{"id":"https://openalex.org/W7214958865","doi":"https://doi.org/10.1002/cbdv.71788","title":"Verrucacrylic Acids A and B From a Marine Sponge\u2010derived Verrucosispora sp. FIM06025","display_name":"Verrucacrylic Acids A and B From a Marine Sponge\u2010derived Verrucosispora sp. FIM06025","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7214958865","doi":"https://doi.org/10.1002/cbdv.71788","pmid":"https://pubmed.ncbi.nlm.nih.gov/42816167","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13626856"},"language":"en","primary_location":{"id":"doi:10.1002/cbdv.71788","doi":"https://doi.org/10.1002/cbdv.71788","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cbdv.71788","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbdv.71788","source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry &amp; Biodiversity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbdv.71788","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5138092933","display_name":"Minghong Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093395","display_name":"Fujian Institute of Microbiology","ror":"https://ror.org/00f5sa326","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210093395","https://openalex.org/I4210096617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minghong Chen","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology  Fuzhou People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology  Fuzhou People's Republic of China","institution_ids":["https://openalex.org/I4210093395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138089331","display_name":"Chengzeng Zhou","orcid":"https://orcid.org/0000-0001-5357-6036","observed_orcids":["https://orcid.org/0000-0001-5357-6036"]},"institutions":[{"id":"https://openalex.org/I4210093395","display_name":"Fujian Institute of Microbiology","ror":"https://ror.org/00f5sa326","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210093395","https://openalex.org/I4210096617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengzeng Zhou","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology  Fuzhou People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-5357-6036","affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology  Fuzhou People's Republic of China","institution_ids":["https://openalex.org/I4210093395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109128497","display_name":"Ru Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093395","display_name":"Fujian Institute of Microbiology","ror":"https://ror.org/00f5sa326","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210093395","https://openalex.org/I4210096617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ru Lin","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology  Fuzhou People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology  Fuzhou People's Republic of China","institution_ids":["https://openalex.org/I4210093395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100334782","display_name":"Yuan Yuan","orcid":"https://orcid.org/0000-0002-8453-0126","observed_orcids":["https://orcid.org/0000-0002-8453-0126"]},"institutions":[{"id":"https://openalex.org/I4210093395","display_name":"Fujian Institute of Microbiology","ror":"https://ror.org/00f5sa326","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210093395","https://openalex.org/I4210096617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Yuan","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology  Fuzhou People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology  Fuzhou People's Republic of China","institution_ids":["https://openalex.org/I4210093395"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049271504","display_name":"Jian Zhou","orcid":"https://orcid.org/0000-0002-6367-8818","observed_orcids":["https://orcid.org/0000-0002-6367-8818"]},"institutions":[{"id":"https://openalex.org/I4210093395","display_name":"Fujian Institute of Microbiology","ror":"https://ror.org/00f5sa326","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210093395","https://openalex.org/I4210096617"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Zhou","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology  Fuzhou People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-6367-8818","affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology  Fuzhou People's Republic of China","institution_ids":["https://openalex.org/I4210093395"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049271504"],"corresponding_institution_ids":["https://openalex.org/I4210093395"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":{"value":3880,"currency":"USD","value_usd":3880},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"10","first_page":"e71788","last_page":"e71788"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.21789999306201935,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/verrucosispora","display_name":"Verrucosispora","score":0.9399999976158142},{"id":"https://openalex.org/keywords/amino-acid-derivatives","display_name":"amino acid derivatives","score":0.671999990940094},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.6119999885559082},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.890999972820282},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8339999914169312},{"id":"https://openalex.org/keywords/t47d-cells","display_name":"T47D cells","score":0.8600000143051147},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9269999861717224}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8769000172615051},{"id":"https://openalex.org/C2778849931","wikidata":"https://www.wikidata.org/wiki/Q18960","display_name":"Sponge","level":2,"score":0.7537000179290771},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5889999866485596},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5436999797821045},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3698999881744385},{"id":"https://openalex.org/C172269249","wikidata":"https://www.wikidata.org/wiki/Q108555493","display_name":"Marine invertebrates","level":2,"score":0.3490000069141388},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.329800009727478},{"id":"https://openalex.org/C2992620220","wikidata":"https://www.wikidata.org/wiki/Q398805","display_name":"China sea","level":2,"score":0.31850001215934753},{"id":"https://openalex.org/C2992957956","wikidata":"https://www.wikidata.org/wiki/Q5364423","display_name":"Marine fish","level":3,"score":0.2500999867916107},{"id":"https://openalex.org/C196405362","wikidata":"https://www.wikidata.org/wiki/Q6764285","display_name":"Marine fungi","level":2,"score":0.24580000340938568}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011161","descriptor_name":"Porifera","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D011161","descriptor_name":"Porifera","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/cbdv.71788","doi":"https://doi.org/10.1002/cbdv.71788","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cbdv.71788","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbdv.71788","source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry &amp; Biodiversity","raw_type":"journal-article"},{"id":"pmid:42816167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42816167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & biodiversity","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13626856","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13626856/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chem Biodivers","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/cbdv.71788","doi":"https://doi.org/10.1002/cbdv.71788","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cbdv.71788","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbdv.71788","source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry &amp; Biodiversity","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000844165","display_name":null,"funder_award_id":"2022J01387","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"}],"funders":[{"id":"https://openalex.org/F4320321878","display_name":"Natural Science Foundation of Fujian Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214958865.pdf","grobid_xml":"https://content.openalex.org/works/W7214958865.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1974857251","https://openalex.org/W1992716708","https://openalex.org/W1996390229","https://openalex.org/W2004078467","https://openalex.org/W2075532968","https://openalex.org/W2079622042","https://openalex.org/W2145005007","https://openalex.org/W2147555834","https://openalex.org/W2161983564","https://openalex.org/W2297759054","https://openalex.org/W2415398384","https://openalex.org/W2424700660","https://openalex.org/W2900602735","https://openalex.org/W2988070851","https://openalex.org/W2989846340","https://openalex.org/W3034310241","https://openalex.org/W3139326034","https://openalex.org/W4409184069"],"related_works":["https://openalex.org/W2043678320","https://openalex.org/W2900602735","https://openalex.org/W6958260593","https://openalex.org/W2354106489","https://openalex.org/W2318419361","https://openalex.org/W3095198556","https://openalex.org/W2297759054","https://openalex.org/W4210535874","https://openalex.org/W1990084723","https://openalex.org/W1994445168"],"abstract_inverted_index":{"Verrucosispora":[0,45],"sp.":[1,46],"FIM06025":[2],"was":[3],"an":[4],"actinomycete":[5],"isolated":[6,43],"from":[7,12,44],"marine":[8],"sponge":[9],"sample":[10],"collected":[11],"the":[13,54],"East":[14],"China":[15],"Sea.":[16],"Three":[17],"new":[18,35],"compounds,":[19,24],"including":[20],"two":[21],"rare":[22],"cyclopropane-containing":[23],"verrucacrylic":[25],"acids":[26],"A":[27],"and":[28,31,33,63,66,76,83,89,91],"B":[29],"(1":[30],"2),":[32],"a":[34,69],"amino":[36],"acid":[37],"derivative,":[38],"methyl":[39],"N-[(2S)-2-methylbutanoyl]-D-tyrosinate":[40],"(3),":[41],"were":[42,50],"FIM06025.":[47],"Compounds":[48],"1-3":[49],"structurally":[51],"elucidated":[52],"on":[53],"basis":[55],"of":[56,71,81],"extensive":[57],"spectroscopic":[58],"data":[59],"analysis":[60],"using":[61],"1D-":[62],"2D-NMR,":[64],"ECD,":[65],"HRESIMS.":[67],"At":[68],"concentration":[70],"100":[72],"\u00b5M,":[73],"compounds":[74],"1":[75],"2":[77],"exhibited":[78],"inhibitory":[79],"rates":[80],"28.6%":[82],"45.2%":[84],"against":[85,93],"T47D":[86],"cells,":[87,95],"respectively,":[88],"30.3%":[90],"47.1%":[92],"HL60":[94],"respectively.":[96]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-10-01T00:00:00"}
