{"id":"https://openalex.org/W7214905772","doi":"https://doi.org/10.7759/cureus.117235","title":"Lithium Toxicity Following Initiation of Semaglutide in a Patient With Bipolar Disorder: A Case Report","display_name":"Lithium Toxicity Following Initiation of Semaglutide in a Patient With Bipolar Disorder: A Case Report","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7214905772","doi":"https://doi.org/10.7759/cureus.117235","pmid":"https://pubmed.ncbi.nlm.nih.gov/42964850","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13722138"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.117235","doi":"https://doi.org/10.7759/cureus.117235","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.117235","pdf_url":"https://www.cureus.com/articles/522090-lithium-toxicity-following-initiation-of-semaglutide-in-a-patient-with-bipolar-disorder-a-case-report.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.cureus.com/articles/522090-lithium-toxicity-following-initiation-of-semaglutide-in-a-patient-with-bipolar-disorder-a-case-report.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5153587879","display_name":"Annika Dhingra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Annika Dhingra","raw_affiliation_strings":["Medicine, Rush University Medical Center, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Rush University Medical Center, Chicago, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148098824","display_name":"Charissa M Nichols","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charissa M Nichols","raw_affiliation_strings":["Psychiatry, Bergen New Bridge Medical Center, Paramus, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatry, Bergen New Bridge Medical Center, Paramus, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014477725","display_name":"Ezekiel Sanchez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133879957","display_name":"St. George's University","ror":"https://ror.org/01m1s6313","country_code":"GD","type":"education","lineage":["https://openalex.org/I133879957"]}],"countries":["GD"],"is_corresponding":false,"raw_author_name":"Ezekiel Sanchez","raw_affiliation_strings":["Medicine, St. George's University, St. George's, GRD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, St. George's University, St. George's, GRD","institution_ids":["https://openalex.org/I133879957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153628677","display_name":"Anurag Ayyagari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133879957","display_name":"St. George's University","ror":"https://ror.org/01m1s6313","country_code":"GD","type":"education","lineage":["https://openalex.org/I133879957"]}],"countries":["GD"],"is_corresponding":false,"raw_author_name":"Anurag Ayyagari","raw_affiliation_strings":["Medicine, St. George's University, St. George's, GRD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, St. George's University, St. George's, GRD","institution_ids":["https://openalex.org/I133879957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119016165","display_name":"Yashvi Rateshwar","orcid":"https://orcid.org/0009-0009-3807-5861","observed_orcids":["https://orcid.org/0009-0009-3807-5861"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yashvi Rateshwar","raw_affiliation_strings":["Academy for Advancement of Science and Technology, Bergen County Academies, Hackensack, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy for Advancement of Science and Technology, Bergen County Academies, Hackensack, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5153670878","display_name":"Nina Narvaez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nina Narvaez","raw_affiliation_strings":["Academy for Advancement of Science and Technology, Bergen County Academies, Hackensack, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy for Advancement of Science and Technology, Bergen County Academies, Hackensack, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5153587879"],"corresponding_institution_ids":["https://openalex.org/I1285301757"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72703455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"9","first_page":"e117235","last_page":"e117235"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.03240000084042549,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lithium-toxicity","display_name":"lithium toxicity","score":0.9350000023841858},{"id":"https://openalex.org/keywords/semaglutide","display_name":"semaglutide","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.9929999709129333},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.6510000228881836},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.7400000095367432},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9832000136375427},{"id":"https://openalex.org/C2909862629","wikidata":"https://www.wikidata.org/wiki/Q27261089","display_name":"Semaglutide","level":5,"score":0.7026000022888184},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5436000227928162},{"id":"https://openalex.org/C2778541603","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium (medication)","level":2,"score":0.5306000113487244},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.359499990940094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34200000762939453},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.31459999084472656},{"id":"https://openalex.org/C2908996549","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium therapy","level":4,"score":0.31150001287460327},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.28279998898506165},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2818000018596649},{"id":"https://openalex.org/C2910163948","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiac toxicity","level":3,"score":0.2757999897003174}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.117235","doi":"https://doi.org/10.7759/cureus.117235","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.117235","pdf_url":"https://www.cureus.com/articles/522090-lithium-toxicity-following-initiation-of-semaglutide-in-a-patient-with-bipolar-disorder-a-case-report.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmid:42964850","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42964850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:13722138","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13722138/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7759/cureus.117235","doi":"https://doi.org/10.7759/cureus.117235","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.117235","pdf_url":"https://www.cureus.com/articles/522090-lithium-toxicity-following-initiation-of-semaglutide-in-a-patient-with-bipolar-disorder-a-case-report.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214905772.pdf","grobid_xml":"https://content.openalex.org/works/W7214905772.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1481112428","https://openalex.org/W1603664273","https://openalex.org/W1969068062","https://openalex.org/W1979310899","https://openalex.org/W2077261270","https://openalex.org/W2106036385","https://openalex.org/W2124160215","https://openalex.org/W2150012656","https://openalex.org/W2163837966","https://openalex.org/W2290542171","https://openalex.org/W2414864695","https://openalex.org/W2425644022","https://openalex.org/W2550011910","https://openalex.org/W2556485520","https://openalex.org/W2599180887","https://openalex.org/W2599193256","https://openalex.org/W2752707491","https://openalex.org/W2756558030","https://openalex.org/W2791728731","https://openalex.org/W2795481136","https://openalex.org/W2898592605","https://openalex.org/W2899257075","https://openalex.org/W3047346931","https://openalex.org/W3127371223","https://openalex.org/W4248590234","https://openalex.org/W4256210470","https://openalex.org/W4391218339","https://openalex.org/W4410853299","https://openalex.org/W4414558398","https://openalex.org/W4416876536","https://openalex.org/W7117471266","https://openalex.org/W7127317087","https://openalex.org/W7163009967","https://openalex.org/W7163055787","https://openalex.org/W7163997542"],"related_works":["https://openalex.org/W4414558398","https://openalex.org/W4416277635","https://openalex.org/W7127317087","https://openalex.org/W4416876536","https://openalex.org/W7214915655","https://openalex.org/W7160510854","https://openalex.org/W7172201098","https://openalex.org/W7117471266","https://openalex.org/W4410853299","https://openalex.org/W3040911634"],"abstract_inverted_index":{"Glucagon-like":[0],"peptide-1":[1],"(GLP-1)":[2],"receptor":[3,220],"agonists":[4,221],"are":[5,43],"increasingly":[6],"prescribed":[7],"for":[8,34,62,111],"type":[9],"2":[10],"diabetes":[11],"mellitus":[12],"and":[13,29,73,81,90,92,114,126,146,156,164,200,222],"obesity,":[14],"including":[15],"among":[16],"patients":[17],"with":[18,36,38,58,69,121,188],"severe":[19],"mental":[20],"illness.":[21],"Their":[22],"effects":[23],"on":[24,65],"gastrointestinal":[25,195],"motility,":[26],"oral":[27,128,198],"intake,":[28,199],"volume":[30,151,202],"status":[31],"raise":[32],"concern":[33],"interactions":[35],"drugs":[37],"narrow":[39],"therapeutic":[40],"indices":[41],"that":[42],"cleared":[44],"almost":[45],"entirely":[46],"by":[47,139],"the":[48,88,95,135,165,192],"kidney,":[49],"such":[50],"as":[51],"lithium.":[52],"We":[53],"describe":[54],"a":[55,140,174,205],"69-year-old":[56],"woman":[57],"bipolar":[59],"disorder,":[60],"stable":[61],"several":[63],"years":[64],"lithium,":[66],"who":[67],"presented":[68],"acute":[70,99],"confusion,":[71],"dysarthria,":[72],"expressive":[74],"aphasia.":[75],"A":[76],"stroke":[77],"protocol":[78],"was":[79,132,154,170,185],"activated,":[80],"noncontrast":[82],"head":[83,89],"CT,":[84],"CT":[85],"angiography":[86],"of":[87,94,150,183,194],"neck,":[91],"MRI":[93],"brain":[96],"showed":[97],"no":[98],"infarct":[100],"or":[101],"hemorrhage.":[102],"Semaglutide":[103],"had":[104,116],"been":[105],"initiated":[106],"approximately":[107],"one":[108],"month":[109],"earlier":[110],"weight":[112,119],"management,":[113],"she":[115],"experienced":[117],"substantial":[118],"loss":[120],"persistent":[122],"nausea,":[123],"intermittent":[124],"vomiting,":[125],"reduced":[127,141,175,197],"intake.":[129],"Serum":[130],"lithium":[131,189,215],"elevated":[133],"above":[134],"reference":[136],"range,":[137],"accompanied":[138],"estimated":[142],"glomerular":[143],"filtration":[144],"rate":[145],"biochemical":[147],"findings":[148],"suggestive":[149],"depletion.":[152,203],"Lithium":[153,169],"held,":[155],"intravenous":[157],"fluids":[158],"were":[159],"administered;":[160],"renal":[161],"function":[162],"improved":[163],"neurologic":[166],"deficits":[167],"resolved.":[168],"subsequently":[171],"resumed":[172],"at":[173],"dose":[176,224],"without":[177],"recurrence.":[178],"In":[179],"this":[180,211],"patient,":[181],"initiation":[182],"semaglutide":[184],"temporally":[186],"associated":[187],"toxicity":[190],"in":[191],"setting":[193],"intolerance,":[196],"suspected":[201],"Although":[204],"single":[206],"case":[207],"cannot":[208],"establish":[209],"causality,":[210],"observation":[212],"supports":[213],"closer":[214],"monitoring":[216],"when":[217],"initiating":[218],"GLP-1":[219],"during":[223],"escalation.":[225]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-01T00:00:00"}