{"id":"https://openalex.org/W7214804646","doi":"https://doi.org/10.64898/2026.09.23.753757","title":"Cellular and Network Effects of Introducing Connexin-36 Expression in an Uncoupled Neuronal Population in the Mouse Hypothalamus","display_name":"Cellular and Network Effects of Introducing Connexin-36 Expression in an Uncoupled Neuronal Population in the Mouse Hypothalamus","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7214804646","doi":"https://doi.org/10.64898/2026.09.23.753757"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.23.753757","doi":"https://doi.org/10.64898/2026.09.23.753757","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.23.753757","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.23.753757.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.23.753757.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5143425958","display_name":"Andriana Mantzafou","orcid":"https://orcid.org/0009-0005-8047-0604","observed_orcids":["https://orcid.org/0009-0005-8047-0604"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Andriana Mantzafou","raw_affiliation_strings":["Dept. of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius v. 16C, 104 05, Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0009-0005-8047-0604","affiliations":[{"raw_affiliation_string":"Dept. of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius v. 16C, 104 05, Stockholm, Sweden","institution_ids":["https://openalex.org/I161593684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049425827","display_name":"Andrea Locarno","orcid":"https://orcid.org/0000-0003-0640-1510","observed_orcids":["https://orcid.org/0000-0003-0640-1510"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Andrea Locarno","raw_affiliation_strings":["Dept. of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius v. 16C, 104 05, Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-0640-1510","affiliations":[{"raw_affiliation_string":"Dept. of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius v. 16C, 104 05, Stockholm, Sweden","institution_ids":["https://openalex.org/I161593684"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084173178","display_name":"Christian Broberger","orcid":"https://orcid.org/0000-0002-7050-8809","observed_orcids":["https://orcid.org/0000-0002-7050-8809"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Christian Broberger","raw_affiliation_strings":["Dept. of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius v. 16C, 104 05, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius v. 16C, 104 05, Stockholm, Sweden","institution_ids":["https://openalex.org/I161593684"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084173178"],"corresponding_institution_ids":["https://openalex.org/I161593684"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/connexin-36","display_name":"connexin 36","score":0.9729999899864197},{"id":"https://openalex.org/keywords/electrical-synapses","display_name":"electrical synapses","score":0.9049999713897705},{"id":"https://openalex.org/keywords/gap-junctions","display_name":"gap junctions","score":0.949999988079071},{"id":"https://openalex.org/keywords/tuberoinfundibular-dopamine-neurons","display_name":"tuberoinfundibular dopamine neurons","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9710000157356262},{"id":"https://openalex.org/keywords/electrical-coupling","display_name":"electrical coupling","score":0.6439999938011169},{"id":"https://openalex.org/keywords/viral-overexpression","display_name":"viral overexpression","score":0.531000018119812},{"id":"https://openalex.org/keywords/species-differences","display_name":"species differences","score":0.5389999747276306},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.9729999899864197}],"concepts":[{"id":"https://openalex.org/C2908872077","wikidata":"https://www.wikidata.org/wiki/Q1187365","display_name":"Electrical Synapses","level":4,"score":0.8485000133514404},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.7578999996185303},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7105000019073486},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6711000204086304},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5432000160217285},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.5019999742507935},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.38760000467300415},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3668999969959259},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36579999327659607},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.3603000044822693},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.3528999984264374},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.3483000099658966},{"id":"https://openalex.org/C2780228694","wikidata":"https://www.wikidata.org/wiki/Q423489","display_name":"Connexin","level":4,"score":0.34360000491142273},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.329800009727478},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.3197999894618988},{"id":"https://openalex.org/C2780196419","wikidata":"https://www.wikidata.org/wiki/Q1762173","display_name":"Nerve net","level":2,"score":0.3125999867916107},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.29829999804496765},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.27649998664855957},{"id":"https://openalex.org/C194051981","wikidata":"https://www.wikidata.org/wiki/Q1337691","display_name":"Economic shortage","level":3,"score":0.2752000093460083},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.2703000009059906},{"id":"https://openalex.org/C2778914748","wikidata":"https://www.wikidata.org/wiki/Q10850","display_name":"Rodent","level":2,"score":0.2556999921798706},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2529999911785126},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.25209999084472656}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.23.753757","doi":"https://doi.org/10.64898/2026.09.23.753757","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.23.753757","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.23.753757.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.23.753757","doi":"https://doi.org/10.64898/2026.09.23.753757","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.23.753757","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.23.753757.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320325669","display_name":"Stockholms Universitet","ror":"https://ror.org/05f0yaq80"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214804646.pdf","grobid_xml":"https://content.openalex.org/works/W7214804646.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W10573418","https://openalex.org/W52281509","https://openalex.org/W1585686121","https://openalex.org/W1788860859","https://openalex.org/W1889733078","https://openalex.org/W1942655489","https://openalex.org/W1951866234","https://openalex.org/W1969183124","https://openalex.org/W1974689666","https://openalex.org/W1983710612","https://openalex.org/W1984646993","https://openalex.org/W1989741977","https://openalex.org/W1992424371","https://openalex.org/W1992962897","https://openalex.org/W2012369431","https://openalex.org/W2024296065","https://openalex.org/W2027822459","https://openalex.org/W2032771021","https://openalex.org/W2034223334","https://openalex.org/W2047845327","https://openalex.org/W2049743441","https://openalex.org/W2054652174","https://openalex.org/W2055557007","https://openalex.org/W2075498034","https://openalex.org/W2080648711","https://openalex.org/W2083786190","https://openalex.org/W2087205687","https://openalex.org/W2087666006","https://openalex.org/W2098074240","https://openalex.org/W2106674032","https://openalex.org/W2117947301","https://openalex.org/W2119347604","https://openalex.org/W2142018640","https://openalex.org/W2143270363","https://openalex.org/W2152551864","https://openalex.org/W2163799569","https://openalex.org/W2164067293","https://openalex.org/W2321773098","https://openalex.org/W2593007651","https://openalex.org/W2610843582","https://openalex.org/W2617668974","https://openalex.org/W2916989061","https://openalex.org/W2919268436","https://openalex.org/W3009111921","https://openalex.org/W3047498213","https://openalex.org/W3159360058","https://openalex.org/W3207681551","https://openalex.org/W4390057516","https://openalex.org/W7160996005"],"related_works":["https://openalex.org/W2067374085","https://openalex.org/W2150857286","https://openalex.org/W2122220430","https://openalex.org/W7042964209","https://openalex.org/W2016628253","https://openalex.org/W2112955454","https://openalex.org/W2485213654","https://openalex.org/W2034556040","https://openalex.org/W3023499015","https://openalex.org/W2005655563"],"abstract_inverted_index":{"Abstract":[0],"Electrical":[1],"synapses":[2,187,232,307],"are":[3,86,298],"prevalent":[4],"throughout":[5],"nervous":[6],"systems,":[7],"including":[8],"the":[9,70,89,123,149,183,189,211,224,261,266,271,312,355],"mammalian":[10],"brain.":[11],"Several":[12],"lines":[13],"of":[14,36,57,69,122,127,185,210,228,260,265,273,322,360,363],"evidence":[15],"implicate":[16],"these":[17,75,192],"gap":[18,97,129,163],"junction":[19],"connections":[20],"in":[21,25,61,64,133,168,180,188,196,233,252,270,292,301,308,316,345],"several":[22,320],"important":[23],"roles":[24],"neural":[26],"networks.":[27],"Yet,":[28,191],"progress":[29],"has":[30],"been":[31],"hampered":[32],"by":[33,107,137,162,217,249,284,339],"a":[34,58,113,234,281,288],"shortage":[35],"experimental":[37,276],"tools":[38],"to":[39,49,116,206,254,286],"investigate":[40],"their":[41],"function":[42],"with":[43,156,182,198],"sufficient":[44],"precision.":[45],"In":[46,73,91],"an":[47],"effort":[48],"address":[50],"this":[51,108,218],"deficit,":[52],"we":[53,111,279],"here":[54],"take":[55],"advantage":[56],"curious":[59],"species-difference":[60],"electrical":[62,79,143,186,231,250,306,323,364],"coupling":[63,144,324],"tuberoinfundibular":[65],"dopamine":[66,294],"(TIDA)":[67],"neurons":[68,95,136,247],"rodent":[71],"hypothalamus.":[72],"rats,":[74],"cells":[76],"exhibit":[77],"strong":[78],"coupling,":[80],"generating":[81],"stereotyped,":[82],"slow":[83],"oscillations":[84],"that":[85,145],"synchronized":[87],"across":[88],"population.":[90,190],"contrast,":[92],"mouse":[93,134,317],"TIDA":[94,135,151,200,318],"lack":[96,305],"junctions":[98],"and":[99,103,119,172,202,226,238,263,325,357],"display":[100],"diverse,":[101],"faster,":[102],"asynchronous":[104],"oscillations.":[105],"Motivated":[106],"natural":[109,289],"discrepancy,":[110],"designed":[112],"gain-of-function":[114,361],"strategy":[115,283],"induce":[117],"localized":[118],"robust":[120],"expression":[121],"main":[124],"pore-forming":[125,313],"protein":[126],"neuronal":[128],"junctions,":[130],"connexin-36":[131],"(Cx36),":[132],"viral":[138],"vectors.":[139],"This":[140],"perturbation":[141],"yielded":[142],"was":[146],"weaker":[147],"than":[148],"rat":[150,199],"system,":[152,237],"but":[153,303],"on":[154],"par":[155],"many":[157],"other":[158],"brain":[159],"populations":[160],"connected":[161],"junctions.":[164],"Cx36":[165,203],"overexpression":[166,204],"resulted":[167],"significantly":[169,337],"increased":[170],"auto-":[171],"cross-correlation,":[173],"as":[174,176],"well":[175],"augmented":[177],"functional":[178],"connectivity,":[179],"agreement":[181],"induction":[184],"measures":[193,321],"were":[194,329,336],"modest":[195],"comparison":[197],"neurons,":[201,296,319],"failed":[205],"alter":[207],"serum":[208],"levels":[209],"hormone":[212,347],"prolactin,":[213],"which":[214,297],"is":[215],"controlled":[216],"neuroendocrine":[219,293],"system.":[220],"These":[221,351],"findings":[222,352],"highlight":[223],"potential":[225],"limitations":[227,359],"experimentally":[229],"inducing":[230],"natively":[235],"uncoupled":[236],"suggest":[239],"directions":[240],"for":[241],"future":[242],"improvements.":[243],"Significance":[244],"statement":[245],"Many":[246],"communicate":[248],"synapses,":[251],"addition":[253],"classical":[255],"chemical":[256],"synapses.":[257],"However,":[258],"understanding":[259],"properties":[262],"role":[264],"former":[267],"remains":[268],"limited":[269],"absence":[272],"sufficiently":[274],"precise":[275],"tools.":[277],"Here,":[278],"applied":[280],"novel":[282],"attempting":[285],"convert":[287],"species":[290],"difference":[291],"(\u201cTIDA\u201d)":[295],"strongly":[299],"coupled":[300],"rats":[302],"completely":[304],"mice.":[309],"By":[310],"overexpressing":[311],"protein,":[314],"connexin-36,":[315],"synchronizing":[326],"network":[327,334],"effects":[328],"induced,":[330],"albeit":[331],"weakly.":[332],"While":[333],"interactions":[335],"altered":[338],"overexpression,":[340],"overall":[341],"circuit":[342],"performance,":[343],"reflected":[344],"target":[346],"levels,":[348],"remained":[349],"stable.":[350],"illustrate":[353],"both":[354],"promise":[356],"current":[358],"manipulations":[362],"coupling.":[365]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-30T00:00:00"}
