{"id":"https://openalex.org/W7214930708","doi":"https://doi.org/10.1016/j.jlr.2026.101162","title":"Autoimmune-Mediated Hypertriglyceridemia in a Young Male with Refractory Immune Thrombocytopenia: A Case Report","display_name":"Autoimmune-Mediated Hypertriglyceridemia in a Young Male with Refractory Immune Thrombocytopenia: A Case Report","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7214930708","doi":"https://doi.org/10.1016/j.jlr.2026.101162","pmid":"https://pubmed.ncbi.nlm.nih.gov/42815576"},"language":"en","primary_location":{"id":"doi:10.1016/j.jlr.2026.101162","doi":"https://doi.org/10.1016/j.jlr.2026.101162","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jlr.2026.101162","pdf_url":"https://www.jlr.org/article/S0022-2275(26)00192-6/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jlr.org/article/S0022-2275(26)00192-6/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5153618259","display_name":"Batya Green","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Batya Green","raw_affiliation_strings":["Hadassah Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hadassah Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004760534","display_name":"Eran Leitersdorf","orcid":"https://orcid.org/0000-0001-8740-9068","observed_orcids":["https://orcid.org/0000-0001-8740-9068"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Eran Leitersdorf","raw_affiliation_strings":["Hadassah Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hadassah Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032804517","display_name":"Shoshana Shpitzen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Shoshana Shpitzen","raw_affiliation_strings":["Hadassah Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hadassah Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078306984","display_name":"Rayan Alyan","orcid":"https://orcid.org/0009-0004-5551-4815","observed_orcids":["https://orcid.org/0009-0004-5551-4815"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Rayan Alyan","raw_affiliation_strings":["Hadassah Medical Center, Jerusalem, Israel"],"raw_orcid":"https://orcid.org/0009-0004-5551-4815","affiliations":[{"raw_affiliation_string":"Hadassah Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108384994","display_name":"Daniel Schurr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Daniel Schurr","raw_affiliation_strings":["Hadassah Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hadassah Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013851094","display_name":"Aviv Talmon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Aviv Talmon","raw_affiliation_strings":["Hadassah Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hadassah Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028592304","display_name":"Yuval Tal","orcid":"https://orcid.org/0000-0002-3633-2520","observed_orcids":["https://orcid.org/0000-0002-3633-2520","https://orcid.org/0009-0003-3980-5236"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yuval Tal","raw_affiliation_strings":["Hadassah Medical Center, Jerusalem, Israel"],"raw_orcid":"https://orcid.org/0000-0002-3633-2520","affiliations":[{"raw_affiliation_string":"Hadassah Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153616421","display_name":"Merielle Kaplan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Merielle Kaplan","raw_affiliation_strings":["Rambam Medical Center, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rambam Medical Center, Haifa, Israel","institution_ids":["https://openalex.org/I2801301638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153567416","display_name":"Ram Weiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ram Weiss","raw_affiliation_strings":["Rambam Medical Center, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rambam Medical Center, Haifa, Israel","institution_ids":["https://openalex.org/I2801301638"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032124115","display_name":"R.Y. Durst","orcid":"https://orcid.org/0000-0003-3559-1050","observed_orcids":["https://orcid.org/0000-0003-3559-1050"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ronen Durst","raw_affiliation_strings":["Hadassah Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hadassah Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.0135,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.95516138,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"101162","last_page":"101162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-thrombocytopenic-purpura","display_name":"idiopathic thrombocytopenic purpura","score":0.902999997138977},{"id":"https://openalex.org/keywords/severe-hypertriglyceridemia","display_name":"severe hypertriglyceridemia","score":0.9110000133514404},{"id":"https://openalex.org/keywords/plozasiran","display_name":"plozasiran","score":0.9629999995231628},{"id":"https://openalex.org/keywords/apolipoprotein-c-iii","display_name":"apolipoprotein C-III","score":0.878000020980835},{"id":"https://openalex.org/keywords/rna-interference-therapy","display_name":"RNA interference therapy","score":0.8889999985694885},{"id":"https://openalex.org/keywords/refractory-immune-thrombocytopenia","display_name":"refractory immune thrombocytopenia","score":0.871999979019165},{"id":"https://openalex.org/keywords/young-male-patient","display_name":"young male patient","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2776919658","wikidata":"https://www.wikidata.org/wiki/Q1467339","display_name":"Hypertriglyceridemia","level":4,"score":0.7864000201225281},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7293999791145325},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6834999918937683},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6104000210762024},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49480000138282776},{"id":"https://openalex.org/C2909983478","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglycerides blood","level":4,"score":0.43529999256134033},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3856000006198883},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3580999970436096},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.3580000102519989},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35670000314712524},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.27000001072883606},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.25360000133514404}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jlr.2026.101162","doi":"https://doi.org/10.1016/j.jlr.2026.101162","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jlr.2026.101162","pdf_url":"https://www.jlr.org/article/S0022-2275(26)00192-6/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmid:42815576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42815576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jlr.2026.101162","doi":"https://doi.org/10.1016/j.jlr.2026.101162","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jlr.2026.101162","pdf_url":"https://www.jlr.org/article/S0022-2275(26)00192-6/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214930708.pdf","grobid_xml":"https://content.openalex.org/works/W7214930708.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W2063780291","https://openalex.org/W2067802636","https://openalex.org/W2167666811","https://openalex.org/W2605150564","https://openalex.org/W2966503756","https://openalex.org/W2991262768","https://openalex.org/W3087164693","https://openalex.org/W4212860488","https://openalex.org/W4402146754","https://openalex.org/W7129040037","https://openalex.org/W7135192271"],"related_works":["https://openalex.org/W7133489972","https://openalex.org/W3031434108","https://openalex.org/W2744676480","https://openalex.org/W7160546397","https://openalex.org/W4413153492","https://openalex.org/W4320034136","https://openalex.org/W4212860488","https://openalex.org/W2076357141","https://openalex.org/W3030217286","https://openalex.org/W3000097504"],"abstract_inverted_index":{"Severe":[0],"hypertriglyceridemia":[1],"(HTG),":[2],"defined":[3],"as":[4],"triglyceride":[5,69],"levels":[6],">500":[7],"mg/dL":[8],"can":[9],"cause":[10],"acute":[11],"pancreatitis":[12],"and":[13,49,86,89],"other":[14],"metabolic":[15],"complications.":[16],"While":[17],"primary":[18],"forms":[19],"are":[20],"typically":[21],"genetic,":[22],"autoimmune-mediated":[23],"HTG":[24,40,85],"is":[25],"rare.":[26],"We":[27],"report":[28],"a":[29],"24-year-old":[30],"male":[31],"with":[32,83],"refractory":[33],"immune":[34],"thrombocytopenia":[35],"(ITP)":[36],"who":[37],"developed":[38],"severe":[39,84],"due":[41],"to":[42],"anti-GPIHBP1":[43],"autoantibodies.":[44],"Conventional":[45],"therapies,":[46],"including":[47],"plasmapheresis":[48],"immunosuppressive":[50],"agents,":[51],"were":[52],"insufficient.":[53],"Compassionate":[54],"use":[55],"of":[56,76],"plozasiran,":[57],"an":[58,65],"RNA":[59],"interference":[60],"agent":[61],"targeting":[62],"APOC3,":[63],"achieved":[64],"80%":[66],"reduction":[67],"in":[68,80],"levels.":[70],"This":[71],"case":[72],"highlights":[73],"the":[74,99],"importance":[75],"considering":[77],"autoimmune":[78,87],"dyslipidemia":[79],"young":[81],"patients":[82],"disorders":[88],"suggests":[90],"that":[91],"targeted":[92],"therapies":[93],"may":[94],"be":[95],"effective":[96],"even":[97],"when":[98],"underlying":[100],"mechanism":[101],"differs":[102],"from":[103],"classical":[104],"genetic":[105],"variants.":[106]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-01T00:00:00"}
