{"id":"https://openalex.org/W7214910306","doi":"https://doi.org/10.64898/2026.09.24.754163","title":"Characterization of Congestive Heart Failure Phenotype in a Murine Model of JAK2V617F-positive Myeloproliferative Neoplasm","display_name":"Characterization of Congestive Heart Failure Phenotype in a Murine Model of JAK2V617F-positive Myeloproliferative Neoplasm","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7214910306","doi":"https://doi.org/10.64898/2026.09.24.754163","pmid":"https://pubmed.ncbi.nlm.nih.gov/42856329","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13648458"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.24.754163","doi":"https://doi.org/10.64898/2026.09.24.754163","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.754163","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.24.754163.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.24.754163.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101583418","display_name":"Xiaochuan Sun","orcid":"https://orcid.org/0000-0002-0666-9886","observed_orcids":["https://orcid.org/0000-0002-0666-9886"]},"institutions":[{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]},{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I4210102711","display_name":"Stony Brook Medicine","ror":"https://ror.org/01882y777","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xiaochuan Sun","raw_affiliation_strings":["Department of Medicine, Stony Brook School of Medicine, Stony Brook, NY, United States","Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Stony Brook School of Medicine, Stony Brook, NY, United States","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China","institution_ids":["https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153628338","display_name":"Haoyi Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094963","display_name":"St. Francis Hospital","ror":"https://ror.org/00mj4n083","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210094963"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haoyi Zheng","raw_affiliation_strings":["Cardiac Imaging, The Heart Center, Saint Francis Hospital, Roslyn, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiac Imaging, The Heart Center, Saint Francis Hospital, Roslyn, NY","institution_ids":["https://openalex.org/I4210094963"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5153583569","display_name":"Huichun Zhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I4210102711","display_name":"Stony Brook Medicine","ror":"https://ror.org/01882y777","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"id":"https://openalex.org/I4210109353","display_name":"Northport VA Medical Center","ror":"https://ror.org/01xtpc441","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210109353"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Huichun Zhan","raw_affiliation_strings":["Department of Medicine, Stony Brook School of Medicine, Stony Brook, NY, United States","Medical Service, Northport VA Medical Center, Northport, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Stony Brook School of Medicine, Stony Brook, NY, United States","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Medical Service, Northport VA Medical Center, Northport, NY, United States","institution_ids":["https://openalex.org/I4210109353"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5153583569"],"corresponding_institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I4210102711","https://openalex.org/I4210109353","https://openalex.org/I59553526"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.2167000025510788,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.060600001364946365,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jak2-v617f-mutation","display_name":"JAK2 V617F mutation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.9829999804496765},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.6470000147819519},{"id":"https://openalex.org/keywords/coronary-microvascular-dysfunction","display_name":"coronary microvascular dysfunction","score":0.7519999742507935},{"id":"https://openalex.org/keywords/coronary-flow-reserve","display_name":"coronary flow reserve","score":0.8899999856948853},{"id":"https://openalex.org/keywords/perivascular-fibrosis","display_name":"perivascular fibrosis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/subendocardial-fibrosis","display_name":"subendocardial fibrosis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/hepatic-congestion","display_name":"hepatic congestion","score":0.9139999747276306},{"id":"https://openalex.org/keywords/left-ventricular-dilation","display_name":"left ventricular dilatation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cardiovascular-phenotyping","display_name":"cardiovascular phenotyping","score":0.6660000085830688},{"id":"https://openalex.org/keywords/endothelial-mesenchymal-transition","display_name":"endothelial-to-mesenchymal transition","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.828499972820282},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6855000257492065},{"id":"https://openalex.org/C2778707443","wikidata":"https://www.wikidata.org/wiki/Q3936479","display_name":"Coronary flow reserve","level":3,"score":0.6251000165939331},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5950000286102295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5594000220298767},{"id":"https://openalex.org/C2776157398","wikidata":"https://www.wikidata.org/wiki/Q497232","display_name":"Coronary circulation","level":3,"score":0.45750001072883606},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.42100000381469727},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.41110000014305115},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40400001406669617},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4000999927520752},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.3779999911785126},{"id":"https://openalex.org/C2778742706","wikidata":"https://www.wikidata.org/wiki/Q18361829","display_name":"Coronary arteries","level":3,"score":0.3634999990463257},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.3547999858856201},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.3463999927043915},{"id":"https://openalex.org/C2777408375","wikidata":"https://www.wikidata.org/wiki/Q707810","display_name":"Arteriogenesis","level":3,"score":0.3328000009059906},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.32690000534057617},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.313400000333786},{"id":"https://openalex.org/C2776417487","wikidata":"https://www.wikidata.org/wiki/Q103142","display_name":"Sinusoid","level":2,"score":0.3125999867916107},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.3057999908924103},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.3028999865055084},{"id":"https://openalex.org/C2909948108","wikidata":"https://www.wikidata.org/wiki/Q494603","display_name":"Pulmonary vasculature","level":3,"score":0.29319998621940613},{"id":"https://openalex.org/C85378888","wikidata":"https://www.wikidata.org/wiki/Q721856","display_name":"Endocardium","level":2,"score":0.2906999886035919},{"id":"https://openalex.org/C2991716557","wikidata":"https://www.wikidata.org/wiki/Q12252367","display_name":"Coronary atherosclerosis","level":3,"score":0.28780001401901245},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.28600001335144043},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.27950000762939453},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.27399998903274536},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.2671999931335449},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.2646999955177307},{"id":"https://openalex.org/C2777543607","wikidata":"https://www.wikidata.org/wiki/Q1153419","display_name":"Interstitial lung disease","level":3,"score":0.2612999975681305},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.257099986076355}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.24.754163","doi":"https://doi.org/10.64898/2026.09.24.754163","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.754163","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.24.754163.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42856329","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42856329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13648458","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648458/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.24.754163","doi":"https://doi.org/10.64898/2026.09.24.754163","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.754163","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.24.754163.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1948962870","display_name":null,"funder_award_id":"BX005584","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4416690017","display_name":null,"funder_award_id":"BX003947","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G9000910065","display_name":"Cell Competition in Myeloproliferative Neoplasms","funder_award_id":"R01CA266294","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214910306.pdf","grobid_xml":"https://content.openalex.org/works/W7214910306.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W164205712","https://openalex.org/W1992826811","https://openalex.org/W1998270029","https://openalex.org/W2004723978","https://openalex.org/W2022292181","https://openalex.org/W2055729264","https://openalex.org/W2059611250","https://openalex.org/W2063731736","https://openalex.org/W2066287407","https://openalex.org/W2073440691","https://openalex.org/W2104768197","https://openalex.org/W2122594103","https://openalex.org/W2126816979","https://openalex.org/W2127791131","https://openalex.org/W2143374037","https://openalex.org/W2149858388","https://openalex.org/W2171952998","https://openalex.org/W2521375971","https://openalex.org/W2578808037","https://openalex.org/W2612219720","https://openalex.org/W2628145035","https://openalex.org/W2736512538","https://openalex.org/W2789551841","https://openalex.org/W2791529560","https://openalex.org/W2792198544","https://openalex.org/W2796704538","https://openalex.org/W2889350311","https://openalex.org/W2891613655","https://openalex.org/W2973311260","https://openalex.org/W2982291252","https://openalex.org/W3084477806","https://openalex.org/W3093370683","https://openalex.org/W3137897103","https://openalex.org/W3139367533","https://openalex.org/W3173789154","https://openalex.org/W3208849489","https://openalex.org/W4239761414","https://openalex.org/W4304631923","https://openalex.org/W4308930794","https://openalex.org/W4318198444","https://openalex.org/W4360599998","https://openalex.org/W4366371744","https://openalex.org/W4389574595","https://openalex.org/W4399048690","https://openalex.org/W4400557621","https://openalex.org/W4416538724","https://openalex.org/W7196962178","https://openalex.org/W7207725000"],"related_works":["https://openalex.org/W4416724226","https://openalex.org/W7202144765","https://openalex.org/W4376150209","https://openalex.org/W4306153819","https://openalex.org/W2746293766","https://openalex.org/W7140327734","https://openalex.org/W1993237363","https://openalex.org/W4389252622","https://openalex.org/W2947313944","https://openalex.org/W2075393250"],"abstract_inverted_index":{"Background:":[0],"(Tie2FF1)":[1],"mice":[2,33,72,126,162],"express":[3],"JAK2V617F":[4],"mutation":[5],"in":[6,109],"both":[7],"hematopoietic":[8],"and":[9,12,34,53,58,62,67,80,98,116,130,145,173,177,204],"endothelial":[10,114,175],"cells":[11],"develop":[13],"spontaneous":[14],"CVD":[15],"on":[16],"a":[17,24,164,193],"standard":[18],"chow":[19],"diet.":[20],"Methods:":[21],"We":[22],"applied":[23],"comprehensive,":[25],"non-invasive":[26,166],"cardiovascular":[27,199],"phenotyping":[28,200],"protocol":[29],"to":[30],"1-year-old":[31],"Tie2FF1":[32,71,125,161],"age-matched":[35],"controls.":[36],"Assessments":[37],"included":[38],"transthoracic":[39],"echocardiography,":[40],"coronary":[41,50,88,103,171],"flow":[42,104],"reserve":[43,105],"by":[44,95],"Doppler":[45],"ultrasound,":[46],"quantitative":[47],"analysis":[48],"of":[49,65,152,170],"arteriolar":[51,96],"structure":[52],"perivascular":[54,100],"fibrosis,":[55,101,141],"endocardial":[56,174],"histology":[57],"subendocardial":[59,118],"collagen":[60],"deposition,":[61],"histologic":[63],"evaluation":[64],"pulmonary":[66,133,139],"hepatic":[68,142],"congestion.":[69],"Results:":[70],"demonstrated":[73],"left":[74,183],"ventricular":[75,184],"dilation,":[76],"increased":[77,99,117,128],"cardiac":[78],"mass,":[79],"mildly":[81,181],"reduced":[82,108,182],"systolic":[83],"function":[84],"without":[85],"obstructive":[86],"epicardial":[87],"disease.":[89],"Coronary":[90],"microvascular":[91,172],"remodeling":[92],"was":[93,106],"evident":[94],"narrowing":[97],"while":[102],"markedly":[107],"an":[110],"exploratory":[111],"cohort.":[112],"Endocardial":[113],"disruption":[115],"fibrosis":[119],"were":[120],"also":[121],"observed.":[122],"In":[123],"addition,":[124],"showed":[127],"lung":[129],"liver":[131],"weights,":[132],"fluid":[134],"accumulation,":[135],"alveolar":[136],"septal":[137],"thickening,":[138],"vascular":[140],"sinusoidal":[143],"dilatation,":[144],"centrilobular":[146],"hepatocyte":[147],"swelling,":[148],"providing":[149],"objective":[150],"evidence":[151],"clinically":[153],"relevant":[154],"heart":[155,178],"failure.":[156],"Significance:":[157],"These":[158],"findings":[159],"establish":[160],"as":[163],"spontaneous,":[165],"model":[167],"with":[168,180],"features":[169],"dysfunction":[176],"failure":[179],"ejection":[185],"fraction.":[186],"The":[187],"integrated":[188],"approach":[189],"described":[190],"here":[191],"provides":[192],"practical":[194],"framework":[195],"for":[196],"comprehensive":[197],"murine":[198],"beyond":[201],"traditional":[202],"atherosclerosis-":[203],"surgery-based":[205],"models.":[206]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-01T00:00:00"}