{"id":"https://openalex.org/W7214791001","doi":"https://doi.org/10.64898/2026.09.29.755255","title":"A family of metabolite damage-control phosphatases modulates ROS-induced autophagy and plant stress resilience","display_name":"A family of metabolite damage-control phosphatases modulates ROS-induced autophagy and plant stress resilience","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7214791001","doi":"https://doi.org/10.64898/2026.09.29.755255"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.29.755255","doi":"https://doi.org/10.64898/2026.09.29.755255","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.29.755255","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.29.755255.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.29.755255.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079081015","display_name":"Florentine Ballhaus","orcid":"https://orcid.org/0000-0002-6496-0102","observed_orcids":["https://orcid.org/0000-0002-6496-0102"]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Florentine Ballhaus","raw_affiliation_strings":["Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-6496-0102","affiliations":[{"raw_affiliation_string":"Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077909615","display_name":"Viviana Vella","orcid":"https://orcid.org/0000-0003-1000-3443","observed_orcids":["https://orcid.org/0000-0003-1000-3443"]},"institutions":[{"id":"https://openalex.org/I162608824","display_name":"University of Sussex","ror":"https://ror.org/00ayhx656","country_code":"GB","type":"education","lineage":["https://openalex.org/I162608824"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Viviana Vella","raw_affiliation_strings":["Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK","institution_ids":["https://openalex.org/I162608824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005148007","display_name":"Yong Zou","orcid":"https://orcid.org/0000-0002-7774-2243","observed_orcids":["https://orcid.org/0000-0002-7774-2243"]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Yong Zou","raw_affiliation_strings":["Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-7774-2243","affiliations":[{"raw_affiliation_string":"Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083393162","display_name":"Glenn R. Hicks","orcid":"https://orcid.org/0000-0002-2502-7782","observed_orcids":["https://orcid.org/0000-0002-2502-7782"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Glenn R Hicks","raw_affiliation_strings":["Department of Botany and Plant Sciences, University of California, Riverside, California, 92521","Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany and Plant Sciences, University of California, Riverside, California, 92521","institution_ids":["https://openalex.org/I103635307"]},{"raw_affiliation_string":"Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032794869","display_name":"Jacob J. Whittaker","orcid":"https://orcid.org/0000-0001-8966-111X","observed_orcids":["https://orcid.org/0000-0001-8966-111X"]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jacob Whittaker","raw_affiliation_strings":["Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-8966-111X","affiliations":[{"raw_affiliation_string":"Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013156401","display_name":"Adrian Su\u00e1rez Covarrubias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Adrian Suarez Covarrubias","raw_affiliation_strings":["Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004266252","display_name":"Flavio Ballante","orcid":"https://orcid.org/0000-0002-4831-3423","observed_orcids":["https://orcid.org/0000-0002-4831-3423"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Flavio Ballante","raw_affiliation_strings":["Chemical Biology Consortium Sweden (CBCS), Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-4831-3423","affiliations":[{"raw_affiliation_string":"Chemical Biology Consortium Sweden (CBCS), Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034090859","display_name":"Ali Ata Moazzami","orcid":"https://orcid.org/0000-0003-0994-3972","observed_orcids":["https://orcid.org/0000-0003-0994-3972"]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ali Moazzami","raw_affiliation_strings":["Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005333248","display_name":"Igor Sablji\u0107","orcid":"https://orcid.org/0000-0001-9044-2678","observed_orcids":["https://orcid.org/0000-0001-9044-2678"]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Igor Sabljic","raw_affiliation_strings":["Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-9044-2678","affiliations":[{"raw_affiliation_string":"Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153504786","display_name":"Mary A Nishiotis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mary A Nishiotis","raw_affiliation_strings":["Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004153707","display_name":"Annette Roos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anette Roos","raw_affiliation_strings":["Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structural Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structural Biology","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050308841","display_name":"Selvaraju Kanagarajan","orcid":"https://orcid.org/0000-0003-4341-9322","observed_orcids":["https://orcid.org/0000-0003-4341-9322"]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Selvaraju Kanagarajan","raw_affiliation_strings":["Department of Plant Breeding, Swedish University of Agricultural Sciences, Lomma, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-4341-9322","affiliations":[{"raw_affiliation_string":"Department of Plant Breeding, Swedish University of Agricultural Sciences, Lomma, Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078318184","display_name":"Stina Berglund Fick","orcid":"https://orcid.org/0000-0003-4968-8830","observed_orcids":["https://orcid.org/0000-0003-4968-8830"]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Stina Berglund-Fick","raw_affiliation_strings":["Chemical Biology Consortium Sweden, Umea University, 901 87 Umea, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology Consortium Sweden, Umea University, 901 87 Umea, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153534803","display_name":"Weixing Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Weixing Qian","raw_affiliation_strings":["Chemical Biology Consortium Sweden, Umea University, 901 87 Umea, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology Consortium Sweden, Umea University, 901 87 Umea, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046804003","display_name":"Gustav Nestor","orcid":"https://orcid.org/0000-0001-8372-8811","observed_orcids":["https://orcid.org/0000-0001-8372-8811"]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gustav Nestor","raw_affiliation_strings":["Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014154714","display_name":"Peter V. Bozhkov","orcid":"https://orcid.org/0000-0002-8819-3884","observed_orcids":["https://orcid.org/0000-0002-8819-3884"]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Peter V Bozhkov","raw_affiliation_strings":["Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-8819-3884","affiliations":[{"raw_affiliation_string":"Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001107522","display_name":"Elena A. Minina","orcid":"https://orcid.org/0000-0002-2619-1859","observed_orcids":["https://orcid.org/0000-0002-2619-1859"]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Elena A Minina","raw_affiliation_strings":["Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden","Department of Plant Biology, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-2619-1859","affiliations":[{"raw_affiliation_string":"Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]},{"raw_affiliation_string":"Department of Plant Biology, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041095587","display_name":"Adrian N. Dauphinee","orcid":"https://orcid.org/0000-0002-3363-198X","observed_orcids":["https://orcid.org/0000-0002-3363-198X"]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Adrian N Dauphinee","raw_affiliation_strings":["Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-3363-198X","affiliations":[{"raw_affiliation_string":"Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5041095587"],"corresponding_institution_ids":["https://openalex.org/I298625061"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10014","display_name":"Plant Stress Responses and Tolerance","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.7870000004768372},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.925000011920929},{"id":"https://openalex.org/keywords/plant-stress-tolerance","display_name":"plant stress tolerance","score":0.7459999918937683},{"id":"https://openalex.org/keywords/chemical-genetics","display_name":"chemical genetics","score":0.6859999895095825},{"id":"https://openalex.org/keywords/ros-scavenging","display_name":"reactive oxygen species scavenging","score":0.6710000038146973},{"id":"https://openalex.org/keywords/autophagic-flux","display_name":"autophagic flux","score":0.6660000085830688},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.8109999895095825},{"id":"https://openalex.org/keywords/chlamydomonas-reinhardtii","display_name":"Chlamydomonas reinhardtii","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protein-crystal-structure","display_name":"protein crystal structure","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.845300018787384},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7890999913215637},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.7386999726295471},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6154999732971191},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5996999740600586},{"id":"https://openalex.org/C2775988993","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Arabidopsis thaliana","level":4,"score":0.5203999876976013},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4830000102519989},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4374000132083893},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.37610000371932983},{"id":"https://openalex.org/C143840085","wikidata":"https://www.wikidata.org/wiki/Q5008102","display_name":"C2 domain","level":3,"score":0.34599998593330383},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3359000086784363},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31779998540878296},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.3156999945640564},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.303600013256073},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.2797999978065491},{"id":"https://openalex.org/C99089365","wikidata":"https://www.wikidata.org/wiki/Q18034356","display_name":"BAG3","level":4,"score":0.2741999924182892},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.2578999996185303},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.25780001282691956},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2522999942302704},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.2515999972820282},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.25049999356269836}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.29.755255","doi":"https://doi.org/10.64898/2026.09.29.755255","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.29.755255","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.29.755255.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.29.755255","doi":"https://doi.org/10.64898/2026.09.29.755255","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.29.755255","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.29.755255.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1677966246","display_name":null,"funder_award_id":"2017-00541","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G1763071280","display_name":"Manipulating autophagy to increase plant productivity","funder_award_id":"2017-00541","funder_id":"https://openalex.org/F4320321033","funder_display_name":"Svenska Forskningsr\u00e5det Formas"},{"id":"https://openalex.org/G2575420132","display_name":"AutoMods: Improving plant fitness and health using chemical genetics","funder_award_id":"2023-00756","funder_id":"https://openalex.org/F4320321033","funder_display_name":"Svenska Forskningsr\u00e5det Formas"},{"id":"https://openalex.org/G2576209410","display_name":"Structure-function understanding of stress granules in plants","funder_award_id":"2019-04250","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G4757375099","display_name":"SwedNMR - a national NMR research infrastructure","funder_award_id":"2021-00167","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G4772758129","display_name":"Modulating Autophagy: New Strategies Toward Improved Crop Fitness and Health","funder_award_id":"2019-01565","funder_id":"https://openalex.org/F4320321033","funder_display_name":"Svenska Forskningsr\u00e5det Formas"},{"id":"https://openalex.org/G7846539133","display_name":"Plant autophagy for sustainable agriculture","funder_award_id":"2021-01812","funder_id":"https://openalex.org/F4320321033","funder_display_name":"Svenska Forskningsr\u00e5det Formas"},{"id":"https://openalex.org/G8108643814","display_name":"Chemical Biology Consortium Sweden","funder_award_id":"2021-00179","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320321033","display_name":"Svenska Forskningsr\u00e5det Formas","ror":"https://ror.org/03pjs1y45"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320322582","display_name":"Sveriges Lantbruksuniversitet","ror":"https://ror.org/02yy8x990"},{"id":"https://openalex.org/F4320325677","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214791001.pdf","grobid_xml":"https://content.openalex.org/works/W7214791001.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1693708315","https://openalex.org/W1976499671","https://openalex.org/W1977738681","https://openalex.org/W1987566410","https://openalex.org/W1988437166","https://openalex.org/W1999118725","https://openalex.org/W2013083986","https://openalex.org/W2035913075","https://openalex.org/W2036301709","https://openalex.org/W2038840577","https://openalex.org/W2039607936","https://openalex.org/W2042129725","https://openalex.org/W2042610900","https://openalex.org/W2045981379","https://openalex.org/W2049519537","https://openalex.org/W2054580728","https://openalex.org/W2059652492","https://openalex.org/W2065674587","https://openalex.org/W2079140917","https://openalex.org/W2082804080","https://openalex.org/W2095000965","https://openalex.org/W2098539276","https://openalex.org/W2101941714","https://openalex.org/W2116122104","https://openalex.org/W2126386203","https://openalex.org/W2130479394","https://openalex.org/W2143794875","https://openalex.org/W2147122257","https://openalex.org/W2154836325","https://openalex.org/W2161605421","https://openalex.org/W2163341755","https://openalex.org/W2164999339","https://openalex.org/W2471994457","https://openalex.org/W2592085627","https://openalex.org/W2767308399","https://openalex.org/W2789450022","https://openalex.org/W2789812805","https://openalex.org/W2793437376","https://openalex.org/W2804822363","https://openalex.org/W2883578019","https://openalex.org/W2895791964","https://openalex.org/W2911116916","https://openalex.org/W2911863753","https://openalex.org/W2914080388","https://openalex.org/W2929174894","https://openalex.org/W2971778440","https://openalex.org/W3007314065","https://openalex.org/W3010491320","https://openalex.org/W3024267519","https://openalex.org/W3042846456","https://openalex.org/W3106357440","https://openalex.org/W3108936441","https://openalex.org/W3189596786","https://openalex.org/W3200045332","https://openalex.org/W4205542864","https://openalex.org/W4221080430","https://openalex.org/W4248872320","https://openalex.org/W4283575177","https://openalex.org/W4288051653","https://openalex.org/W4390141734","https://openalex.org/W4391026543","https://openalex.org/W4391813929","https://openalex.org/W4399298271","https://openalex.org/W4404458588","https://openalex.org/W4406015631","https://openalex.org/W4408808857","https://openalex.org/W4414341141","https://openalex.org/W7140743103"],"related_works":["https://openalex.org/W7220747029","https://openalex.org/W2006951543","https://openalex.org/W3140626781","https://openalex.org/W4413337613","https://openalex.org/W7116908387","https://openalex.org/W4408542676","https://openalex.org/W2141284723","https://openalex.org/W2768076855","https://openalex.org/W2290890598","https://openalex.org/W2561170825"],"abstract_inverted_index":{"Abstract":[0],"Autophagy":[1],"is":[2,92,186],"an":[3,37,46],"intracellular":[4],"recycling":[5],"pathway":[6],"with":[7,158],"profound":[8],"impacts":[9,266],"on":[10,103,267],"development,":[11],"growth,":[12],"and":[13,135,165,175,204,211,219,230,247],"stress":[14,241,269],"tolerance":[15,203,270],"in":[16,47,52,106,131,147,173,191,200,207],"eukaryotes.":[17],"Therefore,":[18],"unravelling":[19],"signalling":[20],"mechanisms":[21],"that":[22,84,114,144,216,242],"modulate":[23],"the":[24,116,132,141,159,166,239],"process":[25],"has":[26],"broad":[27],"applicability.":[28],"Here,":[29],"we":[30,56,69],"characterised":[31],"a":[32,137,179,189],"small":[33],"organic":[34],"molecule":[35],"as":[36,65,74],"enhancer":[38],"of":[39,59,120,129,222,227,235,261],"autophagy":[40,90,184,258],"across":[41],"diverse":[42],"plant":[43,268],"lineages.":[44],"Through":[45],"vivo":[48],"photoaffinity":[49],"proteomics":[50],"approach":[51,255],"Arabidopsis":[53,174,208],"thaliana":[54],"seedlings,":[55],"identified":[57],"Domain":[58],"Unknown":[60],"Function":[61],"89":[62],"(DUF89)":[63],"proteins":[64,73],"molecular":[66],"targets.":[67],"Hereafter,":[68],"refer":[70],"to":[71,98,188,225,238],"these":[72],"Reactive":[75],"Metabolite":[76],"Damage-Control":[77],"Phosphatases":[78],"(RMDPs),":[79],"which":[80,265],"are":[81],"metabolite-repair":[82],"phosphatases":[83],"clear":[85],"reactive":[86,192],"products.":[87],"The":[88,182],"new":[89],"modulator":[91],"called":[93],"RMDP":[94,223,236,262],"inhbitor-1":[95],"(RMDPi-1)":[96],"due":[97],"its":[99],"demonstrated":[100],"inhibitory":[101],"effect":[102],"AtRMDP1":[104,121],"activity":[105,237],"vitro.":[107],"Binding":[108],"was":[109,145],"further":[110],"confirmed":[111],"through":[112],"co-incubation":[113],"thermostabilised":[115],"protein.":[117],"Crystal":[118],"structures":[119],"were":[122],"obtained":[123],"via":[124,259,271],"X-ray":[125],"diffraction,":[126],"confirming":[127],"binding":[128,142,155],"RMDPi-1":[130,163],"catalytic":[133],"site":[134],"revealing":[136],"flexible":[138],"region":[139],"near":[140],"pocket":[143],"absent":[146],"previous":[148],"models.":[149],"Molecular":[150],"docking":[151],"predicted":[152],"two":[153],"possible":[154],"modes":[156],"consistent":[157],"observed":[160,183],"electron":[161],"density.":[162],"treatment":[164],"phosphatase":[167],"gene":[168],"knockout":[169,197],"increased":[170],"autophagic":[171],"flux":[172],"Chlamydomonas":[176],"reinhardtii,":[177],"establishing":[178],"conserved":[180,272],"effect.":[181],"response":[185],"linked":[187],"spike":[190],"oxygen":[193],"species":[194],"(ROS).":[195],"AtRMDP":[196],"also":[198],"results":[199],"higher":[201],"ROS":[202,240],"greater":[205],"biomass":[206],"seedlings.":[209],"Targeted":[210],"untargeted":[212],"metabolomic":[213],"experiments":[214],"revealed":[215],"both":[217],"pharmacological":[218],"genetic":[220],"suppression":[221],"leads":[224],"accumulation":[226],"glycating":[228],"agents":[229],"phosphate":[231],"sugars,":[232],"associating":[233],"loss":[234],"induces":[243],"alternate":[244],"ROS-scavenging":[245],"mechanisms,":[246],"autophagy.":[248],"Taken":[249],"together,":[250],"our":[251],"integrated":[252],"chemical":[253],"genetics":[254],"reveals":[256],"enhanced":[257],"inhibition":[260],"family":[263],"members,":[264],"metabolite":[273],"damage-control":[274],"functions.":[275]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-30T00:00:00"}
