{"id":"https://openalex.org/W7214911736","doi":"https://doi.org/10.64898/2026.09.24.754169","title":"A highly reproducible, safe cranial window surgery for targeted in vivo manipulations in the adult zebrafish telencephalon","display_name":"A highly reproducible, safe cranial window surgery for targeted in vivo manipulations in the adult zebrafish telencephalon","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7214911736","doi":"https://doi.org/10.64898/2026.09.24.754169"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.24.754169","doi":"https://doi.org/10.64898/2026.09.24.754169","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.754169","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.24.754169.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.24.754169.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019548894","display_name":"Konstantin N. Zabegalov","orcid":"https://orcid.org/0000-0002-9748-0324","observed_orcids":["https://orcid.org/0000-0002-9748-0324"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Konstantin N Zabegalov","raw_affiliation_strings":["Life Improvement by Future Technologies (LIFT) Center LLC"],"raw_orcid":"https://orcid.org/0000-0002-9748-0324","affiliations":[{"raw_affiliation_string":"Life Improvement by Future Technologies (LIFT) Center LLC","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019548894"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14411","display_name":"Undergraduate Neuroscience Education and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3304","display_name":"Education"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.8949999809265137},{"id":"https://openalex.org/keywords/telencephalon","display_name":"telencephalon","score":0.9649999737739563},{"id":"https://openalex.org/keywords/craniotomy","display_name":"craniotomy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/neurovascular-integrity","display_name":"neurovascular integrity","score":0.7630000114440918},{"id":"https://openalex.org/keywords/neurostimulation","display_name":"neurostimulation","score":0.9240000247955322}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.8944000005722046},{"id":"https://openalex.org/C105572291","wikidata":"https://www.wikidata.org/wiki/Q7002775","display_name":"Neurovascular bundle","level":2,"score":0.6039999723434448},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5164999961853027},{"id":"https://openalex.org/C533869091","wikidata":"https://www.wikidata.org/wiki/Q75855","display_name":"Cerebrum","level":3,"score":0.5162000060081482},{"id":"https://openalex.org/C2778871575","wikidata":"https://www.wikidata.org/wiki/Q514921","display_name":"Craniotomy","level":2,"score":0.47099998593330383},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.4546999931335449},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4115000069141388},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4066999852657318},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.3903999924659729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3828999996185303},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36480000615119934},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.35760000348091125},{"id":"https://openalex.org/C2777507194","wikidata":"https://www.wikidata.org/wiki/Q499802","display_name":"Mammillary body","level":3,"score":0.3248000144958496},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.28999999165534973},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.2827000021934509},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2816999852657318},{"id":"https://openalex.org/C2988540567","wikidata":"https://www.wikidata.org/wiki/Q12070446","display_name":"Model system","level":2,"score":0.2799000144004822},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.27070000767707825}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.24.754169","doi":"https://doi.org/10.64898/2026.09.24.754169","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.754169","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.24.754169.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.24.754169","doi":"https://doi.org/10.64898/2026.09.24.754169","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.754169","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.24.754169.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1824550896","display_name":null,"funder_award_id":"Priority-2030","funder_id":"https://openalex.org/F4320327756","funder_display_name":"National University of Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320327494","display_name":"Ministry of Science and Higher Education of the Russian Federation","ror":null},{"id":"https://openalex.org/F4320327756","display_name":"National University of Science and Technology","ror":"https://ror.org/019vsm959"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214911736.pdf","grobid_xml":"https://content.openalex.org/works/W7214911736.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1977059167","https://openalex.org/W1981239255","https://openalex.org/W1999285684","https://openalex.org/W2003968022","https://openalex.org/W2018219363","https://openalex.org/W2020681928","https://openalex.org/W2040912132","https://openalex.org/W2042113260","https://openalex.org/W2050762290","https://openalex.org/W2052474126","https://openalex.org/W2062055972","https://openalex.org/W2085320324","https://openalex.org/W2097980270","https://openalex.org/W2118145895","https://openalex.org/W2134997228","https://openalex.org/W2136820200","https://openalex.org/W2141363043","https://openalex.org/W2145630843","https://openalex.org/W2151537708","https://openalex.org/W2166909960","https://openalex.org/W2277956273","https://openalex.org/W2410803912","https://openalex.org/W2503823987","https://openalex.org/W2551740831","https://openalex.org/W2557494316","https://openalex.org/W2890470475","https://openalex.org/W2910933602","https://openalex.org/W2934040352","https://openalex.org/W2950052702","https://openalex.org/W2972662355","https://openalex.org/W2975776078","https://openalex.org/W3040688900","https://openalex.org/W3041975023","https://openalex.org/W3088701716","https://openalex.org/W3089861350","https://openalex.org/W3194856215","https://openalex.org/W3197639778","https://openalex.org/W3200723186","https://openalex.org/W3202866327","https://openalex.org/W4205508073","https://openalex.org/W4285745430","https://openalex.org/W4286615923","https://openalex.org/W4294636647","https://openalex.org/W4311853061","https://openalex.org/W4313813443","https://openalex.org/W4360982890","https://openalex.org/W4366206434","https://openalex.org/W4377291420","https://openalex.org/W4381429384","https://openalex.org/W4381511555","https://openalex.org/W4385296560","https://openalex.org/W4390399236","https://openalex.org/W4399295773","https://openalex.org/W4400246855","https://openalex.org/W4400531176","https://openalex.org/W4401337544","https://openalex.org/W4401764010","https://openalex.org/W4404486406","https://openalex.org/W4405186597","https://openalex.org/W4406839831","https://openalex.org/W4407349099","https://openalex.org/W4408808870","https://openalex.org/W4408900148","https://openalex.org/W4409566733","https://openalex.org/W4410056405","https://openalex.org/W4411849302","https://openalex.org/W4413444538","https://openalex.org/W4414138095","https://openalex.org/W4414154783","https://openalex.org/W4415313549","https://openalex.org/W7126377424","https://openalex.org/W7133355245","https://openalex.org/W7136887594","https://openalex.org/W7154155032","https://openalex.org/W7156799368","https://openalex.org/W7162113327"],"related_works":["https://openalex.org/W7075280761","https://openalex.org/W2088160547","https://openalex.org/W3084988166","https://openalex.org/W2380265212","https://openalex.org/W2982488399","https://openalex.org/W1989391377","https://openalex.org/W2498003626","https://openalex.org/W7100648339","https://openalex.org/W4206792502","https://openalex.org/W2153232075"],"abstract_inverted_index":{"Experimental":[0],"surgery":[1,56],"is":[2,200],"one":[3],"of":[4,9,26,37,175],"the":[5,24,35,47,66,70,77,82,117,145,176],"most":[6,51],"fundamental":[7],"fields":[8],"biomedical":[10],"research,":[11],"recreating":[12],"clinical":[13,20],"conditions":[14],"on":[15],"living":[16],"organisms":[17],"similar":[18],"to":[19,22,65,76,124,140,152,202],"patients,":[21],"facilitate":[23],"design":[25],"novel":[27,103],"therapies.":[28],"For":[29],"modeling":[30],"neurological":[31],"and":[32,91,134,137,142,160,195,210,226],"psychiatric":[33],"disorders,":[34],"majority":[36],"operative":[38,183],"techniques":[39],"mandatorily":[40],"include":[41],"craniotomy":[42],"for":[43,98,113,217],"consecutive":[44],"interactions":[45],"with":[46],"open":[48],"brain.":[49],"The":[50],"wide-spread":[52],"methodology":[53],"involves":[54],"stereotactic":[55],"in":[57,157,168,181,220,228],"rodents,":[58],"implementing":[59],"a":[60,109,229],"specific":[61],"head":[62,73],"holder,":[63],"attached":[64],"coordinate":[67],"table,":[68],"providing":[69],"precise":[71,218],"animal":[72,96],"positioning":[74],"according":[75],"brain":[78,177],"structures":[79,155],"topology.":[80],"Despite":[81],"high":[83,135,182,211],"efficiency,":[84],"such":[85,114],"systems":[86],"require":[87],"complex":[88],"instrumental":[89],"skills":[90],"long":[92],"procedure":[93],"duration":[94],"per":[95],"even":[97],"simple":[99],"implantation":[100],"protocols.":[101],"Hence,":[102],"alternative":[104],"model":[105,232],"species":[106,233],"could":[107],"be":[108],"valuable":[110],"supplementary":[111],"tool":[112],"manipulations.":[115],"Therefore,":[116],"zebrafish":[118,147,170],"(Danio":[119],"rerio)":[120],"fits":[121],"perfectly,":[122],"due":[123],"its":[125],"low":[126],"cost,":[127],"easy":[128],"husbandry,":[129],"rapid":[130],"development,":[131],"optic":[132],"transparency,":[133],"genetic":[136],"physiological":[138],"similarity":[139],"rodents":[141],"humans.":[143],"Furthermore,":[144],"everted":[146],"telencephalon":[148],"provides":[149],"excellent":[150],"accessibility":[151],"critical":[153],"mammalian-like":[154],"involved":[156],"emotion":[158],"processing":[159],"cognition.":[161],"However,":[162],"conventional":[163],"avian-":[164],"or":[165],"rodent-inspired":[166],"craniotomies":[167],"adult":[169],"often":[171],"trigger":[172],"inadvertent":[173],"disruption":[174],"vessels":[178],"network,":[179],"resulting":[180],"mortality.":[184],"A":[185],"novel,":[186],"geometry-driven,":[187],"non-lethal":[188],"cranial":[189],"window":[190],"protocol":[191],"preserving":[192],"neurovascular":[193],"integrity":[194],"ensuring":[196],"90-100%":[197],"post-operative":[198],"survival":[199],"presented":[201],"overcome":[203],"above":[204],"mentioned":[205],"limitations.":[206],"This":[207],"rapid,":[208],"simple,":[209],"reproducible":[212],"technique":[213],"opens":[214],"new":[215],"avenues":[216],"region-specific":[219],"vivo":[221],"neurosurgery,":[222],"high-throughput":[223],"psychopharmacological":[224],"screening,":[225],"neurostimulation":[227],"powerful":[230],"non-mammalian":[231]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-01T00:00:00"}
