{"id":"https://openalex.org/W7214947202","doi":"https://doi.org/10.64898/2026.09.29.755318","title":"Endothelial AMBRA1 loss contributes to vascular dysregulation facilitating metastatic progression in early-stage melanoma","display_name":"Endothelial AMBRA1 loss contributes to vascular dysregulation facilitating metastatic progression in early-stage melanoma","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7214947202","doi":"https://doi.org/10.64898/2026.09.29.755318"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.29.755318","doi":"https://doi.org/10.64898/2026.09.29.755318","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.29.755318","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.29.755318.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.29.755318.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070215739","display_name":"Laura Walker","orcid":"https://orcid.org/0000-0002-5298-924X","observed_orcids":["https://orcid.org/0000-0002-5298-924X"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laura Walker","raw_affiliation_strings":["Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK"],"raw_orcid":"https://orcid.org/0000-0002-5298-924X","affiliations":[{"raw_affiliation_string":"Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045863730","display_name":"Roisin Stout","orcid":"https://orcid.org/0000-0002-6519-5836","observed_orcids":["https://orcid.org/0000-0002-6519-5836"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roisin Stout","raw_affiliation_strings":["Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK"],"raw_orcid":"https://orcid.org/0000-0002-6519-5836","affiliations":[{"raw_affiliation_string":"Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030132924","display_name":"Martina Di Rienzo","orcid":"https://orcid.org/0000-0002-1520-479X","observed_orcids":["https://orcid.org/0000-0002-1520-479X"]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Martina Di Rienzo","raw_affiliation_strings":["Department of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d-IRCCS, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1520-479X","affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d-IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089051063","display_name":"Katie Best","orcid":"https://orcid.org/0000-0002-1745-6392","observed_orcids":["https://orcid.org/0000-0002-1745-6392"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katie Best","raw_affiliation_strings":["Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK"],"raw_orcid":"https://orcid.org/0000-0002-1745-6392","affiliations":[{"raw_affiliation_string":"Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129071651","display_name":"Sofia Bisegna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sofia Bisegna","raw_affiliation_strings":["Department of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d-IRCCS, Rome, Italy","Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena-291, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d-IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]},{"raw_affiliation_string":"Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena-291, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000048105","display_name":"Luca Occhigrossi","orcid":"https://orcid.org/0000-0002-1674-7091","observed_orcids":["https://orcid.org/0000-0002-1674-7091"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Occhigrossi","raw_affiliation_strings":["Department of Biology, University of Rome \u2018Tor Vergata\u2019, Rome, Italy","Department of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d-IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rome \u2018Tor Vergata\u2019, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Department of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d-IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078479245","display_name":"Ioana Cosgarea","orcid":"https://orcid.org/0000-0002-2639-6264","observed_orcids":["https://orcid.org/0000-0002-2639-6264"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ioana Cosgarea","raw_affiliation_strings":["Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024164941","display_name":"Philip Sloan","orcid":"https://orcid.org/0000-0002-0142-0213","observed_orcids":["https://orcid.org/0000-0002-0142-0213"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip Sloan","raw_affiliation_strings":["Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK"],"raw_orcid":"https://orcid.org/0000-0002-0142-0213","affiliations":[{"raw_affiliation_string":"Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153624194","display_name":"Grant Richardson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Grant Richardson","raw_affiliation_strings":["Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017097584","display_name":"Raffaele Strippoli","orcid":"https://orcid.org/0000-0003-3483-8381","observed_orcids":["https://orcid.org/0000-0003-3483-8381"]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Raffaele Strippoli","raw_affiliation_strings":["Department of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d-IRCCS, Rome, Italy","Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena-291, 00161 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3483-8381","affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d-IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]},{"raw_affiliation_string":"Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena-291, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050710377","display_name":"Mauro Piacentini","orcid":"https://orcid.org/0000-0003-2919-1296","observed_orcids":["https://orcid.org/0000-0003-2919-1296"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mauro Piacentini","raw_affiliation_strings":["Department of Biology, University of Rome \u2018Tor Vergata\u2019, Rome, Italy","Department of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d-IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rome \u2018Tor Vergata\u2019, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Department of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d-IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055234275","display_name":"Gian Mar\u00eda Fimia","orcid":"https://orcid.org/0000-0003-4438-3325","observed_orcids":["https://orcid.org/0000-0003-4438-3325"]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gian Maria Fimia","raw_affiliation_strings":["Department of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d-IRCCS, Rome, Italy","Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena-291, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d-IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]},{"raw_affiliation_string":"Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena-291, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082755088","display_name":"Penny E. Lovat","orcid":"https://orcid.org/0000-0002-6657-6825","observed_orcids":["https://orcid.org/0000-0002-6657-6825"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Penny E Lovat","raw_affiliation_strings":["Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK"],"raw_orcid":"https://orcid.org/0000-0002-6657-6825","affiliations":[{"raw_affiliation_string":"Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016998620","display_name":"Jane L. Armstrong","orcid":"https://orcid.org/0000-0002-5822-0597","observed_orcids":["https://orcid.org/0000-0002-5822-0597"]},"institutions":[{"id":"https://openalex.org/I5728261","display_name":"University of Sunderland","ror":"https://ror.org/04p55hr04","country_code":"GB","type":"education","lineage":["https://openalex.org/I5728261"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jane Armstrong","raw_affiliation_strings":["John Dawson Drug Discovery and Development Research Institute, University of Sunderland, Sunderland, UK"],"raw_orcid":"https://orcid.org/0000-0002-5822-0597","affiliations":[{"raw_affiliation_string":"John Dawson Drug Discovery and Development Research Institute, University of Sunderland, Sunderland, UK","institution_ids":["https://openalex.org/I5728261"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5016998620"],"corresponding_institution_ids":["https://openalex.org/I5728261"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.023499999195337296,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ambra1","display_name":"AMBRA1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/early-stage-melanoma","display_name":"early-stage melanoma","score":0.8560000061988831},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6079999804496765},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8450000286102295},{"id":"https://openalex.org/keywords/vascular-dysfunction","display_name":"vascular dysfunction","score":0.8820000290870667},{"id":"https://openalex.org/keywords/endothelial-plasticity","display_name":"endothelial plasticity","score":0.8309999704360962},{"id":"https://openalex.org/keywords/endothelial-mesenchymal-transition","display_name":"endothelial-to-mesenchymal transition","score":0.9399999976158142},{"id":"https://openalex.org/keywords/loricrin","display_name":"loricrin","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.6190000176429749},{"id":"https://openalex.org/keywords/tubulogenesis","display_name":"tubulogenesis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/endothelial-junctions","display_name":"endothelial junctions","score":0.652999997138977},{"id":"https://openalex.org/keywords/lymphatic-vessels","display_name":"lymphatic vessels","score":0.9179999828338623},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.765999972820282},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.45500001311302185},{"id":"https://openalex.org/keywords/slug","display_name":"Slug","score":0.375},{"id":"https://openalex.org/keywords/snails","display_name":"snails","score":0.9079999923706055},{"id":"https://openalex.org/keywords/claudin-5","display_name":"claudin-5","score":0.9169999957084656},{"id":"https://openalex.org/keywords/ve-cadherin","display_name":"VE-cadherin","score":0.8679999709129333},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.9829999804496765}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.652400016784668},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6193000078201294},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6122000217437744},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5248000025749207},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5113000273704529},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.44119998812675476},{"id":"https://openalex.org/C2910366181","wikidata":"https://www.wikidata.org/wiki/Q6708239","display_name":"Lymphatic Endothelium","level":3,"score":0.41350001096725464},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.4068000018596649},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4068000018596649},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.39419999718666077},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.3919999897480011},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.3889000117778778},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.382099986076355},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.3758000135421753},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.353300005197525},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.3248000144958496},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.3221000134944916},{"id":"https://openalex.org/C2776246508","wikidata":"https://www.wikidata.org/wiki/Q5376428","display_name":"Endothelial activation","level":3,"score":0.31220000982284546},{"id":"https://openalex.org/C103041312","wikidata":"https://www.wikidata.org/wiki/Q7916457","display_name":"Vascular endothelial growth factor C","level":5,"score":0.30570000410079956},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.29030001163482666},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.2896000146865845},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28780001401901245},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27869999408721924},{"id":"https://openalex.org/C60781801","wikidata":"https://www.wikidata.org/wiki/Q1424593","display_name":"Vasculogenesis","level":4,"score":0.27230000495910645},{"id":"https://openalex.org/C2776336362","wikidata":"https://www.wikidata.org/wiki/Q18028529","display_name":"Galectin-3","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.26660001277923584},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2630999982357025},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25600001215934753},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.2558000087738037},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2540000081062317},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.25290000438690186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.29.755318","doi":"https://doi.org/10.64898/2026.09.29.755318","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.29.755318","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.29.755318.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.29.755318","doi":"https://doi.org/10.64898/2026.09.29.755318","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.29.755318","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.29.755318.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320013","display_name":"British Skin Foundation","ror":"https://ror.org/02h7g2017"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214947202.pdf","grobid_xml":"https://content.openalex.org/works/W7214947202.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1937985080","https://openalex.org/W1950829641","https://openalex.org/W1983562016","https://openalex.org/W1990065140","https://openalex.org/W1991797784","https://openalex.org/W1992947862","https://openalex.org/W1995168398","https://openalex.org/W2009874228","https://openalex.org/W2016987827","https://openalex.org/W2056663185","https://openalex.org/W2062265555","https://openalex.org/W2062891030","https://openalex.org/W2065896797","https://openalex.org/W2067829376","https://openalex.org/W2071453130","https://openalex.org/W2118613169","https://openalex.org/W2134723973","https://openalex.org/W2136280424","https://openalex.org/W2158659385","https://openalex.org/W2166662937","https://openalex.org/W2230320310","https://openalex.org/W2298872710","https://openalex.org/W2332292689","https://openalex.org/W2649656222","https://openalex.org/W2753686745","https://openalex.org/W2806413494","https://openalex.org/W2902875247","https://openalex.org/W2920994691","https://openalex.org/W2953419714","https://openalex.org/W2969253527","https://openalex.org/W3000943455","https://openalex.org/W3049132659","https://openalex.org/W3092002669","https://openalex.org/W3094599880","https://openalex.org/W3135789526","https://openalex.org/W3156007823","https://openalex.org/W3158285127","https://openalex.org/W3196677920","https://openalex.org/W3205597622","https://openalex.org/W3214318481","https://openalex.org/W3214383150","https://openalex.org/W4220760869","https://openalex.org/W4220856798","https://openalex.org/W4256613767","https://openalex.org/W4283029131","https://openalex.org/W4323066851","https://openalex.org/W4365813924","https://openalex.org/W4377206014","https://openalex.org/W4385492216","https://openalex.org/W4389003102","https://openalex.org/W4399622235","https://openalex.org/W7025044264","https://openalex.org/W7130516439","https://openalex.org/W7134916261","https://openalex.org/W7163338270"],"related_works":["https://openalex.org/W7222205019","https://openalex.org/W4366184454","https://openalex.org/W4399146051","https://openalex.org/W4383499428","https://openalex.org/W3158285127","https://openalex.org/W3214383150","https://openalex.org/W3173234362","https://openalex.org/W4399122712","https://openalex.org/W4412837112","https://openalex.org/W4323066851"],"abstract_inverted_index":{"Abstract":[0],"Validated":[1],"biomarkers":[2],"for":[3],"identifying":[4],"patients":[5],"with":[6,37,153,199],"early-stage":[7,189],"melanomas":[8,166],"at":[9],"high":[10],"risk":[11],"of":[12,22,64,84,91,131,138,143,159,180,194],"metastasis":[13],"are":[14],"limited.":[15],"We":[16],"have":[17],"previously":[18],"shown":[19],"that":[20,43],"loss":[21,63,104,137],"Activating":[23],"Molecule":[24],"in":[25,31,66,71,73,98,140,156,188],"Beclin-1-Regulated":[26],"Autophagy":[27],"(AMBRA1)":[28],"and":[29,51,75,86,95,122,124,128,134,145,148,184,191],"loricrin":[30],"the":[32],"epidermal":[33],"microenvironment":[34,197],"is":[35],"associated":[36,198],"tumour":[38],"recurrence.":[39],"Here":[40],"we":[41],"show":[42],"endothelial":[44,67,92,100,106,132,175,186],"AMBRA1":[45,65,103,139,176],"deficiency":[46],"contributes":[47],"to":[48,58],"vascular":[49,181],"dysfunction":[50],"melanoma":[52,77],"progression.":[53],"Melanoma-conditioned":[54],"media":[55],"or":[56],"exposure":[57],"TGF\u03b21-3":[59],"ligands":[60],"induced":[61],"post-transcriptional":[62],"cells.":[68,101],"Transcriptomic":[69],"profiling":[70],"both":[72],"vitro":[74],"human":[76],"single-cell":[78],"RNA":[79],"sequencing":[80],"datasets":[81],"showed":[82],"activation":[83],"cell-cycle":[85],"metabolic":[87],"programmes":[88],"alongside":[89],"suppression":[90],"junction,":[93],"adhesion":[94],"immune-supportive":[96,185],"pathways":[97],"AMBRA1-deficient":[99],"Functionally,":[102],"increased":[105],"cell":[107],"proliferation,":[108],"accelerated":[109],"early":[110],"tubulogenesis,":[111],"impaired":[112],"three-dimensional":[113],"spheroid":[114],"adhesion,":[115],"stabilised":[116],"endothelial-to-mesenchymal":[117],"transition-associated":[118],"transcription":[119],"factors":[120],"Slug":[121],"Snail,":[123],"reduced":[125],"Claudin-5,":[126],"VE-cadherin":[127],"N-cadherin,":[129],"indicative":[130],"plasticity":[133],"dysfunction.":[135],"Furthermore,":[136],"a":[141,157,178,192,195],"subset":[142],"intratumoural":[144],"peritumoural":[146],"blood":[147],"lymphatic":[149],"vessels":[150],"correlated":[151],"significantly":[152],"metastatic":[154],"progression":[155],"cohort":[158],"121":[160],"non-ulcerated":[161],"primary":[162],"AJCC":[163],"stage":[164],"I/II":[165],"classified":[167],"as":[168,177],"AMBLor":[169],"at-risk.":[170],"Collectively,":[171],"these":[172],"findings":[173],"position":[174],"regulator":[179],"plasticity,":[182],"dysfunction,":[183],"function":[187],"melanomas,":[190],"marker":[193],"permissive":[196],"metastasis.":[200]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-01T00:00:00"}
