{"id":"https://openalex.org/W7214800593","doi":"https://doi.org/10.1016/j.cej.2026.182493","title":"Biological production of kojic acid from sugar beet pulp with enhanced recovery via salt-assisted liquid\u2013liquid extraction","display_name":"Biological production of kojic acid from sugar beet pulp with enhanced recovery via salt-assisted liquid\u2013liquid extraction","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7214800593","doi":"https://doi.org/10.1016/j.cej.2026.182493"},"language":"en","primary_location":{"id":"doi:10.1016/j.cej.2026.182493","doi":"https://doi.org/10.1016/j.cej.2026.182493","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cej.2026.182493","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1385894726099560/pdf","source":{"id":"https://openalex.org/S149937609","display_name":"Chemical Engineering Journal","issn_l":"1385-8947","issn":["1385-8947","1873-3212"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-1","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Engineering Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S1385894726099560/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094295580","display_name":"Kawinharsun Dhodduraj","orcid":"https://orcid.org/0009-0009-6638-5816","observed_orcids":["https://orcid.org/0009-0009-6638-5816"]},"institutions":[{"id":"https://openalex.org/I82284825","display_name":"Cranfield University","ror":"https://ror.org/05cncd958","country_code":"GB","type":"education","lineage":["https://openalex.org/I82284825"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kawinharsun Dhodduraj","raw_affiliation_strings":["Faculty of Engineering and Applied Sciences, Cranfield University, Cranfield, MK43 0AL, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Applied Sciences, Cranfield University, Cranfield, MK43 0AL, United Kingdom","institution_ids":["https://openalex.org/I82284825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023476713","display_name":"Vivek Narisetty","orcid":"https://orcid.org/0000-0002-5533-0600","observed_orcids":["https://orcid.org/0000-0002-5533-0600"]},"institutions":[{"id":"https://openalex.org/I82284825","display_name":"Cranfield University","ror":"https://ror.org/05cncd958","country_code":"GB","type":"education","lineage":["https://openalex.org/I82284825"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vivek Narisetty","raw_affiliation_strings":["Faculty of Engineering and Applied Sciences, Cranfield University, Cranfield, MK43 0AL, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Applied Sciences, Cranfield University, Cranfield, MK43 0AL, United Kingdom","institution_ids":["https://openalex.org/I82284825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153402491","display_name":"Seyed Ali Navabi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seyed Ali Nabavi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5153472287","display_name":"Vinod Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82284825","display_name":"Cranfield University","ror":"https://ror.org/05cncd958","country_code":"GB","type":"education","lineage":["https://openalex.org/I82284825"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Vinod Kumar","raw_affiliation_strings":["Faculty of Engineering and Applied Sciences, Cranfield University, Cranfield, MK43 0AL, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Applied Sciences, Cranfield University, Cranfield, MK43 0AL, United Kingdom","institution_ids":["https://openalex.org/I82284825"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5153472287"],"corresponding_institution_ids":["https://openalex.org/I82284825"],"apc_list":{"value":4830,"currency":"USD","value_usd":4830},"apc_paid":{"value":4830,"currency":"USD","value_usd":4830},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"549","issue":null,"first_page":"182493","last_page":"182493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.6884999871253967,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.6884999871253967,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.11010000109672546,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.04039999842643738,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kojic-acid","display_name":"kojic acid","score":0.9919999837875366},{"id":"https://openalex.org/keywords/aspergillus-flavus","display_name":"Aspergillus flavus","score":0.9409999847412109},{"id":"https://openalex.org/keywords/sugar-beet-pulp","display_name":"sugar beet pulp","score":0.8309999704360962},{"id":"https://openalex.org/keywords/lignocellulosic-hydrolysates","display_name":"lignocellulosic hydrolysates","score":0.9810000061988831},{"id":"https://openalex.org/keywords/ammonium-sulfate","display_name":"ammonium sulfate","score":0.8420000076293945},{"id":"https://openalex.org/keywords/ethyl-acetate-extraction","display_name":"ethyl acetate extraction","score":0.7379999756813049},{"id":"https://openalex.org/keywords/fed-batch-fermentation","display_name":"fed-batch fermentation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/fungal-secondary-metabolites","display_name":"fungal secondary metabolites","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8361999988555908},{"id":"https://openalex.org/C28800991","wikidata":"https://www.wikidata.org/wiki/Q15634405","display_name":"Hydrolysate","level":3,"score":0.6182000041007996},{"id":"https://openalex.org/C4916135","wikidata":"https://www.wikidata.org/wiki/Q4119055","display_name":"Bioprocess","level":2,"score":0.5950000286102295},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.550599992275238},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.5371999740600586},{"id":"https://openalex.org/C528095902","wikidata":"https://www.wikidata.org/wiki/Q2283886","display_name":"Pulp and paper industry","level":1,"score":0.5145999789237976},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.5045999884605408},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.491100013256073},{"id":"https://openalex.org/C2780782300","wikidata":"https://www.wikidata.org/wiki/Q410156","display_name":"Ammonium acetate","level":3,"score":0.48820000886917114},{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.46619999408721924},{"id":"https://openalex.org/C2778805457","wikidata":"https://www.wikidata.org/wiki/Q1969868","display_name":"Beet pulp","level":2,"score":0.42579999566078186},{"id":"https://openalex.org/C2777292910","wikidata":"https://www.wikidata.org/wiki/Q137096","display_name":"Aspergillus flavus","level":2,"score":0.4189999997615814},{"id":"https://openalex.org/C2779227428","wikidata":"https://www.wikidata.org/wiki/Q4915219","display_name":"Bioproduction","level":2,"score":0.3824000060558319},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.3765000104904175},{"id":"https://openalex.org/C2780925461","wikidata":"https://www.wikidata.org/wiki/Q191831","display_name":"Ammonium sulfate","level":2,"score":0.36660000681877136},{"id":"https://openalex.org/C2776936025","wikidata":"https://www.wikidata.org/wiki/Q151964","display_name":"Sugar beet","level":2,"score":0.3628000020980835},{"id":"https://openalex.org/C2779858419","wikidata":"https://www.wikidata.org/wiki/Q407153","display_name":"Ethyl acetate","level":2,"score":0.35920000076293945},{"id":"https://openalex.org/C67568554","wikidata":"https://www.wikidata.org/wiki/Q385442","display_name":"Downstream processing","level":2,"score":0.3587999939918518},{"id":"https://openalex.org/C2779538156","wikidata":"https://www.wikidata.org/wiki/Q416285","display_name":"Kojic acid","level":4,"score":0.35839998722076416},{"id":"https://openalex.org/C2776865271","wikidata":"https://www.wikidata.org/wiki/Q18351432","display_name":"Industrial and production engineering","level":2,"score":0.3513000011444092},{"id":"https://openalex.org/C92397422","wikidata":"https://www.wikidata.org/wiki/Q5062082","display_name":"Central composite design","level":3,"score":0.32919999957084656},{"id":"https://openalex.org/C2777108408","wikidata":"https://www.wikidata.org/wiki/Q11002","display_name":"Sugar","level":2,"score":0.31940001249313354},{"id":"https://openalex.org/C188442228","wikidata":"https://www.wikidata.org/wiki/Q48286","display_name":"Pulp (tooth)","level":2,"score":0.30390000343322754},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.2784000039100647},{"id":"https://openalex.org/C2777580618","wikidata":"https://www.wikidata.org/wiki/Q421982","display_name":"Reducing sugar","level":3,"score":0.27559998631477356},{"id":"https://openalex.org/C2781213060","wikidata":"https://www.wikidata.org/wiki/Q49546","display_name":"Acetone","level":2,"score":0.266400009393692},{"id":"https://openalex.org/C537208039","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen","level":2,"score":0.262800008058548},{"id":"https://openalex.org/C2776382133","wikidata":"https://www.wikidata.org/wiki/Q4087","display_name":"Ammonia","level":2,"score":0.25270000100135803},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2508000135421753}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cej.2026.182493","doi":"https://doi.org/10.1016/j.cej.2026.182493","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cej.2026.182493","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1385894726099560/pdf","source":{"id":"https://openalex.org/S149937609","display_name":"Chemical Engineering Journal","issn_l":"1385-8947","issn":["1385-8947","1873-3212"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-1","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Engineering Journal","raw_type":"journal-article"},{"id":"pmh:oai:dspace.lib.cranfield.ac.uk:1826/25721","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cej.2026.182493","pdf_url":null,"source":{"id":"https://openalex.org/S4306401778","display_name":"CERES (Cranfield University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82284825","host_organization_name":"Cranfield University","host_organization_lineage":["https://openalex.org/I82284825"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.cej.2026.182493","doi":"https://doi.org/10.1016/j.cej.2026.182493","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cej.2026.182493","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1385894726099560/pdf","source":{"id":"https://openalex.org/S149937609","display_name":"Chemical Engineering Journal","issn_l":"1385-8947","issn":["1385-8947","1873-3212"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-1","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Engineering Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Responsible consumption and production","score":1.0,"id":"https://metadata.un.org/sdg/12"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214800593.pdf","grobid_xml":"https://content.openalex.org/works/W7214800593.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1554039806","https://openalex.org/W1977534296","https://openalex.org/W1981444529","https://openalex.org/W1990785657","https://openalex.org/W1994338822","https://openalex.org/W2015741437","https://openalex.org/W2032196136","https://openalex.org/W2033971705","https://openalex.org/W2045950712","https://openalex.org/W2050273443","https://openalex.org/W2063175654","https://openalex.org/W2075321693","https://openalex.org/W2082029309","https://openalex.org/W2084587668","https://openalex.org/W2096567084","https://openalex.org/W2106001253","https://openalex.org/W2148269983","https://openalex.org/W2167991740","https://openalex.org/W2178799332","https://openalex.org/W2313524385","https://openalex.org/W2323570330","https://openalex.org/W2917707818","https://openalex.org/W2969988046","https://openalex.org/W2980555353","https://openalex.org/W2980697069","https://openalex.org/W2998198432","https://openalex.org/W3002379423","https://openalex.org/W3012205261","https://openalex.org/W3083638322","https://openalex.org/W3134648427","https://openalex.org/W3143413756","https://openalex.org/W3155788120","https://openalex.org/W3174990649","https://openalex.org/W3186175497","https://openalex.org/W4200415559","https://openalex.org/W4205496586","https://openalex.org/W4220960790","https://openalex.org/W4225090174","https://openalex.org/W4317568301","https://openalex.org/W4321104671","https://openalex.org/W4322201550","https://openalex.org/W4322491069","https://openalex.org/W4324020779","https://openalex.org/W4361276888","https://openalex.org/W4379517973","https://openalex.org/W4391831817","https://openalex.org/W4394996178","https://openalex.org/W4403964365","https://openalex.org/W4411468798","https://openalex.org/W4416123445","https://openalex.org/W7125241978","https://openalex.org/W7130892763","https://openalex.org/W7155410105","https://openalex.org/W7161696205","https://openalex.org/W7162851884","https://openalex.org/W7208775907"],"related_works":["https://openalex.org/W4289215516","https://openalex.org/W4361276888","https://openalex.org/W2031038568","https://openalex.org/W59601133","https://openalex.org/W2965791640","https://openalex.org/W7001539172","https://openalex.org/W1994338822","https://openalex.org/W2008119696","https://openalex.org/W2228388916","https://openalex.org/W7098160368"],"abstract_inverted_index":{"Kojic":[0],"acid":[1],"(KA)":[2],"is":[3,17],"a":[4,82,103,157],"high-value":[5],"fungal":[6],"secondary":[7],"metabolite":[8],"used":[9],"in":[10,74,139,145],"cosmetics":[11],"and":[12,22,64,142,184,188,222],"pharmaceuticals,":[13],"but":[14],"commercial":[15],"production":[16,33,98,116],"limited":[18],"by":[19,34,182],"costly":[20],"substrates":[21],"inefficient":[23],"recovery.":[24],"This":[25],"study":[26],"developed":[27],"an":[28,65,208],"integrated":[29],"bioprocess":[30],"for":[31,186,212,219],"KA":[32,80,97,115,138,154,177,213],"Aspergillus":[35],"flavus":[36],".":[37],"Agitated":[38],"cultivation":[39,109],"with":[40,81,102,124,166,207],"glucose":[41,52,112,123],"as":[42,60],"the":[43,61,71,151,200,217],"optimal":[44],"carbon":[45],"source":[46],"markedly":[47],"improved":[48],"biosynthesis.":[49],"An":[50],"initial":[51,66],"concentration":[53],"of":[54,68,84,105,121,132,150,202],"80":[55],"g/L,":[56],"corn":[57],"steep":[58],"liquor":[59],"nitrogen":[62],"source,":[63],"pH":[67],"3.6":[69],"provided":[70],"highest":[72,152],"performance":[73],"shake-flask":[75],"cultivation,":[76,90],"producing":[77,135],"47.0":[78],"g/L":[79,101,137,144],"yield":[83,104],"0.61":[85],"g/g.":[86,107],"Under":[87],"batch":[88,140],"bioreactor":[89],"these":[91],"conditions":[92],"were":[93],"successfully":[94],"translated,":[95],"increasing":[96,179],"to":[99,117],"52.8":[100],"0.66":[106],"Fed-batch":[108],"using":[110],"pure":[111,122],"further":[113,220],"increased":[114],"80.2":[118],"g/L.":[119],"Replacement":[120],"non-detoxified":[125],"glucose-rich":[126],"SBP":[127,189,205],"hydrolysate":[128,206],"enabled":[129],"efficient":[130],"co-utilization":[131],"mixed":[133],"sugars,":[134],"38.0":[136],"culture":[141],"72.3":[143],"fed-batch":[146],"fermentation,":[147],"representing":[148],"one":[149],"reported":[153],"titers":[155],"from":[156],"lignocellulosic":[158],"hydrolysate.":[159],"For":[160],"downstream":[161,226],"processing,":[162],"ethyl":[163],"acetate":[164],"extraction":[165,180],"35%":[167],"(":[168],"w":[169],"/":[170],"v":[171],")":[172],"ammonium":[173],"sulphate":[174],"significantly":[175],"enhanced":[176],"recovery,":[178],"yields":[181],"27%":[183],"62%":[185],"glucose-":[187],"hydrolysate-based":[190],"fermentation":[191],"broths,":[192],"respectively,":[193],"at":[194],">99%":[195],"purity.":[196],"These":[197],"findings":[198],"demonstrate":[199],"potential":[201],"integrating":[203],"renewable":[204],"intensified":[209],"recovery":[210],"strategy":[211],"bioproduction,":[214],"while":[215],"highlighting":[216],"need":[218],"process":[221],"product-safety":[223],"validation":[224],"before":[225],"application.":[227]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-30T00:00:00"}