{"id":"https://openalex.org/W7214960815","doi":"https://doi.org/10.3389/fimmu.2026.1910969","title":"Cutaneous efficacy and glucocorticoid-sparing effects of anifrolumab in systemic lupus erythematosus: a systematic review and meta-analysis of randomized controlled trials","display_name":"Cutaneous efficacy and glucocorticoid-sparing effects of anifrolumab in systemic lupus erythematosus: a systematic review and meta-analysis of randomized controlled trials","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7214960815","doi":"https://doi.org/10.3389/fimmu.2026.1910969","pmid":"https://pubmed.ncbi.nlm.nih.gov/42877191","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13662125"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1910969","doi":"https://doi.org/10.3389/fimmu.2026.1910969","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1910969","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1910969/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1910969/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5153649121","display_name":"Jianing Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianing Wang","raw_affiliation_strings":["School of Traditional Chinese Medicine, Beijing University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153645261","display_name":"Feiyin Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feiyin Liu","raw_affiliation_strings":["School of Traditional Chinese Medicine, Beijing University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106619889","display_name":"Qianwen Lou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianwen Lou","raw_affiliation_strings":["School of Traditional Chinese Medicine, Beijing University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153624724","display_name":"Yinan Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinan Yang","raw_affiliation_strings":["School of Traditional Chinese Medicine, Beijing University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5153556499","display_name":"Min Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Min Liu","raw_affiliation_strings":["School of Traditional Chinese Medicine, Beijing University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine","institution_ids":["https://openalex.org/I17747738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5153556499"],"corresponding_institution_ids":["https://openalex.org/I17747738"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.54033413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1910969","last_page":"1910969"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anifrolumab","display_name":"anifrolumab","score":1.0},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":1.0},{"id":"https://openalex.org/keywords/cutaneous-lupus-erythematosus","display_name":"cutaneous lupus erythematosus","score":0.9670000076293945},{"id":"https://openalex.org/keywords/glucocorticoid-sparing-effect","display_name":"glucocorticoid-sparing effect","score":0.8899999856948853},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.5929999947547913},{"id":"https://openalex.org/keywords/flare-rate","display_name":"flare rate","score":0.5299999713897705},{"id":"https://openalex.org/keywords/skin-involvement","display_name":"skin involvement","score":0.3330000042915344}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9199000000953674},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6815999746322632},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.652999997138977},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.64410001039505},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5252000093460083},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4058000147342682},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.40059998631477356},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.3828999996185303},{"id":"https://openalex.org/C2775915377","wikidata":"https://www.wikidata.org/wiki/Q188297","display_name":"Lupus erythematosus","level":3,"score":0.34130001068115234},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3009999990463257},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.2989000082015991},{"id":"https://openalex.org/C202953159","wikidata":"https://www.wikidata.org/wiki/Q382695","display_name":"Intention-to-treat analysis","level":3,"score":0.28940001130104065},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.2838999927043915},{"id":"https://openalex.org/C120195587","wikidata":"https://www.wikidata.org/wiki/Q2138790","display_name":"Absolute risk reduction","level":3,"score":0.28060001134872437},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2694999873638153}],"mesh":[{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1910969","doi":"https://doi.org/10.3389/fimmu.2026.1910969","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1910969","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1910969/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13662125","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13662125/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13662125/pdf/fimmu-17-1910969.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42877191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42877191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:31af19480fc0404f875b9d6b111c2e76","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/31af19480fc0404f875b9d6b111c2e76","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1910969","doi":"https://doi.org/10.3389/fimmu.2026.1910969","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1910969","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1910969/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214960815.pdf","grobid_xml":"https://content.openalex.org/works/W7214960815.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W2047342378","https://openalex.org/W2070527591","https://openalex.org/W2091468965","https://openalex.org/W2119605658","https://openalex.org/W2128073117","https://openalex.org/W2131723901","https://openalex.org/W2143645568","https://openalex.org/W2149063533","https://openalex.org/W2151277711","https://openalex.org/W2154001276","https://openalex.org/W2159860161","https://openalex.org/W2161083732","https://openalex.org/W2556359407","https://openalex.org/W2581830478","https://openalex.org/W2901509748","https://openalex.org/W2927871970","https://openalex.org/W2948488594","https://openalex.org/W2966041078","https://openalex.org/W2970684805","https://openalex.org/W2978795816","https://openalex.org/W2983004004","https://openalex.org/W2995521654","https://openalex.org/W3080315818","https://openalex.org/W3102147393","https://openalex.org/W3112276547","https://openalex.org/W3118615836","https://openalex.org/W3160297138","https://openalex.org/W3165202315","https://openalex.org/W4200255638","https://openalex.org/W4210435204","https://openalex.org/W4210866723","https://openalex.org/W4283645066","https://openalex.org/W4296031303","https://openalex.org/W4296831950","https://openalex.org/W4372355041","https://openalex.org/W4384120360","https://openalex.org/W4386484697","https://openalex.org/W4387569385","https://openalex.org/W4392624759","https://openalex.org/W4406973917","https://openalex.org/W4412057838","https://openalex.org/W4412156626","https://openalex.org/W4412592156","https://openalex.org/W4415824020","https://openalex.org/W7117578042","https://openalex.org/W7151010458"],"related_works":["https://openalex.org/W4409898607","https://openalex.org/W3160297138","https://openalex.org/W7117578042","https://openalex.org/W3165523947","https://openalex.org/W3102147393","https://openalex.org/W4315881076","https://openalex.org/W4388414559","https://openalex.org/W7133243932","https://openalex.org/W4406526967","https://openalex.org/W4412057838"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"evaluate":[2],"the":[3,33,91,168,351,377,394,409,417],"cutaneous":[4],"efficacy":[5,403],"and":[6,16,22,24,36,68,113,123,132,221,254,300,338,362,388,416],"glucocorticoid-sparing":[7],"effects":[8],"of":[9,31,117,121,125,282,312,316,323,381],"anifrolumab":[10,53,178,270,370],"in":[11,90,98,206,376,393],"systemic":[12],"lupus":[13],"erythematosus":[14],"(SLE)":[15],"to":[17,47,151,200,219,229,237,249,264,294,303,331,366],"assess":[18],"composite":[19],"disease":[20],"activity":[21],"flare-related":[23],"safety":[25,419],"outcomes.":[26],"Methods:":[27],"PubMed,":[28],"Embase,":[29],"Web":[30],"Science,":[32],"Cochrane":[34],"Library,":[35],"ClinicalTrials.gov":[37],"were":[38,45,71,85,106,127,144,272,336,341],"searched":[39],"through":[40],"20":[41],"April":[42],"2026.":[43],"Meta-analyses":[44],"restricted":[46],"randomized":[48],"controlled":[49],"trials":[50,143,148,163,187,380],"comparing":[51],"intravenous":[52,147],"300":[54],"mg":[55],"every":[56],"4":[57],"weeks":[58],"plus":[59,64],"standard":[60,65],"therapy":[61],"with":[62,80,94,110,190,383],"placebo":[63],"therapy;":[66],"TULIP-SC":[67],"overlapping":[69],"reports":[70,139],"synthesized":[72],"narratively.":[73],"Risk":[74,120],"ratios":[75,79],"(RRs)":[76],"or":[77,276],"rate":[78,257],"95%":[81,197,216,226,234,246,261,291,328],"confidence":[82],"intervals":[83,349],"(CIs)":[84],"pooled":[86],"using":[87,129],"random-effects":[88],"models":[89,96],"primary":[92],"analyses,":[93],"fixed-effect":[95],"applied":[97],"sensitivity":[99,104,345,411],"analyses.":[100],"Modified":[101,343],"Hartung-Knapp-Sidik-Jonkman":[102],"(HKSJ)":[103],"analyses":[105,311,340,346,412],"performed":[107],"for":[108,353,401,413],"outcomes":[109,404,415],"substantial":[111],"heterogeneity":[112,275],"a":[114],"small":[115],"number":[116],"contributing":[118,379],"studies.":[119],"bias":[122],"certainty":[124],"evidence":[126,172],"assessed":[128],"RoB":[130],"2":[131],"GRADE,":[133],"respectively.":[134],"Results:":[135],"In":[136],"all,":[137],"12":[138],"from":[140],"five":[141],"independent":[142],"included;":[145],"four":[146],"contributed":[149],"up":[150],"1,203":[152],"participants.":[153],"The":[154,280],"Week":[155,180,372],"52":[156,181,373],"CLASI-A50":[157,182,374],"estimate":[158],"was":[159,286],"based":[160,184],"on":[161,185],"two":[162,186,378],"(n":[164],"=":[165,240,252,267],"165),":[166],"not":[167,307],"full":[169],"1,203-participant":[170],"IV":[171],"set.":[173],"Random-effects":[174],"pooling":[175],"showed":[176],"that":[177],"improved":[179,371],"response":[183,223,375],"among":[188],"patients":[189,382],"baseline":[191,213,384],"CLASI-A":[192,385],"\u2265":[193,209,386],"10":[194,210,387],"(RR":[195,214,224,232,244,289,326],"1.52,":[196],"CI":[198,217,227,235,247,262,292,329],"1.04":[199,236],"2.24),":[201],"sustained":[202,390],"oral":[203],"glucocorticoid":[204,391,396],"reduction":[205,392],"those":[207],"receiving":[208],"mg/day":[211],"at":[212],"1.56,":[215],"1.30":[218],"1.87),":[220],"BICLA":[222],"1.66,":[225],"1.41":[228],"1.94).":[230],"SRI-4":[231],"1.39,":[233],"1.87;":[238],"I\u00b2":[239,251,266],"80.8%),":[241],"LLDAS":[242],"attainment":[243],"1.80,":[245],"1.19":[248],"2.73;":[250],"57.2%),":[253],"annualized":[255,356],"flare":[256,357],"(rate":[258],"ratio":[259],"0.65,":[260],"0.47":[263],"0.91;":[265],"56.5%)":[268],"favored":[269,406],"but":[271,408],"affected":[273],"by":[274],"limited":[277,337,418],"trial":[278],"numbers.":[279],"incidence":[281],"any":[283],"adverse":[284,298,304,314,360,363],"events":[285,299,305,315,364],"slightly":[287],"higher":[288],"1.09,":[290],"1.03":[293],"1.16),":[295],"whereas":[296],"serious":[297,359],"discontinuations":[301],"due":[302],"did":[306],"differ":[308],"significantly.":[309],"Supplementary":[310],"selected":[313],"clinical":[317],"interest":[318],"suggested":[319],"an":[320],"increased":[321],"risk":[322],"herpes":[324],"zoster":[325],"3.88,":[327],"1.70":[330],"8.89),":[332],"although":[333],"event":[334],"numbers":[335],"these":[339],"supplementary.":[342],"HKSJ":[344,410],"yielded":[347],"wider":[348],"crossing":[350],"null":[352],"SRI-4,":[354],"LLDAS,":[355],"rate,":[358],"events,":[361],"leading":[365],"discontinuation.":[367],"Conclusions:":[368],"Intravenous":[369],"facilitated":[389],"prespecified":[395],"subgroup.":[397],"DerSimonian-Laird":[398],"point":[399],"estimates":[400],"secondary":[402],"generally":[405],"anifrolumab,":[407],"heterogeneous":[414],"data":[420],"warrant":[421],"cautious":[422],"interpretation.":[423],"Systematic":[424],"Review":[425],"Registration:":[426],"https://www.crd.york.ac.uk/PROSPERO/,":[427],"identifier":[428],"CRD420261367219.":[429]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-01T00:00:00"}
