{"id":"https://openalex.org/W7214922161","doi":"https://doi.org/10.3389/fimmu.2026.1939052","title":"Myeloid cell expression of the VDR and parathyroid hormone control the host response to influenza infection in mice","display_name":"Myeloid cell expression of the VDR and parathyroid hormone control the host response to influenza infection in mice","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7214922161","doi":"https://doi.org/10.3389/fimmu.2026.1939052","pmid":"https://pubmed.ncbi.nlm.nih.gov/42876719","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13661438"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1939052","doi":"https://doi.org/10.3389/fimmu.2026.1939052","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1939052","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1939052/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1939052/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113401930","display_name":"Mengzhu Tang","orcid":"https://orcid.org/0009-0005-3527-871X","observed_orcids":["https://orcid.org/0009-0005-3527-871X"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mengzhu Tang","raw_affiliation_strings":["Department of Veterinary and Biomedical Sciences, The Pennsylvania State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, The Pennsylvania State University","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013198007","display_name":"Nicole E. Froelich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole E. Froelich","raw_affiliation_strings":["Department of Veterinary and Biomedical Sciences, The Pennsylvania State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, The Pennsylvania State University","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153624475","display_name":"Nicholas J. Hanna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas J. Hanna","raw_affiliation_strings":["Department of Veterinary and Biomedical Sciences, The Pennsylvania State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, The Pennsylvania State University","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055120304","display_name":"Veronika C. Weaver","orcid":"https://orcid.org/0000-0002-3558-7660","observed_orcids":["https://orcid.org/0000-0002-3558-7660"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veronika C. Weaver","raw_affiliation_strings":["Department of Veterinary and Biomedical Sciences, The Pennsylvania State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, The Pennsylvania State University","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003967492","display_name":"Gustavo A. Nader","orcid":"https://orcid.org/0000-0002-2220-4296","observed_orcids":["https://orcid.org/0000-0002-2220-4296"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gustavo A. Nader","raw_affiliation_strings":["Department of Kinesiology, The Pennsylvania State University","Huck Institutes of the Life Sciences, The Pennsylvania State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology, The Pennsylvania State University","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Huck Institutes of the Life Sciences, The Pennsylvania State University","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007841025","display_name":"Troy C. Sutton","orcid":"https://orcid.org/0000-0002-7880-4784","observed_orcids":["https://orcid.org/0000-0002-7880-4784"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Troy C. Sutton","raw_affiliation_strings":["Department of Veterinary and Biomedical Sciences, The Pennsylvania State University","Huck Institutes of the Life Sciences, The Pennsylvania State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, The Pennsylvania State University","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Huck Institutes of the Life Sciences, The Pennsylvania State University","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059431026","display_name":"Margherita T. Cantorna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Margherita T. Cantorna","raw_affiliation_strings":["Department of Veterinary and Biomedical Sciences, The Pennsylvania State University","Huck Institutes of the Life Sciences, The Pennsylvania State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, The Pennsylvania State University","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Huck Institutes of the Life Sciences, The Pennsylvania State University","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5059431026"],"corresponding_institution_ids":["https://openalex.org/I130769515"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":3.8276,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.95065978,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"17","issue":null,"first_page":"1939052","last_page":"1939052"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.16269999742507935,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.9900000095367432},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.996999979019165},{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"influenza A virus","score":0.6029999852180481},{"id":"https://openalex.org/keywords/h1n1-influenza","display_name":"H1N1 influenza","score":0.9539999961853027},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6340000033378601},{"id":"https://openalex.org/keywords/interferon-response","display_name":"interferon response","score":0.7289999723434448},{"id":"https://openalex.org/keywords/viral-clearance","display_name":"viral clearance","score":0.7310000061988831},{"id":"https://openalex.org/keywords/pulmonary-pathology","display_name":"lung pathology","score":0.8489999771118164},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/host-resistance","display_name":"host resistance","score":0.6240000128746033},{"id":"https://openalex.org/keywords/vdr-knockout-mice","display_name":"VDR knockout mice","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.9193999767303467},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6509000062942505},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6269000172615051},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5455999970436096},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.5220000147819519},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5008999705314636},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.48750001192092896},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4697999954223633},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.45249998569488525},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.44929999113082886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.446399986743927},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4147999882698059},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.37549999356269836},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36719998717308044},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.3294000029563904},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.3278000056743622},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3181000053882599},{"id":"https://openalex.org/C2779740938","wikidata":"https://www.wikidata.org/wiki/Q4138762","display_name":"vitamin D deficiency","level":3,"score":0.3075000047683716},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2921000123023987},{"id":"https://openalex.org/C2779559532","wikidata":"https://www.wikidata.org/wiki/Q1076369","display_name":"Cytokine storm","level":5,"score":0.2815000116825104},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.27959999442100525},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2721000015735626},{"id":"https://openalex.org/C2993183539","wikidata":"https://www.wikidata.org/wiki/Q754447","display_name":"Respiratory infection","level":3,"score":0.26980000734329224},{"id":"https://openalex.org/C2781416681","wikidata":"https://www.wikidata.org/wiki/Q287246","display_name":"Orthomyxoviridae","level":4,"score":0.2624000012874603},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.26190000772476196},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.26109999418258667},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.258899986743927},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.25850000977516174}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018167","descriptor_name":"Receptors, Calcitriol","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018167","descriptor_name":"Receptors, Calcitriol","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018167","descriptor_name":"Receptors, Calcitriol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1939052","doi":"https://doi.org/10.3389/fimmu.2026.1939052","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1939052","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1939052/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13661438","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13661438/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13661438/pdf/fimmu-17-1939052.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42876719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42876719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b2bca9d4ce694ee09a409ca0e95d9fcb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b2bca9d4ce694ee09a409ca0e95d9fcb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1939052","doi":"https://doi.org/10.3389/fimmu.2026.1939052","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1939052","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1939052/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2032180136","display_name":null,"funder_award_id":"R01AT005378","funder_id":"https://openalex.org/F4320306114","funder_display_name":"U.S. Department of Agriculture"},{"id":"https://openalex.org/G2783495169","display_name":null,"funder_award_id":"PEN04963","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3810637174","display_name":"Vitamin D Fluctuations and the Mucosal Immune Response","funder_award_id":"R01AT005378","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G4215292518","display_name":null,"funder_award_id":"T32DK120509","funder_id":"https://openalex.org/F4320306114","funder_display_name":"U.S. Department of Agriculture"},{"id":"https://openalex.org/G6509347643","display_name":null,"funder_award_id":"7006576","funder_id":"https://openalex.org/F4320332299","funder_display_name":"National Institute of Food and Agriculture"},{"id":"https://openalex.org/G8002268463","display_name":"Integrative Analysis of Metabolic Phenotypes (IAMP) Predoctoral Training Program","funder_award_id":"T32DK120509","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000860011","display_name":"Ribosomal control of muscle mass: Transcriptional and epigenetic mechanisms","funder_award_id":"R01AR078430","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000918775","display_name":"Research Training in Physiological Adaptations to Stress","funder_award_id":"T32GM154124","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332299","display_name":"National Institute of Food and Agriculture","ror":"https://ror.org/05qx3fv49"},{"id":"https://openalex.org/F4320333182","display_name":"Huck Institutes of the Life Sciences","ror":null},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214922161.pdf","grobid_xml":"https://content.openalex.org/works/W7214922161.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W241397209","https://openalex.org/W1645379154","https://openalex.org/W1792672594","https://openalex.org/W1825694147","https://openalex.org/W1891008369","https://openalex.org/W1973923791","https://openalex.org/W1975937841","https://openalex.org/W1983483525","https://openalex.org/W1984501300","https://openalex.org/W1986017638","https://openalex.org/W2001765973","https://openalex.org/W2004857322","https://openalex.org/W2027992218","https://openalex.org/W2058607861","https://openalex.org/W2071688420","https://openalex.org/W2087668602","https://openalex.org/W2091129202","https://openalex.org/W2095053527","https://openalex.org/W2112450413","https://openalex.org/W2115710851","https://openalex.org/W2122445377","https://openalex.org/W2125921830","https://openalex.org/W2127755180","https://openalex.org/W2133378877","https://openalex.org/W2137836062","https://openalex.org/W2150990505","https://openalex.org/W2151546806","https://openalex.org/W2156379640","https://openalex.org/W2159866507","https://openalex.org/W2169830704","https://openalex.org/W2170814415","https://openalex.org/W2295770513","https://openalex.org/W2588906490","https://openalex.org/W2614987262","https://openalex.org/W2666138241","https://openalex.org/W2768741494","https://openalex.org/W2775569101","https://openalex.org/W2790803666","https://openalex.org/W2891820668","https://openalex.org/W2961206609","https://openalex.org/W2976125998","https://openalex.org/W2982716340","https://openalex.org/W2999491357","https://openalex.org/W3133513361","https://openalex.org/W3141482986","https://openalex.org/W3177830510","https://openalex.org/W4211252841","https://openalex.org/W4212905956","https://openalex.org/W4214676446","https://openalex.org/W4288068828","https://openalex.org/W4390585832","https://openalex.org/W7131666816"],"related_works":["https://openalex.org/W7171564307","https://openalex.org/W3163110827","https://openalex.org/W7221812486","https://openalex.org/W7171518428","https://openalex.org/W1998577849","https://openalex.org/W7161539191","https://openalex.org/W2886032093","https://openalex.org/W3040090996","https://openalex.org/W2901751456","https://openalex.org/W2809614871"],"abstract_inverted_index":{"Introduction:":[0],"Respiratory":[1],"infections":[2],"caused":[3],"by":[4,142,207],"seasonal":[5],"influenza":[6,40,70,89,109,175,204,242],"viruses":[7],"remain":[8],"a":[9,87,191],"major":[10],"global":[11],"health":[12],"burden.":[13],"Vitamin":[14],"D":[15],"receptor":[16],"(VDR)":[17],"signaling":[18],"regulates":[19],"immune":[20,239],"responses,":[21],"but":[22],"the":[23,26,56,61,151,196,209,214,219,223,236],"role":[24],"of":[25,55,111,137,211,216],"VDR":[27,47,57,119,227],"and":[28,60,82,97,101,131,146,160,178,213],"its":[29],"interaction":[30],"with":[31,68,77,86],"parathyroid":[32],"hormone":[33],"(PTH)":[34],"in":[35,115,150,194,218,229],"host":[36,201],"resistance":[37,202],"to":[38,165,182,203,241],"H1N1":[39,69,88,108],"infection":[41,110],"is":[42,232],"not":[43],"understood.":[44],"Methods:":[45],"Global":[46],"knockout":[48],"(KO)":[49],"mice,":[50],"or":[51,80],"myeloid":[52,230],"(M)":[53],"deletion":[54],"(M-VDR":[58],"KO)":[59],"respective":[62],"wildtype":[63],"(WT)":[64],"littermates":[65],"were":[66,105],"infected":[67,84],"virus.":[71,91],"Additional":[72],"experiments":[73],"treated":[74,184],"WT":[75,112,166,169,185],"mice":[76,113,121,155,170],"intermittent":[78],"PTH":[79],"vehicle":[81,183],"then":[83],"them":[85],"A":[90],"Disease":[92],"severity,":[93],"mortality,":[94,124],"viral":[95,126,162],"burden":[96],"clearance,":[98,127],"lung":[99,132],"pathology,":[100],"inflammatory":[102],"cytokine":[103,179],"responses":[104,149,180],"evaluated.":[106],"Results:":[107],"resulted":[114],"non-lethal":[116],"disease,":[117],"whereas":[118],"KO":[120,154],"had":[122,156,171],"21%":[123],"delayed":[125,161],"more":[128],"severe":[129],"symptoms":[130],"pathology.":[133],"The":[134,188],"increased":[135,157,172],"severity":[136,159],"respiratory":[138],"disease":[139,158,206],"was":[140],"accompanied":[141],"higher":[143],"type":[144],"I":[145],"II":[147],"interferon":[148],"lungs.":[152],"M-VDR":[153],"clearance":[163],"compared":[164,181],"littermates.":[167],"PTH-treated":[168],"clinical":[173],"scores,":[174],"M":[176],"gene,":[177],"mice.":[186],"Discussion:":[187],"work":[189],"describes":[190],"novel":[192],"paradigm":[193],"which":[195],"vitamin":[197],"D-PTH":[198],"axis":[199],"governs":[200],"virus":[205,217],"controlling":[208,235],"amount":[210,215],"inflammation":[212],"lung.":[220],"In":[221],"addition,":[222],"data":[224],"suggest":[225],"that":[226],"expression":[228],"cells":[231],"critical":[233],"for":[234],"early":[237],"innate":[238],"response":[240],"viruses.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-01T00:00:00"}