{"id":"https://openalex.org/W7214945643","doi":"https://doi.org/10.33854/heme.v8i3.2495","title":"Laboratory Biomarkers for Early Screening of Metabolic Kidney Disease Risk in Older Adults","display_name":"Laboratory Biomarkers for Early Screening of Metabolic Kidney Disease Risk in Older Adults","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7214945643","doi":"https://doi.org/10.33854/heme.v8i3.2495"},"language":"en","primary_location":{"id":"doi:10.33854/heme.v8i3.2495","doi":"https://doi.org/10.33854/heme.v8i3.2495","is_oa":true,"landing_page_url":"https://doi.org/10.33854/heme.v8i3.2495","pdf_url":"https://jurnal.unbrah.ac.id/index.php/heme/article/download/2495/725","source":{"id":"https://openalex.org/S4210214502","display_name":"Health & Medical Journal","issn_l":"2685-404X","issn":["2685-404X","2685-2772"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210157074","host_organization_name":"Universitas Baiturrahmah","host_organization_lineage":["https://openalex.org/I4210157074"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health and Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://jurnal.unbrah.ac.id/index.php/heme/article/download/2495/725","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013007473","display_name":"Debie Anggraini","orcid":"https://orcid.org/0000-0002-6180-7380","observed_orcids":["https://orcid.org/0000-0002-6180-7380"]},"institutions":[{"id":"https://openalex.org/I4210157074","display_name":"Universitas Baiturrahmah","ror":"https://ror.org/055rtmw65","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210157074"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Debie Anggraini","raw_affiliation_strings":["(ORCID : 0000-0002-6180-7380, Scopus ID : 58198560800) - Universitas Baiturrahmah"],"raw_orcid":"https://orcid.org/0000-0002-6180-7380","affiliations":[{"raw_affiliation_string":"(ORCID : 0000-0002-6180-7380, Scopus ID : 58198560800) - Universitas Baiturrahmah","institution_ids":["https://openalex.org/I4210157074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116478067","display_name":"Meta Zulyati Oktora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157074","display_name":"Universitas Baiturrahmah","ror":"https://ror.org/055rtmw65","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210157074"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Meta Zulyati Oktora","raw_affiliation_strings":["Universitas Baiturrahmah, Padang, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Baiturrahmah, Padang, Indonesia","institution_ids":["https://openalex.org/I4210157074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045846317","display_name":"Prima Adelin","orcid":"https://orcid.org/0000-0003-2209-8937","observed_orcids":["https://orcid.org/0000-0003-2209-8937"]},"institutions":[{"id":"https://openalex.org/I4210157074","display_name":"Universitas Baiturrahmah","ror":"https://ror.org/055rtmw65","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210157074"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Prima Adelin","raw_affiliation_strings":["Universitas Baiturrahmah, Padang, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Baiturrahmah, Padang, Indonesia","institution_ids":["https://openalex.org/I4210157074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210157074"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"3","first_page":"268","last_page":"283"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.972000002861023},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9200000166893005},{"id":"https://openalex.org/keywords/laboratory-markers","display_name":"laboratory biomarkers","score":0.9800000190734863},{"id":"https://openalex.org/keywords/early-screening","display_name":"early screening","score":0.890999972820282},{"id":"https://openalex.org/keywords/glycemic-markers","display_name":"glycemic markers","score":0.8500000238418579},{"id":"https://openalex.org/keywords/lipid-biomarkers","display_name":"lipid biomarkers","score":0.9919999837875366},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.9049999713897705},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7239999771118164},{"id":"https://openalex.org/keywords/renal-biomarkers","display_name":"renal biomarkers","score":0.8510000109672546},{"id":"https://openalex.org/keywords/subclinical-kidney-injury","display_name":"subclinical kidney injury","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8234000205993652},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.7278000116348267},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6104000210762024},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5848000049591064},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.5235999822616577},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.43540000915527344},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.4196000099182129},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4178999960422516},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.41499999165534973},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.40059998631477356},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.40059998631477356},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38749998807907104},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.3368000090122223},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3325999975204468},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.33180001378059387},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.3294000029563904},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.328900009393692},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.3165000081062317},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.2874000072479248},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.2736000120639801},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.2662999927997589},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.2644999921321869},{"id":"https://openalex.org/C3017616150","wikidata":"https://www.wikidata.org/wiki/Q1069330","display_name":"Diagnostic biomarker","level":3,"score":0.263700008392334},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.33854/heme.v8i3.2495","doi":"https://doi.org/10.33854/heme.v8i3.2495","is_oa":true,"landing_page_url":"https://doi.org/10.33854/heme.v8i3.2495","pdf_url":"https://jurnal.unbrah.ac.id/index.php/heme/article/download/2495/725","source":{"id":"https://openalex.org/S4210214502","display_name":"Health & Medical Journal","issn_l":"2685-404X","issn":["2685-404X","2685-2772"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210157074","host_organization_name":"Universitas Baiturrahmah","host_organization_lineage":["https://openalex.org/I4210157074"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health and Medical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.33854/heme.v8i3.2495","doi":"https://doi.org/10.33854/heme.v8i3.2495","is_oa":true,"landing_page_url":"https://doi.org/10.33854/heme.v8i3.2495","pdf_url":"https://jurnal.unbrah.ac.id/index.php/heme/article/download/2495/725","source":{"id":"https://openalex.org/S4210214502","display_name":"Health & Medical Journal","issn_l":"2685-404X","issn":["2685-404X","2685-2772"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210157074","host_organization_name":"Universitas Baiturrahmah","host_organization_lineage":["https://openalex.org/I4210157074"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health and Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214945643.pdf","grobid_xml":"https://content.openalex.org/works/W7214945643.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W4400572432","https://openalex.org/W4400770129","https://openalex.org/W4409974964"],"related_works":["https://openalex.org/W4380625836","https://openalex.org/W3114510630","https://openalex.org/W7127037677","https://openalex.org/W2276919123","https://openalex.org/W4402858908","https://openalex.org/W7223139320","https://openalex.org/W7161125503","https://openalex.org/W7126057175","https://openalex.org/W4402951942","https://openalex.org/W4410859880"],"abstract_inverted_index":{"Background:":[0],"Population":[1],"aging":[2],"and":[3,29,61,77,91,123,143,164,172,179,187,207,231,252,266,273],"the":[4,13,66,80,153,268],"increasing":[5],"prevalence":[6],"of":[7,15,69,83,152,212,237,270],"metabolic":[8,24,70,112,157,169,238],"disorders":[9],"have":[10],"substantially":[11],"increased":[12],"burden":[14],"chronic":[16],"kidney":[17,25,71,113,161,189,239],"disease":[18,26,49,72,240],"(CKD)":[19],"among":[20],"older":[21,75,214,242],"adults.":[22,243],"Because":[23],"develops":[27],"gradually":[28],"often":[30],"remains":[31],"asymptomatic":[32],"during":[33],"its":[34],"early":[35,37,67,235,259],"stages,":[36],"identification":[38,211],"using":[39],"laboratory":[40,63,108,147,198,224],"biomarkers":[41,64,109,148,166,174,184,199],"has":[42],"become":[43],"an":[44,84],"important":[45],"strategy":[46,233],"for":[47,65,88,234],"preventing":[48],"progression.":[50],"Objective:":[51],"This":[52],"review":[53,97],"aimed":[54],"to":[55,78,159],"summarize":[56],"current":[57],"evidence":[58,103],"regarding":[59],"conventional":[60],"emerging":[62],"screening":[68,236],"risk":[73,89,202,260],"in":[74,241],"adults":[76,215],"discuss":[79],"clinical":[81,141],"value":[82],"integrated":[85,223],"multimarker":[86,245],"approach":[87,226],"stratification":[90,203],"preventive":[92,264],"nephrology.":[93,275],"Methods:":[94],"A":[95],"narrative":[96],"was":[98],"conducted":[99],"by":[100],"synthesizing":[101],"recent":[102],"from":[104,156],"peer-reviewed":[105],"literature":[106],"on":[107,137],"associated":[110],"with":[111,135],"disease.":[114],"Conventional":[115],"biomarkers,":[116,132],"including":[117],"glycemic,":[118],"lipid,":[119],"renal,":[120],"inflammatory,":[121],"metabolic,":[122],"hematological":[124,173],"parameters,":[125],"as":[126,128],"well":[127],"selected":[129],"novel":[130],"renal":[131,183],"were":[133],"evaluated":[134],"emphasis":[136],"their":[138],"biological":[139],"rationale,":[140],"applicability,":[142],"limitations.":[144],"Results:":[145],"Individual":[146],"reflect":[149,185],"different":[150],"stages":[151],"pathophysiological":[154],"continuum":[155],"dysregulation":[158],"subclinical":[160],"injury.":[162],"Glycemic":[163],"lipid":[165],"identify":[167],"upstream":[168],"abnormalities,":[170],"inflammatory":[171],"indicate":[175],"systemic":[176],"immune":[177],"activation":[178],"oxidative":[180],"stress,":[181],"whereas":[182],"structural":[186],"functional":[188],"impairment.":[190],"Evidence":[191],"suggests":[192],"that":[193],"integrating":[194],"these":[195],"routinely":[196],"available":[197],"provides":[200],"better":[201],"than":[204],"single-marker":[205],"assessment":[206,246],"may":[208,257],"facilitate":[209],"earlier":[210],"high-risk":[213],"before":[216],"clinically":[217],"overt":[218],"CKD":[219],"develops.":[220],"Conclusion:":[221],"An":[222],"biomarker":[225],"represents":[227],"a":[228],"practical,":[229],"accessible,":[230],"promising":[232],"Incorporating":[244],"into":[247],"primary":[248],"healthcare,":[249],"geriatric":[250],"services,":[251],"routine":[253],"medical":[254],"check-up":[255],"programs":[256],"improve":[258],"prediction,":[261],"support":[262],"personalized":[263],"interventions,":[265],"advance":[267],"implementation":[269],"predictive,":[271],"preventive,":[272],"precision":[274]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-10-01T00:00:00"}
