{"id":"https://openalex.org/W7214985236","doi":"https://doi.org/10.1007/s00204-026-04554-1","title":"Applicability of NAMs to support a read-across based hazard assessment workflow for systemic toxicity: a conazole case study","display_name":"Applicability of NAMs to support a read-across based hazard assessment workflow for systemic toxicity: a conazole case study","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7214985236","doi":"https://doi.org/10.1007/s00204-026-04554-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/42814138"},"language":"en","primary_location":{"id":"doi:10.1007/s00204-026-04554-1","doi":"https://doi.org/10.1007/s00204-026-04554-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00204-026-04554-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00204-026-04554-1.pdf","source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00204-026-04554-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016773569","display_name":"Barira Islam","orcid":"https://orcid.org/0000-0001-5882-6903","observed_orcids":["https://orcid.org/0000-0001-5882-6903"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Barira Islam","raw_affiliation_strings":["MID3, Certara UK, 1 Concourse Way, Level 2-Acero, Sheffield, S1 2BJ, United Kingdom. barira.islam@certara.com"],"raw_orcid":"https://orcid.org/0000-0001-5882-6903","affiliations":[{"raw_affiliation_string":"MID3, Certara UK, 1 Concourse Way, Level 2-Acero, Sheffield, S1 2BJ, United Kingdom. barira.islam@certara.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003133604","display_name":"Jenny Irwan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111966","display_name":"Fraunhofer Institute for Toxicology and Experimental Medicine","ror":"https://ror.org/02byjcr11","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210111966","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jenny Irwan","raw_affiliation_strings":["Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Munich, Germany","institution_ids":["https://openalex.org/I4210111966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050568899","display_name":"Lukas Wijaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Lukas Wijaya","raw_affiliation_strings":["Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019533826","display_name":"Bas ter Braak","orcid":"https://orcid.org/0000-0002-7290-4119","observed_orcids":["https://orcid.org/0000-0002-7290-4119"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bas ter Braak","raw_affiliation_strings":["Toxys B.V, Leiden Bio Science Park, Oegstgeest, 2342 DH, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toxys B.V, Leiden Bio Science Park, Oegstgeest, 2342 DH, the Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000258319","display_name":"Amer Jamalpoor","orcid":"https://orcid.org/0000-0001-5630-4159","observed_orcids":["https://orcid.org/0000-0001-5630-4159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amer Jamalpoor","raw_affiliation_strings":["Toxys B.V, Leiden Bio Science Park, Oegstgeest, 2342 DH, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-5630-4159","affiliations":[{"raw_affiliation_string":"Toxys B.V, Leiden Bio Science Park, Oegstgeest, 2342 DH, the Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010827750","display_name":"Tamara Meijer","orcid":"https://orcid.org/0000-0002-4623-3753","observed_orcids":["https://orcid.org/0000-0002-4623-3753"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tamara Meijer","raw_affiliation_strings":["Toxys B.V, Leiden Bio Science Park, Oegstgeest, 2342 DH, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-4623-3753","affiliations":[{"raw_affiliation_string":"Toxys B.V, Leiden Bio Science Park, Oegstgeest, 2342 DH, the Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033863197","display_name":"Cl\u00e9mence Budin","orcid":"https://orcid.org/0000-0003-0747-9985","observed_orcids":["https://orcid.org/0000-0003-0747-9985"]},"institutions":[{"id":"https://openalex.org/I3211772741","display_name":"BioDetection Systems (Netherlands)","ror":"https://ror.org/05396f476","country_code":"NL","type":"company","lineage":["https://openalex.org/I3211772741"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Clemence Budin","raw_affiliation_strings":["BioDetection Systems, Science Park 406, Amsterdam, 1098 XH, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioDetection Systems, Science Park 406, Amsterdam, 1098 XH, the Netherlands","institution_ids":["https://openalex.org/I3211772741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139399655","display_name":"Tjalf de Boer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3211772741","display_name":"BioDetection Systems (Netherlands)","ror":"https://ror.org/05396f476","country_code":"NL","type":"company","lineage":["https://openalex.org/I3211772741"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tjalf de Boer","raw_affiliation_strings":["BioDetection Systems, Science Park 406, Amsterdam, 1098 XH, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioDetection Systems, Science Park 406, Amsterdam, 1098 XH, the Netherlands","institution_ids":["https://openalex.org/I3211772741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104179310","display_name":"Shu Liu","orcid":"https://orcid.org/0000-0002-2904-0271","observed_orcids":["https://orcid.org/0000-0002-2904-0271"]},"institutions":[{"id":"https://openalex.org/I2801133538","display_name":"German Federal Institute for Risk Assessment (BfR)","ror":"https://ror.org/03k3ky186","country_code":"DE","type":"government","lineage":["https://openalex.org/I2801133538","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Shu Liu","raw_affiliation_strings":["German Centre for the Protection of Laboratory Animals (Bf3R) and Experimental Toxicology, German Federal Institute for Risk Assessment (BfR), Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2904-0271","affiliations":[{"raw_affiliation_string":"German Centre for the Protection of Laboratory Animals (Bf3R) and Experimental Toxicology, German Federal Institute for Risk Assessment (BfR), Berlin, Germany","institution_ids":["https://openalex.org/I2801133538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106939953","display_name":"Marlene Wedler","orcid":"https://orcid.org/0009-0004-4702-1324","observed_orcids":["https://orcid.org/0009-0004-4702-1324"]},"institutions":[{"id":"https://openalex.org/I2801133538","display_name":"German Federal Institute for Risk Assessment (BfR)","ror":"https://ror.org/03k3ky186","country_code":"DE","type":"government","lineage":["https://openalex.org/I2801133538","https://openalex.org/I2801963157"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marlene Wedler","raw_affiliation_strings":["German Centre for the Protection of Laboratory Animals (Bf3R) and Experimental Toxicology, German Federal Institute for Risk Assessment (BfR), Berlin, Germany","Institute for Biology, Freie Universit\u00e4t Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0009-0004-4702-1324","affiliations":[{"raw_affiliation_string":"German Centre for the Protection of Laboratory Animals (Bf3R) and Experimental Toxicology, German Federal Institute for Risk Assessment (BfR), Berlin, Germany","institution_ids":["https://openalex.org/I2801133538"]},{"raw_affiliation_string":"Institute for Biology, Freie Universit\u00e4t Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080208281","display_name":"Baiba Gukalova","orcid":"https://orcid.org/0000-0002-7057-4726","observed_orcids":["https://orcid.org/0000-0002-7057-4726"]},"institutions":[{"id":"https://openalex.org/I4405272566","display_name":"National Institute of Research and Innovation","ror":"https://ror.org/04bjckx48","country_code":"LV","type":"facility","lineage":["https://openalex.org/I4405272566"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Baiba Gukalova","raw_affiliation_strings":["National Institute of Research and Innovation, Riga, Latvia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Research and Innovation, Riga, Latvia","institution_ids":["https://openalex.org/I4405272566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153625632","display_name":"Edgars Liepins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272566","display_name":"National Institute of Research and Innovation","ror":"https://ror.org/04bjckx48","country_code":"LV","type":"facility","lineage":["https://openalex.org/I4405272566"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Edgars Liepins","raw_affiliation_strings":["National Institute of Research and Innovation, Riga, Latvia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Research and Innovation, Riga, Latvia","institution_ids":["https://openalex.org/I4405272566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123821873","display_name":"Jaione Telleria","orcid":"https://orcid.org/0009-0008-2630-5298","observed_orcids":["https://orcid.org/0009-0008-2630-5298"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaione Telleria","raw_affiliation_strings":["MedBioInformatics Solutions, Rambla de Catalu\u00f1a 14, 7\u00ba, 1\u00aa, Barcelona, 08007, Spain"],"raw_orcid":"https://orcid.org/0009-0008-2630-5298","affiliations":[{"raw_affiliation_string":"MedBioInformatics Solutions, Rambla de Catalu\u00f1a 14, 7\u00ba, 1\u00aa, Barcelona, 08007, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028427590","display_name":"Laura Ines Furlong","orcid":"https://orcid.org/0000-0002-9383-528X","observed_orcids":["https://orcid.org/0000-0002-9383-528X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Furlong","raw_affiliation_strings":["MedBioInformatics Solutions, Rambla de Catalu\u00f1a 14, 7\u00ba, 1\u00aa, Barcelona, 08007, Spain"],"raw_orcid":"https://orcid.org/0000-0002-9383-528X","affiliations":[{"raw_affiliation_string":"MedBioInformatics Solutions, Rambla de Catalu\u00f1a 14, 7\u00ba, 1\u00aa, Barcelona, 08007, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079921789","display_name":"Guillaume Ollitrault","orcid":"https://orcid.org/0009-0008-5119-9044","observed_orcids":["https://orcid.org/0009-0008-5119-9044"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210137329","display_name":"Unit of Functional and Adaptive Biology","ror":"https://ror.org/02z0jq636","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210137329"]},{"id":"https://openalex.org/I4403386693","display_name":"Physiologie De L'Axe Gonadotrope","ror":"https://ror.org/04gh2v067","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4403386693"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guillame Ollitrault","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, INSERM U1133, CNRS UMR 8251, Paris, France"],"raw_orcid":"https://orcid.org/0009-0008-5119-9044","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, INSERM U1133, CNRS UMR 8251, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210137329","https://openalex.org/I4403386693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153587845","display_name":"Sam Davidse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sam Davidse","raw_affiliation_strings":["Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092054222","display_name":"Tessa M. S. Hagens","orcid":"https://orcid.org/0009-0007-8381-0111","observed_orcids":["https://orcid.org/0009-0007-8381-0111"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tessa M. S. Hagens","raw_affiliation_strings":["Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117848912","display_name":"Sibel Bahtiri","orcid":"https://orcid.org/0009-0000-4111-0634","observed_orcids":["https://orcid.org/0009-0000-4111-0634"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sibel Bahtiri","raw_affiliation_strings":["Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005294445","display_name":"Olivier Taboureau","orcid":"https://orcid.org/0000-0001-7081-2491","observed_orcids":["https://orcid.org/0000-0001-7081-2491"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210137329","display_name":"Unit of Functional and Adaptive Biology","ror":"https://ror.org/02z0jq636","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210137329"]},{"id":"https://openalex.org/I4403386693","display_name":"Physiologie De L'Axe Gonadotrope","ror":"https://ror.org/04gh2v067","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4403386693"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Taboureau","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, INSERM U1133, CNRS UMR 8251, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, INSERM U1133, CNRS UMR 8251, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210137329","https://openalex.org/I4403386693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036171850","display_name":"Nadine Dreser","orcid":"https://orcid.org/0000-0002-7103-0990","observed_orcids":["https://orcid.org/0000-0002-7103-0990"]},"institutions":[{"id":"https://openalex.org/I189712700","display_name":"University of Konstanz","ror":"https://ror.org/0546hnb39","country_code":"DE","type":"education","lineage":["https://openalex.org/I189712700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nadine Dreser","raw_affiliation_strings":["Department of in vitro toxicology and biomedicine, Faculty of Sciences, University of Konstanz, Konstanz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of in vitro toxicology and biomedicine, Faculty of Sciences, University of Konstanz, Konstanz, Germany","institution_ids":["https://openalex.org/I189712700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035873021","display_name":"Philip Marx\u2010Stoelting","orcid":"https://orcid.org/0000-0002-6487-2153","observed_orcids":["https://orcid.org/0000-0002-6487-2153"]},"institutions":[{"id":"https://openalex.org/I2801133538","display_name":"German Federal Institute for Risk Assessment (BfR)","ror":"https://ror.org/03k3ky186","country_code":"DE","type":"government","lineage":["https://openalex.org/I2801133538","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philip Marx-Stoelting","raw_affiliation_strings":["German Centre for the Protection of Laboratory Animals (Bf3R) and Experimental Toxicology, German Federal Institute for Risk Assessment (BfR), Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6487-2153","affiliations":[{"raw_affiliation_string":"German Centre for the Protection of Laboratory Animals (Bf3R) and Experimental Toxicology, German Federal Institute for Risk Assessment (BfR), Berlin, Germany","institution_ids":["https://openalex.org/I2801133538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153668053","display_name":"Annika J\u00e4rvinen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Annika J\u00e4rvinen","raw_affiliation_strings":["Department of Pharmacy, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079220895","display_name":"Per Artursson","orcid":"https://orcid.org/0000-0002-3708-7395","observed_orcids":["https://orcid.org/0000-0002-3708-7395"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Per Artursson","raw_affiliation_strings":["Department of Pharmacy, Uppsala University, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-3708-7395","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029622436","display_name":"Patrik Lundquist","orcid":"https://orcid.org/0000-0002-7458-7882","observed_orcids":["https://orcid.org/0000-0002-7458-7882"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Patrik Lundquist","raw_affiliation_strings":["Department of Pharmacy, Uppsala University, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-7458-7882","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103125077","display_name":"Kathrin Bothe","orcid":"https://orcid.org/0000-0001-6470-8882","observed_orcids":["https://orcid.org/0000-0001-6470-8882"]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kathrin Bothe","raw_affiliation_strings":["Crop Science, Bayer AG, Monheim am Rhein, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6470-8882","affiliations":[{"raw_affiliation_string":"Crop Science, Bayer AG, Monheim am Rhein, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153662304","display_name":"Hennicke Kamp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801133538","display_name":"German Federal Institute for Risk Assessment (BfR)","ror":"https://ror.org/03k3ky186","country_code":"DE","type":"government","lineage":["https://openalex.org/I2801133538","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hennicke Kamp","raw_affiliation_strings":["German Federal Institute for Risk Assessment (BfR), Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Federal Institute for Risk Assessment (BfR), Berlin, Germany","institution_ids":["https://openalex.org/I2801133538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022661690","display_name":"Marcel Leist","orcid":"https://orcid.org/0000-0002-3778-8693","observed_orcids":["https://orcid.org/0000-0002-3778-8693"]},"institutions":[{"id":"https://openalex.org/I189712700","display_name":"University of Konstanz","ror":"https://ror.org/0546hnb39","country_code":"DE","type":"education","lineage":["https://openalex.org/I189712700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marcel Leist","raw_affiliation_strings":["Department of in vitro toxicology and biomedicine, Faculty of Sciences, University of Konstanz, Konstanz, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3778-8693","affiliations":[{"raw_affiliation_string":"Department of in vitro toxicology and biomedicine, Faculty of Sciences, University of Konstanz, Konstanz, Germany","institution_ids":["https://openalex.org/I189712700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061698316","display_name":"Bob Water","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bob van de Water","raw_affiliation_strings":["Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133279032","display_name":"Andrew White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342131907","display_name":"Unilever (United Kingdom)","ror":"https://ror.org/05n8ah907","country_code":"GB","type":"company","lineage":["https://openalex.org/I1342131907"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew White","raw_affiliation_strings":["Unilever Safety Environmental and Regulatory Science, Bedfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unilever Safety Environmental and Regulatory Science, Bedfordshire, UK","institution_ids":["https://openalex.org/I1342131907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091199838","display_name":"Mirjam Luijten","orcid":"https://orcid.org/0000-0002-5277-1443","observed_orcids":["https://orcid.org/0000-0002-5277-1443"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mirjam Luijten","raw_affiliation_strings":["Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-5277-1443","affiliations":[{"raw_affiliation_string":"Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133846799","display_name":"Iain Gardner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iain Gardner","raw_affiliation_strings":["MID3, Certara UK, 1 Concourse Way, Level 2-Acero, Sheffield, S1 2BJ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MID3, Certara UK, 1 Concourse Way, Level 2-Acero, Sheffield, S1 2BJ, United Kingdom","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064824221","display_name":"Sylvia E. Escher","orcid":"https://orcid.org/0000-0001-9616-527X","observed_orcids":["https://orcid.org/0000-0001-9616-527X"]},"institutions":[{"id":"https://openalex.org/I4210111966","display_name":"Fraunhofer Institute for Toxicology and Experimental Medicine","ror":"https://ror.org/02byjcr11","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210111966","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sylvia E. Escher","raw_affiliation_strings":["Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Munich, Germany","institution_ids":["https://openalex.org/I4210111966"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5016773569"],"corresponding_institution_ids":[],"apc_list":{"value":5690,"currency":"USD","value_usd":5690},"apc_paid":{"value":5690,"currency":"USD","value_usd":5690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.4426000118255615,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.4426000118255615,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.12630000710487366,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.1080000028014183,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/new-approach-methodologies","display_name":"new approach methodologies","score":0.8550000190734863},{"id":"https://openalex.org/keywords/read-across","display_name":"read-across","score":0.9819999933242798},{"id":"https://openalex.org/keywords/systemic-toxicity","display_name":"systemic toxicity","score":0.9309999942779541},{"id":"https://openalex.org/keywords/difenoconazole","display_name":"difenoconazole","score":0.8149999976158142},{"id":"https://openalex.org/keywords/point-of-departure","display_name":"point of departure","score":0.7689999938011169},{"id":"https://openalex.org/keywords/human-equivalent-dose","display_name":"human equivalent dose","score":0.8479999899864197},{"id":"https://openalex.org/keywords/physiologically-based-kinetic-modeling","display_name":"physiologically based kinetic modeling","score":0.9120000004768372},{"id":"https://openalex.org/keywords/human-hepatocytes","display_name":"human hepatocytes","score":0.7250000238418579},{"id":"https://openalex.org/keywords/molecular-similarity","display_name":"molecular similarity","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.7419999837875366},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6284999847412109},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.5947999954223633},{"id":"https://openalex.org/C206355099","wikidata":"https://www.wikidata.org/wiki/Q3614972","display_name":"Hazard analysis","level":2,"score":0.5358999967575073},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4756999909877777},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.46160000562667847},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.41019999980926514},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3781999945640564},{"id":"https://openalex.org/C49261128","wikidata":"https://www.wikidata.org/wiki/Q1132455","display_name":"Hazard","level":2,"score":0.3264999985694885},{"id":"https://openalex.org/C2776418720","wikidata":"https://www.wikidata.org/wiki/Q9368","display_name":"Human liver","level":3,"score":0.31139999628067017},{"id":"https://openalex.org/C2984588014","wikidata":"https://www.wikidata.org/wiki/Q730675","display_name":"Quantitative assessment","level":2,"score":0.29019999504089355},{"id":"https://openalex.org/C3019060180","wikidata":"https://www.wikidata.org/wiki/Q184199","display_name":"Automated method","level":2,"score":0.2815999984741211},{"id":"https://openalex.org/C25343380","wikidata":"https://www.wikidata.org/wiki/Q277521","display_name":"Relation (database)","level":2,"score":0.2800999879837036},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2800999879837036},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27379998564720154},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.26919999718666077},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.26910001039505005},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.26840001344680786},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.2542000114917755}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1007/s00204-026-04554-1","doi":"https://doi.org/10.1007/s00204-026-04554-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00204-026-04554-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00204-026-04554-1.pdf","source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},{"id":"pmid:42814138","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42814138","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:9940770930902711","doi":null,"is_oa":true,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/handle/1887/5003731","pdf_url":"https://scholarlypublications.universiteitleiden.nl/download/1887/5003731/1?col=81522199720002711","source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archives of Toxicology","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:publica.fraunhofer.de:publica/525633","doi":null,"is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/525633","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1007/s00204-026-04554-1","doi":"https://doi.org/10.1007/s00204-026-04554-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00204-026-04554-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00204-026-04554-1.pdf","source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G983923995","display_name":null,"funder_award_id":"681002","funder_id":"https://openalex.org/F4320335254","funder_display_name":"Horizon 2020"}],"funders":[{"id":"https://openalex.org/F4320335254","display_name":"Horizon 2020","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214985236.pdf","grobid_xml":"https://content.openalex.org/works/W7214985236.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1490420359","https://openalex.org/W1600673060","https://openalex.org/W1971116820","https://openalex.org/W1972085353","https://openalex.org/W1997437509","https://openalex.org/W2000873867","https://openalex.org/W2032978676","https://openalex.org/W2039693707","https://openalex.org/W2047399603","https://openalex.org/W2047544230","https://openalex.org/W2058201728","https://openalex.org/W2096541451","https://openalex.org/W2096810557","https://openalex.org/W2116310353","https://openalex.org/W2143613977","https://openalex.org/W2144149632","https://openalex.org/W2151690949","https://openalex.org/W2156241187","https://openalex.org/W2164392191","https://openalex.org/W2168398891","https://openalex.org/W2169678694","https://openalex.org/W2179438025","https://openalex.org/W2214815552","https://openalex.org/W2240043123","https://openalex.org/W2317467438","https://openalex.org/W2319741579","https://openalex.org/W2344893489","https://openalex.org/W2473190403","https://openalex.org/W2511228596","https://openalex.org/W2769853272","https://openalex.org/W2772752440","https://openalex.org/W2790282224","https://openalex.org/W2794565592","https://openalex.org/W2852929461","https://openalex.org/W2907521148","https://openalex.org/W2934080398","https://openalex.org/W2953077772","https://openalex.org/W2963301982","https://openalex.org/W2966395481","https://openalex.org/W2973521279","https://openalex.org/W2983166786","https://openalex.org/W2990824114","https://openalex.org/W3011894284","https://openalex.org/W3022828338","https://openalex.org/W3083058234","https://openalex.org/W3117179187","https://openalex.org/W3137864305","https://openalex.org/W3203361503","https://openalex.org/W3203735717","https://openalex.org/W4220678256","https://openalex.org/W4220845226","https://openalex.org/W4223601057","https://openalex.org/W4246570196","https://openalex.org/W4281766325","https://openalex.org/W4283762273","https://openalex.org/W4297239221","https://openalex.org/W4312221564","https://openalex.org/W4316465206","https://openalex.org/W4318149619","https://openalex.org/W4321443372","https://openalex.org/W4385490569","https://openalex.org/W4400559503","https://openalex.org/W4403331593","https://openalex.org/W4409735641","https://openalex.org/W4411674519","https://openalex.org/W4412691851","https://openalex.org/W4415225263","https://openalex.org/W4416841311","https://openalex.org/W4417274352","https://openalex.org/W7154729943"],"related_works":["https://openalex.org/W7220893901","https://openalex.org/W2990824114","https://openalex.org/W7043647993","https://openalex.org/W3117179187","https://openalex.org/W4391310631","https://openalex.org/W4283776750","https://openalex.org/W3121083171","https://openalex.org/W6888820130","https://openalex.org/W3165681495","https://openalex.org/W4200447203"],"abstract_inverted_index":{"This":[0,162,225],"work":[1],"explores":[2],"the":[3,21,31,56,65,79,85,119,126,134,148,157,160,166,189,220,235],"applicability":[4,237],"of":[5,29,75,92,118,147,159,170,192,238,247],"new":[6],"approach":[7,13,139],"methodologies":[8],"(NAMs)":[9],"using":[10,70],"a":[11,27,130,174,239],"read-across":[12,86,138,241],"to":[14,55,78,114,124,152,182,206,243],"predict":[15,153,183],"systemic":[16],"toxicity":[17],"with":[18,165,202],"liver":[19],"as":[20,40,156,232,234],"critical":[22],"target":[23,32],"organ,":[24],"and":[25,47,108,121,123,188,194],"derive":[26],"point":[28],"departurefor":[30],"compound":[33],"(TC)":[34],"difenoconazole.":[35],"Eight":[36],"conazoles":[37],"were":[38,180],"used":[39,113,151,181],"source":[41],"compounds":[42],"(SCs),":[43],"alongside":[44],"metabolites":[45],"hydroxyitraconazole":[46],"1,2,4-triazole.":[48],"The":[49,210],"case":[50,226],"study":[51,227],"was":[52,112,150,215],"structured":[53],"according":[54],"Alternative":[57],"Safety":[58],"Profiling":[59],"Algorithm":[60],"(ASPA)":[61],"workflow":[62],"developed":[63],"within":[64],"RISK-HUNT3R":[66],"project.":[67],"Hierarchical":[68],"clustering":[69],"chemical":[71],"fingerprints":[72],"identified":[73],"similarity":[74],"different":[76],"SCs":[77,122],"TC,":[80,195],"supporting":[81],"their":[82],"inclusion":[83],"in":[84,104,167,204,207],"analysis.":[87],"A":[88],"broad":[89],"screening":[90],"panel":[91],"NAMs,":[93],"including":[94],"nuclear":[95],"receptor":[96],"reporter":[97],"assays,":[98,111],"ToxProfiler,":[99],"Cell":[100],"Painting":[101],"PLUS,":[102],"transcriptomics":[103],"primary":[105],"human":[106,143,184],"hepatocytes":[107],"H295R":[109],"steroidogenesis":[110],"characterize":[115],"biological":[116],"activity":[117],"TC":[120],"substantiate":[125],"structure-based":[127],"read-across.":[128],"In":[129,173],"first":[131],"prediction":[132],"round,":[133],"nearest":[135],"neighbour":[136],"quantitative":[137,203],"(based":[140],"on":[141,197],"allometrically-scaled":[142],"lowest-observed-adverse-effect":[144],"levels":[145],"(LOAELs)":[146],"SC)":[149],"6.57":[154],"mg/kg/day":[155],"LOAEL":[158],"TC.":[161],"closely":[163],"aligned":[164],"vivo-based":[168],"value":[169],"4.88":[171],"mg/kg/day.":[172],"second":[175],"approach,":[176],"data":[177],"from":[178,213,222],"NAMs":[179,214],"equivalent":[185],"dose":[186],"(HED),":[187],"respective":[190],"LOAELs":[191,221],"SC":[193],"based":[196,199],"physiologically":[198],"kinetic":[200],"modelling":[201],"vitro":[205],"vivo":[208],"extrapolation.":[209],"HED":[211],"derived":[212],"approximately":[216],"ten-fold":[217],"lower":[218],"than":[219],"traditional":[223],"approaches.":[224],"illustrates":[228],"suitable":[229],"(ASPA-guided)":[230],"approaches":[231],"well":[233],"toxicological":[236],"NAM-based":[240],"assessment":[242],"obtain":[244],"safe/conservative":[245],"estimates":[246],"toxicity.":[248]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-01T00:00:00"}