{"id":"https://openalex.org/W7214929576","doi":"https://doi.org/10.3389/fimmu.2026.1949983","title":"Stereotyped CLL-like immunoglobulin rearrangements in healthy repertoires: implications for leukemogenesis","display_name":"Stereotyped CLL-like immunoglobulin rearrangements in healthy repertoires: implications for leukemogenesis","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7214929576","doi":"https://doi.org/10.3389/fimmu.2026.1949983","pmid":"https://pubmed.ncbi.nlm.nih.gov/42877012","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13662601"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1949983","doi":"https://doi.org/10.3389/fimmu.2026.1949983","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1949983","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1949983/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1949983/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013360540","display_name":"Davide Bagnara","orcid":"https://orcid.org/0000-0001-7889-8103","observed_orcids":["https://orcid.org/0000-0001-7889-8103"]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Davide Bagnara","raw_affiliation_strings":["Department of Experimental Medicine, University of Genoa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, University of Genoa","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153623753","display_name":"Monica Colombo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Monica Colombo","raw_affiliation_strings":["Molecular Pathology Unit, AOM - IRCCS Ospedale Policlinico San Martino"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pathology Unit, AOM - IRCCS Ospedale Policlinico San Martino","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061626798","display_name":"Fabio Ghiotto","orcid":"https://orcid.org/0000-0002-2301-8698","observed_orcids":["https://orcid.org/0000-0002-2301-8698"]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Ghiotto","raw_affiliation_strings":["Department of Experimental Medicine, University of Genoa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, University of Genoa","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119996385","display_name":"Niccol\u00f2 Cardente","orcid":"https://orcid.org/0009-0009-4021-1631","observed_orcids":["https://orcid.org/0009-0009-4021-1631"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Niccol\u00f2 Cardente","raw_affiliation_strings":["Department of Immunology, University of Oslo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Oslo","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003334973","display_name":"Giovanna Cutrona","orcid":"https://orcid.org/0000-0002-3335-1101","observed_orcids":["https://orcid.org/0000-0002-3335-1101"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanna Cutrona","raw_affiliation_strings":["Molecular Pathology Unit, AOM - IRCCS Ospedale Policlinico San Martino"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pathology Unit, AOM - IRCCS Ospedale Policlinico San Martino","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028725821","display_name":"Manlio Ferrarini","orcid":"https://orcid.org/0000-0002-6154-2570","observed_orcids":["https://orcid.org/0000-0002-6154-2570"]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Manlio Ferrarini","raw_affiliation_strings":["Department of Experimental Medicine, University of Genoa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, University of Genoa","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063912176","display_name":"Franco Fais","orcid":"https://orcid.org/0000-0002-6643-7083","observed_orcids":["https://orcid.org/0000-0002-6643-7083"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Franco Fais","raw_affiliation_strings":["Department of Experimental Medicine, University of Genoa","Molecular Pathology Unit, AOM - IRCCS Ospedale Policlinico San Martino"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, University of Genoa","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"Molecular Pathology Unit, AOM - IRCCS Ospedale Policlinico San Martino","institution_ids":["https://openalex.org/I4210146472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063912176"],"corresponding_institution_ids":["https://openalex.org/I4210146472","https://openalex.org/I83816512"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.5548048,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1949983","last_page":"1949983"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/stereotyped-b-cell-receptor","display_name":"stereotyped B-cell receptor","score":0.7559999823570251},{"id":"https://openalex.org/keywords/immunoglobulin-gene-rearrangement","display_name":"immunoglobulin gene rearrangement","score":0.8059999942779541},{"id":"https://openalex.org/keywords/b-cell-repertoire","display_name":"B cell receptor repertoire","score":0.8569999933242798},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.8080000281333923},{"id":"https://openalex.org/keywords/clonal-selection","display_name":"clonal selection","score":0.6660000085830688},{"id":"https://openalex.org/keywords/antigen-driven-selection","display_name":"antigen-driven selection","score":0.5400000214576721},{"id":"https://openalex.org/keywords/light-chain-restriction","display_name":"light chain restriction","score":0.6380000114440918},{"id":"https://openalex.org/keywords/autoreactive-b-cells","display_name":"autoreactive B cells","score":0.7580000162124634},{"id":"https://openalex.org/keywords/b-cell-subsets","display_name":"B cell subsets","score":0.5059999823570251},{"id":"https://openalex.org/keywords/transitional-b-cells","display_name":"transitional B cells","score":0.5199999809265137},{"id":"https://openalex.org/keywords/memory-b-cells","display_name":"memory B cells","score":0.7160000205039978},{"id":"https://openalex.org/keywords/marginal-zone-b-cells","display_name":"marginal zone B cells","score":0.6140000224113464},{"id":"https://openalex.org/keywords/naive-b-cells","display_name":"naive B cells","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7202000021934509},{"id":"https://openalex.org/C2778473898","wikidata":"https://www.wikidata.org/wiki/Q2145110","display_name":"Repertoire","level":2,"score":0.5885999798774719},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.5735999941825867},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5720000267028809},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5421000123023987},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5239999890327454},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5116000175476074},{"id":"https://openalex.org/C157695867","wikidata":"https://www.wikidata.org/wiki/Q1100474","display_name":"B-cell receptor","level":4,"score":0.49959999322891235},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.4726000130176544},{"id":"https://openalex.org/C128526571","wikidata":"https://www.wikidata.org/wiki/Q619302","display_name":"Somatic hypermutation","level":4,"score":0.4535999894142151},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4237000048160553},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3971000015735626},{"id":"https://openalex.org/C2992511266","wikidata":"https://www.wikidata.org/wiki/Q1093098","display_name":"Gene rearrangement","level":3,"score":0.3720000088214874},{"id":"https://openalex.org/C2777991845","wikidata":"https://www.wikidata.org/wiki/Q2396793","display_name":"Isotype","level":4,"score":0.34279999136924744},{"id":"https://openalex.org/C2779459141","wikidata":"https://www.wikidata.org/wiki/Q1198115","display_name":"Stereotypy","level":4,"score":0.3352000117301941},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.33320000767707825},{"id":"https://openalex.org/C2777868816","wikidata":"https://www.wikidata.org/wiki/Q5134952","display_name":"Clonal deletion","level":5,"score":0.3303000032901764},{"id":"https://openalex.org/C2776954793","wikidata":"https://www.wikidata.org/wiki/Q1150780","display_name":"Clonal selection","level":2,"score":0.3059999942779541},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.3043999969959259},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.30239999294281006},{"id":"https://openalex.org/C7386963","wikidata":"https://www.wikidata.org/wiki/Q3954859","display_name":"Negative selection","level":4,"score":0.2971999943256378},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2797999978065491},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.2736999988555908},{"id":"https://openalex.org/C96007430","wikidata":"https://www.wikidata.org/wiki/Q3776943","display_name":"Immunoglobulin heavy chain","level":3,"score":0.27300000190734863},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.2711000144481659}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015322","descriptor_name":"Gene Rearrangement, B-Lymphocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1949983","doi":"https://doi.org/10.3389/fimmu.2026.1949983","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1949983","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1949983/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13662601","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13662601/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13662601/pdf/fimmu-17-1949983.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42877012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42877012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:11450ea7358c48c6b30170cb8d606f73","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/11450ea7358c48c6b30170cb8d606f73","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1949983","doi":"https://doi.org/10.3389/fimmu.2026.1949983","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1949983","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1949983/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1429694166","display_name":null,"funder_award_id":"ID.15426","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G1570170231","display_name":null,"funder_award_id":"RF-2021-12374376","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G2070943811","display_name":null,"funder_award_id":"15426","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G2428027536","display_name":null,"funder_award_id":"ID.15426","funder_id":"https://openalex.org/F4320327458","funder_display_name":"Associazione Italiana Contro le Leucemie-Linfomi e Mieloma"},{"id":"https://openalex.org/G255694563","display_name":null,"funder_award_id":"5\u00d71000","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G387172998","display_name":null,"funder_award_id":"\u201c5\u00d71000\u201d","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G4099307329","display_name":null,"funder_award_id":"ID.15426","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G532297962","display_name":null,"funder_award_id":"ID.1426","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G5418085942","display_name":null,"funder_award_id":"ID.1426","funder_id":"https://openalex.org/F4320327458","funder_display_name":"Associazione Italiana Contro le Leucemie-Linfomi e Mieloma"},{"id":"https://openalex.org/G5830467628","display_name":null,"funder_award_id":"2025-2027","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G6202232488","display_name":null,"funder_award_id":"RF-2021-12374376","funder_id":"https://openalex.org/F4320327458","funder_display_name":"Associazione Italiana Contro le Leucemie-Linfomi e Mieloma"},{"id":"https://openalex.org/G6499642291","display_name":null,"funder_award_id":"RF-2021-12374376","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G7486359090","display_name":null,"funder_award_id":"15426","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G7849772051","display_name":null,"funder_award_id":"ID.1426","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"}],"funders":[{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320327458","display_name":"Associazione Italiana Contro le Leucemie-Linfomi e Mieloma","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214929576.pdf","grobid_xml":"https://content.openalex.org/works/W7214929576.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W34261213","https://openalex.org/W207056551","https://openalex.org/W1243376384","https://openalex.org/W1429374962","https://openalex.org/W1970584505","https://openalex.org/W1976466233","https://openalex.org/W1990159135","https://openalex.org/W2004801769","https://openalex.org/W2020835540","https://openalex.org/W2051321376","https://openalex.org/W2068868786","https://openalex.org/W2070232733","https://openalex.org/W2077980507","https://openalex.org/W2078493126","https://openalex.org/W2091664866","https://openalex.org/W2102586974","https://openalex.org/W2104168678","https://openalex.org/W2106892290","https://openalex.org/W2111609050","https://openalex.org/W2113218550","https://openalex.org/W2113475715","https://openalex.org/W2117365099","https://openalex.org/W2132968206","https://openalex.org/W2140384293","https://openalex.org/W2142160913","https://openalex.org/W2142978323","https://openalex.org/W2166526425","https://openalex.org/W2172019913","https://openalex.org/W2342038428","https://openalex.org/W2407499086","https://openalex.org/W2513719242","https://openalex.org/W2543345947","https://openalex.org/W2623503441","https://openalex.org/W2799628826","https://openalex.org/W2904888645","https://openalex.org/W2910384850","https://openalex.org/W2911980279","https://openalex.org/W2950612260","https://openalex.org/W2970931443","https://openalex.org/W2975704296","https://openalex.org/W3010653318","https://openalex.org/W3037761071","https://openalex.org/W3090488793","https://openalex.org/W3205749390","https://openalex.org/W3208311331","https://openalex.org/W4236535870","https://openalex.org/W4283319414","https://openalex.org/W4286249404","https://openalex.org/W4327733735","https://openalex.org/W4392762915","https://openalex.org/W4407794744","https://openalex.org/W4410358150","https://openalex.org/W4413368225","https://openalex.org/W4415397261","https://openalex.org/W4416268104","https://openalex.org/W7117589892","https://openalex.org/W7119169476","https://openalex.org/W7123626009","https://openalex.org/W7124989541","https://openalex.org/W7134107701","https://openalex.org/W7138934215"],"related_works":["https://openalex.org/W4415397261","https://openalex.org/W3010653318","https://openalex.org/W4283319414","https://openalex.org/W4327733735","https://openalex.org/W2113475715","https://openalex.org/W7098890267","https://openalex.org/W2979837784","https://openalex.org/W2158819525","https://openalex.org/W2163657625","https://openalex.org/W2342574262"],"abstract_inverted_index":{"Chronic":[0],"lymphocytic":[1],"leukemia":[2],"(CLL)":[3],"is":[4,131],"characterized":[5],"by":[6,16],"a":[7,55],"highly":[8],"biased":[9],"B-cell":[10,71,94,127,243],"receptor":[11,139,199,225],"(BcR)":[12],"immunoglobulin":[13,34,83],"repertoire":[14],"and":[15,67,88,115,118,125,133,147,201,240],"recurrent":[17,61,246],"stereotyped":[18,82],"receptors":[19],"defined":[20],"as":[21],"quasi-identical":[22],"BcR":[23,62],"recurring":[24],"in":[25,44,85,109,165,188,210],"unrelated":[26],"patients.":[27],"High-throughput":[28],"sequencing":[29],"studies":[30,97],"have":[31],"shown":[32],"that":[33,99,137,193],"rearrangements":[35,84,101,152],"resembling":[36],"these":[37,52,100],"CLL":[38,190],"stereotypes":[39,209],"can":[40],"also":[41],"be":[42],"detected":[43],"healthy":[45,86,178,211],"individuals.":[46],"Beyond":[47],"their":[48,90,174],"relevance":[49],"to":[50,58,143,252],"leukemogenesis,":[51],"findings":[53],"provide":[54],"distinctive":[56],"opportunity":[57],"investigate":[59],"how":[60,223,231,241],"configurations":[63,140,235],"are":[64,102,141,153,161],"generated,":[65],"selected,":[66],"maintained":[68],"during":[69],"normal":[70,93,242],"development.":[72],"In":[73],"this":[74],"review,":[75],"we":[76],"examine":[77],"the":[78,106,170,183,205,215],"occurrence":[79],"of":[80,105,173,207,217],"CLL-like":[81,208],"repertoires":[87,244],"discuss":[89],"implications":[91],"for":[92],"biology.":[95],"Available":[96],"indicate":[98],"physiological":[103,229],"components":[104],"repertoire,":[107],"detectable":[108],"cord":[110],"blood,":[111,117],"bone":[112],"marrow,":[113],"spleen,":[114],"peripheral":[116],"distributed":[119],"across":[120],"transitional,":[121],"na\u00efve,":[122],"marginal":[123],"zone-like,":[124],"memory":[126],"compartments.":[128],"Their":[129],"representation":[130],"non-random":[132],"subset":[134],"specific,":[135],"suggesting":[136],"different":[138],"subject":[142],"distinct":[144],"developmental,":[145],"tolerance,":[146],"antigen-driven":[148],"selection":[149],"pressures.":[150],"Some":[151],"preferentially":[154],"associated":[155],"with":[156],"antigen-inexperienced":[157],"compartments,":[158],"whereas":[159],"others":[160],"more":[162],"frequently":[163],"found":[164],"post-germinal-center":[166],"populations,":[167],"partially":[168],"recapitulating":[169],"mutational":[171],"context":[172],"leukemic":[175,194,219],"counterparts.":[176],"However,":[177],"B":[179],"cells":[180],"generally":[181],"lack":[182],"stringent":[184],"light-chain":[185],"restriction":[186],"observed":[187],"established":[189],"subsets,":[191],"indicating":[192],"stereotypy":[195],"results":[196],"from":[197],"additional":[198],"refinement":[200],"clonal":[202],"selection.":[203],"Overall,":[204],"study":[206],"individuals":[212],"extends":[213],"beyond":[214],"identification":[216],"putative":[218],"precursors.":[220],"It":[221],"reveals":[222],"convergent":[224],"architectures":[226],"arise":[227],"within":[228],"immunity,":[230],"autoreactive":[232],"or":[233],"polyreactive":[234],"may":[236],"escape":[237],"complete":[238],"censoring,":[239],"accommodate":[245],"immunogenetic":[247],"solutions":[248],"without":[249],"necessarily":[250],"progressing":[251],"malignancy.":[253]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-01T00:00:00"}
