{"id":"https://openalex.org/W7214917535","doi":"https://doi.org/10.1016/j.jbc.2026.113586","title":"Natural Asp-tRNA synthetase fragment targets myofibroblasts to abrogate tissue fibrosis","display_name":"Natural Asp-tRNA synthetase fragment targets myofibroblasts to abrogate tissue fibrosis","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7214917535","doi":"https://doi.org/10.1016/j.jbc.2026.113586","pmid":"https://pubmed.ncbi.nlm.nih.gov/42815638"},"language":"en","primary_location":{"id":"doi:10.1016/j.jbc.2026.113586","doi":"https://doi.org/10.1016/j.jbc.2026.113586","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2026.113586","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jbc.2026.113586","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111952025","display_name":"Ryan A. Adams","orcid":"https://orcid.org/0000-0001-5602-3971","observed_orcids":["https://orcid.org/0000-0001-5602-3971"]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan A. Adams","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":"https://orcid.org/0000-0001-5602-3971","affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101953941","display_name":"Ying-Ting Wang","orcid":"https://orcid.org/0000-0003-3958-0455","observed_orcids":["https://orcid.org/0000-0003-3958-0455"]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying-Ting Wang","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074932422","display_name":"Alison G. Barber","orcid":"https://orcid.org/0000-0001-8308-9327","observed_orcids":["https://orcid.org/0000-0001-8308-9327"]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison G. Barber","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":"https://orcid.org/0000-0001-8308-9327","affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153585468","display_name":"Kristina Hamel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristina Hamel","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153655919","display_name":"Andrew Imfeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Imfeld","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009355300","display_name":"Luke Burman","orcid":"https://orcid.org/0000-0002-8758-8120","observed_orcids":["https://orcid.org/0000-0002-8758-8120"]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke Burman","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077320383","display_name":"Kaitlyn Rauch","orcid":"https://orcid.org/0000-0002-3845-5997","observed_orcids":["https://orcid.org/0000-0002-3845-5997"]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaitlyn Rauch","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029224249","display_name":"Yeeting Esther Chong","orcid":"https://orcid.org/0000-0002-8396-8898","observed_orcids":["https://orcid.org/0000-0002-8396-8898"]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yeeting E. Chong","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":"https://orcid.org/0000-0002-8396-8898","affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038538256","display_name":"Ang\u00e9lica Villanueva","orcid":"https://orcid.org/0009-0009-6816-5630","observed_orcids":["https://orcid.org/0009-0009-6816-5630"]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angelica Villanueva","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":"https://orcid.org/0009-0009-6816-5630","affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083251708","display_name":"Lauren Guy","orcid":"https://orcid.org/0000-0002-6341-9736","observed_orcids":["https://orcid.org/0000-0002-6341-9736"]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Guy","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":"https://orcid.org/0000-0002-6341-9736","affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124817872","display_name":"Wayne Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayne Liu","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153657117","display_name":"Crystal Manzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crystal Manzo","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012481584","display_name":"Sofia Klopp-Savino","orcid":"https://orcid.org/0000-0003-0509-8935","observed_orcids":["https://orcid.org/0000-0003-0509-8935"]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sofia Klopp-Savino","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060935963","display_name":"Clara Polizzi","orcid":"https://orcid.org/0009-0003-0752-0260","observed_orcids":["https://orcid.org/0009-0003-0752-0260"]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clara Polizzi","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":"https://orcid.org/0009-0003-0752-0260","affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073792511","display_name":"Jasmine Stamps","orcid":"https://orcid.org/0000-0003-4515-7290","observed_orcids":["https://orcid.org/0000-0003-4515-7290"]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jasmine Stamps","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":"https://orcid.org/0000-0003-4515-7290","affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077142465","display_name":"Max Pastenes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Max Pastenes","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102314929","display_name":"Hong-Lei Tian","orcid":"https://orcid.org/0000-0002-5175-9338","observed_orcids":["https://orcid.org/0000-0002-5175-9338"]},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Honglei Tian","raw_affiliation_strings":["IAS HKUST R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0002-5175-9338","affiliations":[{"raw_affiliation_string":"IAS HKUST R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015871780","display_name":"Chun Po Fung","orcid":"https://orcid.org/0000-0001-6655-619X","observed_orcids":["https://orcid.org/0000-0001-6655-619X"]},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Chun Po Fung","raw_affiliation_strings":["IAS HKUST R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0001-6655-619X","affiliations":[{"raw_affiliation_string":"IAS HKUST R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037191391","display_name":"Yingyi Zhang","orcid":"https://orcid.org/0000-0002-6478-476X","observed_orcids":["https://orcid.org/0000-0002-6478-476X"]},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yingyi Zhang","raw_affiliation_strings":["Biological Cryo-EM Center, The Hong Kong University of Science and Technology, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0002-6478-476X","affiliations":[{"raw_affiliation_string":"Biological Cryo-EM Center, The Hong Kong University of Science and Technology, Hong Kong, China","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153564603","display_name":"Kwok Wa Hugo Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Kwok Wa Hugo Ho","raw_affiliation_strings":["Biological Cryo-EM Center, The Hong Kong University of Science and Technology, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Cryo-EM Center, The Hong Kong University of Science and Technology, Hong Kong, China","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079615184","display_name":"Bruno Sangiorgi","orcid":"https://orcid.org/0000-0003-4197-8921","observed_orcids":["https://orcid.org/0000-0003-4197-8921"]},"institutions":[{"id":"https://openalex.org/I4405266888","display_name":"Alimentiv Inc. (Canada)","ror":"https://ror.org/006rbxt37","country_code":"CA","type":"company","lineage":["https://openalex.org/I4405266888"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Bruno Sangiorgi","raw_affiliation_strings":["Alimentiv Inc, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alimentiv Inc, London, Ontario, Canada","institution_ids":["https://openalex.org/I4405266888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153580072","display_name":"Blythe Dillingham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blythe Dillingham","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038973103","display_name":"Tarsis F. Brust","orcid":"https://orcid.org/0000-0003-0912-8273","observed_orcids":["https://orcid.org/0000-0003-0912-8273"]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tarsis F. Brust","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":"https://orcid.org/0000-0003-0912-8273","affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110712235","display_name":"Kyle P. Chiang","orcid":"https://orcid.org/0009-0005-3571-5545","observed_orcids":["https://orcid.org/0009-0005-3571-5545"]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle P. Chiang","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":"https://orcid.org/0009-0005-3571-5545","affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108050916","display_name":"Zhenguo Wu","orcid":"https://orcid.org/0000-0003-3049-8324","observed_orcids":["https://orcid.org/0000-0003-3049-8324"]},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Zhenguo Wu","raw_affiliation_strings":["Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062006944","display_name":"Zhiwen Xu","orcid":"https://orcid.org/0000-0001-6473-8328","observed_orcids":["https://orcid.org/0000-0001-6473-8328"]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiwen Xu","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":"https://orcid.org/0000-0001-6473-8328","affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110532636","display_name":"Christoph Burkart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christoph Burkart","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA","institution_ids":["https://openalex.org/I4210151019"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056710753","display_name":"Leslie A. Nangle","orcid":"https://orcid.org/0009-0000-6953-7998","observed_orcids":["https://orcid.org/0009-0000-6953-7998"]},"institutions":[{"id":"https://openalex.org/I4210151019","display_name":"aTyr Pharma (United States)","ror":"https://ror.org/05edt5833","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151019"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leslie A. Nangle","raw_affiliation_strings":["aTyr Pharma, San Diego, California, USA. Electronic address: lnangle@atyrpharma.com"],"raw_orcid":"https://orcid.org/0009-0000-6953-7998","affiliations":[{"raw_affiliation_string":"aTyr Pharma, San Diego, California, USA. Electronic address: lnangle@atyrpharma.com","institution_ids":["https://openalex.org/I4210151019"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5056710753"],"corresponding_institution_ids":["https://openalex.org/I4210151019"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"302","issue":"11","first_page":"113586","last_page":"113586"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.6952999830245972,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.6952999830245972,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.10239999741315842,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.06369999796152115,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspartyl-trna-synthetase","display_name":"aspartyl-tRNA synthetase","score":0.9810000061988831},{"id":"https://openalex.org/keywords/aminoacyl-trna-synthetase","display_name":"aminoacyl-tRNA synthetase","score":0.8159999847412109},{"id":"https://openalex.org/keywords/myofibroblasts","display_name":"myofibroblasts","score":0.9190000295639038},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/ltbp1","display_name":"LTBP1","score":0.8479999899864197},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.9169999957084656},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8539999723434448},{"id":"https://openalex.org/keywords/bleomycin-induced-pulmonary-fibrosis","display_name":"bleomycin-induced lung fibrosis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.8309999704360962},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.8154000043869019},{"id":"https://openalex.org/C2776235265","wikidata":"https://www.wikidata.org/wiki/Q18392052","display_name":"Fragment (logic)","level":2,"score":0.7276999950408936},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5835999846458435},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5227000117301941},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4984000027179718},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41359999775886536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30720001459121704},{"id":"https://openalex.org/C2776581183","wikidata":"https://www.wikidata.org/wiki/Q25104725","display_name":"Tissue remodeling","level":3,"score":0.28380000591278076},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2754000127315521},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.2612999975681305}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jbc.2026.113586","doi":"https://doi.org/10.1016/j.jbc.2026.113586","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2026.113586","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:42815638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42815638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jbc.2026.113586","doi":"https://doi.org/10.1016/j.jbc.2026.113586","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2026.113586","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8529288224","display_name":"Developing Innovative Therapeutic Candidates for Fibrosis-related Diseases by Targeting Novel Anti-fibrotic Signaling of tRNA-synthetases","funder_award_id":"PRP/019/24FX","funder_id":"https://openalex.org/F4320321920","funder_display_name":"Innovation and Technology Commission"}],"funders":[{"id":"https://openalex.org/F4320315424","display_name":"aTyr","ror":"https://ror.org/05edt5833"},{"id":"https://openalex.org/F4320321920","display_name":"Innovation and Technology Commission","ror":"https://ror.org/04vf9tr09"},{"id":"https://openalex.org/F4320324196","display_name":"Innovation and Technology Commission - Hong Kong","ror":"https://ror.org/04vf9tr09"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W27555781","https://openalex.org/W1508696496","https://openalex.org/W1983357763","https://openalex.org/W1985410214","https://openalex.org/W1990299806","https://openalex.org/W1999618218","https://openalex.org/W2001518113","https://openalex.org/W2044788332","https://openalex.org/W2045142779","https://openalex.org/W2050299992","https://openalex.org/W2050717189","https://openalex.org/W2052676309","https://openalex.org/W2085382985","https://openalex.org/W2094058129","https://openalex.org/W2103590517","https://openalex.org/W2117814548","https://openalex.org/W2123106337","https://openalex.org/W2130410032","https://openalex.org/W2136990296","https://openalex.org/W2146747110","https://openalex.org/W2748216636","https://openalex.org/W2774240027","https://openalex.org/W2776738147","https://openalex.org/W2782417153","https://openalex.org/W2792088252","https://openalex.org/W2951158909","https://openalex.org/W2952391626","https://openalex.org/W2956457443","https://openalex.org/W2972058749","https://openalex.org/W2974204766","https://openalex.org/W2984472267","https://openalex.org/W2990290007","https://openalex.org/W2994591473","https://openalex.org/W3095498657","https://openalex.org/W3109793392","https://openalex.org/W3129476455","https://openalex.org/W3164692211","https://openalex.org/W3166067883","https://openalex.org/W3192131670","https://openalex.org/W3216312149","https://openalex.org/W4225291593","https://openalex.org/W4307844981","https://openalex.org/W4309438410","https://openalex.org/W4365513089","https://openalex.org/W4385381520","https://openalex.org/W4394581121","https://openalex.org/W4396830646","https://openalex.org/W4408346017"],"related_works":["https://openalex.org/W4396799971","https://openalex.org/W1802741882","https://openalex.org/W2770244024","https://openalex.org/W2161515282","https://openalex.org/W4405010526","https://openalex.org/W2587396893","https://openalex.org/W2767392280","https://openalex.org/W2098977806","https://openalex.org/W2982291379","https://openalex.org/W4200115215"],"abstract_inverted_index":{"Fibrosis":[0],"remains":[1],"a":[2,47,115,139,146,155],"major":[3],"global":[4],"health":[5],"challenge":[6],"with":[7],"limited":[8],"therapies":[9],"that":[10,57,136],"only":[11,96],"slow":[12],"disease":[13],"progression.":[14],"While":[15],"the":[16,36,39,74,143,160],"aminoacyl-tRNA":[17],"synthetase":[18,53],"(aaRS)":[19],"family":[20],"is":[21,42],"known":[22],"to":[23,103,125,145],"utilize":[24],"evolutionarily":[25],"appended":[26],"domains":[27],"as":[28,154],"extracellular":[29,75],"signaling":[30],"molecules,":[31],"their":[32],"role":[33],"in":[34,61,90,129],"regulating":[35],"homeostasis":[37],"of":[38,51,82,105,110,118,162],"fibrotic":[40],"process":[41,161],"poorly":[43],"defined.":[44],"We":[45,112],"identify":[46],"natural":[48],"proteolytic":[49],"fragment":[50,81],"aspartyl-tRNA":[52],"(DARS),":[54],"termed":[55],"DARS-N1,":[56],"selectively":[58],"triggers":[59],"apoptosis":[60],"myofibroblasts":[62,97],"by":[63],"targeting":[64],"latent-transforming":[65],"growth":[66],"factor":[67],"beta":[68],"binding":[69],"protein":[70],"1":[71],"(LTBP-1)":[72],"on":[73],"matrix":[76],"(ECM).":[77],"This":[78],"active":[79],"N-terminal":[80],"DARS":[83],"reduces":[84],"focal":[85],"adhesion":[86],"kinase":[87],"(FAK)":[88],"activation":[89],"undifferentiated":[91],"fibroblasts":[92],"and":[93,108],"myofibroblasts,":[94],"while":[95],"exhibit":[98],"inadequate":[99],"cell-matrix":[100],"attachment":[101],"leading":[102],"loss":[104],"anchorage-dependent":[106],"survival":[107],"promotion":[109],"apoptosis.":[111],"utilized":[113],"ATYR0101,":[114],"therapeutic":[116],"form":[117],"DARS-N1":[119],"engineered":[120],"for":[121,158],"extended":[122],"serum":[123],"exposure,":[124],"demonstrate":[126],"anti-fibrotic":[127],"activity":[128],"lung":[130],"(bleomycin).":[131],"Spatial":[132],"transcriptomics":[133],"analysis":[134],"showed":[135],"ATYR0101":[137],"activates":[138],"restorative":[140],"program":[141],"promoting":[142],"return":[144],"healthy":[147],"state.":[148],"These":[149],"findings":[150],"highlight":[151],"ATYR0101's":[152],"potential":[153],"transformative":[156],"therapy":[157],"disrupting":[159],"chronic":[163],"tissue":[164],"fibrosis.":[165]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-10-01T00:00:00"}
