{"id":"https://openalex.org/W7214916773","doi":"https://doi.org/10.23750/abm.2026.18929","title":"Atherogenic index of plasma as a stroke-subtype\u2013independent predictor of acute cognitive dysfunction in ischemic stroke: A cross-sectional analytic study","display_name":"Atherogenic index of plasma as a stroke-subtype\u2013independent predictor of acute cognitive dysfunction in ischemic stroke: A cross-sectional analytic study","publication_year":2026,"publication_date":"2026-04-28","ids":{"openalex":"https://openalex.org/W7214916773","doi":"https://doi.org/10.23750/abm.2026.18929"},"language":"en","primary_location":{"id":"pmh:oai:mattioli1885journals.com:article/18929","doi":"https://doi.org/10.23750/abm.2026.18929","is_oa":true,"landing_page_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/18929","pdf_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/download/18929/13285","source":{"id":"https://openalex.org/S4393915150","display_name":"Acta bio-medica dell'Ateneo parmense/Acta biomedica","issn_l":"0392-4203","issn":["0392-4203","2531-6745"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0392-4203","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/download/18929/13285","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5153620011","display_name":"David Christian Haurissa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Haurissa, David","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111207781","display_name":"Muhammad Yunus Amran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405274271","display_name":"Rumah Sakit Umum Pusat Dr. Wahidin Sudirohusodo","ror":"https://ror.org/01d3fv830","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4405274271"]},{"id":"https://openalex.org/I98301867","display_name":"Hasanuddin University","ror":"https://ror.org/00da1gf19","country_code":"ID","type":"education","lineage":["https://openalex.org/I98301867"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Amran, Muhammad Yunus","raw_affiliation_strings":["Division of Interventional Neurology and Neuroendovascular Therapy, Department of  Neurology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Brain Centre, Dr. Wahidin Sudirohusodo General Hospital, Makassar, Indonesia; Hasanuddin University Teaching Hospital, Makassar, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Interventional Neurology and Neuroendovascular Therapy, Department of  Neurology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Brain Centre, Dr. Wahidin Sudirohusodo General Hospital, Makassar, Indonesia; Hasanuddin University Teaching Hospital, Makassar, Indonesia","institution_ids":["https://openalex.org/I4405274271","https://openalex.org/I98301867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153567685","display_name":"Muhammad Akbar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98301867","display_name":"Hasanuddin University","ror":"https://ror.org/00da1gf19","country_code":"ID","type":"education","lineage":["https://openalex.org/I98301867"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Akbar, Muhammad","raw_affiliation_strings":["Department of Neurology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Hasanuddin University Teaching Hospital, Makassar, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Hasanuddin University Teaching Hospital, Makassar, Indonesia","institution_ids":["https://openalex.org/I98301867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108759621","display_name":"Abdul Muis","orcid":"https://orcid.org/0009-0006-6960-5683","observed_orcids":["https://orcid.org/0009-0006-6960-5683"]},"institutions":[{"id":"https://openalex.org/I4405274271","display_name":"Rumah Sakit Umum Pusat Dr. Wahidin Sudirohusodo","ror":"https://ror.org/01d3fv830","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4405274271"]},{"id":"https://openalex.org/I98301867","display_name":"Hasanuddin University","ror":"https://ror.org/00da1gf19","country_code":"ID","type":"education","lineage":["https://openalex.org/I98301867"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Muis, Abdul","raw_affiliation_strings":["Department of Neurology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia;  Brain Centre, Dr. Wahidin Sudirohusodo General Hospital, Makassar, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia;  Brain Centre, Dr. Wahidin Sudirohusodo General Hospital, Makassar, Indonesia","institution_ids":["https://openalex.org/I4405274271","https://openalex.org/I98301867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055972680","display_name":"Yudy Goysal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405274271","display_name":"Rumah Sakit Umum Pusat Dr. Wahidin Sudirohusodo","ror":"https://ror.org/01d3fv830","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4405274271"]},{"id":"https://openalex.org/I98301867","display_name":"Hasanuddin University","ror":"https://ror.org/00da1gf19","country_code":"ID","type":"education","lineage":["https://openalex.org/I98301867"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Goysal, Yudy","raw_affiliation_strings":["Department of Neurology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Brain Centre, Dr. Wahidin Sudirohusodo General Hospital, Makassar, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Brain Centre, Dr. Wahidin Sudirohusodo General Hospital, Makassar, Indonesia","institution_ids":["https://openalex.org/I4405274271","https://openalex.org/I98301867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5153670504","display_name":"Andi Alfian Zainuddin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alfian Zainuddin, Andi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.6812000274658203,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.6812000274658203,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.2460000067949295,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atherogenic-index-of-plasma","display_name":"atherogenic index of plasma","score":0.9599999785423279},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.8220000267028809},{"id":"https://openalex.org/keywords/stroke-subtypes","display_name":"stroke subtypes","score":0.9190000295639038},{"id":"https://openalex.org/keywords/lacunar-stroke","display_name":"lacunar stroke","score":0.9739999771118164},{"id":"https://openalex.org/keywords/triglyceride-to-hdl-cholesterol-ratio","display_name":"triglyceride to HDL cholesterol ratio","score":0.8309999704360962},{"id":"https://openalex.org/keywords/atherogenic-dyslipidemia","display_name":"atherogenic dyslipidemia","score":0.8690000176429749},{"id":"https://openalex.org/keywords/vascular-risk-markers","display_name":"vascular risk markers","score":0.7070000171661377},{"id":"https://openalex.org/keywords/montreal-cognitive-assessment","display_name":"Montreal Cognitive Assessment","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7710999846458435},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.7333999872207642},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6733999848365784},{"id":"https://openalex.org/C2779285336","wikidata":"https://www.wikidata.org/wiki/Q6469117","display_name":"Lacunar stroke","level":4,"score":0.6218000054359436},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5945000052452087},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4742000102996826},{"id":"https://openalex.org/C2776632958","wikidata":"https://www.wikidata.org/wiki/Q6906262","display_name":"Montreal Cognitive Assessment","level":4,"score":0.46129998564720154},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.3747999966144562},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.35089999437332153},{"id":"https://openalex.org/C3018755981","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischaemic stroke","level":3,"score":0.3472000062465668},{"id":"https://openalex.org/C117812244","wikidata":"https://www.wikidata.org/wiki/Q5141157","display_name":"Cognitive Assessment System","level":4,"score":0.3353999853134155},{"id":"https://openalex.org/C3020166492","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Acute stroke","level":3,"score":0.31310001015663147},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.3034999966621399},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.29490000009536743},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C6057870","wikidata":"https://www.wikidata.org/wiki/Q5141248","display_name":"Cognitive test","level":3,"score":0.28119999170303345},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.28029999136924744},{"id":"https://openalex.org/C2781111876","wikidata":"https://www.wikidata.org/wiki/Q567869","display_name":"Anosognosia","level":3,"score":0.2766000032424927},{"id":"https://openalex.org/C2780566141","wikidata":"https://www.wikidata.org/wiki/Q3065932","display_name":"Cognitive disorder","level":4,"score":0.2750999927520752},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.27410000562667847},{"id":"https://openalex.org/C159744936","wikidata":"https://www.wikidata.org/wiki/Q1126730","display_name":"Spearman's rank correlation coefficient","level":2,"score":0.2685000002384186},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.2630000114440918},{"id":"https://openalex.org/C2776191500","wikidata":"https://www.wikidata.org/wiki/Q2123166","display_name":"Leukoaraiosis","level":4,"score":0.26190000772476196},{"id":"https://openalex.org/C2778820722","wikidata":"https://www.wikidata.org/wiki/Q4862390","display_name":"Brain ischemia","level":3,"score":0.2597000002861023},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:mattioli1885journals.com:article/18929","doi":"https://doi.org/10.23750/abm.2026.18929","is_oa":true,"landing_page_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/18929","pdf_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/download/18929/13285","source":{"id":"https://openalex.org/S4393915150","display_name":"Acta bio-medica dell'Ateneo parmense/Acta biomedica","issn_l":"0392-4203","issn":["0392-4203","2531-6745"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0392-4203","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:mattioli1885journals.com:article/18929","doi":"https://doi.org/10.23750/abm.2026.18929","is_oa":true,"landing_page_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/18929","pdf_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/download/18929/13285","source":{"id":"https://openalex.org/S4393915150","display_name":"Acta bio-medica dell'Ateneo parmense/Acta biomedica","issn_l":"0392-4203","issn":["0392-4203","2531-6745"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0392-4203","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214916773.pdf","grobid_xml":"https://content.openalex.org/works/W7214916773.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W43735165","https://openalex.org/W1994922079","https://openalex.org/W2037426713","https://openalex.org/W2041123861","https://openalex.org/W2138595885","https://openalex.org/W2894776090","https://openalex.org/W2903201307","https://openalex.org/W2946066695","https://openalex.org/W2947924379","https://openalex.org/W3093001455","https://openalex.org/W3207526407","https://openalex.org/W4200346704","https://openalex.org/W4220799853","https://openalex.org/W4296916969","https://openalex.org/W4313417586","https://openalex.org/W4383906895","https://openalex.org/W4387575999","https://openalex.org/W4391365490"],"related_works":["https://openalex.org/W4401432416","https://openalex.org/W4416206643","https://openalex.org/W4200452731","https://openalex.org/W3207526407","https://openalex.org/W4387575999","https://openalex.org/W7220878643","https://openalex.org/W3203228134","https://openalex.org/W7201871767","https://openalex.org/W4413442995","https://openalex.org/W7160329072"],"abstract_inverted_index":{"Background":[0],"and":[1,54,102,127,143,158,171],"aim:":[2],"Cognitive":[3,65,137],"impairment":[4,166],"is":[5,227],"a":[6,27,180],"common":[7],"complication":[8],"in":[9,233],"the":[10,50,63,234],"acute":[11,95,235],"phase":[12,236],"of":[13,20,30,59,237,253],"ischaemic":[14,96,113,238],"stroke":[15,41,97,144,195,204,254],"(IS).":[16],"The":[17],"Atherogenic":[18],"Index":[19],"Plasma":[21],"(AIP)":[22],"has":[23],"been":[24],"proposed":[25],"as":[26,134,148],"potential":[28],"marker":[29],"vascular":[31],"risk;":[32],"however,":[33],"its":[34],"relationship":[35],"with":[36,57,93,184,202,229],"cognitive":[37,55,165,199,231,250],"function":[38,138],"across":[39],"different":[40],"subtypes":[42,220],"remains":[43],"unclear.":[44],"This":[45,240],"study":[46,74],"aimed":[47],"to":[48,86,248],"evaluate":[49],"association":[51],"between":[52,219],"AIP":[53,131,173,178,214,226],"performance,":[56],"consideration":[58],"IS":[60],"subtypes,":[61],"using":[62,141],"Montreal":[64],"Assessment":[66],"Indonesian":[67],"Version":[68],"(MoCA-Ina).":[69],"Methods:":[70],"A":[71],"cross-sectional":[72],"analytic":[73],"was":[75,132,139,146],"conducted":[76],"at":[77],"Dr.":[78],"Wahidin":[79],"Sudirohusodo":[80],"General":[81],"Hospital,":[82],"Makassar,":[83],"from":[84],"July":[85],"December":[87],"2025.":[88],"Patients":[89],"aged":[90],"\u226540":[91],"years":[92],"first-ever":[94],"(onset":[98],"24":[99],"hours\u20137":[100],"days)":[101],"preserved":[103],"consciousness":[104],"were":[105],"included.":[106],"Exclusion":[107],"criteria":[108],"comprised":[109],"recurrent":[110],"stroke,":[111],"transient":[112],"attack,":[114],"aphasia,":[115],"pre-existing":[116],"dementia,":[117],"systemic":[118],"or":[119,124,150],"psychiatric":[120],"conditions":[121],"affecting":[122],"cognition":[123],"lipid":[125],"metabolism,":[126],"prior":[128],"lipid-lowering":[129],"therapy.":[130],"calculated":[133],"log\u2081\u2080":[135],"(triglyceride/HDL-C).":[136],"assessed":[140],"MoCA-Ina,":[142],"subtype":[145],"classified":[147],"lacunar":[149,203],"non-lacunar.":[151],"Statistical":[152],"analyses":[153],"included":[154],"Spearman":[155],"correlation,":[156],"Mann\u2013Whitney,":[157],"independent":[159],"t-tests.":[160],"Results:":[161],"Most":[162],"patients":[163,196],"showed":[164,197],"(74%;":[167],"median":[168],"MoCA-Ina":[169,186],"23.00)":[170],"high-risk":[172],"levels":[174],"(65%;":[175],"mean":[176],"0.285).":[177],"demonstrated":[179],"significant":[181],"negative":[182],"correlation":[183],"total":[185],"score":[187],"(r":[188],"=":[189,192,210,222],"-0.342;":[190],"p":[191,209],"0.001).":[193],"Non-lacunar":[194],"lower":[198],"scores":[200],"compared":[201],"(mean":[205],"19.02":[206],"vs":[207],"21.90;":[208],"0.028).":[211],"In":[212],"contrast,":[213],"values":[215],"did":[216],"not":[217],"differ":[218],"(p":[221],"0.991).":[223],"Conclusions:":[224],"Higher":[225],"associated":[228],"worse":[230],"performance":[232],"stroke.":[239],"finding":[241],"suggests":[242],"that":[243],"atherogenic":[244],"dyslipidaemia":[245],"may":[246],"contribute":[247],"early":[249],"decline":[251],"irrespective":[252],"subtype.":[255]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-10-01T00:00:00"}