{"id":"https://openalex.org/W7214979890","doi":"https://doi.org/10.3390/ijms27198732","title":"Ameliorative Effects of Citrus Unshiu Peel Extract in Cellular and Mouse Models of Pelizaeus\u2013Merzbacher Disease","display_name":"Ameliorative Effects of Citrus Unshiu Peel Extract in Cellular and Mouse Models of Pelizaeus\u2013Merzbacher Disease","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7214979890","doi":"https://doi.org/10.3390/ijms27198732","pmid":"https://pubmed.ncbi.nlm.nih.gov/42883976","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13665114"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27198732","doi":"https://doi.org/10.3390/ijms27198732","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27198732","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27198732","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5153575481","display_name":"Miyu Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286413","display_name":"National Research Institute for Child Health and Development","ror":"https://ror.org/022h8bf50","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210132193","https://openalex.org/I4405286413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miyu Yamamoto","raw_affiliation_strings":["Department of Precision Medicine and Drug Discovery, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Precision Medicine and Drug Discovery, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan","institution_ids":["https://openalex.org/I4405286413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101715129","display_name":"Hideya Sakaguchi","orcid":"https://orcid.org/0000-0001-9628-9360","observed_orcids":["https://orcid.org/0000-0001-9628-9360"]},"institutions":[{"id":"https://openalex.org/I4405286413","display_name":"National Research Institute for Child Health and Development","ror":"https://ror.org/022h8bf50","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210132193","https://openalex.org/I4405286413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideya Sakaguchi","raw_affiliation_strings":["Department of Precision Medicine and Drug Discovery, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan"],"raw_orcid":"https://orcid.org/0000-0001-9628-9360","affiliations":[{"raw_affiliation_string":"Department of Precision Medicine and Drug Discovery, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan","institution_ids":["https://openalex.org/I4405286413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036427967","display_name":"Moeri Yagi","orcid":"https://orcid.org/0000-0002-9975-5598","observed_orcids":["https://orcid.org/0000-0002-9975-5598"]},"institutions":[{"id":"https://openalex.org/I4210127889","display_name":"Tsumura (Japan)","ror":"https://ror.org/02r19bt50","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210127889"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Moeri Yagi","raw_affiliation_strings":["Tsumura Advanced Technology Research Laboratories, Tsumura & Co., Ibaraki 300-1192, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsumura Advanced Technology Research Laboratories, Tsumura & Co., Ibaraki 300-1192, Japan","institution_ids":["https://openalex.org/I4210127889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153611941","display_name":"Yuta Muraki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127889","display_name":"Tsumura (Japan)","ror":"https://ror.org/02r19bt50","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210127889"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuta Muraki","raw_affiliation_strings":["Tsumura Advanced Technology Research Laboratories, Tsumura & Co., Ibaraki 300-1192, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsumura Advanced Technology Research Laboratories, Tsumura & Co., Ibaraki 300-1192, Japan","institution_ids":["https://openalex.org/I4210127889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103252737","display_name":"Akinori Nishi","orcid":"https://orcid.org/0000-0002-0495-3023","observed_orcids":["https://orcid.org/0000-0002-0495-3023"]},"institutions":[{"id":"https://openalex.org/I4210127889","display_name":"Tsumura (Japan)","ror":"https://ror.org/02r19bt50","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210127889"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akinori Nishi","raw_affiliation_strings":["Tsumura Advanced Technology Research Laboratories, Tsumura & Co., Ibaraki 300-1192, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0495-3023","affiliations":[{"raw_affiliation_string":"Tsumura Advanced Technology Research Laboratories, Tsumura & Co., Ibaraki 300-1192, Japan","institution_ids":["https://openalex.org/I4210127889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012602203","display_name":"Hideji Yako","orcid":"https://orcid.org/0000-0003-2632-8488","observed_orcids":["https://orcid.org/0000-0003-2632-8488"]},"institutions":[{"id":"https://openalex.org/I149964584","display_name":"Tokyo University of Pharmacy and Life Sciences","ror":"https://ror.org/057jm7w82","country_code":"JP","type":"education","lineage":["https://openalex.org/I149964584"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideji Yako","raw_affiliation_strings":["Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan"],"raw_orcid":"https://orcid.org/0000-0003-2632-8488","affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan","institution_ids":["https://openalex.org/I149964584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027742984","display_name":"Junji Yamauchi","orcid":"https://orcid.org/0000-0002-3618-998X","observed_orcids":["https://orcid.org/0000-0002-3618-998X"]},"institutions":[{"id":"https://openalex.org/I149964584","display_name":"Tokyo University of Pharmacy and Life Sciences","ror":"https://ror.org/057jm7w82","country_code":"JP","type":"education","lineage":["https://openalex.org/I149964584"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Junji Yamauchi","raw_affiliation_strings":["Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3618-998X","affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan","institution_ids":["https://openalex.org/I149964584"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071195833","display_name":"Yuki Miyamoto","orcid":"https://orcid.org/0000-0001-9298-5799","observed_orcids":["https://orcid.org/0000-0001-9298-5799"]},"institutions":[{"id":"https://openalex.org/I149964584","display_name":"Tokyo University of Pharmacy and Life Sciences","ror":"https://ror.org/057jm7w82","country_code":"JP","type":"education","lineage":["https://openalex.org/I149964584"]},{"id":"https://openalex.org/I4405286413","display_name":"National Research Institute for Child Health and Development","ror":"https://ror.org/022h8bf50","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210132193","https://openalex.org/I4405286413"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yuki Miyamoto","raw_affiliation_strings":["Department of Precision Medicine and Drug Discovery, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan","Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan"],"raw_orcid":"https://orcid.org/0000-0001-9298-5799","affiliations":[{"raw_affiliation_string":"Department of Precision Medicine and Drug Discovery, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan","institution_ids":["https://openalex.org/I4405286413"]},{"raw_affiliation_string":"Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan","institution_ids":["https://openalex.org/I149964584"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5027742984","https://openalex.org/A5071195833"],"corresponding_institution_ids":["https://openalex.org/I149964584","https://openalex.org/I4405286413"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"19","first_page":"8732","last_page":"8732"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.5634999871253967,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.5634999871253967,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.11869999766349792,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.08919999748468399,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pelizaeus-merzbacher-disease","display_name":"Pelizaeus-Merzbacher disease","score":0.9589999914169312},{"id":"https://openalex.org/keywords/plp1","display_name":"PLP1","score":0.8610000014305115},{"id":"https://openalex.org/keywords/oligodendrocyte-differentiation","display_name":"oligodendrocyte differentiation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.7940000295639038},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.7990000247955322},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.7879999876022339},{"id":"https://openalex.org/keywords/myelin-proteins","display_name":"myelin proteins","score":0.7570000290870667},{"id":"https://openalex.org/keywords/motor-coordination","display_name":"motor coordination","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.7753999829292297},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.6707000136375427},{"id":"https://openalex.org/C7821365","wikidata":"https://www.wikidata.org/wiki/Q14912011","display_name":"Proteolipid protein 1","level":5,"score":0.6380000114440918},{"id":"https://openalex.org/C2776835245","wikidata":"https://www.wikidata.org/wiki/Q875262","display_name":"Citrus unshiu","level":2,"score":0.5649999976158142},{"id":"https://openalex.org/C2776100374","wikidata":"https://www.wikidata.org/wiki/Q1821559","display_name":"Leukodystrophy","level":3,"score":0.5587999820709229},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5489000082015991},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5163000226020813},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4790000021457672},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4645000100135803},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.43860000371932983},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3935999870300293},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3864000141620636},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.38190001249313354},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.367900013923645},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.3465999960899353},{"id":"https://openalex.org/C2780876595","wikidata":"https://www.wikidata.org/wiki/Q410974","display_name":"Myelin basic protein","level":4,"score":0.3440999984741211},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3409000039100647},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.33660000562667847},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.32359999418258667},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3165000081062317},{"id":"https://openalex.org/C2777619251","wikidata":"https://www.wikidata.org/wiki/Q7312279","display_name":"Remyelination","level":4,"score":0.2992999851703644},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.29109999537467957},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.27160000801086426},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25929999351501465},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2590000033378601}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002957","descriptor_name":"Citrus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018991","descriptor_name":"Myelin Proteolipid Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018991","descriptor_name":"Myelin Proteolipid Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020371","descriptor_name":"Pelizaeus-Merzbacher Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020371","descriptor_name":"Pelizaeus-Merzbacher Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020371","descriptor_name":"Pelizaeus-Merzbacher Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020371","descriptor_name":"Pelizaeus-Merzbacher Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms27198732","doi":"https://doi.org/10.3390/ijms27198732","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27198732","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13665114","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13665114/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13665114/pdf/ijms-27-08732.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:42883976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42883976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms27198732","doi":"https://doi.org/10.3390/ijms27198732","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27198732","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1067750656","display_name":"Elucidation of the pathophysiological mechanism of demyelinating neuropathies using a novel co-culture model","funder_award_id":"23K06821","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320319611","display_name":"Japan Foundation for Pediatric Research","ror":"https://ror.org/02n1qj055"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320321945","display_name":"Ministry of Health, Labour and Welfare","ror":"https://ror.org/03mwa7s65"},{"id":"https://openalex.org/F4320327353","display_name":"Mishima Kaiun Memorial Foundation","ror":null},{"id":"https://openalex.org/F4320327980","display_name":"Tsumura and Company","ror":"https://ror.org/02r19bt50"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"},{"id":"https://openalex.org/F4320338075","display_name":"Core Research for Evolutional Science and Technology","ror":"https://ror.org/00097mb19"},{"id":"https://openalex.org/F4320338262","display_name":"Daiichi Sankyo Europe","ror":"https://ror.org/01qhj1g70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214979890.pdf","grobid_xml":"https://content.openalex.org/works/W7214979890.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1938046568","https://openalex.org/W1972262740","https://openalex.org/W1980775054","https://openalex.org/W1987452529","https://openalex.org/W2003047178","https://openalex.org/W2014625189","https://openalex.org/W2031052253","https://openalex.org/W2036564199","https://openalex.org/W2038811384","https://openalex.org/W2042763192","https://openalex.org/W2046207649","https://openalex.org/W2048517810","https://openalex.org/W2055550014","https://openalex.org/W2164942167","https://openalex.org/W2275046410","https://openalex.org/W2591152970","https://openalex.org/W2752981360","https://openalex.org/W2772611711","https://openalex.org/W2780509972","https://openalex.org/W2913926159","https://openalex.org/W2924166170","https://openalex.org/W2944786249","https://openalex.org/W3013127812","https://openalex.org/W3038941211","https://openalex.org/W3040700551","https://openalex.org/W3048545828","https://openalex.org/W3112699753","https://openalex.org/W3118826478","https://openalex.org/W3170503105","https://openalex.org/W4211106851","https://openalex.org/W4220898903","https://openalex.org/W4281608566","https://openalex.org/W4283822848","https://openalex.org/W4308430173","https://openalex.org/W4308992116","https://openalex.org/W4386691571","https://openalex.org/W4391227729","https://openalex.org/W4393992120","https://openalex.org/W4398183758","https://openalex.org/W4411475714","https://openalex.org/W4414036932","https://openalex.org/W7130387493","https://openalex.org/W7134040484"],"related_works":["https://openalex.org/W3038941211","https://openalex.org/W1562818493","https://openalex.org/W2602225333","https://openalex.org/W2014625189","https://openalex.org/W2750793844","https://openalex.org/W4393992120","https://openalex.org/W2187832887","https://openalex.org/W3013127812","https://openalex.org/W2054432362","https://openalex.org/W2975010038"],"abstract_inverted_index":{"Hypomyelinating":[0],"leukodystrophy":[1],"1":[2,33],"(HLD1),":[3],"also":[4],"known":[5],"as":[6,158,188],"Pelizaeus-Merzbacher":[7],"disease":[8],"(PMD),":[9],"is":[10],"a":[11,189],"severe":[12],"X-linked":[13],"hereditary":[14],"hypomyelinating/demyelinating":[15],"disorder":[16],"caused":[17],"primarily":[18],"by":[19,160],"genomic":[20],"duplications":[21],"or":[22],"multiplications":[23],"that":[24,116,168],"lead":[25],"to":[26,83,111,141],"the":[27,46,61,66,70,130,150],"increased":[28],"expression":[29,37,131,148],"of":[30,53,68,100,132,139],"proteolipid":[31],"protein":[32,147,183],"(PLP1).":[34],"Aberrant":[35],"PLP1":[36,142],"impairs":[38],"oligodendrocyte":[39,105],"differentiation":[40,126,176],"and":[41,81,95,127,152,178],"disrupts":[42],"myelin":[43,134,146,182],"formation":[44],"in":[45,77,92,96,124,149,181],"central":[47],"nervous":[48],"system":[49],"(CNS).":[50],"Despite":[51],"decades":[52],"research,":[54],"effective":[55],"disease-modifying":[56],"therapies":[57],"remain":[58],"unavailable.":[59],"In":[60],"present":[62],"study,":[63],"we":[64,114],"investigated":[65],"potential":[67,187],"Chinpi,":[69],"Citrus":[71],"Unshiu":[72],"Peel":[73],"extract":[74],"commonly":[75],"utilized":[76],"traditional":[78],"herbal":[79],"medicine":[80],"reported":[82],"protect":[84],"cells":[85],"from":[86],"various":[87],"cellular":[88,94],"stresses,":[89],"using":[90],"both":[91],"vitro":[93],"vivo":[97],"animal":[98],"models":[99],"PMD.":[101,193],"Using":[102],"an":[103],"FBD-102b":[104],"precursor":[106],"model":[107],"cell":[108],"line":[109],"engineered":[110],"overexpress":[112],"PLP1,":[113],"demonstrated":[115],"treatment":[117],"with":[118],"Chinpi":[119,140,169],"significantly":[120,153],"ameliorates":[121],"critical":[122],"defects":[123,177],"morphological":[125,175],"successfully":[128],"restores":[129],"major":[133],"proteins.":[135],"Furthermore,":[136],"oral":[137],"administration":[138],"transgenic":[143],"mice":[144],"improves":[145],"brain":[151],"alleviates":[154],"progressive":[155],"motor":[156],"incoordination,":[157],"assessed":[159],"behavioral":[161],"tests.":[162],"Taken":[163],"together,":[164],"these":[165],"findings":[166],"suggest":[167],"exerts":[170],"protective":[171],"effects":[172],"against":[173],"PLP1-induced":[174],"subsequent":[179],"reductions":[180],"expression,":[184],"highlighting":[185],"its":[186],"recovery":[190],"approach":[191],"for":[192]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-10-01T00:00:00"}