{"id":"https://openalex.org/W7214799585","doi":"https://doi.org/10.3390/curroncol33100582","title":"Lactate Dehydrogenase-to-Albumin Ratio and Glasgow Prognostic Score as Prognostic Markers in Metastatic Breast Cancer Treated with CDK4/6 Inhibitors","display_name":"Lactate Dehydrogenase-to-Albumin Ratio and Glasgow Prognostic Score as Prognostic Markers in Metastatic Breast Cancer Treated with CDK4/6 Inhibitors","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7214799585","doi":"https://doi.org/10.3390/curroncol33100582","pmid":"https://pubmed.ncbi.nlm.nih.gov/42930149","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13703568"},"language":"en","primary_location":{"id":"doi:10.3390/curroncol33100582","doi":"https://doi.org/10.3390/curroncol33100582","is_oa":true,"landing_page_url":"https://doi.org/10.3390/curroncol33100582","pdf_url":null,"source":{"id":"https://openalex.org/S113449754","display_name":"Current Oncology","issn_l":"1198-0052","issn":["1198-0052","1718-7729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Oncology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7214799585"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/curroncol33100582","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119580550","display_name":"Ece \u015eahin Haf\u0131zo\u011flu","orcid":"https://orcid.org/0009-0007-7753-1482","observed_orcids":["https://orcid.org/0009-0007-7753-1482"]},"institutions":[{"id":"https://openalex.org/I16748637","display_name":"Manisa Celal Bayar University","ror":"https://ror.org/053f2w588","country_code":"TR","type":"education","lineage":["https://openalex.org/I16748637"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ece Sahin Hafizoglu","raw_affiliation_strings":["Division of Medical Oncology, Faculty of Medicine, Celal Bayar University, 45030 Manisa, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Faculty of Medicine, Celal Bayar University, 45030 Manisa, Turkey","institution_ids":["https://openalex.org/I16748637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075773553","display_name":"Ferhat Ekinci","orcid":"https://orcid.org/0000-0002-9317-942X","observed_orcids":["https://orcid.org/0000-0002-9317-942X"]},"institutions":[{"id":"https://openalex.org/I16748637","display_name":"Manisa Celal Bayar University","ror":"https://ror.org/053f2w588","country_code":"TR","type":"education","lineage":["https://openalex.org/I16748637"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ferhat Ekinci","raw_affiliation_strings":["Division of Medical Oncology, Faculty of Medicine, Celal Bayar University, 45030 Manisa, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-9317-942X","affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Faculty of Medicine, Celal Bayar University, 45030 Manisa, Turkey","institution_ids":["https://openalex.org/I16748637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021174559","display_name":"Mustafa \u015eahbazlar","orcid":"https://orcid.org/0000-0003-1857-593X","observed_orcids":["https://orcid.org/0000-0003-1857-593X"]},"institutions":[{"id":"https://openalex.org/I16748637","display_name":"Manisa Celal Bayar University","ror":"https://ror.org/053f2w588","country_code":"TR","type":"education","lineage":["https://openalex.org/I16748637"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa Sahbazlar","raw_affiliation_strings":["Division of Medical Oncology, Faculty of Medicine, Celal Bayar University, 45030 Manisa, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-1857-593X","affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Faculty of Medicine, Celal Bayar University, 45030 Manisa, Turkey","institution_ids":["https://openalex.org/I16748637"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030982886","display_name":"Atike P\u0131nar Erdo\u011fan","orcid":"https://orcid.org/0000-0003-4859-7574","observed_orcids":["https://orcid.org/0000-0003-4859-7574"]},"institutions":[{"id":"https://openalex.org/I16748637","display_name":"Manisa Celal Bayar University","ror":"https://ror.org/053f2w588","country_code":"TR","type":"education","lineage":["https://openalex.org/I16748637"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Atike Pinar Erdogan","raw_affiliation_strings":["Division of Medical Oncology, Faculty of Medicine, Celal Bayar University, 45030 Manisa, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Faculty of Medicine, Celal Bayar University, 45030 Manisa, Turkey","institution_ids":["https://openalex.org/I16748637"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030982886"],"corresponding_institution_ids":["https://openalex.org/I16748637"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":2.4016,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.82769208,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"33","issue":"10","first_page":"582","last_page":"582"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.861299991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.861299991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.09380000084638596,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.03420000150799751,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lactate-dehydrogenase-to-albumin-ratio","display_name":"lactate dehydrogenase-to-albumin ratio","score":0.9779999852180481},{"id":"https://openalex.org/keywords/glasgow-prognostic-score","display_name":"Glasgow Prognostic Score","score":0.9950000047683716},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7459999918937683},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cdk4-6-inhibitors","display_name":"CDK4/6 inhibitors","score":0.9629999995231628},{"id":"https://openalex.org/keywords/palbociclib","display_name":"palbociclib","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ribociclib","display_name":"ribociclib","score":1.0},{"id":"https://openalex.org/keywords/endocrine-therapy","display_name":"endocrine therapy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hr-her2-breast-cancer","display_name":"hormone receptor-positive HER2-negative breast cancer","score":0.8410000205039978},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8930000066757202},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":1.0},{"id":"https://openalex.org/keywords/serum-albumin","display_name":"serum albumin","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9271000027656555},{"id":"https://openalex.org/C2779744173","wikidata":"https://www.wikidata.org/wiki/Q15269707","display_name":"Palbociclib","level":5,"score":0.7537999749183655},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.7336999773979187},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7031999826431274},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6707000136375427},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.6668000221252441},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6236000061035156},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6194999814033508},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.4316999912261963},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.39660000801086426},{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.36309999227523804},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.3571999967098236},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3237000107765198},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.3084000051021576},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.30320000648498535},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.3001999855041504},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.2867000102996826},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.2831000089645386},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.27889999747276306},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.26980000734329224},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2696000039577484},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.25589999556541443},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.2551000118255615},{"id":"https://openalex.org/C126674687","wikidata":"https://www.wikidata.org/wiki/Q1662573","display_name":"Akaike information criterion","level":2,"score":0.25220000743865967},{"id":"https://openalex.org/C2780275930","wikidata":"https://www.wikidata.org/wiki/Q1628266","display_name":"Hormone therapy","level":4,"score":0.2515999972820282}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051358","descriptor_name":"Cyclin-Dependent Kinase 4","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051361","descriptor_name":"Cyclin-Dependent Kinase 6","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/curroncol33100582","doi":"https://doi.org/10.3390/curroncol33100582","is_oa":true,"landing_page_url":"https://doi.org/10.3390/curroncol33100582","pdf_url":null,"source":{"id":"https://openalex.org/S113449754","display_name":"Current Oncology","issn_l":"1198-0052","issn":["1198-0052","1718-7729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13703568","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13703568/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13703568/pdf/curroncol-33-00582.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Oncol","raw_type":"Text"},{"id":"pmid:42930149","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42930149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current oncology (Toronto, Ont.)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d0c291b588bc4afd8f3894fd426d70fb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d0c291b588bc4afd8f3894fd426d70fb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Oncology, Vol 33, Iss 10, p 582 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/curroncol33100582","doi":"https://doi.org/10.3390/curroncol33100582","is_oa":true,"landing_page_url":"https://doi.org/10.3390/curroncol33100582","pdf_url":null,"source":{"id":"https://openalex.org/S113449754","display_name":"Current Oncology","issn_l":"1198-0052","issn":["1198-0052","1718-7729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214799585.pdf","grobid_xml":"https://content.openalex.org/works/W7214799585.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1963697247","https://openalex.org/W1988902102","https://openalex.org/W2105370872","https://openalex.org/W2290950904","https://openalex.org/W2318725321","https://openalex.org/W2552099557","https://openalex.org/W2896846857","https://openalex.org/W2941737343","https://openalex.org/W2969958630","https://openalex.org/W3081745571","https://openalex.org/W3083198770","https://openalex.org/W3121669596","https://openalex.org/W3133509869","https://openalex.org/W3183813119","https://openalex.org/W3207557929","https://openalex.org/W4205756620","https://openalex.org/W4206666777","https://openalex.org/W4220709633","https://openalex.org/W4221128551","https://openalex.org/W4322743317","https://openalex.org/W4387865857","https://openalex.org/W4393935425","https://openalex.org/W4403545913","https://openalex.org/W4406919503","https://openalex.org/W4407378749","https://openalex.org/W4412065651","https://openalex.org/W4413270740","https://openalex.org/W4414035685","https://openalex.org/W4415815907","https://openalex.org/W7211884131"],"related_works":["https://openalex.org/W3092032531","https://openalex.org/W7161630604","https://openalex.org/W7203551490","https://openalex.org/W4402551314","https://openalex.org/W7134260675","https://openalex.org/W2890776561","https://openalex.org/W4396237547","https://openalex.org/W7155352833","https://openalex.org/W4412065651","https://openalex.org/W7070817718"],"abstract_inverted_index":{"Background:":[0],"CDK4/6":[1,60],"inhibitors":[2],"with":[3,96,128,159,183,234,241],"endocrine":[4,82],"therapy":[5,83],"are":[6,22,39],"standard":[7],"first-line":[8],"treatment":[9],"for":[10,106,248],"hormone":[11],"receptor-positive,":[12],"HER2-negative":[13],"metastatic":[14],"breast":[15],"cancer,":[16],"yet":[17],"simple":[18],"pretreatment":[19],"prognostic":[20],"markers":[21],"lacking.":[23],"The":[24],"LDH-to-albumin":[25],"ratio":[26],"(LAR)":[27],"and":[28,38,53,136,150,172,208,254],"the":[29,93,217],"Glasgow":[30],"Prognostic":[31],"Score":[32],"(GPS)":[33],"both":[34,66,118,235,249],"incorporate":[35],"serum":[36],"albumin":[37],"each":[40,121],"reported":[41],"as":[42],"prognostic,":[43],"but":[44,190,210],"have":[45],"not":[46,56,191,213,256],"been":[47,57],"compared":[48],"within":[49],"a":[50,123,142],"single":[51],"cohort,":[52],"LAR":[54,88,155],"has":[55],"examined":[58],"during":[59],"inhibitor":[61],"therapy.":[62],"This":[63],"study":[64],"evaluated":[65],"indices":[67,218,250],"in":[68,113],"this":[69],"setting.":[70],"Methods:":[71],"Consecutive":[72],"patients":[73],"(n":[74],"=":[75,188,196],"139)":[76],"receiving":[77],"palbociclib":[78],"or":[79],"ribociclib":[80],"plus":[81],"(2020\u20132025)":[84],"were":[85,132],"analysed":[86],"retrospectively.":[87],"was":[89,111,156,180,232,239,246],"modelled":[90],"continuously":[91],"on":[92],"logarithmic":[94],"scale,":[95],"hazard":[97],"ratios":[98],"per":[99,164],"doubling;":[100],"an":[101,228],"external":[102],"cut-off":[103],"(46.27)":[104],"served":[105],"Kaplan\u2013Meier":[107],"illustration":[108],"only.":[109],"GPS":[110,179,238],"calculated":[112],"its":[114],"original":[115],"form.":[116],"As":[117],"contain":[119],"albumin,":[120],"entered":[122],"separate":[124],"multivariable":[125],"Cox":[126],"model":[127],"identical":[129],"covariates.":[130],"Endpoints":[131],"overall":[133,242],"survival":[134,138,243],"(OS)":[135],"progression-free":[137],"(PFS).":[139],"Results:":[140],"Over":[141],"median":[143],"follow-up":[144],"of":[145],"50.0":[146],"months,":[147],"72":[148],"deaths":[149],"110":[151],"progression":[152],"events":[153],"occurred.":[154],"independently":[157,181],"associated":[158,182,233,240],"OS":[160,184],"(adjusted":[161],"HR":[162],"2.87":[163],"doubling,":[165],"95%":[166],"CI":[167],"1.78\u20134.62,":[168],"p":[169,176,187,195,222],"<":[170,177],"0.001)":[171],"PFS":[173,192],"(2.21,":[174],"1.45\u20133.35,":[175],"0.001).":[178],"(1.72,":[185],"1.05\u20132.82,":[186],"0.032)":[189],"(1.32,":[193],"0.88\u20131.98,":[194],"0.187).":[197],"LAR-based":[198],"models":[199],"had":[200],"lower":[201],"Akaike":[202],"information":[203],"criterion":[204],"values":[205],"(\u0394AIC":[206],"12.3":[207],"10.9),":[209],"concordance":[211],"did":[212,255],"differ":[214,257],"significantly":[215,258],"between":[216,259],"(\u0394C":[219],"\u2248":[220],"0.04,":[221],">":[223],"0.20).":[224],"Conclusions:":[225],"Baseline":[226],"LAR,":[227],"inexpensive":[229],"routine":[230],"index,":[231],"endpoints,":[236],"whereas":[237],"alone.":[244],"Discrimination":[245],"modest":[247],"(C-index":[251],"\u2264":[252],"0.61)":[253],"them.":[260],"External":[261],"validation":[262],"is":[263],"required.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-09-30T00:00:00"}