{"id":"https://openalex.org/W7214909354","doi":"https://doi.org/10.1038/s41591-026-04705-y","title":"Intravenous hyaluronidase-expressing oncolytic adenovirus with chemotherapy in metastatic pancreatic cancer: a randomized phase 2b trial","display_name":"Intravenous hyaluronidase-expressing oncolytic adenovirus with chemotherapy in metastatic pancreatic cancer: a randomized phase 2b trial","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7214909354","doi":"https://doi.org/10.1038/s41591-026-04705-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/42816596"},"language":"en","primary_location":{"id":"doi:10.1038/s41591-026-04705-y","doi":"https://doi.org/10.1038/s41591-026-04705-y","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41591-026-04705-y","pdf_url":null,"source":{"id":"https://openalex.org/S203256638","display_name":"Nature Medicine","issn_l":"1078-8956","issn":["1078-8956","1546-170X","1744-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048223620","display_name":"Rocio Garc\u00eda\u2010Carbonero","orcid":"https://orcid.org/0000-0002-3342-397X","observed_orcids":["https://orcid.org/0000-0002-3342-397X"]},"institutions":[{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Rocio Garcia-Carbonero","raw_affiliation_strings":["Medical Oncology Department, Hospital Universitario 12 de Octubre (IIS Imas12), UCM, Madrid, Spain. rgcarbonero@gmail.com"],"raw_orcid":"https://orcid.org/0000-0002-3342-397X","affiliations":[{"raw_affiliation_string":"Medical Oncology Department, Hospital Universitario 12 de Octubre (IIS Imas12), UCM, Madrid, Spain. rgcarbonero@gmail.com","institution_ids":["https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012440329","display_name":"Roberto Pazo-Cid","orcid":"https://orcid.org/0000-0002-8026-7391","observed_orcids":["https://orcid.org/0000-0002-8026-7391"]},"institutions":[{"id":"https://openalex.org/I4210114530","display_name":"Hospital Universitario Miguel Servet","ror":"https://ror.org/01r13mt55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210114530"]},{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Roberto Pazo Cid","raw_affiliation_strings":["Aragon Health Research Institute (IIS Arag\u00f3n), Zaragoza, Spain","Miguel Servet University Hospital, Zaragoza, Spain"],"raw_orcid":"https://orcid.org/0000-0002-8026-7391","affiliations":[{"raw_affiliation_string":"Aragon Health Research Institute (IIS Arag\u00f3n), Zaragoza, Spain","institution_ids":["https://openalex.org/I4210136512"]},{"raw_affiliation_string":"Miguel Servet University Hospital, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210114530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082191671","display_name":"Teresa Mercade Macarulla","orcid":"https://orcid.org/0000-0002-5856-4082","observed_orcids":["https://orcid.org/0000-0002-5856-4082","https://orcid.org/0000-0002-1881-362X"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Teresa Macarulla","raw_affiliation_strings":["Departament of Medicine, University of Barcelona, Barcelona, Spain","Medical Oncology Department, Cl\u00ednic Barcelona Comprehensive Cancer Center, Hospital Cl\u00ednic Barcelona, Barcelona, Spain","Translational Oncology in Upper Gastrointestinal Cancer Group, IDIBAPS, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departament of Medicine, University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Medical Oncology Department, Cl\u00ednic Barcelona Comprehensive Cancer Center, Hospital Cl\u00ednic Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"Translational Oncology in Upper Gastrointestinal Cancer Group, IDIBAPS, Barcelona, Spain","institution_ids":["https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153663142","display_name":"Berta Laquente","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]},{"id":"https://openalex.org/I4210143012","display_name":"Duran i Reynals Hospital","ror":"https://ror.org/03qwghy04","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210143012"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Berta Laquente","raw_affiliation_strings":["Medical Oncology Department, ICO - Institut Catal\u00e0 d'Oncologia l'Hospitalet (Hospital Duran i Reynals), L'Hospitalet de Llobregat, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department, ICO - Institut Catal\u00e0 d'Oncologia l'Hospitalet (Hospital Duran i Reynals), L'Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I4210107147","https://openalex.org/I4210143012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010833419","display_name":"Alana Nguyen","orcid":"https://orcid.org/0000-0002-7316-073X","observed_orcids":["https://orcid.org/0000-0002-7316-073X"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alana Nguyen","raw_affiliation_strings":["Weill Cornell Medicine/NYP Hospital, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine/NYP Hospital, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050960262","display_name":"Carmen Guill\u00e9n\u2010Ponce","orcid":"https://orcid.org/0000-0002-3594-1084","observed_orcids":["https://orcid.org/0000-0002-3594-1084"]},"institutions":[{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carmen Guill\u00e9n-Ponce","raw_affiliation_strings":["Medical Oncology Department, Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-3594-1084","affiliations":[{"raw_affiliation_string":"Medical Oncology Department, Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain","institution_ids":["https://openalex.org/I4210127475","https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100979059","display_name":"Andres Munoz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I4405268975","display_name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/02p8e3h61","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4405268975"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Andr\u00e9s Mu\u00f1oz","raw_affiliation_strings":["Medical Oncology Service, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Universidad Complutense, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Service, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Universidad Complutense, Madrid, Spain","institution_ids":["https://openalex.org/I121748325","https://openalex.org/I4405268975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100728167","display_name":"Edward Jae-Hoon Kim","orcid":"https://orcid.org/0000-0002-8660-7465","observed_orcids":["https://orcid.org/0000-0002-8660-7465"]},"institutions":[{"id":"https://openalex.org/I4390039352","display_name":"UC Davis Comprehensive Cancer Center","ror":"https://ror.org/02kcc1z29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856","https://openalex.org/I4390039352"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward J. Kim","raw_affiliation_strings":["UC Davis Comprehensive Cancer Center, Sacramento, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UC Davis Comprehensive Cancer Center, Sacramento, CA, USA","institution_ids":["https://openalex.org/I4390039352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042059807","display_name":"Mireya Cazorla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157481","display_name":"Hospital Cl\u00ednico Universitario Virgen de la Victoria","ror":"https://ror.org/05xxs2z38","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210157481"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mireya Cazorla","raw_affiliation_strings":["Medical Oncology, HUVV - Hospital Universitario Virgen de la Victoria, Malaga, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, HUVV - Hospital Universitario Virgen de la Victoria, Malaga, Spain","institution_ids":["https://openalex.org/I4210157481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006677988","display_name":"Seery Tara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307629703","display_name":"Hoag Memorial Hospital Presbyterian","ror":"https://ror.org/05nmfef18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307629703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tara Seery","raw_affiliation_strings":["Hoag Memorial Hospital Presbyterian, Newport Beach, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hoag Memorial Hospital Presbyterian, Newport Beach, CA, USA","institution_ids":["https://openalex.org/I1307629703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022388012","display_name":"M. Lobo de Mena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127649","display_name":"Hospital General Universitario De Valencia","ror":"https://ror.org/03sz8rb35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127649"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miriam Lobo de Mena","raw_affiliation_strings":["Consorcio Hospital General Universitario de Valencia, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consorcio Hospital General Universitario de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I4210127649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080264243","display_name":"Chris Nevala-Plagemann","orcid":"https://orcid.org/0000-0003-4048-2692","observed_orcids":["https://orcid.org/0000-0003-4048-2692"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Nevala-Plagemann","raw_affiliation_strings":["Huntsman Cancer Institute at University of Utah, Salt Lake City, UT, USA"],"raw_orcid":"https://orcid.org/0000-0003-4048-2692","affiliations":[{"raw_affiliation_string":"Huntsman Cancer Institute at University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153556020","display_name":"Vivek Sharma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivek Sharma","raw_affiliation_strings":["University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002421509","display_name":"Eva Mart\u00ednez de Castro","orcid":"https://orcid.org/0000-0002-5772-0741","observed_orcids":["https://orcid.org/0000-0002-5772-0741"]},"institutions":[{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210113075","display_name":"Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla","ror":"https://ror.org/025gxrt12","country_code":"ES","type":"other","lineage":["https://openalex.org/I13134134","https://openalex.org/I4210113075"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eva Mart\u00ednez de Castro","raw_affiliation_strings":["Servicio de Oncolog\u00eda M\u00e9dica, Hospital Universitario Marqu\u00e9s de Valdecilla, Instituto de investigaci\u00f3n IDIVAL, Santander, Spain"],"raw_orcid":"https://orcid.org/0000-0002-5772-0741","affiliations":[{"raw_affiliation_string":"Servicio de Oncolog\u00eda M\u00e9dica, Hospital Universitario Marqu\u00e9s de Valdecilla, Instituto de investigaci\u00f3n IDIVAL, Santander, Spain","institution_ids":["https://openalex.org/I4210099858","https://openalex.org/I4210113075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040856826","display_name":"Mohammad Issa Hojouj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4405267803","display_name":"Simbec Research Ltd. (United Kingdom)","ror":"https://ror.org/04er29560","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405267803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mohammad Hojouj","raw_affiliation_strings":["Division of Cancer Sciences, The University of Manchester, Manchester, UK","Simbec Orion, Merthyr Tydfil, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Sciences, The University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Simbec Orion, Merthyr Tydfil, UK","institution_ids":["https://openalex.org/I4405267803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148899805","display_name":"Charles Le","orcid":"https://orcid.org/0009-0007-5110-1185","observed_orcids":["https://orcid.org/0009-0007-5110-1185"]},"institutions":[{"id":"https://openalex.org/I4210146958","display_name":"Theriva Biologics (United States)","ror":"https://ror.org/04trz4q34","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146958"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Le","raw_affiliation_strings":["Theriva Biologics, Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theriva Biologics, Rockville, MD, USA","institution_ids":["https://openalex.org/I4210146958"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046300715","display_name":"Ana Mato-Berciano","orcid":"https://orcid.org/0009-0005-0811-3581","observed_orcids":["https://orcid.org/0009-0005-0811-3581"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Mato-Berciano","raw_affiliation_strings":["Theriva Biologics, Parets del Vall\u00e8s, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theriva Biologics, Parets del Vall\u00e8s, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048270390","display_name":"Sheila Connelly","orcid":"https://orcid.org/0000-0003-0951-3593","observed_orcids":["https://orcid.org/0000-0003-0951-3593"]},"institutions":[{"id":"https://openalex.org/I4210146958","display_name":"Theriva Biologics (United States)","ror":"https://ror.org/04trz4q34","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146958"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheila Connelly","raw_affiliation_strings":["Theriva Biologics, Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theriva Biologics, Rockville, MD, USA","institution_ids":["https://openalex.org/I4210146958"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041491431","display_name":"Mike Kaleko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146958","display_name":"Theriva Biologics (United States)","ror":"https://ror.org/04trz4q34","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146958"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mike Kaleko","raw_affiliation_strings":["Theriva Biologics, Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theriva Biologics, Rockville, MD, USA","institution_ids":["https://openalex.org/I4210146958"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067346260","display_name":"Luis Alfonso Rojas","orcid":"https://orcid.org/0000-0001-9218-4086","observed_orcids":["https://orcid.org/0000-0001-9218-4086"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luis A. Rojas","raw_affiliation_strings":["Theriva Biologics, Parets del Vall\u00e8s, Spain"],"raw_orcid":"https://orcid.org/0000-0001-9218-4086","affiliations":[{"raw_affiliation_string":"Theriva Biologics, Parets del Vall\u00e8s, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071897628","display_name":"Vincent J. Wacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146958","display_name":"Theriva Biologics (United States)","ror":"https://ror.org/04trz4q34","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146958"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent J. Wacher","raw_affiliation_strings":["Theriva Biologics, Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theriva Biologics, Rockville, MD, USA","institution_ids":["https://openalex.org/I4210146958"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029226462","display_name":"Mary Ann Shallcross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146958","display_name":"Theriva Biologics (United States)","ror":"https://ror.org/04trz4q34","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146958"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Ann Shallcross","raw_affiliation_strings":["Theriva Biologics, Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theriva Biologics, Rockville, MD, USA","institution_ids":["https://openalex.org/I4210146958"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148902686","display_name":"Carmen Blasco","orcid":"https://orcid.org/0009-0003-2565-9995","observed_orcids":["https://orcid.org/0009-0003-2565-9995"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmen Blasco","raw_affiliation_strings":["Theriva Biologics, Parets del Vall\u00e8s, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theriva Biologics, Parets del Vall\u00e8s, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035766272","display_name":"Manel Cascall\u00f3","orcid":"https://orcid.org/0009-0002-3260-600X","observed_orcids":["https://orcid.org/0009-0002-3260-600X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manel Cascallo","raw_affiliation_strings":["Theriva Biologics, Parets del Vall\u00e8s, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theriva Biologics, Parets del Vall\u00e8s, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086660695","display_name":"Manuel M. Hidalgo","orcid":"https://orcid.org/0000-0002-3765-3318","observed_orcids":["https://orcid.org/0000-0002-3765-3318"]},"institutions":[{"id":"https://openalex.org/I4390039310","display_name":"NYU Langone\u2019s Laura and Isaac Perlmutter Cancer Center","ror":"https://ror.org/00sa8g751","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933","https://openalex.org/I4390039310"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Manuel Hidalgo","raw_affiliation_strings":["Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY, USA. manuel.hidalgo@nyulangone.org"],"raw_orcid":"https://orcid.org/0000-0002-3765-3318","affiliations":[{"raw_affiliation_string":"Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY, USA. manuel.hidalgo@nyulangone.org","institution_ids":["https://openalex.org/I4390039310","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":28,"corresponding_author_ids":["https://openalex.org/A5048223620","https://openalex.org/A5086660695"],"corresponding_institution_ids":["https://openalex.org/I4210101691","https://openalex.org/I4390039310","https://openalex.org/I57206974"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.3149000108242035,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncolytic-adenovirus","display_name":"oncolytic adenovirus","score":0.8679999709129333},{"id":"https://openalex.org/keywords/hyaluronidase","display_name":"hyaluronidase","score":0.9259999990463257},{"id":"https://openalex.org/keywords/metastatic-pancreatic-ductal-adenocarcinoma","display_name":"metastatic pancreatic ductal adenocarcinoma","score":0.9760000109672546},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.9210000038146973},{"id":"https://openalex.org/keywords/nab-paclitaxel","display_name":"nab-paclitaxel","score":0.9860000014305115},{"id":"https://openalex.org/keywords/intravenous-gene-therapy","display_name":"intravenous gene therapy","score":0.6069999933242798},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.8399999737739563},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9580000042915344},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9610000252723694},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.4449999928474426},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.671999990940094},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8605999946594238},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6920999884605408},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6499000191688538},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.6202999949455261},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6043000221252441},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5077000260353088},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4943000078201294},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.46309998631477356},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.45570001006126404},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.45170000195503235},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.40939998626708984},{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.3871000111103058},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3752000033855438},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.3580999970436096},{"id":"https://openalex.org/C2776737053","wikidata":"https://www.wikidata.org/wiki/Q7130407","display_name":"Pancreatic disease","level":3,"score":0.35429999232292175},{"id":"https://openalex.org/C2777283488","wikidata":"https://www.wikidata.org/wiki/Q7095181","display_name":"Oncolytic adenovirus","level":4,"score":0.33889999985694885},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3165999948978424},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.31200000643730164},{"id":"https://openalex.org/C61470247","wikidata":"https://www.wikidata.org/wiki/Q7229825","display_name":"Population study","level":3,"score":0.2992999851703644},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2833000123500824},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.27079999446868896},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.26919999718666077},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.2662999927997589},{"id":"https://openalex.org/C2777844706","wikidata":"https://www.wikidata.org/wiki/Q422504","display_name":"Deoxycytidine","level":4,"score":0.2529999911785126},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.25200000405311584},{"id":"https://openalex.org/C202953159","wikidata":"https://www.wikidata.org/wiki/Q382695","display_name":"Intention-to-treat analysis","level":3,"score":0.25119999051094055}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s41591-026-04705-y","doi":"https://doi.org/10.1038/s41591-026-04705-y","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41591-026-04705-y","pdf_url":null,"source":{"id":"https://openalex.org/S203256638","display_name":"Nature Medicine","issn_l":"1078-8956","issn":["1078-8956","1546-170X","1744-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Medicine","raw_type":"journal-article"},{"id":"pmid:42816596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42816596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1966397710","https://openalex.org/W2044363258","https://openalex.org/W2044473939","https://openalex.org/W2083463424","https://openalex.org/W2093189160","https://openalex.org/W2097995306","https://openalex.org/W2100158834","https://openalex.org/W2126759268","https://openalex.org/W2151253787","https://openalex.org/W2152897456","https://openalex.org/W2165480504","https://openalex.org/W2166373990","https://openalex.org/W2166662937","https://openalex.org/W2173158842","https://openalex.org/W2174280796","https://openalex.org/W2514534355","https://openalex.org/W2527905628","https://openalex.org/W2779221466","https://openalex.org/W2909786746","https://openalex.org/W2948788617","https://openalex.org/W3119086885","https://openalex.org/W3197559541","https://openalex.org/W3214163957","https://openalex.org/W4220993301","https://openalex.org/W4386614978","https://openalex.org/W4387364366","https://openalex.org/W4387784232","https://openalex.org/W4401305294","https://openalex.org/W4401800465","https://openalex.org/W4404923724","https://openalex.org/W4406725994","https://openalex.org/W4409682522","https://openalex.org/W4416746739","https://openalex.org/W7162952636","https://openalex.org/W7163898817","https://openalex.org/W7202180933"],"related_works":["https://openalex.org/W4415942009","https://openalex.org/W7154754027","https://openalex.org/W2977952891","https://openalex.org/W2977802273","https://openalex.org/W4400272960","https://openalex.org/W4220993301","https://openalex.org/W3214163957","https://openalex.org/W2560499060","https://openalex.org/W4389024344","https://openalex.org/W2875898565"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-01T00:00:00"}