{"id":"https://openalex.org/W7214940298","doi":"https://doi.org/10.64898/2026.09.24.754187","title":"Functional validation and characterization of Slc39a8 genotype effects on ethanol consumption and related phenotypes","display_name":"Functional validation and characterization of Slc39a8 genotype effects on ethanol consumption and related phenotypes","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7214940298","doi":"https://doi.org/10.64898/2026.09.24.754187","pmid":"https://pubmed.ncbi.nlm.nih.gov/42856339","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13648464"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.24.754187","doi":"https://doi.org/10.64898/2026.09.24.754187","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.754187","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.24.754187.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.24.754187.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117850189","display_name":"Andr\u00e9 Lucas Silva-Borges","orcid":"https://orcid.org/0009-0003-7134-8370","observed_orcids":["https://orcid.org/0009-0003-7134-8370"]},"institutions":[{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Lucas Silva-Borges","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA"],"raw_orcid":"https://orcid.org/0009-0003-7134-8370","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA","institution_ids":["https://openalex.org/I4405255059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153582709","display_name":"Donna-Jael G Paredes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donna-Jael G. Paredes","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA","institution_ids":["https://openalex.org/I4405255059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153640196","display_name":"Rebeka Sultana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebeka Sultana","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA","institution_ids":["https://openalex.org/I4405255059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153622773","display_name":"Cecilia G Pareja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cecilia G. Pareja","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA","institution_ids":["https://openalex.org/I4405255059"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049141102","display_name":"Amanda M. Barkley\u2010Levenson","orcid":"https://orcid.org/0000-0003-3722-7578","observed_orcids":["https://orcid.org/0000-0003-3722-7578"]},"institutions":[{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amanda M. Barkley-Levenson","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA"],"raw_orcid":"https://orcid.org/0000-0003-3722-7578","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA","institution_ids":["https://openalex.org/I4405255059"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049141102"],"corresponding_institution_ids":["https://openalex.org/I4405255059"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.5019999742507935,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.5019999742507935,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.37869998812675476,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.037700001150369644,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/slc39a8","display_name":"SLC39A8","score":1.0},{"id":"https://openalex.org/keywords/zip8","display_name":"ZIP8","score":0.9900000095367432},{"id":"https://openalex.org/keywords/zinc-transport","display_name":"zinc transport","score":0.7009999752044678},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.5730000138282776},{"id":"https://openalex.org/keywords/voluntary-ethanol-consumption","display_name":"voluntary ethanol consumption","score":0.7400000095367432},{"id":"https://openalex.org/keywords/heterozygous-knockout-mice","display_name":"heterozygous knockout mice","score":0.8519999980926514},{"id":"https://openalex.org/keywords/two-bottle-choice","display_name":"two-bottle choice","score":0.8130000233650208},{"id":"https://openalex.org/keywords/drinking-in-the-dark","display_name":"drinking in the dark","score":0.8920000195503235},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.9430000185966492},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":1.0},{"id":"https://openalex.org/keywords/brain-iron","display_name":"brain iron","score":0.5839999914169312},{"id":"https://openalex.org/keywords/trace-metals","display_name":"trace metals","score":0.718999981880188},{"id":"https://openalex.org/keywords/alcohol-metabolism","display_name":"alcohol metabolism","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7617999911308289},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.6506999731063843},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.5353999733924866},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4666000008583069},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.46639999747276306},{"id":"https://openalex.org/C3019635848","wikidata":"https://www.wikidata.org/wiki/Q154","display_name":"Alcohol consumption","level":3,"score":0.45570001006126404},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43799999356269836},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.4106000065803528},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.383899986743927},{"id":"https://openalex.org/C2994499388","wikidata":"https://www.wikidata.org/wiki/Q656732","display_name":"Gene deletion","level":4,"score":0.38179999589920044},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3792000114917755},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3621000051498413},{"id":"https://openalex.org/C30153976","wikidata":"https://www.wikidata.org/wiki/Q6011565","display_name":"Ethanol metabolism","level":3,"score":0.3594000041484833},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3515999913215637},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3352000117301941},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.29739999771118164},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.2964000105857849},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2935999929904938},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2831000089645386},{"id":"https://openalex.org/C200844832","wikidata":"https://www.wikidata.org/wiki/Q5533517","display_name":"Genotype-phenotype distinction","level":4,"score":0.28220000863075256},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.28209999203681946},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2770000100135803},{"id":"https://openalex.org/C2908875944","wikidata":"https://www.wikidata.org/wiki/Q7331102","display_name":"Excessive alcohol consumption","level":4,"score":0.27570000290870667},{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.27309998869895935},{"id":"https://openalex.org/C2779436514","wikidata":"https://www.wikidata.org/wiki/Q4713263","display_name":"Alcohol dependence","level":3,"score":0.2687000036239624},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.267300009727478},{"id":"https://openalex.org/C2777595113","wikidata":"https://www.wikidata.org/wiki/Q61457","display_name":"Acetaldehyde","level":3,"score":0.2637999951839447},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.26170000433921814},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.26109999418258667},{"id":"https://openalex.org/C2779314966","wikidata":"https://www.wikidata.org/wiki/Q409999","display_name":"Frataxin","level":4,"score":0.2590000033378601},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.2574999928474426},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.25429999828338623}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.24.754187","doi":"https://doi.org/10.64898/2026.09.24.754187","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.754187","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.24.754187.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13648464","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648464/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648464/pdf/nihpp-2026.09.24.754187v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42856339","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42856339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.09.24.754187","doi":"https://doi.org/10.64898/2026.09.24.754187","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.754187","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.24.754187.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5294327789","display_name":"Identification and Characterization of Novel Genetic Mechanisms in Alcohol Use Disorder and Excessive Drinking","funder_award_id":"R00AA027835","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000866300","display_name":"University of New Mexico Center for Metals in Biology and Medicine","funder_award_id":"P20GM130422","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214940298.pdf","grobid_xml":"https://content.openalex.org/works/W7214940298.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1482980322","https://openalex.org/W1576438053","https://openalex.org/W1930085052","https://openalex.org/W1967292684","https://openalex.org/W2000341672","https://openalex.org/W2010416288","https://openalex.org/W2020975063","https://openalex.org/W2022939126","https://openalex.org/W2039153962","https://openalex.org/W2050409980","https://openalex.org/W2055223893","https://openalex.org/W2055544195","https://openalex.org/W2057644086","https://openalex.org/W2080003243","https://openalex.org/W2086235593","https://openalex.org/W2086911005","https://openalex.org/W2104108238","https://openalex.org/W2107258454","https://openalex.org/W2125118264","https://openalex.org/W2132471916","https://openalex.org/W2140597890","https://openalex.org/W2159950826","https://openalex.org/W2166059093","https://openalex.org/W2504926893","https://openalex.org/W2605095000","https://openalex.org/W2610163363","https://openalex.org/W2612345436","https://openalex.org/W2777388159","https://openalex.org/W2811499973","https://openalex.org/W2820006500","https://openalex.org/W2895170936","https://openalex.org/W2897405036","https://openalex.org/W2905226148","https://openalex.org/W2947306452","https://openalex.org/W2950625872","https://openalex.org/W3014806942","https://openalex.org/W3091818954","https://openalex.org/W3096966615","https://openalex.org/W3131982609","https://openalex.org/W3210477925","https://openalex.org/W3211921280","https://openalex.org/W4281878980","https://openalex.org/W4282945056","https://openalex.org/W4283729547","https://openalex.org/W4285012838","https://openalex.org/W4287147673","https://openalex.org/W4294281304","https://openalex.org/W4367183716","https://openalex.org/W4375859145","https://openalex.org/W4375951111","https://openalex.org/W4384944995","https://openalex.org/W4388590557","https://openalex.org/W4388655207","https://openalex.org/W4403662815","https://openalex.org/W4408813567","https://openalex.org/W7164139842"],"related_works":["https://openalex.org/W84567616","https://openalex.org/W6908250848","https://openalex.org/W2031676788","https://openalex.org/W6986562369","https://openalex.org/W4281878980","https://openalex.org/W1705261965","https://openalex.org/W7151219935","https://openalex.org/W2016149358","https://openalex.org/W2522130691","https://openalex.org/W3130482867"],"abstract_inverted_index":{"Abstract":[0],"Alcohol":[1],"use":[2],"disorders":[3],"are":[4,18],"heritable,":[5],"and":[6,23,45,52,73,98,103,105,144,151,164,169,189,213,233,272],"large-scale":[7],"genome-wide":[8],"association":[9],"studies":[10],"have":[11],"recently":[12],"identified":[13],"novel":[14],"genetic":[15],"loci":[16],"that":[17,110,176,249,266],"correlated":[19],"with":[20,60],"alcohol":[21,25,63,92,115,152,166],"consumption":[22,93],"problematic":[24,62],"use.":[26,64],"One":[27],"such":[28],"gene":[29,85],"is":[30,49],"Slc39a8":[31,48,68,148,160,211,244],",":[32],"which":[33],"encodes":[34],"the":[35,81,96,119,141,187,199,207],"ion":[36],"transporter":[37],"ZIP8,":[38],"responsible":[39],"for":[40,129,239,282],"cellular":[41],"import":[42],"of":[43,83,90,159,172,198,202,209,231,243],"zinc":[44,173,184,232,277],"other":[46],"metals.":[47],"highly":[50],"pleiotropic,":[51],"a":[53,240],"common":[54],"missense":[55],"variant":[56],"has":[57],"been":[58],"associated":[59],"decreased":[61,156],"Here,":[65],"we":[66,264],"used":[67],"heterozygous":[69],"(HET)":[70],"knockout":[71],"mice":[72,112,163,178,215],"their":[74],"wild":[75],"type":[76],"(WT)":[77],"littermates":[78],"to":[79,253,256],"characterize":[80],"effects":[82],"reduced":[84],"function":[86],"on":[87],"two":[88],"models":[89],"voluntary":[91],"(drinking":[94],"in":[95,118,132,140,161,186,192,206,229,245,276],"dark":[97],"intermittent":[99,120],"access":[100,121],"two-bottle":[101,122],"choice),":[102],"anxiety-":[104],"depression-like":[106,138],"behavior.":[107],"We":[108],"found":[109,128],"HET":[111,162,177,212],"consumed":[113],"less":[114],"than":[116,194],"WT":[117,195,214],"choice":[123],"procedure.":[124],"No":[125],"evidence":[126,238],"was":[127],"genotypic":[130,227],"differences":[131,228],"baseline":[133],"locomotor":[134,261],"activity,":[135],"anxiety-like,":[136],"or":[137,260],"behavior":[139,248],"open":[142],"field":[143],"forced":[145],"swim":[146],"tests.":[147],"mRNA":[149],"expression":[150,158],"metabolism":[153],"experiments":[154],"confirmed":[155],"brain":[157,273],"unchanged":[165],"metabolism.":[167],"Basal":[168],"post-alcohol":[170],"measurement":[171],"levels":[174,230],"showed":[175,225],"after":[179],"ethanol":[180,246],"exposure":[181],"had":[182],"lower":[183],"concentrations":[185,191],"liver":[188],"higher":[190],"blood":[193],"animals.":[196],"Analysis":[197],"spatial":[200],"distribution":[201],"multiple":[203],"trace":[204],"metals":[205],"brains":[208],"na\u00efve":[210],"using":[216],"Laser":[217],"Ablation":[218],"Inductively":[219],"Coupled":[220],"Plasma":[221],"Mass":[222],"Spectrometry":[223],"(LA-ICP-MS)":[224],"region-specific":[226,274],"iron.":[234],"These":[235],"results":[236],"provide":[237],"direct":[241],"role":[242],"consummatory":[247],"does":[250],"not":[251],"appear":[252],"be":[254],"due":[255],"metabolism,":[257],"affective":[258],"state,":[259],"activity.":[262],"Moreover,":[263],"confirm":[265],"this":[267],"animal":[268],"model":[269],"shows":[270],"tissue-":[271],"alterations":[275],"levels,":[278],"highlighting":[279],"potential":[280],"mechanisms":[281],"future":[283],"study.":[284]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-01T00:00:00"}