{"id":"https://openalex.org/W7214797635","doi":"https://doi.org/10.31083/jin52929","title":"Longitudinal Changes in Hippocampal-Default Mode Network Connectivity and Cognition During Electroacupuncture Intervention in Type 2 Diabetes-Associated Cognitive Decline: A Pilot Resting-State fMRI Study","display_name":"Longitudinal Changes in Hippocampal-Default Mode Network Connectivity and Cognition During Electroacupuncture Intervention in Type 2 Diabetes-Associated Cognitive Decline: A Pilot Resting-State fMRI Study","publication_year":2026,"publication_date":"2026-09-21","ids":{"openalex":"https://openalex.org/W7214797635","doi":"https://doi.org/10.31083/jin52929","pmid":"https://pubmed.ncbi.nlm.nih.gov/42811891"},"language":"en","primary_location":{"id":"doi:10.31083/jin52929","doi":"https://doi.org/10.31083/jin52929","is_oa":true,"landing_page_url":"https://doi.org/10.31083/jin52929","pdf_url":"https://storage.imrpress.com/IMR/2101963114489372700/application/1757-448X-25-9-52929.pdf","source":{"id":"https://openalex.org/S137215245","display_name":"Journal of Integrative Neuroscience","issn_l":"0219-6352","issn":["0219-6352","1757-448X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","medline","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Integrative Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://storage.imrpress.com/IMR/2101963114489372700/application/1757-448X-25-9-52929.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035585197","display_name":"Lin Yao","orcid":"https://orcid.org/0000-0002-5948-2249","observed_orcids":["https://orcid.org/0000-0002-5948-2249"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Yao","raw_affiliation_strings":["Institute of Acupuncture and Massage, Northeast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China"],"raw_orcid":"https://orcid.org/0000-0002-5948-2249","affiliations":[{"raw_affiliation_string":"Institute of Acupuncture and Massage, Northeast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100415398","display_name":"Mengyuan Li","orcid":"https://orcid.org/0000-0002-0039-6661","observed_orcids":["https://orcid.org/0000-0002-0039-6661"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng-yuan Li","raw_affiliation_strings":["Institute of Acupuncture and Massage, Northeast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China"],"raw_orcid":"https://orcid.org/0000-0002-0039-6661","affiliations":[{"raw_affiliation_string":"Institute of Acupuncture and Massage, Northeast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001014685","display_name":"Yanze Liu","orcid":"https://orcid.org/0000-0001-8858-8571","observed_orcids":["https://orcid.org/0000-0001-8858-8571"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-ze Liu","raw_affiliation_strings":["Acupuncture and Tuina Center, The Third Affiliated Clinical Hospital of Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China"],"raw_orcid":"https://orcid.org/0000-0001-8858-8571","affiliations":[{"raw_affiliation_string":"Acupuncture and Tuina Center, The Third Affiliated Clinical Hospital of Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048455507","display_name":"Jiazhen Cao","orcid":"https://orcid.org/0000-0002-2597-4106","observed_orcids":["https://orcid.org/0000-0002-2597-4106"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia-zhen Cao","raw_affiliation_strings":["College of nursing, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China"],"raw_orcid":"https://orcid.org/0000-0002-2597-4106","affiliations":[{"raw_affiliation_string":"College of nursing, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127972035","display_name":"Zheng Lian","orcid":"https://orcid.org/0009-0009-3132-3762","observed_orcids":["https://orcid.org/0009-0009-3132-3762"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Lian","raw_affiliation_strings":["College of Acupuncture and Massage, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China"],"raw_orcid":"https://orcid.org/0009-0009-3132-3762","affiliations":[{"raw_affiliation_string":"College of Acupuncture and Massage, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055709760","display_name":"Zhu Hong-nan","orcid":"https://orcid.org/0009-0004-0704-5997","observed_orcids":["https://orcid.org/0009-0004-0704-5997"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-nan Zhu","raw_affiliation_strings":["College of Acupuncture and Massage, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China"],"raw_orcid":"https://orcid.org/0009-0004-0704-5997","affiliations":[{"raw_affiliation_string":"College of Acupuncture and Massage, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035342939","display_name":"Haipeng Huang","orcid":"https://orcid.org/0000-0001-5375-7558","observed_orcids":["https://orcid.org/0000-0001-5375-7558"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai-peng Huang","raw_affiliation_strings":["College of Acupuncture and Massage, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China"],"raw_orcid":"https://orcid.org/0000-0001-5375-7558","affiliations":[{"raw_affiliation_string":"College of Acupuncture and Massage, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111232160","display_name":"Zhen Zhong","orcid":"https://orcid.org/0000-0002-9956-5671","observed_orcids":["https://orcid.org/0000-0002-9956-5671"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhen Zhong","raw_affiliation_strings":["College of Acupuncture and Massage, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China"],"raw_orcid":"https://orcid.org/0000-0002-9956-5671","affiliations":[{"raw_affiliation_string":"College of Acupuncture and Massage, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210128075"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100674672","display_name":"Hongfeng Wang","orcid":"https://orcid.org/0000-0002-3147-5581","observed_orcids":["https://orcid.org/0000-0002-3147-5581"]},"institutions":[{"id":"https://openalex.org/I4210128075","display_name":"Changchun University of Chinese Medicine","ror":"https://ror.org/035cyhw15","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128075"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hong-feng Wang","raw_affiliation_strings":["College of Acupuncture and Massage, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China"],"raw_orcid":"https://orcid.org/0000-0002-3147-5581","affiliations":[{"raw_affiliation_string":"College of Acupuncture and Massage, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210128075"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100674672","https://openalex.org/A5111232160"],"corresponding_institution_ids":["https://openalex.org/I4210128075"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"9","first_page":"52929","last_page":"52929"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.05869999900460243,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8790000081062317},{"id":"https://openalex.org/keywords/diabetes-associated-cognitive-decline","display_name":"diabetes-associated cognitive decline","score":0.8870000243186951},{"id":"https://openalex.org/keywords/electroacupuncture","display_name":"electroacupuncture","score":0.9800000190734863},{"id":"https://openalex.org/keywords/resting-state-functional-connectivity","display_name":"resting-state functional connectivity","score":0.8690000176429749},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8140000104904175},{"id":"https://openalex.org/keywords/default-mode-network","display_name":"default mode network","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.4580000042915344},{"id":"https://openalex.org/keywords/executive-function","display_name":"executive function","score":0.824999988079071},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.9049999713897705},{"id":"https://openalex.org/keywords/anterior-hippocampus","display_name":"anterior hippocampus","score":0.6110000014305115},{"id":"https://openalex.org/keywords/posterior-hippocampus","display_name":"posterior hippocampus","score":0.8920000195503235},{"id":"https://openalex.org/keywords/angular-gyrus","display_name":"angular gyrus","score":0.7889999747276306},{"id":"https://openalex.org/keywords/middle-occipital-gyrus","display_name":"middle occipital gyrus","score":0.878000020980835},{"id":"https://openalex.org/keywords/flanker-task","display_name":"flanker task","score":0.5249999761581421},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.5899999737739563},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9929999709129333},{"id":"https://openalex.org/keywords/non-pharmacological-treatment","display_name":"non-pharmacological treatment","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C141516989","wikidata":"https://www.wikidata.org/wiki/Q1182555","display_name":"Default mode network","level":3,"score":0.7829999923706055},{"id":"https://openalex.org/C2776632958","wikidata":"https://www.wikidata.org/wiki/Q6906262","display_name":"Montreal Cognitive Assessment","level":4,"score":0.71670001745224},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6952999830245972},{"id":"https://openalex.org/C2776202274","wikidata":"https://www.wikidata.org/wiki/Q11784952","display_name":"Electroacupuncture","level":4,"score":0.6626999974250793},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.6150000095367432},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.5537999868392944},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5115000009536743},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.5015000104904175},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.48969998955726624},{"id":"https://openalex.org/C2780621315","wikidata":"https://www.wikidata.org/wiki/Q5407200","display_name":"Middle temporal gyrus","level":3,"score":0.4503999948501587},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.4262999892234802},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.3910999894142151},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.35589998960494995},{"id":"https://openalex.org/C2778811784","wikidata":"https://www.wikidata.org/wiki/Q956517","display_name":"Postcentral gyrus","level":3,"score":0.3546999990940094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3546000123023987},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.3506999909877777},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.33959999680519104},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3379000127315521},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.33410000801086426},{"id":"https://openalex.org/C2778402161","wikidata":"https://www.wikidata.org/wiki/Q2121931","display_name":"Anterior cingulate cortex","level":3,"score":0.3246000111103058},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.32120001316070557},{"id":"https://openalex.org/C83849319","wikidata":"https://www.wikidata.org/wiki/Q7295720","display_name":"Rating scale","level":2,"score":0.32019999623298645},{"id":"https://openalex.org/C2777470907","wikidata":"https://www.wikidata.org/wiki/Q1038781","display_name":"Angular gyrus","level":3,"score":0.30329999327659607},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.29980000853538513},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.29019999504089355},{"id":"https://openalex.org/C2778739829","wikidata":"https://www.wikidata.org/wiki/Q17027611","display_name":"Hospital Anxiety and Depression Scale","level":3,"score":0.27970001101493835},{"id":"https://openalex.org/C120843803","wikidata":"https://www.wikidata.org/wiki/Q4955807","display_name":"Brain activity and meditation","level":3,"score":0.2793000042438507},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.2784000039100647},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.273499995470047},{"id":"https://openalex.org/C2778818304","wikidata":"https://www.wikidata.org/wiki/Q1819478","display_name":"Rehabilitation","level":2,"score":0.27239999175071716},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2687999904155731},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.2676999866962433},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.2667999863624573},{"id":"https://openalex.org/C2779991468","wikidata":"https://www.wikidata.org/wiki/Q3063753","display_name":"Middle frontal gyrus","level":3,"score":0.2653999924659729},{"id":"https://openalex.org/C2776466505","wikidata":"https://www.wikidata.org/wiki/Q385555","display_name":"Hamilton Rating Scale for Depression","level":4,"score":0.26179999113082886},{"id":"https://openalex.org/C2778733324","wikidata":"https://www.wikidata.org/wiki/Q2998088","display_name":"Posterior cingulate","level":3,"score":0.2572999894618988},{"id":"https://openalex.org/C2909801347","wikidata":"https://www.wikidata.org/wiki/Q5141214","display_name":"Cognitive Intervention","level":3,"score":0.25679999589920044},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.251800000667572}],"mesh":[{"descriptor_ui":"D000082702","descriptor_name":"Default Mode Network","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000082702","descriptor_name":"Default Mode Network","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000099312","descriptor_name":"Cognitive Enhancement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015671","descriptor_name":"Electroacupuncture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D063132","descriptor_name":"Connectome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.31083/jin52929","doi":"https://doi.org/10.31083/jin52929","is_oa":true,"landing_page_url":"https://doi.org/10.31083/jin52929","pdf_url":"https://storage.imrpress.com/IMR/2101963114489372700/application/1757-448X-25-9-52929.pdf","source":{"id":"https://openalex.org/S137215245","display_name":"Journal of Integrative Neuroscience","issn_l":"0219-6352","issn":["0219-6352","1757-448X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","medline","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Integrative Neuroscience","raw_type":"journal-article"},{"id":"pmid:42811891","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42811891","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of integrative neuroscience","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.31083/jin52929","doi":"https://doi.org/10.31083/jin52929","is_oa":true,"landing_page_url":"https://doi.org/10.31083/jin52929","pdf_url":"https://storage.imrpress.com/IMR/2101963114489372700/application/1757-448X-25-9-52929.pdf","source":{"id":"https://openalex.org/S137215245","display_name":"Journal of Integrative Neuroscience","issn_l":"0219-6352","issn":["0219-6352","1757-448X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","medline","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311754","host_organization_name":"Imperial College Press","host_organization_lineage":["https://openalex.org/P4310311754"],"host_organization_lineage_names":["Imperial College Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Integrative Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G2604623120","display_name":null,"funder_award_id":"82074548","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3310096939","display_name":null,"funder_award_id":"YDZJ202401680ZYTS","funder_id":"https://openalex.org/F4320310121","funder_display_name":"Natural Science Foundation of Jilin Province"}],"funders":[{"id":"https://openalex.org/F4320310121","display_name":"Natural Science Foundation of Jilin Province","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214797635.pdf","grobid_xml":"https://content.openalex.org/works/W7214797635.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1987599891","https://openalex.org/W1990134753","https://openalex.org/W1991771535","https://openalex.org/W2000697043","https://openalex.org/W2008138994","https://openalex.org/W2108052506","https://openalex.org/W2110772266","https://openalex.org/W2117101773","https://openalex.org/W2132049928","https://openalex.org/W2133492826","https://openalex.org/W2134305330","https://openalex.org/W2135176444","https://openalex.org/W2144138308","https://openalex.org/W2165758561","https://openalex.org/W2168434488","https://openalex.org/W2169463832","https://openalex.org/W2170182466","https://openalex.org/W2534656414","https://openalex.org/W2597348720","https://openalex.org/W2766936425","https://openalex.org/W2889843430","https://openalex.org/W2923093269","https://openalex.org/W3028012765","https://openalex.org/W3118912716","https://openalex.org/W3130052667","https://openalex.org/W3172677681","https://openalex.org/W3179426622","https://openalex.org/W4210514750","https://openalex.org/W4224021938","https://openalex.org/W4235479662","https://openalex.org/W4295750005","https://openalex.org/W4296579330","https://openalex.org/W4310223491","https://openalex.org/W4312064760","https://openalex.org/W4313639242","https://openalex.org/W4327844772","https://openalex.org/W4361190072","https://openalex.org/W4380763283","https://openalex.org/W4381799391","https://openalex.org/W4385971392","https://openalex.org/W4386222366","https://openalex.org/W4386752693","https://openalex.org/W4387357769","https://openalex.org/W4387477557","https://openalex.org/W4387504306","https://openalex.org/W4388007469","https://openalex.org/W4389043362","https://openalex.org/W4394565912","https://openalex.org/W4394570779","https://openalex.org/W4400087679","https://openalex.org/W4402723008","https://openalex.org/W4403158306","https://openalex.org/W4403638245","https://openalex.org/W4404844069","https://openalex.org/W4406882187","https://openalex.org/W4409054676","https://openalex.org/W4412753507","https://openalex.org/W4417523995"],"related_works":["https://openalex.org/W4389801383","https://openalex.org/W3036272231","https://openalex.org/W4402723008","https://openalex.org/W2066669089","https://openalex.org/W2316660397","https://openalex.org/W4283583048","https://openalex.org/W4385544892","https://openalex.org/W4390884418","https://openalex.org/W4393990291","https://openalex.org/W4309684933"],"abstract_inverted_index":{"Background:":[0],"Type":[1],"2":[2,107],"diabetes":[3,108],"mellitus-associated":[4],"cognitive":[5,28,330],"dysfunction":[6],"(T2DACD)":[7],"is":[8],"strongly":[9],"linked":[10],"to":[11,104,152,159,201,306,381],"disruption":[12],"of":[13,346,369],"cognition-supporting":[14],"brain":[15],"networks.":[16],"Electroacupuncture":[17],"(EA)":[18],"has":[19],"increasingly":[20],"been":[21,41],"examined":[22],"as":[23,316,362],"a":[24,112,370],"nonpharmacological":[25],"intervention":[26,207,339],"targeting":[27],"impairment;":[29],"however,":[30],"the":[31,186,206,242,250,347,352,357,384],"longitudinal":[32,146,191],"neurobiological":[33],"patterns":[34],"accompanying":[35],"EA":[36,338],"in":[37,52,66,263,273,282,329,340,395],"T2DACD":[38,84,100,171],"have":[39],"not":[40],"fully":[42],"characterized.":[43],"In":[44,320,344],"this":[45,72,321],"exploratory":[46,322],"pilot":[47,77,323],"study,":[48,324],"we":[49,79,325],"evaluated":[50],"alterations":[51,210,328,389],"resting-state":[53,136],"functional":[54,137],"connectivity":[55],"(RSFC)":[56],"across":[57],"hippocampal":[58],"subregions":[59],"and":[60,85,111,125,134,178,182,217,229,249,266,280,332,351,387,392],"default":[61],"mode":[62],"network":[63],"(DMN)":[64],"nodes":[65],"individuals":[67,82,169,341],"with":[68,83,161,170,189,342],"T2DACD.":[69,343],"Methods:":[70],"For":[71,293],"exploratory,":[73],"open-label,":[74,353],"non-randomized,":[75,354],"uncontrolled":[76,355],"investigation,":[78],"enrolled":[80],"20":[81],"26":[86],"healthy":[87],"controls":[88],"(HCs).":[89],"Longitudinal":[90],"analyses":[91,147,156,237],"included":[92],"15":[93,187],"participants":[94,160,188],"who":[95],"had":[96,179],"usable":[97,162],"post-treatment":[98],"data.":[99],"was":[101,285,304],"defined":[102],"according":[103,151],"clinical":[105,311],"type":[106],"mellitus":[109],"criteria,":[110],"Montreal":[113],"Cognitive":[114],"Assessment":[115],"(MoCA)":[116],"score":[117],"<26.":[118],"Patients":[119],"underwent":[120],"an":[121,336],"8-week":[122,337],"Adjust":[123],"Zang-fu":[124],"Arouse":[126],"Spirit":[127],"electroacupuncture":[128],"(AZASE)":[129],"intervention.":[130],"Cognitive,":[131],"emotional,":[132],"metabolic,":[133],"seed-based":[135],"magnetic":[138],"resonance":[139],"imaging":[140,155],"(rs-fMRI)":[141],"outcomes":[142,312,331],"were":[143,148,157,211],"evaluated.":[144],"Clinical":[145,397],"carried":[149],"out":[150],"protocol,":[153],"whereas":[154],"limited":[158],"scans":[163,259],"after":[164,290],"treatment.":[165],"Results:":[166],"At":[167],"baseline,":[168],"showed":[172],"lower":[173],"MoCA":[174,194],"scores":[175,195],"than":[176,366],"HCs":[177],"poorer":[180],"executive":[181],"working-memory":[183],"outcomes.":[184],"Among":[185],"complete":[190],"neuroimaging":[192,294],"data,":[193],"increased":[196],"from":[197],"23.27":[198],"\u00b1":[199,203],"1.71":[200],"26.07":[202],"1.53":[204],"over":[205,335],"period.":[208],"Within-group":[209],"observed":[212,385],"for":[213,241,308],"Flanker-conflict":[214],"reaction":[215,220,223],"time":[216],"accuracy,":[218],"Stroop-conflict":[219,283],"time,":[221,224],"1-back":[222],"Self-Rating":[225],"Anxiety":[226],"Scale":[227,233],"score,":[228],"Hamilton":[230],"Depression":[231],"Rating":[232],"score.":[234],"Omnibus":[235],"group":[236],"detected":[238],"significant":[239,289],"effects":[240],"left":[243,251,274],"anterior":[244,275],"hippocampus-left":[245,276],"angular":[246,277],"gyrus":[247,256,278],"connection":[248],"posterior":[252],"hippocampus-right":[253],"middle":[254],"occipital":[255],"connection.":[257],"Post-treatment":[258],"demonstrated":[260],"reduced":[261],"RSFC":[262,279],"several":[264],"hippocampal-DMN":[265,333],"intra-DMN":[267],"connections.":[268],"The":[269],"association":[270],"between":[271],"change":[272,281],"performance":[284],"no":[286],"longer":[287],"statistically":[288],"Bonferroni":[291],"correction.":[292],"outcomes,":[295],"cluster-level":[296],"family-wise":[297],"error":[298],"(FWE)":[299],"correction":[300],"(p":[301],"<":[302],"0.05)":[303],"applied":[305],"control":[307],"multiple":[309],"comparisons;":[310],"are":[313,390],"reported":[314],"descriptively":[315],"hypothesis-generating":[317,363],"findings.":[318],"Conclusions:":[319],"identified":[326],"preliminary":[327],"connections":[334],"view":[345],"small":[348],"sample":[349],"size":[350],"design,":[356],"findings":[358],"should":[359],"be":[360,379],"interpreted":[361],"observations":[364],"rather":[365],"definitive":[367],"evidence":[368],"specific":[371],"causal":[372],"treatment":[373],"effect.":[374],"Larger":[375],"controlled":[376],"studies":[377],"will":[378],"needed":[380],"determine":[382],"whether":[383],"neural":[386],"behavioral":[388],"reproducible":[391],"clinically":[393],"meaningful":[394],"practice.":[396],"Trial":[398],"Registration:":[399],"No:":[400],"ChiCTR2000040268,":[401],"https://www.chictr.org.cn/hvshowproject.html?id=76145&v=1.3.":[402]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-30T00:00:00"}
