{"id":"https://openalex.org/W7214974993","doi":"https://doi.org/10.64898/2026.09.24.749599","title":"Snurportin-1 maintains muscle niche integrity and myogenic progenitor homeostasis","display_name":"Snurportin-1 maintains muscle niche integrity and myogenic progenitor homeostasis","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7214974993","doi":"https://doi.org/10.64898/2026.09.24.749599"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.24.749599","doi":"https://doi.org/10.64898/2026.09.24.749599","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.749599","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.24.749599.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.24.749599.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005783321","display_name":"Hilal P\u0131r\u0131l Sara\u00e7o\u011flu","orcid":"https://orcid.org/0000-0002-3734-489X","observed_orcids":["https://orcid.org/0000-0002-3734-489X"]},"institutions":[{"id":"https://openalex.org/I1351752","display_name":"Ko\u00e7 University","ror":"https://ror.org/00jzwgz36","country_code":"TR","type":"education","lineage":["https://openalex.org/I1351752"]},{"id":"https://openalex.org/I4405280879","display_name":"Ko\u00e7 \u00dcniversitesi Translasyonel T\u0131p Ara\u015ft\u0131rma Merkezi","ror":"https://ror.org/03j1wrb54","country_code":"TR","type":"facility","lineage":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hilal P\u0131r\u0131l Sara\u00e7o\u011flu","raw_affiliation_strings":["Laboratory of Functional Genomics, Department of Medical Genetics, Ko\u00e7 University, School of Medicine (KUSoM), Istanbul, Turkey","Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-3734-489X","affiliations":[{"raw_affiliation_string":"Laboratory of Functional Genomics, Department of Medical Genetics, Ko\u00e7 University, School of Medicine (KUSoM), Istanbul, Turkey","institution_ids":["https://openalex.org/I1351752"]},{"raw_affiliation_string":"Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey","institution_ids":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084211315","display_name":"Marwan Nashabat","orcid":"https://orcid.org/0000-0001-9467-5604","observed_orcids":["https://orcid.org/0000-0001-9467-5604"]},"institutions":[{"id":"https://openalex.org/I1351752","display_name":"Ko\u00e7 University","ror":"https://ror.org/00jzwgz36","country_code":"TR","type":"education","lineage":["https://openalex.org/I1351752"]},{"id":"https://openalex.org/I4405280879","display_name":"Ko\u00e7 \u00dcniversitesi Translasyonel T\u0131p Ara\u015ft\u0131rma Merkezi","ror":"https://ror.org/03j1wrb54","country_code":"TR","type":"facility","lineage":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Marwan Nashabat","raw_affiliation_strings":["Laboratory of Functional Genomics, Department of Medical Genetics, Ko\u00e7 University, School of Medicine (KUSoM), Istanbul, Turkey","Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-9467-5604","affiliations":[{"raw_affiliation_string":"Laboratory of Functional Genomics, Department of Medical Genetics, Ko\u00e7 University, School of Medicine (KUSoM), Istanbul, Turkey","institution_ids":["https://openalex.org/I1351752"]},{"raw_affiliation_string":"Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey","institution_ids":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153560007","display_name":"Duygu Naz Kutlu","orcid":"https://orcid.org/0009-0004-4909-7074","observed_orcids":["https://orcid.org/0009-0004-4909-7074"]},"institutions":[{"id":"https://openalex.org/I1351752","display_name":"Ko\u00e7 University","ror":"https://ror.org/00jzwgz36","country_code":"TR","type":"education","lineage":["https://openalex.org/I1351752"]},{"id":"https://openalex.org/I4405280879","display_name":"Ko\u00e7 \u00dcniversitesi Translasyonel T\u0131p Ara\u015ft\u0131rma Merkezi","ror":"https://ror.org/03j1wrb54","country_code":"TR","type":"facility","lineage":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Duygu Naz Kutlu-Bilgili","raw_affiliation_strings":["Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0009-0004-4909-7074","affiliations":[{"raw_affiliation_string":"Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey","institution_ids":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015912983","display_name":"Burak Sar\u0131ba\u015f","orcid":"https://orcid.org/0000-0003-4329-0418","observed_orcids":["https://orcid.org/0000-0003-4329-0418"]},"institutions":[{"id":"https://openalex.org/I1351752","display_name":"Ko\u00e7 University","ror":"https://ror.org/00jzwgz36","country_code":"TR","type":"education","lineage":["https://openalex.org/I1351752"]},{"id":"https://openalex.org/I4405280879","display_name":"Ko\u00e7 \u00dcniversitesi Translasyonel T\u0131p Ara\u015ft\u0131rma Merkezi","ror":"https://ror.org/03j1wrb54","country_code":"TR","type":"facility","lineage":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Burak Sar\u0131ba\u015f","raw_affiliation_strings":["Laboratory of Functional Genomics, Department of Medical Genetics, Ko\u00e7 University, School of Medicine (KUSoM), Istanbul, Turkey","Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-4329-0418","affiliations":[{"raw_affiliation_string":"Laboratory of Functional Genomics, Department of Medical Genetics, Ko\u00e7 University, School of Medicine (KUSoM), Istanbul, Turkey","institution_ids":["https://openalex.org/I1351752"]},{"raw_affiliation_string":"Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey","institution_ids":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075363092","display_name":"Elanur Y\u0131lmaz","orcid":"https://orcid.org/0000-0001-7045-5068","observed_orcids":["https://orcid.org/0000-0001-7045-5068"]},"institutions":[{"id":"https://openalex.org/I1351752","display_name":"Ko\u00e7 University","ror":"https://ror.org/00jzwgz36","country_code":"TR","type":"education","lineage":["https://openalex.org/I1351752"]},{"id":"https://openalex.org/I4405280879","display_name":"Ko\u00e7 \u00dcniversitesi Translasyonel T\u0131p Ara\u015ft\u0131rma Merkezi","ror":"https://ror.org/03j1wrb54","country_code":"TR","type":"facility","lineage":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Elanur Y\u0131lmaz","raw_affiliation_strings":["Laboratory of Functional Genomics, Department of Medical Genetics, Ko\u00e7 University, School of Medicine (KUSoM), Istanbul, Turkey","Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-7045-5068","affiliations":[{"raw_affiliation_string":"Laboratory of Functional Genomics, Department of Medical Genetics, Ko\u00e7 University, School of Medicine (KUSoM), Istanbul, Turkey","institution_ids":["https://openalex.org/I1351752"]},{"raw_affiliation_string":"Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey","institution_ids":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008506618","display_name":"Seymanur Tur","orcid":"https://orcid.org/0000-0003-0260-9349","observed_orcids":["https://orcid.org/0000-0003-0260-9349"]},"institutions":[{"id":"https://openalex.org/I1351752","display_name":"Ko\u00e7 University","ror":"https://ror.org/00jzwgz36","country_code":"TR","type":"education","lineage":["https://openalex.org/I1351752"]},{"id":"https://openalex.org/I4405280879","display_name":"Ko\u00e7 \u00dcniversitesi Translasyonel T\u0131p Ara\u015ft\u0131rma Merkezi","ror":"https://ror.org/03j1wrb54","country_code":"TR","type":"facility","lineage":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u015eeymanur Tur","raw_affiliation_strings":["Laboratory of Functional Genomics, Department of Medical Genetics, Ko\u00e7 University, School of Medicine (KUSoM), Istanbul, Turkey","Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-0260-9349","affiliations":[{"raw_affiliation_string":"Laboratory of Functional Genomics, Department of Medical Genetics, Ko\u00e7 University, School of Medicine (KUSoM), Istanbul, Turkey","institution_ids":["https://openalex.org/I1351752"]},{"raw_affiliation_string":"Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey","institution_ids":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026370929","display_name":"H\u00fclya Kayserili","orcid":"https://orcid.org/0000-0003-0376-499X","observed_orcids":["https://orcid.org/0000-0003-0376-499X","https://orcid.org/0000-0002-9563-3884"]},"institutions":[{"id":"https://openalex.org/I1351752","display_name":"Ko\u00e7 University","ror":"https://ror.org/00jzwgz36","country_code":"TR","type":"education","lineage":["https://openalex.org/I1351752"]},{"id":"https://openalex.org/I4405280879","display_name":"Ko\u00e7 \u00dcniversitesi Translasyonel T\u0131p Ara\u015ft\u0131rma Merkezi","ror":"https://ror.org/03j1wrb54","country_code":"TR","type":"facility","lineage":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"H\u00fclya Kayserili","raw_affiliation_strings":["Diagnostic Center for Genetic Diseases, Department of Medical Genetics, Ko\u00e7 University Hospital, Istanbul, Turkey","Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-9563-3884","affiliations":[{"raw_affiliation_string":"Diagnostic Center for Genetic Diseases, Department of Medical Genetics, Ko\u00e7 University Hospital, Istanbul, Turkey","institution_ids":["https://openalex.org/I1351752"]},{"raw_affiliation_string":"Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey","institution_ids":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028397897","display_name":"Emre Yaksi","orcid":"https://orcid.org/0000-0003-3761-0235","observed_orcids":["https://orcid.org/0000-0003-3761-0235"]},"institutions":[{"id":"https://openalex.org/I1351752","display_name":"Ko\u00e7 University","ror":"https://ror.org/00jzwgz36","country_code":"TR","type":"education","lineage":["https://openalex.org/I1351752"]},{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]},{"id":"https://openalex.org/I4387153589","display_name":"Kavli Institute for Systems Neuroscience","ror":"https://ror.org/01tvrq624","country_code":"NO","type":"facility","lineage":["https://openalex.org/I4387153589"]},{"id":"https://openalex.org/I4405280879","display_name":"Ko\u00e7 \u00dcniversitesi Translasyonel T\u0131p Ara\u015ft\u0131rma Merkezi","ror":"https://ror.org/03j1wrb54","country_code":"TR","type":"facility","lineage":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}],"countries":["NO","TR"],"is_corresponding":false,"raw_author_name":"Emre Yak\u015fi","raw_affiliation_strings":["Kavli Institute for Systems Neuroscience and Centre for Algorithms in the Cortex, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway","Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-3761-0235","affiliations":[{"raw_affiliation_string":"Kavli Institute for Systems Neuroscience and Centre for Algorithms in the Cortex, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway","institution_ids":["https://openalex.org/I204778367","https://openalex.org/I4387153589"]},{"raw_affiliation_string":"Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey","institution_ids":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004645871","display_name":"Nasrinsadat Nabavizadeh","orcid":"https://orcid.org/0000-0002-1629-6956","observed_orcids":["https://orcid.org/0000-0002-1629-6956"]},"institutions":[{"id":"https://openalex.org/I1351752","display_name":"Ko\u00e7 University","ror":"https://ror.org/00jzwgz36","country_code":"TR","type":"education","lineage":["https://openalex.org/I1351752"]},{"id":"https://openalex.org/I4405280879","display_name":"Ko\u00e7 \u00dcniversitesi Translasyonel T\u0131p Ara\u015ft\u0131rma Merkezi","ror":"https://ror.org/03j1wrb54","country_code":"TR","type":"facility","lineage":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nasrinsadat Nabavizadeh","raw_affiliation_strings":["Laboratory of Functional Genomics, Department of Medical Genetics, Ko\u00e7 University, School of Medicine (KUSoM), Istanbul, Turkey","Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-1629-6956","affiliations":[{"raw_affiliation_string":"Laboratory of Functional Genomics, Department of Medical Genetics, Ko\u00e7 University, School of Medicine (KUSoM), Istanbul, Turkey","institution_ids":["https://openalex.org/I1351752"]},{"raw_affiliation_string":"Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey","institution_ids":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081131359","display_name":"Nathalie Escande\u2010Beillard","orcid":"https://orcid.org/0000-0002-7706-1608","observed_orcids":["https://orcid.org/0000-0002-7706-1608"]},"institutions":[{"id":"https://openalex.org/I1351752","display_name":"Ko\u00e7 University","ror":"https://ror.org/00jzwgz36","country_code":"TR","type":"education","lineage":["https://openalex.org/I1351752"]},{"id":"https://openalex.org/I4405280879","display_name":"Ko\u00e7 \u00dcniversitesi Translasyonel T\u0131p Ara\u015ft\u0131rma Merkezi","ror":"https://ror.org/03j1wrb54","country_code":"TR","type":"facility","lineage":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Nathalie Escande-Beillard","raw_affiliation_strings":["Laboratory of Functional Genomics, Department of Medical Genetics, Ko\u00e7 University, School of Medicine (KUSoM), Istanbul, Turkey","Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-7706-1608","affiliations":[{"raw_affiliation_string":"Laboratory of Functional Genomics, Department of Medical Genetics, Ko\u00e7 University, School of Medicine (KUSoM), Istanbul, Turkey","institution_ids":["https://openalex.org/I1351752"]},{"raw_affiliation_string":"Research Center for Translational Medicine (KUTTAM), Ko\u00e7 University School of Medicine (KUSoM), Istanbul, Turkey","institution_ids":["https://openalex.org/I1351752","https://openalex.org/I4405280879"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5081131359"],"corresponding_institution_ids":["https://openalex.org/I1351752","https://openalex.org/I4405280879"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/limb-girdle-muscular-dystrophy","display_name":"limb-girdle muscular dystrophy","score":0.9509999752044678},{"id":"https://openalex.org/keywords/skeletal-muscle-homeostasis","display_name":"skeletal muscle homeostasis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/myogenic-progenitor-cells","display_name":"myogenic progenitor cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/pax7","display_name":"Pax7","score":0.8799999952316284},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.9240000247955322},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.925000011920929},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.7940000295639038},{"id":"https://openalex.org/keywords/muscle-regeneration","display_name":"muscle regeneration","score":0.5659999847412109},{"id":"https://openalex.org/keywords/locomotor-disability","display_name":"locomotor impairment","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7870000004768372},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7265999913215637},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.7160000205039978},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.713699996471405},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5960999727249146},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.483599990606308},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4348999857902527},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.429500013589859},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.42500001192092896},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4203999936580658},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4075999855995178},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.3953999876976013},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3806000053882599},{"id":"https://openalex.org/C2909145422","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxin","level":3,"score":0.3653999865055084},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.3540000021457672},{"id":"https://openalex.org/C2779030066","wikidata":"https://www.wikidata.org/wiki/Q1137767","display_name":"Muscular dystrophy","level":2,"score":0.3416000008583069},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3156000077724457},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.3138999938964844},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.29809999465942383},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.28949999809265137},{"id":"https://openalex.org/C181709278","wikidata":"https://www.wikidata.org/wiki/Q18028020","display_name":"ITGA7","level":3,"score":0.2858000099658966},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.2759000062942505},{"id":"https://openalex.org/C2778943923","wikidata":"https://www.wikidata.org/wiki/Q1648484","display_name":"Duchenne muscular dystrophy","level":2,"score":0.2705000042915344},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2700999975204468},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2653000056743622},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.26409998536109924},{"id":"https://openalex.org/C2908584439","wikidata":"https://www.wikidata.org/wiki/Q2076770","display_name":"Small nuclear ribonucleoprotein","level":5,"score":0.26330000162124634},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.26179999113082886},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.26170000433921814},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.2551000118255615}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.24.749599","doi":"https://doi.org/10.64898/2026.09.24.749599","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.749599","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.24.749599.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.24.749599","doi":"https://doi.org/10.64898/2026.09.24.749599","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.749599","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.24.749599.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7427514699","display_name":null,"funder_award_id":"118C318","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"}],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"},{"id":"https://openalex.org/F4320329955","display_name":"Ko\u00e7 \u00dcniversitesi Translasyonel T\u0131p Ara\u015ft\u0131rma Merkezi","ror":"https://ror.org/03j1wrb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214974993.pdf","grobid_xml":"https://content.openalex.org/works/W7214974993.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W4391898944"],"related_works":["https://openalex.org/W4391898944","https://openalex.org/W6929521413","https://openalex.org/W7155074478","https://openalex.org/W4386517603","https://openalex.org/W2972896236","https://openalex.org/W7214735703","https://openalex.org/W2039625108","https://openalex.org/W2768156229","https://openalex.org/W2284667418","https://openalex.org/W2157672028"],"abstract_inverted_index":{"Abstract":[0],"Loss-of-function":[1],"variants":[2],"in":[3,36,43,52,73,110,187],"SNUPN":[4],",":[5],"encoding":[6],"the":[7,32,47,68,134],"nuclear":[8,17],"import":[9],"factor":[10],"Snurportin-1":[11],"(SPN1)":[12],"required":[13],"for":[14,190],"spliceosomal":[15],"small":[16],"ribonucleoprotein":[18],"(snRNP)":[19],"transport,":[20],"cause":[21],"a":[22,50,58,164],"recently":[23],"described":[24],"form":[25],"of":[26,34,49,67,120,133,167],"limb-girdle":[27],"muscular":[28],"dystrophy":[29],"(LGMD).":[30],"However,":[31],"role":[33],"SPN1":[35,162],"skeletal":[37,69,168],"muscle":[38,70,92,135,154,169,202],"homeostasis":[39,170],"remains":[40],"poorly":[41],"understood,":[42],"part":[44],"due":[45],"to":[46,174],"lack":[48],"suitable":[51],"vivo":[53,188],"model.":[54],"Here,":[55],"we":[56],"generated":[57],"zebrafish":[59,183],"snupn":[60],"loss-of-function":[61],"model":[62,184],"that":[63],"recapitulates":[64],"key":[65,165],"features":[66],"phenotype":[71],"observed":[72],"patients.":[74],"Mutant":[75],"larvae":[76],"developed":[77],"severe":[78],"locomotor":[79],"impairment":[80],"by":[81,87,131],"6":[82,98],"days":[83],"post-fertilization":[84],"(dpf),":[85],"accompanied":[86],"sarcomeric":[88],"disorganization":[89],"and":[90,104,113,122,147,156,178,195,204],"impaired":[91],"fiber":[93],"integrity.":[94],"Transcriptomic":[95],"profiling":[96],"at":[97,138,200],"dpf":[99],"revealed":[100],"widespread":[101],"alternative":[102],"splicing":[103],"transcriptional":[105],"dysregulation,":[106],"with":[107,118,141,152],"prominent":[108],"alterations":[109],"extracellular":[111,175],"matrix":[112],"basement":[114],"membrane":[115],"components,":[116],"together":[117,151],"upregulation":[119],"stress-":[121],"inflammation-associated":[123],"genes.":[124],"Notably,":[125],"these":[126,159],"late-stage":[127],"abnormalities":[128],"were":[129],"preceded":[130],"disruption":[132],"progenitor":[136,145,180],"population":[137],"2":[139],"dpf,":[140],"reduced":[142],"Pax7":[143],"+":[144],"abundance":[146],"myogenic":[148,179],"gene":[149],"expression":[150],"altered":[153],"differentiation":[155],"organization.":[157],"Together,":[158],"findings":[160],"identify":[161],"as":[163],"regulator":[166],"linking":[171],"RNA":[172],"processing":[173],"niche":[176],"integrity":[177],"maintenance.":[181],"This":[182],"provides":[185],"an":[186],"platform":[189],"dissecting":[191],"LGMD-associated":[192],"disease":[193],"mechanisms":[194],"developing":[196],"therapeutic":[197],"strategies":[198],"aimed":[199],"restoring":[201],"function":[203],"regenerative":[205],"capacity.":[206]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-01T00:00:00"}
