{"id":"https://openalex.org/W7214865468","doi":null,"title":"The Double-Edged Sword of ROS in Muscle Wasting and COPD: Insights from Aging-Related Sarcopenia","display_name":"The Double-Edged Sword of ROS in Muscle Wasting and COPD: Insights from Aging-Related Sarcopenia","publication_year":2024,"publication_date":"2024-07-22","ids":{"openalex":"https://openalex.org/W7214865468"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/31417058","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/The_Double-Edged_Sword_of_ROS_in_Muscle_Wasting_and_COPD_Insights_from_Aging-Related_Sarcopenia/31417058","pdf_url":null,"source":{"id":"https://openalex.org/S4306402074","display_name":"RMIT Research Repository (RMIT University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82951845","host_organization_name":"RMIT University","host_organization_lineage":["https://openalex.org/I82951845"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/journal_contribution/The_Double-Edged_Sword_of_ROS_in_Muscle_Wasting_and_COPD_Insights_from_Aging-Related_Sarcopenia/31417058","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5153449158","display_name":"Ming Hang Stanley Chan (18029743)","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming Hang Stanley Chan (18029743)","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047909615","display_name":"Stavros Selemidis","orcid":"https://orcid.org/0000-0002-3989-7615","observed_orcids":["https://orcid.org/0000-0002-3989-7615"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stavros Selemidis (18028159)","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060211723","display_name":"Ross Vlahos","orcid":"https://orcid.org/0000-0001-8443-7071","observed_orcids":["https://orcid.org/0000-0001-8443-7071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ross Vlahos (18026866)","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32989854,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.05380000174045563,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.030300000682473183,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":1.0},{"id":"https://openalex.org/keywords/skeletal-muscle-atrophy","display_name":"skeletal muscle atrophy","score":0.800000011920929},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9440000057220459},{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.968999981880188},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8389999866485596},{"id":"https://openalex.org/keywords/antioxidant-supplementation","display_name":"antioxidant supplementation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/exercise-adaptation","display_name":"exercise adaptation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/muscle-function","display_name":"muscle function","score":0.5450000166893005},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2779764123","wikidata":"https://www.wikidata.org/wiki/Q7972881","display_name":"Wasting","level":2,"score":0.8647000193595886},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.8547999858856201},{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.7062000036239624},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.6455000042915344},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5570999979972839},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5024999976158142},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44290000200271606},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.4408000111579895},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4392000138759613},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.38179999589920044},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.35600000619888306},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3513000011444092},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.337799996137619},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.33500000834465027},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.32359999418258667},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.29409998655319214},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.2847000062465668},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.28450000286102295},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.2768000066280365},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2727000117301941},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.265500009059906},{"id":"https://openalex.org/C2777488582","wikidata":"https://www.wikidata.org/wiki/Q29630","display_name":"Myostatin","level":3,"score":0.2653000056743622},{"id":"https://openalex.org/C2777300911","wikidata":"https://www.wikidata.org/wiki/Q692536","display_name":"Myopathy","level":2,"score":0.25949999690055847},{"id":"https://openalex.org/C2992644362","wikidata":"https://www.wikidata.org/wiki/Q692536","display_name":"Muscle disease","level":3,"score":0.2563999891281128},{"id":"https://openalex.org/C2777321227","wikidata":"https://www.wikidata.org/wiki/Q5420062","display_name":"Exercise intolerance","level":3,"score":0.2556000053882599},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.25029999017715454}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:figshare.com:article/31417058","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/The_Double-Edged_Sword_of_ROS_in_Muscle_Wasting_and_COPD_Insights_from_Aging-Related_Sarcopenia/31417058","pdf_url":null,"source":{"id":"https://openalex.org/S4306402074","display_name":"RMIT Research Repository (RMIT University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82951845","host_organization_name":"RMIT University","host_organization_lineage":["https://openalex.org/I82951845"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/31417058","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/The_Double-Edged_Sword_of_ROS_in_Muscle_Wasting_and_COPD_Insights_from_Aging-Related_Sarcopenia/31417058","pdf_url":null,"source":{"id":"https://openalex.org/S4306402074","display_name":"RMIT Research Repository (RMIT University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82951845","host_organization_name":"RMIT University","host_organization_lineage":["https://openalex.org/I82951845"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2003937692","https://openalex.org/W4200557461","https://openalex.org/W2965860628","https://openalex.org/W2917910566","https://openalex.org/W2136598956","https://openalex.org/W3017180994","https://openalex.org/W2148129304","https://openalex.org/W2045886232","https://openalex.org/W4223892450","https://openalex.org/W2528998746"],"abstract_inverted_index":{"An":[0],"elevation":[1,40],"in":[2,41,43,57,91,96,119],"reactive":[3],"oxygen":[4],"species":[5],"(ROS)":[6],"is":[7,46,67,87],"widely":[8],"accepted":[9],"to":[10,36,60,89,126,131,142],"be":[11,32,102],"a":[12,34,48,84,111],"key":[13,64],"mechanism":[14],"that":[15,38,68,79],"drives":[16],"chronic":[17],"obstructive":[18],"pulmonary":[19],"disease":[20],"(COPD)":[21],"and":[22,56,123,128],"its":[23],"major":[24],"co-morbidity,":[25],"skeletal":[26,44,53,93,120,137],"muscle":[27,45,54,94,121,138],"wasting.":[28],"However,":[29],"it":[30,99],"will":[31,100,129],"perhaps":[33],"surprise":[35],"many":[37],"an":[39],"ROS":[42,69,77,118],"also":[47,101],"critical":[49,104,133],"process":[50],"for":[51],"normal":[52],"function":[55],"the":[58,80],"adaptations":[59],"physical":[61],"exercise.":[62],"The":[63],"message":[65],"here":[66],"are":[70],"not":[71],"solely":[72],"detrimental.":[73],"This":[74],"duality":[75,116],"of":[76,83,117],"suggests":[78],"mere":[81],"use":[82],"broad-acting":[85],"antioxidant":[86],"destined":[88],"fail":[90],"alleviating":[92],"wasting":[95,139],"COPD":[97,127],"because":[98],"influencing":[103],"physiological":[105],"ROS-dependent":[106],"processes.":[107],"Here,":[108],"we":[109],"take":[110],"close":[112],"look":[113],"at":[114],"this":[115],"physiology":[122],"pathophysiology":[124],"pertaining":[125],"aim":[130],"gain":[132],"insights":[134],"from":[135],"other":[136],"conditions":[140],"due":[141],"aging":[143],"such":[144],"as":[145],"sarcopenia.":[146]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-30T00:00:00"}
