{"id":"https://openalex.org/W7214905453","doi":"https://doi.org/10.64898/2026.09.29.755188","title":"THE MICROANATOMY OF INTRACRANIAL HUMAN THROMBI BY SINGLE NUCLEI TRANSCRIPTOMICS","display_name":"THE MICROANATOMY OF INTRACRANIAL HUMAN THROMBI BY SINGLE NUCLEI TRANSCRIPTOMICS","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7214905453","doi":"https://doi.org/10.64898/2026.09.29.755188","pmid":"https://pubmed.ncbi.nlm.nih.gov/42856272","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13648590"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.29.755188","doi":"https://doi.org/10.64898/2026.09.29.755188","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.29.755188","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.29.755188.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.29.755188.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027383140","display_name":"Valia P. Leifer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valia P. Leifer","raw_affiliation_strings":["Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069062178","display_name":"Michael Argenziano","orcid":"https://orcid.org/0000-0003-3374-9037","observed_orcids":["https://orcid.org/0000-0003-3374-9037"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G. Argenziano","raw_affiliation_strings":["Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075850084","display_name":"Colin P. Sperring","orcid":"https://orcid.org/0000-0003-0042-5351","observed_orcids":["https://orcid.org/0000-0003-0042-5351","https://orcid.org/0009-0007-8595-3888"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Colin P. Sperring","raw_affiliation_strings":["Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102794985","display_name":"Wenting Zhao","orcid":"https://orcid.org/0000-0002-5927-2006","observed_orcids":["https://orcid.org/0000-0002-5927-2006"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenting Zhao","raw_affiliation_strings":["Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029686811","display_name":"Julia E Alexander","orcid":"https://orcid.org/0000-0003-3251-4623","observed_orcids":["https://orcid.org/0000-0003-3251-4623"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia E. Alexander","raw_affiliation_strings":["Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057263352","display_name":"Aayushi Mahajan","orcid":"https://orcid.org/0000-0003-3966-2936","observed_orcids":["https://orcid.org/0000-0003-3966-2936"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aayushi Mahajan","raw_affiliation_strings":["Department of Pathology & Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology & Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032581302","display_name":"Julia Lynn Furnari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia L. Furnari","raw_affiliation_strings":["Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064065924","display_name":"Corina P. Kotidis","orcid":"https://orcid.org/0000-0003-2728-0359","observed_orcids":["https://orcid.org/0000-0003-2728-0359"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corina P. Kotidis","raw_affiliation_strings":["Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033341063","display_name":"Grace K Mandigo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace K. Mandigo","raw_affiliation_strings":["Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046673359","display_name":"Peter Canoll","orcid":"https://orcid.org/0000-0002-7001-0226","observed_orcids":["https://orcid.org/0000-0002-7001-0226"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter D. Canoll","raw_affiliation_strings":["Department of Pathology & Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology & Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153614046","display_name":"Peter A. Sims","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter A. Sims","raw_affiliation_strings":["Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112410545","display_name":"Sean D. Lavine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean D. Lavine","raw_affiliation_strings":["Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033495424","display_name":"Edward Sander Connolly","orcid":"https://orcid.org/0000-0002-6877-3371","observed_orcids":["https://orcid.org/0000-0002-6877-3371"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Sander Connolly","raw_affiliation_strings":["Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030083975","display_name":"Eleonora F. Spinazzi","orcid":"https://orcid.org/0000-0002-2046-0560","observed_orcids":["https://orcid.org/0000-0002-2046-0560"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eleonora F. Spinazzi","raw_affiliation_strings":["Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075850084"],"corresponding_institution_ids":["https://openalex.org/I2799503643"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.5,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.5,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.40720000863075256,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.04919999837875366,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.765999972820282},{"id":"https://openalex.org/keywords/large-vessel-occlusion","display_name":"large vessel occlusion","score":0.8259999752044678},{"id":"https://openalex.org/keywords/mechanical-thrombectomy","display_name":"mechanical thrombectomy","score":0.9160000085830688},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.5910000205039978},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cellular-plasticity","display_name":"cellular plasticity","score":0.7730000019073486},{"id":"https://openalex.org/keywords/carotid-plaque","display_name":"carotid plaque","score":0.8659999966621399},{"id":"https://openalex.org/keywords/ligand-receptor-interactions","display_name":"ligand-receptor interactions","score":0.8709999918937683},{"id":"https://openalex.org/keywords/endothelial-activation","display_name":"endothelial activation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.593999981880188},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6571000218391418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5360000133514404},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45089998841285706},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.450300008058548},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.44690001010894775},{"id":"https://openalex.org/C60870556","wikidata":"https://www.wikidata.org/wiki/Q2300675","display_name":"Transdifferentiation","level":3,"score":0.4189999997615814},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41339999437332153},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.40689998865127563},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4000999927520752},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.399399995803833},{"id":"https://openalex.org/C2777408375","wikidata":"https://www.wikidata.org/wiki/Q707810","display_name":"Arteriogenesis","level":3,"score":0.39750000834465027},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3905999958515167},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.3765000104904175},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3370000123977661},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.3160000145435333},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.3127000033855438},{"id":"https://openalex.org/C60781801","wikidata":"https://www.wikidata.org/wiki/Q1424593","display_name":"Vasculogenesis","level":4,"score":0.29739999771118164},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.2912999987602234},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.29109999537467957},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2840000092983246},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.28200000524520874},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2799000144004822},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.2728999853134155},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27239999175071716},{"id":"https://openalex.org/C2909041971","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Intracranial Thrombosis","level":4,"score":0.26260000467300415},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.26030001044273376},{"id":"https://openalex.org/C2780152582","wikidata":"https://www.wikidata.org/wiki/Q1340830","display_name":"Endothelial progenitor cell","level":4,"score":0.2533000111579895},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2524999976158142}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.29.755188","doi":"https://doi.org/10.64898/2026.09.29.755188","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.29.755188","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.29.755188.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42856272","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42856272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13648590","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648590/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.29.755188","doi":"https://doi.org/10.64898/2026.09.29.755188","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.29.755188","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.29.755188.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000917834","display_name":"Brief Research In Aging and Interdisciplinary Neurosciences (BRAIN)","funder_award_id":"T35AG044303","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214905453.pdf","grobid_xml":"https://content.openalex.org/works/W7214905453.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W35912857","https://openalex.org/W379165252","https://openalex.org/W1668035141","https://openalex.org/W1848530711","https://openalex.org/W1980073907","https://openalex.org/W1988054680","https://openalex.org/W2002875429","https://openalex.org/W2010141405","https://openalex.org/W2021272086","https://openalex.org/W2043131254","https://openalex.org/W2054115613","https://openalex.org/W2058792228","https://openalex.org/W2070050178","https://openalex.org/W2093547654","https://openalex.org/W2099730228","https://openalex.org/W2107505658","https://openalex.org/W2110996033","https://openalex.org/W2112630596","https://openalex.org/W2117156688","https://openalex.org/W2127845947","https://openalex.org/W2158387165","https://openalex.org/W2159689462","https://openalex.org/W2161962636","https://openalex.org/W2170383324","https://openalex.org/W2277258071","https://openalex.org/W2509853338","https://openalex.org/W2587953391","https://openalex.org/W2588374458","https://openalex.org/W2605810679","https://openalex.org/W2616922646","https://openalex.org/W2734414396","https://openalex.org/W2754967293","https://openalex.org/W2759615793","https://openalex.org/W2788833165","https://openalex.org/W2803306216","https://openalex.org/W2807357176","https://openalex.org/W2883808647","https://openalex.org/W2885793429","https://openalex.org/W2940606863","https://openalex.org/W2951764674","https://openalex.org/W2958840595","https://openalex.org/W2980365046","https://openalex.org/W2980641678","https://openalex.org/W2988417388","https://openalex.org/W2989807288","https://openalex.org/W3015000162","https://openalex.org/W3045942095","https://openalex.org/W3086286834","https://openalex.org/W3088819072","https://openalex.org/W3093119237","https://openalex.org/W3105148124","https://openalex.org/W3128683618","https://openalex.org/W3143736157","https://openalex.org/W3154434038","https://openalex.org/W3155488878","https://openalex.org/W3158609865","https://openalex.org/W3159463772","https://openalex.org/W3163526729","https://openalex.org/W3164231886","https://openalex.org/W3193313498","https://openalex.org/W3199389252","https://openalex.org/W3199448247","https://openalex.org/W3206010712","https://openalex.org/W3207231267","https://openalex.org/W3207314618","https://openalex.org/W3214595370","https://openalex.org/W4206375117","https://openalex.org/W4212766367","https://openalex.org/W4225370524","https://openalex.org/W4285085042","https://openalex.org/W4290237344","https://openalex.org/W4295106815","https://openalex.org/W4312094403","https://openalex.org/W4317611824","https://openalex.org/W4323664804","https://openalex.org/W4378212544","https://openalex.org/W4383555172","https://openalex.org/W4385813810","https://openalex.org/W4387059123","https://openalex.org/W4387951810","https://openalex.org/W4389204527","https://openalex.org/W4392600814","https://openalex.org/W4400088778","https://openalex.org/W4400090986","https://openalex.org/W4400738537","https://openalex.org/W4402604581","https://openalex.org/W4402704655","https://openalex.org/W4405064038","https://openalex.org/W4405231405"],"related_works":["https://openalex.org/W4391448223","https://openalex.org/W7153335523","https://openalex.org/W4319008079","https://openalex.org/W3214891849","https://openalex.org/W7213558344","https://openalex.org/W3196429001","https://openalex.org/W7169712659","https://openalex.org/W4390810876","https://openalex.org/W4400893438","https://openalex.org/W4402009629"],"abstract_inverted_index":{"Rationale:":[0],"Thrombi":[1],"are":[2],"fragile,":[3],"heterogeneous,":[4],"and":[5,17,28,40,55,61,79,92,101,122,127,141,148,173,202,206,213,242],"difficult":[6],"to":[7,24,51,74,183,189,207],"study":[8],"with":[9,112,238],"available":[10,114],"methods,":[11],"yet":[12],"understanding":[13],"their":[14,76],"molecular":[15,77],"composition":[16,78],"local":[18],"microenvironment":[19],"in":[20,159,198,229],"stroke":[21,26,230],"is":[22],"critical":[23],"elucidating":[25],"pathophysiology":[27],"improving":[29],"patient":[30],"outcomes.":[31],"Objective:":[32],"We":[33,63,107,134,161],"used":[34],"a":[35],"novel":[36,179,203,235],"platform":[37],"for":[38,47],"harvesting":[39],"analyzing":[41],"intracranial":[42,72],"thrombi":[43,73,142,155],"from":[44,120,130],"endovascular":[45],"thrombectomy":[46,184],"large":[48],"vessel":[49],"occlusion":[50],"define":[52,75],"the":[53,152,171,191,217,225],"cellular":[54,88,211,226],"transcriptomic":[56],"landscape":[57],"of":[58,105,175,181,194,210,219,224,234,246],"thrombi.":[59],"Methods":[60],"results:":[62],"performed":[64],"single-nuclei":[65],"RNA":[66],"sequencing":[67],"(snRNA-seq)":[68],"on":[69,99],"three":[70],"human":[71],"microenvironment.":[80],"Across":[81],"5,143":[82],"nuclei,":[83],"we":[84],"identified":[85,135],"8":[86],"distinct":[87],"populations,":[89,205],"including":[90,146,200],"monocytes":[91,143,156],"T":[93],"cells.":[94],"Monocytes":[95],"displayed":[96],"transcriptional":[97,137],"changes":[98],"gene":[100],"regulon":[102],"levels":[103],"suggestive":[104],"transdifferentiation.":[106],"integrated":[108],"our":[109],"snRNA-seq":[110,182],"data":[111,119,129],"publicly":[113],"single":[115],"cell":[116,195,204],"RNA-sequencing":[117],"(scRNA-seq)":[118],"asymptomatic":[121],"symptomatic":[123],"atherosclerotic":[124],"carotid":[125,140],"plaques,":[126],"scRNA-seq":[128],"healthy":[131],"brain":[132],"vasculature.":[133],"shared":[136],"programs":[138],"between":[139],"along":[144],"dimensions":[145],"inflammation":[147],"endothelial":[149],"activation,":[150],"supporting":[151],"notion":[153],"that":[154,167],"undergo":[157],"transdifferentiation":[158],"stroke.":[160],"also":[162],"inferred":[163],"potential":[164],"ligand-receptor":[165],"interactions":[166],"may":[168],"occur":[169],"at":[170,216],"site":[172,218],"time":[174],"occlusion.":[176,220],"Conclusion:":[177],"Our":[178],"application":[180],"specimens":[185],"has":[186],"allowed":[187],"us":[188],"uncover":[190],"full":[192],"diversity":[193],"types":[196],"present":[197],"thrombi,":[199],"low-abundance":[201],"provide":[208],"evidence":[209],"plasticity":[212],"intercellular":[214],"communication":[215],"This":[221],"detailed":[222],"definition":[223],"populations":[227],"involved":[228],"will":[231],"facilitate":[232,243],"mapping":[233],"interventional":[236],"targets":[237],"direct":[239],"functional":[240],"relevance":[241],"greater":[244],"personalization":[245],"post-reperfusion":[247],"therapy.":[248]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-01T00:00:00"}