name":"Terpene","level":2,"score":0.31709998846054077},{"id":"https://openalex.org/C205345274","wikidata":"https://www.wikidata.org/wiki/Q873009","display_name":"Gas chromatography\u2013mass spectrometry","level":3,"score":0.31029999256134033},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.3050000071525574},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.26100000739097595},{"id":"https://openalex.org/C2777143434","wikidata":"https://www.wikidata.org/wiki/Q53476","display_name":"Lamiaceae","level":2,"score":0.2590999901294708},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.2565999925136566},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.2563999891281128},{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.2549999952316284},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.25270000100135803}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2174/0118715265468377260910101619","doi":"https://doi.org/10.2174/0118715265468377260910101619","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0118715265468377260910101619","pdf_url":null,"source":{"id":"https://openalex.org/S2765027702","display_name":"Infectious Disorders - Drug Targets","issn_l":"1871-5265","issn":["1871-5265","2212-3989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infectious Disorders - Drug Targets","raw_type":"journal-article"},{"id":"pmid:42816990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42816990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infectious disorders drug targets","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2808616981","https://openalex.org/W6931093565","https://openalex.org/W2290313797","https://openalex.org/W7131648209","https://openalex.org/W2740813565","https://openalex.org/W3180151005","https://openalex.org/W4400491785","https://openalex.org/W7125162107","https://openalex.org/W2908155919","https://openalex.org/W3117210664"],"abstract_inverted_index":{"INTRODUCTION:":[0],"This":[1,212],"study":[2],"aimed":[3],"to":[4,159],"characterize":[5],"the":[6,66,70,87,91,101,109,117,129,145,160,163,175,185,192,200],"chemical":[7,46],"and":[8,21,35,40,55,69,131,139,204,232],"biological":[9],"properties":[10],"of":[11,86,90,108,137,154,191],"Ocimum":[12],"lamiifolium":[13,93,225],"Hochst.":[14],"ex":[15],"Benth.":[16],"(family:":[17],"Lamiaceae)":[18],"leaf":[19],"extracts":[20,123,133,226],"explore":[22],"their":[23],"potential":[24,228],"applications.":[25],"METHODS:":[26],"Plant":[27],"leaves":[28],"were":[29,48,73,98,113],"extracted":[30],"with":[31,128,144,208],"ethanol":[32],"via":[33],"maceration":[34],"hydrodistillation,":[36],"yielding":[37],"5.95%":[38],"(w/w)":[39],"2.25%":[41],"(v/w)":[42],"extracts,":[43],"respectively.":[44],"The":[45,121,170],"compositions":[47],"identified":[49,99,194],"using":[50],"gas":[51],"chromatography-mass":[52],"spectrometry":[53],"(GC-MS)":[54],"Fourier-transform":[56],"infrared":[57],"spectroscopy":[58],"(FTIR).":[59],"Using":[60],"1,1-diphenyl-2-picrylhydrazyl":[61],"(DPPH)":[62],"scavenging":[63],"assays,":[64],"both":[65],"ethanolic":[67,103,119],"extract":[68,165,177],"essential":[71,94],"oil":[72],"evaluated":[74],"for":[75,84,106],"antioxidant":[76,126,233],"activity.":[77],"RESULTS:":[78],"Thirty":[79],"compounds,":[80],"primarily":[81],"monoterpenoids,":[82],"accounted":[83],"81.13%":[85],"total":[88],"components":[89,195],"O.":[92,224],"oil.":[95],"55":[96],"compounds":[97,216],"in":[100,116],"crude":[102,118],"extract,":[104,162],"accounting":[105],"99%":[107],"total.":[110],"Hydrocarbon":[111],"terpenes":[112],"particularly":[114],"abundant":[115],"extract.":[120],"plant":[122],"showed":[124],"promising":[125],"activity,":[127],"EO":[130,161],"EE":[132,164,176],"having":[134],"IC50":[135,153],"values":[136],"1.56":[138],"2.52":[140],"\u03bcg/mL,":[141],"respectively,":[142],"compared":[143],"reference":[146],"stand-ard":[147],"ascorbic":[148],"acid,":[149],"which":[150],"had":[151],"an":[152],"3.90":[155],"\u03bcg/mL.":[156],"DISCUSSION:":[157],"Compared":[158],"exhibited":[166,199],"larger":[167],"inhibition":[168],"zones.":[169],"antimicrobial":[171],"results":[172],"suggest":[173],"that":[174,197,214],"contains":[178],"more":[179],"active":[180],"components,":[181],"as":[182,219,230],"proven":[183],"by":[184],"GC-MS":[186],"results.":[187],"Molecular":[188],"docking":[189],"analysis":[190],"three":[193],"revealed":[196],"\u03b4-cadinene":[198],"highest":[201],"binding":[202],"affinity":[203],"formed":[205],"hydrophobic":[206],"interactions":[207],"8":[209],"amino":[210],"acids.":[211],"implies":[213],"these":[215],"may":[217],"function":[218],"DNA":[220],"gyrase":[221],"inhibitors.":[222],"CONCLUSION:":[223],"have":[227],"applications":[229],"antibacterial":[231],"agents.":[234]},"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2026-10-02T00:00:00"}