{"id":"https://openalex.org/W7214983276","doi":"https://doi.org/10.3389/fcvm.2026.1930278","title":"GLP-1-Based therapies for obesity-related heart failure with preserved ejection fraction: an umbrella review incorporating broader heart failure and cardiometabolic evidence","display_name":"GLP-1-Based therapies for obesity-related heart failure with preserved ejection fraction: an umbrella review incorporating broader heart failure and cardiometabolic evidence","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7214983276","doi":"https://doi.org/10.3389/fcvm.2026.1930278","pmid":"https://pubmed.ncbi.nlm.nih.gov/42876799","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13661543"},"language":"en","primary_location":{"id":"doi:10.3389/fcvm.2026.1930278","doi":"https://doi.org/10.3389/fcvm.2026.1930278","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1930278","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1930278/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1930278/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100429902","display_name":"Qiang Li","orcid":"https://orcid.org/0000-0001-8317-4978","observed_orcids":["https://orcid.org/0000-0001-8317-4978"]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Li","raw_affiliation_strings":["Heilongjiang Academy of Chinese Medicine Sciences","Heilongjiang University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heilongjiang Academy of Chinese Medicine Sciences","institution_ids":[]},{"raw_affiliation_string":"Heilongjiang University of Chinese Medicine","institution_ids":["https://openalex.org/I192327786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105986973","display_name":"Tianyi Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tianyi Yang","raw_affiliation_strings":["Heilongjiang Academy of Chinese Medicine Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heilongjiang Academy of Chinese Medicine Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153594132","display_name":"Guannan Jin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guannan Jin","raw_affiliation_strings":["Heilongjiang Academy of Chinese Medicine Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heilongjiang Academy of Chinese Medicine Sciences","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5153579570","display_name":"Yabin Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192327786","display_name":"Heilongjiang University of Chinese Medicine","ror":"https://ror.org/05x1ptx12","country_code":"CN","type":"education","lineage":["https://openalex.org/I192327786"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yabin Zhou","raw_affiliation_strings":["Heilongjiang University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heilongjiang University of Chinese Medicine","institution_ids":["https://openalex.org/I192327786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5153579570"],"corresponding_institution_ids":["https://openalex.org/I192327786"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.57255405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"1930278","last_page":"1930278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cardiometabolic-outcomes","display_name":"cardiometabolic outcomes","score":0.7020000219345093},{"id":"https://openalex.org/keywords/heart-failure-hospitalization","display_name":"heart failure hospitalization","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.6399999856948853},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.5260000228881836},{"id":"https://openalex.org/keywords/major-adverse-cardiovascular-events","display_name":"major adverse cardiovascular events","score":0.7509999871253967},{"id":"https://openalex.org/keywords/methodological-quality-of-reviews","display_name":"methodological quality of reviews","score":0.6690000295639038},{"id":"https://openalex.org/keywords/functional-status","display_name":"functional status","score":0.6460000276565552},{"id":"https://openalex.org/keywords/obesity-cardiomyopathy","display_name":"obesity cardiomyopathy","score":0.5019999742507935},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8736000061035156},{"id":"https://openalex.org/C2777099384","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Heart failure with preserved ejection fraction","level":4,"score":0.7174000144004822},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6844000220298767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47620001435279846},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.459199994802475},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.45559999346733093},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4496000111103058},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4377000033855438},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.42179998755455017},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.4180000126361847},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.36970001459121704},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.35370001196861267},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.35179999470710754},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.32679998874664307},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C2779295919","wikidata":"https://www.wikidata.org/wiki/Q4677930","display_name":"Acute decompensated heart failure","level":3,"score":0.2919999957084656},{"id":"https://openalex.org/C148482608","wikidata":"https://www.wikidata.org/wiki/Q17007018","display_name":"Clinical study design","level":3,"score":0.29030001163482666},{"id":"https://openalex.org/C3020318244","wikidata":"https://www.wikidata.org/wiki/Q4812187","display_name":"Large sample","level":2,"score":0.28610000014305115},{"id":"https://openalex.org/C2780224610","wikidata":"https://www.wikidata.org/wiki/Q1530061","display_name":"Credibility","level":2,"score":0.2529999911785126},{"id":"https://openalex.org/C19648533","wikidata":"https://www.wikidata.org/wiki/Q691640","display_name":"Evidence-based medicine","level":3,"score":0.251800000667572}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcvm.2026.1930278","doi":"https://doi.org/10.3389/fcvm.2026.1930278","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1930278","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1930278/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13661543","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13661543/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13661543/pdf/fcvm-13-1930278.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cardiovasc Med","raw_type":"Text"},{"id":"pmid:42876799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42876799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cardiovascular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7c3c6be538894fd5abda0a06075217cf","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7c3c6be538894fd5abda0a06075217cf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cardiovascular Medicine, Vol 13 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcvm.2026.1930278","doi":"https://doi.org/10.3389/fcvm.2026.1930278","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1930278","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1930278/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214983276.pdf","grobid_xml":"https://content.openalex.org/works/W7214983276.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W164205712","https://openalex.org/W807162506","https://openalex.org/W1617328014","https://openalex.org/W1976196376","https://openalex.org/W2029071587","https://openalex.org/W2090590132","https://openalex.org/W2127254785","https://openalex.org/W2152072062","https://openalex.org/W2231944090","https://openalex.org/W2282578582","https://openalex.org/W2364450135","https://openalex.org/W2425644022","https://openalex.org/W2519510391","https://openalex.org/W2604584410","https://openalex.org/W2754041380","https://openalex.org/W2756578555","https://openalex.org/W2793653079","https://openalex.org/W2795481136","https://openalex.org/W2804236523","https://openalex.org/W2804511116","https://openalex.org/W2808403888","https://openalex.org/W2894746763","https://openalex.org/W2948612418","https://openalex.org/W2971294569","https://openalex.org/W3013711965","https://openalex.org/W3118615836","https://openalex.org/W3127371223","https://openalex.org/W3177365549","https://openalex.org/W3193297191","https://openalex.org/W3193598686","https://openalex.org/W4206445899","https://openalex.org/W4220946720","https://openalex.org/W4280544373","https://openalex.org/W4281934192","https://openalex.org/W4293354639","https://openalex.org/W4386154055","https://openalex.org/W4388592674","https://openalex.org/W4393255879","https://openalex.org/W4398781461","https://openalex.org/W4403339499","https://openalex.org/W4404437149","https://openalex.org/W4408488509","https://openalex.org/W4411215447","https://openalex.org/W4412154434","https://openalex.org/W4415681582","https://openalex.org/W4415854982","https://openalex.org/W4417298229","https://openalex.org/W7125792640","https://openalex.org/W7130849519","https://openalex.org/W7159955339"],"related_works":["https://openalex.org/W7161179691","https://openalex.org/W7127576885","https://openalex.org/W4415681582","https://openalex.org/W7142902321","https://openalex.org/W7223549912","https://openalex.org/W7093331247","https://openalex.org/W4407853982","https://openalex.org/W4415795099","https://openalex.org/W7160032459","https://openalex.org/W7128033928"],"abstract_inverted_index":{"Background":[0],"The":[1,117,272,338],"cardiometabolic":[2,100],"phenotype":[3],"of":[4,38,68,85,105,125,136,192,226,372,433],"obesity-related":[5,96,392],"heart":[6,205,230,384],"failure":[7,206,231,385],"with":[8,131,382],"preserved":[9],"ejection":[10],"fraction":[11],"(HFpEF)":[12],"is":[13],"increasing":[14],"in":[15,48,95,269,364,391,431],"clinical":[16,181],"prevalence.":[17],"Existing":[18,263],"systematic":[19,86,118,187],"reviews":[20,140,188,264,322,356],"and":[21,36,46,66,89,98,107,134,163,183,229,252,293,329,348,357,387,436],"meta-analyses":[22,91],"have":[23,51],"primarily":[24],"summarized":[25],"efficacy":[26,77],"estimates":[27,197,352],"for":[28,287,291,299,414],"glucagon-like":[29],"peptide-1":[30],"(GLP-1)-based":[31],"therapies,":[32],"but":[33],"the":[34,61,69,108,114,123,144,165,200,208,224,306,370,395],"credibility":[35],"independence":[37],"these":[39],"syntheses":[40],"remain":[41],"uncertain":[42],"because":[43],"methodological":[44,62,179,327,336,434],"limitations":[45,435],"overlap":[47,135,162,438],"primary":[49,137,155],"trials":[50,156],"not":[52,359,399],"been":[53],"systematically":[54],"evaluated.":[55],"This":[56],"umbrella":[57,83,366],"review":[58,84,119,209,273,307],"therefore":[59],"appraised":[60],"quality,":[63,180],"overlap,":[64],"consistency,":[65,175],"robustness":[67],"existing":[70,373],"review-level":[71,202,396],"evidence":[72,374,397],"rather":[73],"than":[74],"generating":[75],"another":[76],"synthesis.":[78,203],"Methods":[79],"We":[80],"conducted":[81],"an":[82],"reviews,":[87],"meta-analyses,":[88],"network":[90],"evaluating":[92],"GLP-1-based":[93,376,407],"regimens":[94],"HFpEF":[97],"adjacent":[99],"populations.":[101],"PubMed,":[102],"Embase,":[103],"Web":[104],"Science,":[106],"Cochrane":[109],"Library":[110],"were":[111,157,169,351,358],"searched":[112],"over":[113],"preceding":[115],"decade.":[116],"or":[120,361,405],"meta-analysis":[121,152],"was":[122,129,141,153,304,340],"unit":[124],"analysis.":[126],"Methodological":[127],"quality":[128],"assessed":[130],"AMSTAR":[132,318],"2,":[133],"studies":[138],"across":[139],"quantified":[142],"using":[143],"corrected":[145],"covered":[146],"area":[147],"(CCA).":[148],"No":[149],"de":[150],"novo":[151],"performed;":[154],"examined":[158],"only":[159],"to":[160,172,199],"assess":[161],"calculate":[164],"CCA.":[166],"Review-level":[167],"findings":[168,290],"synthesized":[170],"according":[171],"effect":[173],"direction,":[174],"precision,":[176],"sample":[177],"size,":[178],"relevance,":[182],"overlap.":[184,344],"Results":[185],"Seventeen":[186],"underwent":[189],"qualitative":[190],"profiling,":[191],"which":[193],"11":[194],"reported":[195,214,236,246,257,278,312,353],"quantitative":[196],"relevant":[198],"core":[201],"For":[204,223],"hospitalization,":[207,232],"by":[210,274,308,354],"Diallo":[211,233],"et":[212,234,244,255,276,310],"al.":[213,235,245,256,277,311],"HR":[215,237,247,313],"0.78":[216],"(95%":[217,239,249,260,281,315],"CI":[218,240,250,261,282,316],"0.73\u20130.84;":[219],"n":[220,284],"=":[221,285],"25,440).":[222],"composite":[225],"cardiovascular":[227,292,302],"death":[228],"0.84":[238],"0.78\u20130.89),":[241],"Ahmed":[242,253],"HM":[243],"0.76":[248],"0.64\u20130.90),":[251],"M":[254],"RR":[258],"0.73":[259],"0.57\u20130.93).":[262],"also":[265],"consistently":[266,380],"suggested":[267],"improvements":[268],"functional":[270,389],"status.":[271],"Gera":[275],"OR":[279,349],"0.85":[280],"0.77\u20130.93;":[283],"85,373)":[286],"stroke,":[288],"whereas":[289],"all-cause":[294],"mortality":[295,403],"remained":[296],"inconsistent.":[297],"Evidence":[298],"major":[300],"adverse":[301],"events":[303],"limited;":[305],"Gonzales-Uribe":[309],"0.71":[314],"0.60\u20130.86).":[317],"2":[319],"classified":[320],"six":[321],"as":[323,331,409,421],"having":[324,332],"low":[325,334],"overall":[326,335],"confidence":[328],"five":[330],"critically":[333],"confidence.":[337],"CCA":[339],"13.2%,":[341],"indicating":[342],"high":[343,437],"All":[345],"HR,":[346],"RR,":[347],"values":[350],"included":[355],"recalculated":[360],"quantitatively":[362],"combined":[363],"this":[365],"review.":[367],"Conclusions":[368],"At":[369],"level":[371],"syntheses,":[375],"therapies":[377,424],"appear":[378],"most":[379],"associated":[381],"fewer":[383],"hospitalizations":[386],"improved":[388],"capacity":[390],"HFpEF.":[393,415],"However,":[394],"does":[398],"establish":[400],"a":[401,410],"consistent":[402],"benefit":[404],"support":[406],"therapy":[408],"universal":[411],"mortality-modifying":[412],"treatment":[413],"These":[416],"agents":[417],"are":[418],"better":[419],"interpreted":[420],"emerging":[422],"metabolic-functional":[423],"whose":[425],"apparent":[426],"benefits":[427],"must":[428],"be":[429],"considered":[430],"light":[432],"among":[439],"reviews.":[440]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-01T00:00:00"}