{"id":"https://openalex.org/W7214775327","doi":"https://doi.org/10.64898/2026.09.23.752815","title":"HIV-1 prime-boost vaccination shapes distinct clonal trajectories and memory precursor states of Env- and Gag-specific T cells","display_name":"HIV-1 prime-boost vaccination shapes distinct clonal trajectories and memory precursor states of Env- and Gag-specific T cells","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7214775327","doi":"https://doi.org/10.64898/2026.09.23.752815","pmid":"https://pubmed.ncbi.nlm.nih.gov/42856183","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13648340"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.23.752815","doi":"https://doi.org/10.64898/2026.09.23.752815","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.23.752815","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.23.752815.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.23.752815.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025907714","display_name":"Guoyue Xu","orcid":"https://orcid.org/0000-0002-7699-8837","observed_orcids":["https://orcid.org/0000-0002-7699-8837"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guoyue Xu","raw_affiliation_strings":["Department of Global Health, University of Washington, Seattle, USA","Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA"],"raw_orcid":"https://orcid.org/0000-0002-7699-8837","affiliations":[{"raw_affiliation_string":"Department of Global Health, University of Washington, Seattle, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033096496","display_name":"Joshua X. Yee","orcid":"https://orcid.org/0000-0002-3661-2071","observed_orcids":["https://orcid.org/0000-0002-3661-2071"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua X. Yee","raw_affiliation_strings":["Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA"],"raw_orcid":"https://orcid.org/0000-0002-3661-2071","affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007409264","display_name":"Saskia Ilcisin","orcid":"https://orcid.org/0000-0002-1045-735X","observed_orcids":["https://orcid.org/0000-0002-1045-735X"]},"institutions":[{"id":"https://openalex.org/I4210104555","display_name":"Allen Institute for Immunology","ror":"https://ror.org/0154kn471","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210104555","https://openalex.org/I4210140341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saskia M. Ilcisin","raw_affiliation_strings":["Allen Institute for Immunology, Seattle, USA"],"raw_orcid":"https://orcid.org/0000-0002-1045-735X","affiliations":[{"raw_affiliation_string":"Allen Institute for Immunology, Seattle, USA","institution_ids":["https://openalex.org/I4210104555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041681695","display_name":"N Kaul","orcid":"https://orcid.org/0009-0001-8265-8169","observed_orcids":["https://orcid.org/0009-0001-8265-8169"]},"institutions":[{"id":"https://openalex.org/I4210104555","display_name":"Allen Institute for Immunology","ror":"https://ror.org/0154kn471","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210104555","https://openalex.org/I4210140341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saransh N. Kaul","raw_affiliation_strings":["Allen Institute for Immunology, Seattle, USA"],"raw_orcid":"https://orcid.org/0009-0001-8265-8169","affiliations":[{"raw_affiliation_string":"Allen Institute for Immunology, Seattle, USA","institution_ids":["https://openalex.org/I4210104555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056092267","display_name":"Koshlan Mayer-Blackwell","orcid":"https://orcid.org/0000-0002-1652-4023","observed_orcids":["https://orcid.org/0000-0002-1652-4023"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koshlan Mayer-Blackwell","raw_affiliation_strings":["Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA"],"raw_orcid":"https://orcid.org/0000-0002-1652-4023","affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099012576","display_name":"Ernest Moelhman","orcid":"https://orcid.org/0009-0006-7664-8091","observed_orcids":["https://orcid.org/0009-0006-7664-8091"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ernest Moelhman","raw_affiliation_strings":["Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077937026","display_name":"David Richard Glass","orcid":"https://orcid.org/0000-0001-9924-167X","observed_orcids":["https://orcid.org/0000-0001-9924-167X"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R. Glass","raw_affiliation_strings":["Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA"],"raw_orcid":"https://orcid.org/0000-0001-9924-167X","affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025724173","display_name":"Anastasia A. Minervina","orcid":"https://orcid.org/0000-0001-9884-6351","observed_orcids":["https://orcid.org/0000-0001-9884-6351"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anastasia A. Minervina","raw_affiliation_strings":["Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA"],"raw_orcid":"https://orcid.org/0000-0001-9884-6351","affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065306968","display_name":"Shelly Karuna","orcid":"https://orcid.org/0000-0001-5946-9733","observed_orcids":["https://orcid.org/0000-0001-5946-9733"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelly T. Karuna","raw_affiliation_strings":["Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA"],"raw_orcid":"https://orcid.org/0000-0001-5946-9733","affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087375152","display_name":"Magdalena E. Sobieszczyk","orcid":"https://orcid.org/0000-0002-7112-3118","observed_orcids":["https://orcid.org/0000-0002-7112-3118"]},"institutions":[{"id":"https://openalex.org/I157122930","display_name":"Aaron Diamond AIDS Research Center","ror":"https://ror.org/04jdq2t93","country_code":"US","type":"facility","lineage":["https://openalex.org/I157122930"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Magdalena E. Sobieszczyk","raw_affiliation_strings":["Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, USA","Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, USA"],"raw_orcid":"https://orcid.org/0000-0002-7112-3118","affiliations":[{"raw_affiliation_string":"Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, USA","institution_ids":["https://openalex.org/I157122930","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033798138","display_name":"Matthew R. Hart","orcid":"https://orcid.org/0000-0002-3260-5886","observed_orcids":["https://orcid.org/0000-0002-3260-5886"]},"institutions":[{"id":"https://openalex.org/I4210104555","display_name":"Allen Institute for Immunology","ror":"https://ror.org/0154kn471","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210104555","https://openalex.org/I4210140341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew R. Hart","raw_affiliation_strings":["Allen Institute for Immunology, Seattle, USA"],"raw_orcid":"https://orcid.org/0000-0002-3260-5886","affiliations":[{"raw_affiliation_string":"Allen Institute for Immunology, Seattle, USA","institution_ids":["https://openalex.org/I4210104555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005724506","display_name":"Paul Glyndwr Thomas","orcid":"https://orcid.org/0000-0001-7955-0256","observed_orcids":["https://orcid.org/0000-0001-7955-0256"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul G. Thomas","raw_affiliation_strings":["Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA"],"raw_orcid":"https://orcid.org/0000-0001-7955-0256","affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072662718","display_name":"Peter J. Skene","orcid":"https://orcid.org/0000-0001-8965-5326","observed_orcids":["https://orcid.org/0000-0001-8965-5326"]},"institutions":[{"id":"https://openalex.org/I4210104555","display_name":"Allen Institute for Immunology","ror":"https://ror.org/0154kn471","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210104555","https://openalex.org/I4210140341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Skene","raw_affiliation_strings":["Allen Institute for Immunology, Seattle, USA"],"raw_orcid":"https://orcid.org/0000-0001-8965-5326","affiliations":[{"raw_affiliation_string":"Allen Institute for Immunology, Seattle, USA","institution_ids":["https://openalex.org/I4210104555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108707946","display_name":"Stephen C. De Rosa","orcid":"https://orcid.org/0000-0003-3871-4618","observed_orcids":["https://orcid.org/0000-0003-3871-4618"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen C. De Rosa","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, University of Washington, Seattle, USA","Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA"],"raw_orcid":"https://orcid.org/0000-0003-3871-4618","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084520588","display_name":"M. Juliana McElrath","orcid":"https://orcid.org/0000-0003-2276-7117","observed_orcids":["https://orcid.org/0000-0003-2276-7117"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Juliana McElrath","raw_affiliation_strings":["Department of Global Health, University of Washington, Seattle, USA","Department of Medicine, University of Washington, Seattle, USA","Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA"],"raw_orcid":"https://orcid.org/0000-0003-2276-7117","affiliations":[{"raw_affiliation_string":"Department of Global Health, University of Washington, Seattle, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038421647","display_name":"Andrew J. Fiore-Gartland","orcid":"https://orcid.org/0000-0001-7627-2166","observed_orcids":["https://orcid.org/0000-0001-7627-2166"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Fiore-Gartland","raw_affiliation_strings":["Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA"],"raw_orcid":"https://orcid.org/0000-0001-7627-2166","affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060666271","display_name":"Evan William Newell","orcid":"https://orcid.org/0000-0002-2889-243X","observed_orcids":["https://orcid.org/0000-0002-2889-243X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Evan W. Newell","raw_affiliation_strings":["Department of Global Health, University of Washington, Seattle, USA","Department of Laboratory Medicine and Pathology, University of Washington, Seattle, USA","Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA"],"raw_orcid":"https://orcid.org/0000-0002-2889-243X","affiliations":[{"raw_affiliation_string":"Department of Global Health, University of Washington, Seattle, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5060666271"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210089486"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-vaccine","display_name":"HIV-1 vaccine","score":0.9179999828338623},{"id":"https://openalex.org/keywords/prime-boost-vaccination","display_name":"prime-boost vaccination","score":0.8460000157356262},{"id":"https://openalex.org/keywords/dna-prime","display_name":"DNA prime","score":0.5630000233650208},{"id":"https://openalex.org/keywords/cd8-t-cell-memory","display_name":"CD8+ T cell memory","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.6650000214576721},{"id":"https://openalex.org/keywords/clonal-expansion","display_name":"clonal expansion","score":0.9300000071525574}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7214000225067139},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6690999865531921},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.4876999855041504},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47699999809265137},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4715000092983246},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4611999988555908},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.45730000734329224},{"id":"https://openalex.org/C2777367678","wikidata":"https://www.wikidata.org/wiki/Q2304808","display_name":"Memory T cell","level":4,"score":0.45010000467300415},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.4059000015258789},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.396699994802475},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3939000070095062},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38260000944137573},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.3776000142097473},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32170000672340393},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31529998779296875},{"id":"https://openalex.org/C2991763054","wikidata":"https://www.wikidata.org/wiki/Q38103695","display_name":"Immunological memory","level":4,"score":0.31459999084472656},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3131999969482422},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3073999881744385},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2985999882221222},{"id":"https://openalex.org/C2776638159","wikidata":"https://www.wikidata.org/wiki/Q18343761","display_name":"Memory cell","level":4,"score":0.2969000041484833},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.28060001134872437},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.27320000529289246},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.25040000677108765}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.23.752815","doi":"https://doi.org/10.64898/2026.09.23.752815","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.23.752815","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.23.752815.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13648340","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648340/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648340/pdf/nihpp-2026.09.23.752815v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42856183","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42856183","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.09.23.752815","doi":"https://doi.org/10.64898/2026.09.23.752815","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.23.752815","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.23.752815.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1305388156","display_name":null,"funder_award_id":"P30CA015704","funder_id":"https://openalex.org/F4320308793","funder_display_name":"Fred Hutchinson Cancer Research Center"},{"id":"https://openalex.org/G2358037835","display_name":null,"funder_award_id":"AI-068618","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6714156533","display_name":null,"funder_award_id":"HIV-1","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8356847483","display_name":null,"funder_award_id":"UM1 AI068618","funder_id":"https://openalex.org/F4320308793","funder_display_name":"Fred Hutchinson Cancer Research Center"},{"id":"https://openalex.org/G9000165950","display_name":null,"funder_award_id":"AI068618","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000856781","display_name":"HIV Vaccine Trials Network Laboratory Center","funder_award_id":"UM1AI068618","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000859741","display_name":"Decoding the interactions between T cell receptors and peptide-MHC","funder_award_id":"R01AI136514","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000880613","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA015704","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000888389","display_name":"The roles of EBV-specific T cells in response to checkpoint blockade immunotherapy of EBV-driven nasopharyngeal carcinoma","funder_award_id":"R01CA264646","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000898953","display_name":"Immune Responses to Malaria, HIV and SARS-CoV-2 Infection and Immunization","funder_award_id":"U19AI128914","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000927039","display_name":null,"funder_award_id":"AI136514","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320308793","display_name":"Fred Hutchinson Cancer Research Center","ror":"https://ror.org/007ps6h72"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214775327.pdf","grobid_xml":"https://content.openalex.org/works/W7214775327.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1727208131","https://openalex.org/W1910012553","https://openalex.org/W1956539927","https://openalex.org/W1974433492","https://openalex.org/W2038599188","https://openalex.org/W2043496713","https://openalex.org/W2043793366","https://openalex.org/W2080568999","https://openalex.org/W2080720232","https://openalex.org/W2146375469","https://openalex.org/W2149551637","https://openalex.org/W2152048324","https://openalex.org/W2164147266","https://openalex.org/W2170904230","https://openalex.org/W2242638094","https://openalex.org/W2263060953","https://openalex.org/W2345073400","https://openalex.org/W2563681779","https://openalex.org/W2586387227","https://openalex.org/W2588064566","https://openalex.org/W2765584638","https://openalex.org/W2783789749","https://openalex.org/W2889239280","https://openalex.org/W2944986551","https://openalex.org/W2952324549","https://openalex.org/W2980897730","https://openalex.org/W3005830045","https://openalex.org/W3008885059","https://openalex.org/W3015447668","https://openalex.org/W3015538440","https://openalex.org/W3020888809","https://openalex.org/W3025534864","https://openalex.org/W3049615191","https://openalex.org/W3097190616","https://openalex.org/W3161548793","https://openalex.org/W4292259931","https://openalex.org/W4304091689","https://openalex.org/W4320710214","https://openalex.org/W4384155878","https://openalex.org/W4385637617","https://openalex.org/W4386923904","https://openalex.org/W4389389081","https://openalex.org/W4390876711","https://openalex.org/W4392563766","https://openalex.org/W4409207648","https://openalex.org/W4411737315","https://openalex.org/W4414788481","https://openalex.org/W4415629987","https://openalex.org/W4416339463"],"related_works":["https://openalex.org/W2053035745","https://openalex.org/W2152273943","https://openalex.org/W2031894834","https://openalex.org/W3217459667","https://openalex.org/W2735115013","https://openalex.org/W7070648036","https://openalex.org/W2046208891","https://openalex.org/W1998179482","https://openalex.org/W2147145711","https://openalex.org/W2017325329"],"abstract_inverted_index":{"Abstract":[0],"Despite":[1],"decades":[2],"of":[3,12,83,193],"HIV-1":[4,74,194],"vaccine":[5,64,183],"development,":[6],"the":[7,49,116,120,188],"clonal":[8,84,173],"and":[9,34,41,76,79,87,93,102,149,175,185,190],"cellular":[10,176,196],"determinants":[11],"durable":[13],"vaccine-induced":[14],"T":[15,26,45,96,147,168],"cell":[16,27,97,169],"memory":[17,43,90,122,131,170],"remain":[18],"incompletely":[19],"understood.":[20],"Here,":[21],"we":[22],"combined":[23],"antigen-":[24],"specific":[25,195],"receptor":[28],"(TCR)":[29],"identification,":[30],"longitudinal":[31],"TCR":[32],"sequencing,":[33],"single-cell":[35],"multi-":[36],"omics":[37],"to":[38,72,89,115,119],"characterize":[39],"Env-":[40,75,92],"Gag-specific":[42,77,94,117,150],"precursor":[44,123,132],"cells":[46,148],"elicited":[47],"by":[48],"HIV":[50],"Vaccine":[51],"Trials":[52],"Network":[53],"(HVTN)":[54],"505":[55],"DNA":[56,100],"prime\u2013recombinant":[57],"adenovirus":[58],"serotype":[59],"5":[60],"(rAd5)":[61],"boost":[62,104],"(DNA/rAd5)":[63],"regimen.":[65],"We":[66],"developed":[67],"a":[68,153],"generalizable":[69],"high-throughput":[70],"approach":[71],"identify":[73],"TCRs":[78],"found":[80],"distinct":[81,130,172],"patterns":[82],"expansion,":[85],"persistence,":[86],"contribution":[88],"between":[91],"CD8\u207a":[95,146,167],"responses.":[98],"The":[99],"prime":[101],"rAd5":[103],"differentially":[105],"shaped":[106],"these":[107,158],"repertoires,":[108],"with":[109,134,171],"rAd5-induced":[110],"clones":[111],"contributing":[112],"proportionally":[113],"more":[114],"than":[118],"Env-specific":[121,135],"compartment.":[124],"Single-cell":[125],"immune":[126],"profiling":[127],"further":[128],"revealed":[129],"states,":[133],"responses":[136,151],"enriched":[137],"for":[138],"GZMB":[139],"+":[140,142],"PRF1":[141],"cytotoxic":[143],"effector-memory":[144],"(EM)":[145],"containing":[152],"larger":[154],"cycling/proliferative":[155],"population.":[156],"Together,":[157],"findings":[159],"demonstrate":[160],"that":[161],"heterologous":[162],"DNA/rAd5":[163],"vaccination":[164],"generates":[165],"antigen-specific":[166],"trajectories":[174],"programs,":[177],"providing":[178],"new":[179],"insights":[180],"into":[181],"how":[182],"platform":[184],"antigen-specificity":[186],"shape":[187],"durability":[189],"functional":[191],"properties":[192],"immunity.":[197]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-30T00:00:00"}
