{"id":"https://openalex.org/W7214958825","doi":"https://doi.org/10.64898/2026.09.29.755524","title":"Stress\u2013recovery dynamics reveal a separatrix in transcriptomic landscapes across organs and aging","display_name":"Stress\u2013recovery dynamics reveal a separatrix in transcriptomic landscapes across organs and aging","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7214958825","doi":"https://doi.org/10.64898/2026.09.29.755524"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.29.755524","doi":"https://doi.org/10.64898/2026.09.29.755524","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.29.755524","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.29.755524.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.29.755524.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058335659","display_name":"Bingxian Xu","orcid":"https://orcid.org/0000-0003-0406-563X","observed_orcids":["https://orcid.org/0000-0003-0406-563X"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I4405270701","display_name":"Shenzhen-Hong Kong Institute of Brain Science","ror":"https://ror.org/016fc9j78","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405270701"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Bingxian Xu","raw_affiliation_strings":["Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA","Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Guangdong Provincial Key Laboratory of Brain Connectome and Behaviour, CAS Key Laboratory of Brain Connectome and Manipulation, Shenzhen-Hong Kong Institute of Brain Science\u2013Shenzhen Fundamental Research Institutions, Shenzhen, China"],"raw_orcid":"https://orcid.org/0000-0003-0406-563X","affiliations":[{"raw_affiliation_string":"Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Guangdong Provincial Key Laboratory of Brain Connectome and Behaviour, CAS Key Laboratory of Brain Connectome and Manipulation, Shenzhen-Hong Kong Institute of Brain Science\u2013Shenzhen Fundamental Research Institutions, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761","https://openalex.org/I4405270701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153597856","display_name":"Shuqin Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]},{"id":"https://openalex.org/I4405255904","display_name":"Shenzhen University of Advanced Technology","ror":"https://ror.org/03hz5th67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405255904"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuqin Ji","raw_affiliation_strings":["Department of Urology and Andrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China","Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology (SUAT), Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology and Andrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]},{"raw_affiliation_string":"Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology (SUAT), Shenzhen, China","institution_ids":["https://openalex.org/I4405255904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121059956","display_name":"Ziyi Lin","orcid":"https://orcid.org/0000-0002-9165-9657","observed_orcids":["https://orcid.org/0000-0002-9165-9657"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I4405255904","display_name":"Shenzhen University of Advanced Technology","ror":"https://ror.org/03hz5th67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405255904"]},{"id":"https://openalex.org/I4405270701","display_name":"Shenzhen-Hong Kong Institute of Brain Science","ror":"https://ror.org/016fc9j78","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405270701"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyi Lin","raw_affiliation_strings":["Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology (SUAT), Shenzhen, China","Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Guangdong Provincial Key Laboratory of Brain Connectome and Behaviour, CAS Key Laboratory of Brain Connectome and Manipulation, Shenzhen-Hong Kong Institute of Brain Science\u2013Shenzhen Fundamental Research Institutions, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology (SUAT), Shenzhen, China","institution_ids":["https://openalex.org/I4405255904"]},{"raw_affiliation_string":"Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Guangdong Provincial Key Laboratory of Brain Connectome and Behaviour, CAS Key Laboratory of Brain Connectome and Manipulation, Shenzhen-Hong Kong Institute of Brain Science\u2013Shenzhen Fundamental Research Institutions, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761","https://openalex.org/I4405270701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066432407","display_name":"Chunhua Deng","orcid":"https://orcid.org/0009-0002-3512-4057","observed_orcids":["https://orcid.org/0009-0002-3512-4057","https://orcid.org/0000-0002-4969-2875"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunhua Deng","raw_affiliation_strings":["Department of Urology and Andrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology and Andrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100440316","display_name":"Lei Li","orcid":"https://orcid.org/0000-0002-4485-1937","observed_orcids":["https://orcid.org/0000-0002-4485-1937","https://orcid.org/0000-0003-0530-8015"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I4405255904","display_name":"Shenzhen University of Advanced Technology","ror":"https://ror.org/03hz5th67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405255904"]},{"id":"https://openalex.org/I4405270701","display_name":"Shenzhen-Hong Kong Institute of Brain Science","ror":"https://ror.org/016fc9j78","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405270701"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Li","raw_affiliation_strings":["Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology (SUAT), Shenzhen, China","Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Guangdong Provincial Key Laboratory of Brain Connectome and Behaviour, CAS Key Laboratory of Brain Connectome and Manipulation, Shenzhen-Hong Kong Institute of Brain Science\u2013Shenzhen Fundamental Research Institutions, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology (SUAT), Shenzhen, China","institution_ids":["https://openalex.org/I4405255904"]},{"raw_affiliation_string":"Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Guangdong Provincial Key Laboratory of Brain Connectome and Behaviour, CAS Key Laboratory of Brain Connectome and Manipulation, Shenzhen-Hong Kong Institute of Brain Science\u2013Shenzhen Fundamental Research Institutions, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761","https://openalex.org/I4405270701"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5100440316"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761","https://openalex.org/I4405255904","https://openalex.org/I4405270701"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.6851000189781189,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.6851000189781189,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.1835000067949295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.06030000001192093,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9670000076293945},{"id":"https://openalex.org/keywords/sleep-deprivation","display_name":"sleep deprivation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/stress-recovery","display_name":"stress recovery","score":0.8759999871253967},{"id":"https://openalex.org/keywords/transcriptome-dynamics","display_name":"transcriptome dynamics","score":0.7730000019073486},{"id":"https://openalex.org/keywords/separatrix","display_name":"separatrix","score":0.7229999899864197},{"id":"https://openalex.org/keywords/neural-odes","display_name":"neural ordinary differential equations","score":0.828000009059906},{"id":"https://openalex.org/keywords/organ-specific-gene-expression","display_name":"organ-specific gene expression","score":0.6880000233650208},{"id":"https://openalex.org/keywords/testis","display_name":"testis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/gene-expression-stability","display_name":"gene expression stability","score":0.5899999737739563},{"id":"https://openalex.org/keywords/perturbation-recovery","display_name":"perturbation recovery","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.8314999938011169},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6309999823570251},{"id":"https://openalex.org/C177918212","wikidata":"https://www.wikidata.org/wiki/Q803623","display_name":"Perturbation (astronomy)","level":2,"score":0.6202999949455261},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4553999900817871},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45339998602867126},{"id":"https://openalex.org/C76379757","wikidata":"https://www.wikidata.org/wiki/Q2902561","display_name":"Separatrix","level":3,"score":0.4108999967575073},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3804999887943268},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.37400001287460327},{"id":"https://openalex.org/C207821765","wikidata":"https://www.wikidata.org/wiki/Q405372","display_name":"Instability","level":2,"score":0.3192000091075897},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3181999921798706},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.30559998750686646},{"id":"https://openalex.org/C2780799671","wikidata":"https://www.wikidata.org/wiki/Q17087362","display_name":"Transient (computer programming)","level":2,"score":0.2992999851703644},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.29919999837875366},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2797999978065491},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.27410000562667847},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.26989999413490295},{"id":"https://openalex.org/C63584917","wikidata":"https://www.wikidata.org/wiki/Q333286","display_name":"Bounding overwatch","level":2,"score":0.2624000012874603}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.29.755524","doi":"https://doi.org/10.64898/2026.09.29.755524","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.29.755524","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.29.755524.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.29.755524","doi":"https://doi.org/10.64898/2026.09.29.755524","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.29.755524","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.29.755524.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7015251395","display_name":null,"funder_award_id":"NSFC32171154","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320325287","display_name":"SENSHIN Medical Research Foundation","ror":"https://ror.org/021tj4g88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214958825.pdf","grobid_xml":"https://content.openalex.org/works/W7214958825.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1535321247","https://openalex.org/W1815920130","https://openalex.org/W2027272551","https://openalex.org/W2035618305","https://openalex.org/W2048438929","https://openalex.org/W2051313501","https://openalex.org/W2056827131","https://openalex.org/W2063854986","https://openalex.org/W2070583401","https://openalex.org/W2088616087","https://openalex.org/W2088957204","https://openalex.org/W2103017472","https://openalex.org/W2117375244","https://openalex.org/W2123544560","https://openalex.org/W2130410032","https://openalex.org/W2166097443","https://openalex.org/W2166574880","https://openalex.org/W2179438025","https://openalex.org/W2889326414","https://openalex.org/W2902652978","https://openalex.org/W2990967024","https://openalex.org/W3153147243","https://openalex.org/W3154288382","https://openalex.org/W3164240006","https://openalex.org/W3175752499","https://openalex.org/W3179857518","https://openalex.org/W3200454510","https://openalex.org/W4242289937","https://openalex.org/W4313531093","https://openalex.org/W4405965123"],"related_works":["https://openalex.org/W7221596535","https://openalex.org/W4416702579","https://openalex.org/W7212274896","https://openalex.org/W4379374180","https://openalex.org/W7016043166","https://openalex.org/W4390021758","https://openalex.org/W7159630263","https://openalex.org/W4321499330","https://openalex.org/W4388725868","https://openalex.org/W3036902097"],"abstract_inverted_index":{"SUMMARY":[0],"Aging":[1],"is":[2],"often":[3],"characterized":[4],"statically":[5],"as":[6,133],"molecular":[7],"profiles,":[8],"but":[9],"how":[10],"these":[11,90],"profiles":[12],"may":[13],"affect":[14],"the":[15,22,109,116],"capacity":[16],"of":[17,106],"systems":[18],"to":[19,21,79],"respond":[20],"external":[23],"environment":[24],"remains":[25],"elusive.":[26],"We":[27],"perturbed":[28,120,148],"young":[29,110],"and":[30,37,46,62,131,141],"aged":[31],"mice":[32,111],"via":[33],"transient":[34,129],"sleep":[35],"deprivation":[36],"profiled":[38],"transcriptomes":[39],"from":[40,75,89,108],"six":[41],"organs":[42],"immediately":[43],"after":[44],"stress":[45],"following":[47],"recovery.":[48,83],"The":[49],"same":[50],"perturbation":[51,130],"induced":[52],"complex":[53],"temporal":[54],"dynamics":[55],"for":[56,136],"each":[57],"gene":[58],"in":[59],"an":[60],"organ-":[61],"age-dependent":[63,138],"manner.":[64],"A":[65],"shape":[66],"parameter":[67],"distinguished":[68],"genes":[69],"that":[70,77,105,144],"recovered":[71],"toward":[72,124],"control":[73],"expression":[74],"those":[76],"continued":[78],"drift":[80],"away":[81],"during":[82],"Transcriptomic":[84],"vector":[85],"fields":[86],"were":[87],"inferred":[88],"transitions":[91],"using":[92],"neural":[93],"ordinary":[94],"differential":[95],"equations,":[96],"revealing":[97],"distinct":[98],"stability":[99,140],"regimes":[100],"across":[101],"organ":[102],"systems.":[103],"Interestingly,":[104],"testis":[107],"contained":[112],"a":[113,134,147],"separatrix":[114],"bounding":[115],"region":[117],"within":[118],"which":[119],"state":[121],"can":[122,150],"return":[123],"control.":[125],"These":[126],"findings":[127],"establish":[128],"recovery":[132],"framework":[135],"probing":[137],"transcriptomic":[139],"identifying":[142],"boundaries":[143],"determine":[145],"whether":[146],"system":[149],"return.":[151]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-01T00:00:00"}