{"id":"https://openalex.org/W7214905433","doi":"https://doi.org/10.7759/cureus.117250","title":"Manganese Deposition Encephalopathy Associated With Prolonged Total Parenteral Nutrition: A Case Report","display_name":"Manganese Deposition Encephalopathy Associated With Prolonged Total Parenteral Nutrition: A Case Report","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7214905433","doi":"https://doi.org/10.7759/cureus.117250","pmid":"https://pubmed.ncbi.nlm.nih.gov/42965242","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13722496"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.117250","doi":"https://doi.org/10.7759/cureus.117250","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.117250","pdf_url":"https://www.cureus.com/articles/532137-manganese-deposition-encephalopathy-associated-with-prolonged-total-parenteral-nutrition-a-case-report.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.cureus.com/articles/532137-manganese-deposition-encephalopathy-associated-with-prolonged-total-parenteral-nutrition-a-case-report.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056196599","display_name":"Bruno Zanardo Faggion","orcid":"https://orcid.org/0000-0001-6168-9911","observed_orcids":["https://orcid.org/0000-0001-6168-9911"]},"institutions":[{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]},{"id":"https://openalex.org/I4210126369","display_name":"Polydoro Ernani de S\u00e3o Thiago University Hospital","ror":"https://ror.org/0303d1x26","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210126369"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Bruno Zanardo Faggion","raw_affiliation_strings":["General Surgery, Hospital Universit\u00e1rio Polydoro Ernani de S\u00e3o Thiago, Universidade Federal de Santa Catarina (UFSC), Florian\u00f3polis, BRA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Surgery, Hospital Universit\u00e1rio Polydoro Ernani de S\u00e3o Thiago, Universidade Federal de Santa Catarina (UFSC), Florian\u00f3polis, BRA","institution_ids":["https://openalex.org/I4104125","https://openalex.org/I4210126369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153555531","display_name":"Laura A Vicenzi Souza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]},{"id":"https://openalex.org/I4210126369","display_name":"Polydoro Ernani de S\u00e3o Thiago University Hospital","ror":"https://ror.org/0303d1x26","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210126369"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Laura A Vicenzi Souza","raw_affiliation_strings":["Critical Care Medicine, Hospital Universit\u00e1rio Polydoro Ernani de S\u00e3o Thiago, Universidade Federal de Santa Catarina (UFSC), Florian\u00f3polis, BRA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care Medicine, Hospital Universit\u00e1rio Polydoro Ernani de S\u00e3o Thiago, Universidade Federal de Santa Catarina (UFSC), Florian\u00f3polis, BRA","institution_ids":["https://openalex.org/I4104125","https://openalex.org/I4210126369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153586712","display_name":"Giancarlo Beluzzo da Mota de Lima Sinke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]},{"id":"https://openalex.org/I4210126369","display_name":"Polydoro Ernani de S\u00e3o Thiago University Hospital","ror":"https://ror.org/0303d1x26","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210126369"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Giancarlo Beluzzo da Mota de Lima Sinke","raw_affiliation_strings":["General Surgery, Hospital Universit\u00e1rio Polydoro Ernani de S\u00e3o Thiago, Universidade Federal de Santa Catarina (UFSC), Florian\u00f3polis, BRA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Surgery, Hospital Universit\u00e1rio Polydoro Ernani de S\u00e3o Thiago, Universidade Federal de Santa Catarina (UFSC), Florian\u00f3polis, BRA","institution_ids":["https://openalex.org/I4104125","https://openalex.org/I4210126369"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5153563445","display_name":"Rafaela Colla\u00e7o de Oliveira Valente","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]},{"id":"https://openalex.org/I4210126369","display_name":"Polydoro Ernani de S\u00e3o Thiago University Hospital","ror":"https://ror.org/0303d1x26","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210126369"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafaela Colla\u00e7o de Oliveira Valente","raw_affiliation_strings":["General Surgery, Hospital Universit\u00e1rio Polydoro Ernani de S\u00e3o Thiago, Universidade Federal de Santa Catarina (UFSC), Florian\u00f3polis, BRA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Surgery, Hospital Universit\u00e1rio Polydoro Ernani de S\u00e3o Thiago, Universidade Federal de Santa Catarina (UFSC), Florian\u00f3polis, BRA","institution_ids":["https://openalex.org/I4104125","https://openalex.org/I4210126369"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056196599"],"corresponding_institution_ids":["https://openalex.org/I4104125","https://openalex.org/I4210126369"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.64737724,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"9","first_page":"e117250","last_page":"e117250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/manganese-encephalopathy","display_name":"manganese encephalopathy","score":0.9210000038146973},{"id":"https://openalex.org/keywords/total-parenteral-nutrition","display_name":"total parenteral nutrition","score":0.9729999899864197},{"id":"https://openalex.org/keywords/manganese-toxicity","display_name":"manganese toxicity","score":0.8009999990463257},{"id":"https://openalex.org/keywords/critical-illness","display_name":"critical illness","score":0.48100000619888306},{"id":"https://openalex.org/keywords/acute-pancreatitis","display_name":"acute pancreatitis","score":0.765999972820282},{"id":"https://openalex.org/keywords/cholestasis","display_name":"cholestasis","score":0.699999988079071},{"id":"https://openalex.org/keywords/globus-pallidus","display_name":"globus pallidus","score":0.746999979019165},{"id":"https://openalex.org/keywords/parkinsonism","display_name":"parkinsonism","score":0.984000027179718},{"id":"https://openalex.org/keywords/levodopa-benserazide","display_name":"levodopa/benserazide","score":0.953000009059906},{"id":"https://openalex.org/keywords/trace-element-monitoring","display_name":"trace element monitoring","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9646999835968018},{"id":"https://openalex.org/C64297162","wikidata":"https://www.wikidata.org/wiki/Q1987070","display_name":"Deposition (geology)","level":3,"score":0.5889999866485596},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.5178999900817871},{"id":"https://openalex.org/C528890316","wikidata":"https://www.wikidata.org/wiki/Q731","display_name":"Manganese","level":2,"score":0.47099998593330383},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41339999437332153},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41269999742507935},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2847999930381775},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2728999853134155},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.2215999960899353},{"id":"https://openalex.org/C2780724011","wikidata":"https://www.wikidata.org/wiki/Q1295316","display_name":"Emergency department","level":2,"score":0.20080000162124634}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.117250","doi":"https://doi.org/10.7759/cureus.117250","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.117250","pdf_url":"https://www.cureus.com/articles/532137-manganese-deposition-encephalopathy-associated-with-prolonged-total-parenteral-nutrition-a-case-report.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13722496","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13722496/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13722496/pdf/cureus-0018-00000117250.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"},{"id":"pmid:42965242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42965242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.7759/cureus.117250","doi":"https://doi.org/10.7759/cureus.117250","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.117250","pdf_url":"https://www.cureus.com/articles/532137-manganese-deposition-encephalopathy-associated-with-prolonged-total-parenteral-nutrition-a-case-report.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214905433.pdf","grobid_xml":"https://content.openalex.org/works/W7214905433.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1817978154","https://openalex.org/W1863826824","https://openalex.org/W2022795644","https://openalex.org/W2054051657","https://openalex.org/W2058522772","https://openalex.org/W2253488282","https://openalex.org/W2342068523","https://openalex.org/W2609032371","https://openalex.org/W3017575718","https://openalex.org/W3131383968","https://openalex.org/W4214768398","https://openalex.org/W4313897237","https://openalex.org/W4387422850"],"related_works":["https://openalex.org/W3017575718","https://openalex.org/W7099601657","https://openalex.org/W4410783882","https://openalex.org/W17486369","https://openalex.org/W2054051657","https://openalex.org/W2134316971","https://openalex.org/W2469822292","https://openalex.org/W2107069703","https://openalex.org/W2133603394","https://openalex.org/W2058522772"],"abstract_inverted_index":{"Manganese":[0],"encephalopathy":[1,26],"is":[2],"a":[3,20,34,145],"rare":[4],"neurological":[5,113,203],"disorder":[6],"most":[7],"commonly":[8],"associated":[9,27,161],"with":[10,28,38,50,63,138,142,148,162],"chronic":[11],"occupational":[12],"exposure":[13],"or":[14],"impaired":[15,197],"hepatobiliary":[16],"elimination.":[17],"We":[18],"report":[19],"case":[21,176],"of":[22,180,196,207],"suspected":[23],"manganese":[24,116,139,182],"deposition":[25],"prolonged":[29,89,189],"total":[30,93],"parenteral":[31,94,190],"nutrition":[32],"in":[33,132,159,184,193],"critically":[35,185],"ill":[36,186],"patient":[37,168],"severe":[39,51,150],"abdominal":[40,52,79],"disease":[41],"and":[42,56,68,85,92,103,109,124,152,200,205],"cholestatic":[43],"dysfunction.":[44],"A":[45],"50-year-old":[46],"man":[47],"was":[48,76,117,169],"admitted":[49],"pain,":[53],"vomiting,":[54],"tachycardia,":[55],"jaundice.":[57],"Computed":[58],"tomography":[59],"demonstrated":[60,129],"acute":[61],"pancreatitis":[62],"pancreatic":[64],"necrosis,":[65],"choledocholithiasis,":[66],"cholelithiasis,":[67],"superior":[69],"mesenteric":[70],"artery":[71],"thrombosis.":[72],"His":[73],"clinical":[74],"course":[75],"complicated":[77],"by":[78],"sepsis,":[80],"anasarca,":[81],"anemia,":[82],"spontaneous":[83],"hematomas,":[84],"the":[86,107,133,178,194],"need":[87],"for":[88],"intensive":[90],"care":[91],"nutrition.":[95],"On":[96],"hospital":[97,172],"day":[98,173],"41,":[99],"he":[100],"developed":[101],"rigidity":[102],"involuntary":[104],"movements":[105],"involving":[106],"tongue":[108],"upper":[110],"limbs,":[111],"prompting":[112],"assessment.":[114],"Serum":[115],"3.1":[118],"\u00b5g/L":[119],"(reference":[120],"value:":[121],"2":[122],"\u00b5g/L),":[123],"brain":[125],"magnetic":[126],"resonance":[127],"imaging":[128],"T1":[130],"hyperintensity":[131],"globus":[134],"pallidus,":[135],"findings":[136],"compatible":[137],"encephalopathy.":[140],"Treatment":[141],"levodopa/benserazide":[143],"produced":[144],"limited":[146],"response,":[147],"persistent":[149],"parkinsonism":[151],"inability":[153],"to":[154],"ambulate":[155],"despite":[156],"gradual":[157],"improvement":[158],"tetraparesis":[160],"concurrent":[163],"critical":[164],"illness":[165],"neuropathy.":[166],"The":[167],"discharged":[170],"on":[171],"129.":[174],"This":[175],"highlights":[177],"importance":[179],"considering":[181],"toxicity":[183],"patients":[187],"receiving":[188],"nutrition,":[191],"particularly":[192],"setting":[195],"biliary":[198],"elimination,":[199],"supports":[201],"early":[202],"surveillance":[204],"monitoring":[206],"trace":[208],"elements.":[209]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-01T00:00:00"}