{"id":"https://openalex.org/W7214894435","doi":"https://doi.org/10.1177/15579883261493263","title":"Associations of Gut Microbiota Composition and Fecal Metabolomic Profiles in Patients With Acquired Premature Ejaculation: A Cross-Sectional Pilot Study","display_name":"Associations of Gut Microbiota Composition and Fecal Metabolomic Profiles in Patients With Acquired Premature Ejaculation: A Cross-Sectional Pilot Study","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7214894435","doi":"https://doi.org/10.1177/15579883261493263","pmid":"https://pubmed.ncbi.nlm.nih.gov/42813505","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13735473"},"language":"en","primary_location":{"id":"doi:10.1177/15579883261493263","doi":"https://doi.org/10.1177/15579883261493263","is_oa":true,"landing_page_url":"https://doi.org/10.1177/15579883261493263","pdf_url":null,"source":{"id":"https://openalex.org/S90816027","display_name":"American Journal of Men s Health","issn_l":"1557-9883","issn":["1557-9883","1557-9891"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Men's Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/15579883261493263","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5135731279","display_name":"Shuyi Huang","orcid":"https://orcid.org/0009-0006-8716-1684","observed_orcids":["https://orcid.org/0009-0006-8716-1684"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuyi Huang","raw_affiliation_strings":["Southeast University"],"raw_orcid":"https://orcid.org/0009-0006-8716-1684","affiliations":[{"raw_affiliation_string":"Southeast University","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030385976","display_name":"Sijia Sun","orcid":"https://orcid.org/0009-0000-6554-2028","observed_orcids":["https://orcid.org/0009-0000-6554-2028"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sijia Sun","raw_affiliation_strings":["Southeast University"],"raw_orcid":"https://orcid.org/0009-0000-6554-2028","affiliations":[{"raw_affiliation_string":"Southeast University","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019182690","display_name":"Zhou Zhao","orcid":"https://orcid.org/0000-0002-6547-646X","observed_orcids":["https://orcid.org/0000-0002-6547-646X","https://orcid.org/0009-0001-2395-7046"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhou Zhao","raw_affiliation_strings":["Southeast University"],"raw_orcid":"https://orcid.org/0009-0001-2395-7046","affiliations":[{"raw_affiliation_string":"Southeast University","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084029986","display_name":"Dawei Gao","orcid":"https://orcid.org/0000-0001-8737-1071","observed_orcids":["https://orcid.org/0000-0001-8737-1071"]},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Dawei Gao","raw_affiliation_strings":["Macau University of Science and Technology"],"raw_orcid":"https://orcid.org/0000-0001-8737-1071","affiliations":[{"raw_affiliation_string":"Macau University of Science and Technology","institution_ids":["https://openalex.org/I111950717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032324275","display_name":"Wenxiu Zhang","orcid":"https://orcid.org/0000-0002-0212-9401","observed_orcids":["https://orcid.org/0000-0002-0212-9401"]},"institutions":[{"id":"https://openalex.org/I116265982","display_name":"Qinghai University","ror":"https://ror.org/05h33bt13","country_code":"CN","type":"education","lineage":["https://openalex.org/I116265982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenxiu Zhang","raw_affiliation_strings":["Qinghai University Medical College"],"raw_orcid":"https://orcid.org/0000-0002-0212-9401","affiliations":[{"raw_affiliation_string":"Qinghai University Medical College","institution_ids":["https://openalex.org/I116265982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102818329","display_name":"Nianchao Zhou","orcid":"https://orcid.org/0009-0009-3901-7524","observed_orcids":["https://orcid.org/0009-0009-3901-7524"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nianchao Zhou","raw_affiliation_strings":["Southeast University"],"raw_orcid":"https://orcid.org/0009-0009-3901-7524","affiliations":[{"raw_affiliation_string":"Southeast University","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153584008","display_name":"Yihan Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yihan Jin","raw_affiliation_strings":["Southeast University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southeast University","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135776269","display_name":"Baofang Jin","orcid":"https://orcid.org/0000-0002-5604-2897","observed_orcids":["https://orcid.org/0000-0002-5604-2897"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Baofang Jin","raw_affiliation_strings":["Southeast University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southeast University","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101527947","display_name":"Dalin Sun","orcid":"https://orcid.org/0000-0002-1442-9962","observed_orcids":["https://orcid.org/0000-0002-1442-9962"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dalin Sun","raw_affiliation_strings":["Southeast University"],"raw_orcid":"https://orcid.org/0000-0002-1442-9962","affiliations":[{"raw_affiliation_string":"Southeast University","institution_ids":["https://openalex.org/I76569877"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101527947","https://openalex.org/A5135776269"],"corresponding_institution_ids":["https://openalex.org/I76569877"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":{"value":2650,"currency":"USD","value_usd":2650},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60034289,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"5","first_page":"15579883261493263","last_page":"15579883261493263"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/premature-ejaculation","display_name":"premature ejaculation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8899999856948853},{"id":"https://openalex.org/keywords/fecal-metabolomics","display_name":"fecal metabolomics","score":0.746999979019165},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/bifidobacteriaceae","display_name":"Bifidobacteriaceae","score":0.8690000176429749},{"id":"https://openalex.org/keywords/blautia","display_name":"Blautia","score":0.9390000104904175},{"id":"https://openalex.org/keywords/ruminococcus","display_name":"Ruminococcus","score":0.7670000195503235},{"id":"https://openalex.org/keywords/peroxisome-proliferator-activated-receptor-signaling","display_name":"peroxisome proliferator-activated receptor signaling","score":0.9079999923706055},{"id":"https://openalex.org/keywords/male-sexual-dysfunction","display_name":"male sexual dysfunction","score":0.8320000171661377},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.8148999810218811},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.7870000004768372},{"id":"https://openalex.org/C2780027724","wikidata":"https://www.wikidata.org/wiki/Q288892","display_name":"Ruminococcus","level":3,"score":0.7189000248908997},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6990000009536743},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.6676999926567078},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.5884000062942505},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.4932999908924103},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.48030000925064087},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.3905999958515167},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.3878999948501587},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.38350000977516174},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3652999997138977},{"id":"https://openalex.org/C177857423","wikidata":"https://www.wikidata.org/wiki/Q17077315","display_name":"Gut\u2013brain axis","level":3,"score":0.3589000105857849},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.3517000079154968},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.34279999136924744},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29100000858306885},{"id":"https://openalex.org/C2780092757","wikidata":"https://www.wikidata.org/wiki/Q5405346","display_name":"Eubacterium","level":3,"score":0.28279998898506165},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.28200000524520874},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.27810001373291016},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.250900000333786}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061686","descriptor_name":"Premature Ejaculation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061686","descriptor_name":"Premature Ejaculation","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1177/15579883261493263","doi":"https://doi.org/10.1177/15579883261493263","is_oa":true,"landing_page_url":"https://doi.org/10.1177/15579883261493263","pdf_url":null,"source":{"id":"https://openalex.org/S90816027","display_name":"American Journal of Men s Health","issn_l":"1557-9883","issn":["1557-9883","1557-9891"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Men's Health","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-9632664/v1","doi":"https://doi.org/10.21203/rs.3.rs-9632664/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-9632664/v1","pdf_url":"https://www.researchsquare.com/article/rs-9632664/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13735473","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13735473/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13735473/pdf/10.1177_15579883261493263.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Mens Health","raw_type":"Text"},{"id":"pmid:42813505","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42813505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of men's health","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7d8b4c5d6bbb49ea8e7233a3dbb8378c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7d8b4c5d6bbb49ea8e7233a3dbb8378c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Men's Health, Vol 20 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/15579883261493263","doi":"https://doi.org/10.1177/15579883261493263","is_oa":true,"landing_page_url":"https://doi.org/10.1177/15579883261493263","pdf_url":null,"source":{"id":"https://openalex.org/S90816027","display_name":"American Journal of Men s Health","issn_l":"1557-9883","issn":["1557-9883","1557-9891"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Men's Health","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G7953278896","display_name":null,"funder_award_id":"82374459","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8949179787","display_name":null,"funder_award_id":"82374459","funder_id":"https://openalex.org/F4320324856","funder_display_name":"Southeast University"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324856","display_name":"Southeast University","ror":"https://ror.org/04ct4d772"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214894435.pdf","grobid_xml":"https://content.openalex.org/works/W7214894435.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1493398136","https://openalex.org/W1833421650","https://openalex.org/W1991956843","https://openalex.org/W2000142370","https://openalex.org/W2004549986","https://openalex.org/W2079080809","https://openalex.org/W2125826054","https://openalex.org/W2151615266","https://openalex.org/W2171499783","https://openalex.org/W2624106029","https://openalex.org/W3004054088","https://openalex.org/W3016292796","https://openalex.org/W3159630622","https://openalex.org/W3173550964","https://openalex.org/W3193421084","https://openalex.org/W3194054376","https://openalex.org/W4200419056","https://openalex.org/W4206791370","https://openalex.org/W4285600295","https://openalex.org/W4293092902","https://openalex.org/W4297860766","https://openalex.org/W4308974852","https://openalex.org/W4387674279","https://openalex.org/W4388567871","https://openalex.org/W4390675639","https://openalex.org/W4391514643","https://openalex.org/W4392783067","https://openalex.org/W4408161720","https://openalex.org/W4410839468","https://openalex.org/W4410861835","https://openalex.org/W4414620075"],"related_works":["https://openalex.org/W7164327880","https://openalex.org/W4309573649","https://openalex.org/W4412551139","https://openalex.org/W4409050711","https://openalex.org/W4411065847","https://openalex.org/W2792417089","https://openalex.org/W2915231433","https://openalex.org/W2587689012","https://openalex.org/W4295809201","https://openalex.org/W3046058023"],"abstract_inverted_index":{"Abstract":[0],"Premature":[1],"ejaculation":[2],"(PE)":[3],"is":[4],"a":[5],"prevalent":[6],"male":[7],"sexual":[8],"disorder":[9],"with":[10,62,173,176],"an":[11],"incompletely":[12],"understood":[13],"pathogenesis":[14,27,197],"and":[15,28,43,49,64,72,75,88,109,117,129,142,179,198],"limited":[16],"effective":[17],"therapeutic":[18,78,201],"strategies.":[19],"Intestinal":[20],"microbiota":[21,58,169],"dysbiosis":[22],"may":[23],"contribute":[24],"to":[25,54,184],"PE":[26,63,71,87,92,151,174,185,196],"progression":[29],"by":[30],"affecting":[31],"intestinal":[32,57],"barrier":[33],"integrity,":[34],"autonomic":[35],"nervous":[36],"system":[37],"activity,":[38],"immune":[39],"regulation,":[40],"metabolic":[41],"processes,":[42],"neuroendocrine":[44],"signaling":[45,147],"pathways.":[46],"Metabolomic":[47,112],"analyses":[48],"metagenomic":[50],"sequencing":[51],"were":[52],"performed":[53],"compare":[55],"the":[56,68,122,138,143,150,159],"profiles":[59],"between":[60,70,86,121],"patients":[61,172],"healthy":[65,177],"controls,":[66],"investigate":[67],"association":[69],"gut":[73,168],"microbiota,":[74],"identify":[76,199],"potential":[77,146,200],"targets.":[79,202],"Comprehensive":[80],"analysis":[81,133],"revealed":[82],"distinct":[83,167],"microbial":[84],"signatures":[85],"control":[89],"groups.":[90,124],"The":[91,190],"group":[93],"exhibited":[94],"significantly":[95],"reduced":[96],"relative":[97],"abundances":[98],"of":[99,127,137,162,195],"Bifidobacteriaceae":[100],"bacterium,":[101],"Blautia,":[102],"Coprobacillus,":[103],"Ruminococcus":[104],"sp.":[105],"ctHOG1,":[106],"Siphoviridae":[107],",":[108],"Alistipes":[110],".":[111],"profiling":[113],"identified":[114],"150":[115],"upregulated":[116],"73":[118],"downregulated":[119],"metabolites":[120],"two":[123],"Kyoto":[125],"encyclopedia":[126],"genes":[128],"genomes":[130],"pathway":[131],"enrichment":[132,136],"indicated":[134],"significant":[135],"peroxisome":[139],"proliferator-activated":[140],"receptor":[141,145],"transient":[144],"pathways":[148,182],"in":[149,171],"group.":[152],"These":[153],"results":[154],"provide":[155],"novel":[156],"insights":[157],"into":[158],"pathophysiological":[160],"mechanism":[161],"PE.":[163],"This":[164],"study":[165],"characterized":[166],"features":[170],"compared":[175],"controls":[178],"investigated":[180],"microbiota-associated":[181],"contributing":[183],"through":[186],"integrated":[187],"metabolomics":[188],"analysis.":[189],"findings":[191],"advance":[192],"our":[193],"understanding":[194]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-01T00:00:00"}