{"id":"https://openalex.org/W7214770489","doi":"https://doi.org/10.3389/fcimb.2026.1930709","title":"Gut microbial dynamics and antibiotic resistance during rifaximin therapy in severe cirrhosis: a ProPILA-Rifax ancillary study","display_name":"Gut microbial dynamics and antibiotic resistance during rifaximin therapy in severe cirrhosis: a ProPILA-Rifax ancillary study","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7214770489","doi":"https://doi.org/10.3389/fcimb.2026.1930709","pmid":"https://pubmed.ncbi.nlm.nih.gov/42871147","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13658500"},"language":"en","primary_location":{"id":"doi:10.3389/fcimb.2026.1930709","doi":"https://doi.org/10.3389/fcimb.2026.1930709","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1930709","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1930709/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1930709/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093215021","display_name":"Ruben Ladeira","orcid":"https://orcid.org/0009-0006-9113-1381","observed_orcids":["https://orcid.org/0009-0006-9113-1381"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210087978","display_name":"Centre Hospitalier Universitaire de Besan\u00e7on","ror":"https://ror.org/0084te143","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210087978"]},{"id":"https://openalex.org/I4210104630","display_name":"Laboratoire Chrono-Environnement","ror":"https://ror.org/028cef883","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1314251682","https://openalex.org/I2738703131","https://openalex.org/I2802818602","https://openalex.org/I4210102700","https://openalex.org/I4210104630","https://openalex.org/I4210107625","https://openalex.org/I4210110412","https://openalex.org/I4210139971","https://openalex.org/I4210155116","https://openalex.org/I4405256580"]},{"id":"https://openalex.org/I4405256580","display_name":"Universit\u00e9 Marie et Louis Pasteur","ror":"https://ror.org/04asdee31","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405256580"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Ruben Ladeira","raw_affiliation_strings":["Bioinformatique et Big Data Au Service de La Sant\u00e9, Oncobiologie G\u00e9n\u00e9tique Bioinformatique, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","Universit\u00e9 Marie et Louis Pasteur, Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 6249 Chrono-environnement"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatique et Big Data Au Service de La Sant\u00e9, Oncobiologie G\u00e9n\u00e9tique Bioinformatique, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","institution_ids":["https://openalex.org/I4210087978"]},{"raw_affiliation_string":"Universit\u00e9 Marie et Louis Pasteur, Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 6249 Chrono-environnement","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210104630","https://openalex.org/I4405256580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084425000","display_name":"Adrien Biguenet","orcid":"https://orcid.org/0000-0002-7036-8922","observed_orcids":["https://orcid.org/0000-0002-7036-8922"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210087978","display_name":"Centre Hospitalier Universitaire de Besan\u00e7on","ror":"https://ror.org/0084te143","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210087978"]},{"id":"https://openalex.org/I4210104630","display_name":"Laboratoire Chrono-Environnement","ror":"https://ror.org/028cef883","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1314251682","https://openalex.org/I2738703131","https://openalex.org/I2802818602","https://openalex.org/I4210102700","https://openalex.org/I4210104630","https://openalex.org/I4210107625","https://openalex.org/I4210110412","https://openalex.org/I4210139971","https://openalex.org/I4210155116","https://openalex.org/I4405256580"]},{"id":"https://openalex.org/I4405256580","display_name":"Universit\u00e9 Marie et Louis Pasteur","ror":"https://ror.org/04asdee31","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405256580"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Adrien Biguenet","raw_affiliation_strings":["Bioinformatique et Big Data Au Service de La Sant\u00e9, Oncobiologie G\u00e9n\u00e9tique Bioinformatique, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","Hygi\u00e8ne Hospitali\u00e8re, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","Universit\u00e9 Marie et Louis Pasteur, Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 6249 Chrono-environnement"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatique et Big Data Au Service de La Sant\u00e9, Oncobiologie G\u00e9n\u00e9tique Bioinformatique, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","institution_ids":["https://openalex.org/I4210087978"]},{"raw_affiliation_string":"Hygi\u00e8ne Hospitali\u00e8re, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","institution_ids":["https://openalex.org/I4210087978"]},{"raw_affiliation_string":"Universit\u00e9 Marie et Louis Pasteur, Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 6249 Chrono-environnement","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210104630","https://openalex.org/I4405256580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008640250","display_name":"Alexandre Meunier","orcid":"https://orcid.org/0000-0001-7260-2535","observed_orcids":["https://orcid.org/0000-0001-7260-2535"]},"institutions":[{"id":"https://openalex.org/I4210087978","display_name":"Centre Hospitalier Universitaire de Besan\u00e7on","ror":"https://ror.org/0084te143","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210087978"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexandre Meunier","raw_affiliation_strings":["Hygi\u00e8ne Hospitali\u00e8re, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hygi\u00e8ne Hospitali\u00e8re, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","institution_ids":["https://openalex.org/I4210087978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130742155","display_name":"Marion Gonthier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210087978","display_name":"Centre Hospitalier Universitaire de Besan\u00e7on","ror":"https://ror.org/0084te143","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210087978"]},{"id":"https://openalex.org/I4210104630","display_name":"Laboratoire Chrono-Environnement","ror":"https://ror.org/028cef883","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1314251682","https://openalex.org/I2738703131","https://openalex.org/I2802818602","https://openalex.org/I4210102700","https://openalex.org/I4210104630","https://openalex.org/I4210107625","https://openalex.org/I4210110412","https://openalex.org/I4210139971","https://openalex.org/I4210155116","https://openalex.org/I4405256580"]},{"id":"https://openalex.org/I4405256580","display_name":"Universit\u00e9 Marie et Louis Pasteur","ror":"https://ror.org/04asdee31","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405256580"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marion Gonthier","raw_affiliation_strings":["Hygi\u00e8ne Hospitali\u00e8re, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","Universit\u00e9 Marie et Louis Pasteur, Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 6249 Chrono-environnement"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hygi\u00e8ne Hospitali\u00e8re, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","institution_ids":["https://openalex.org/I4210087978"]},{"raw_affiliation_string":"Universit\u00e9 Marie et Louis Pasteur, Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 6249 Chrono-environnement","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210104630","https://openalex.org/I4405256580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039684397","display_name":"Vincent Di Martino","orcid":"https://orcid.org/0000-0002-2022-690X","observed_orcids":["https://orcid.org/0000-0002-2022-690X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210087978","display_name":"Centre Hospitalier Universitaire de Besan\u00e7on","ror":"https://ror.org/0084te143","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210087978"]},{"id":"https://openalex.org/I4405256580","display_name":"Universit\u00e9 Marie et Louis Pasteur","ror":"https://ror.org/04asdee31","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405256580"]},{"id":"https://openalex.org/I4405257954","display_name":"Interactions H\u00f4te-Greffon-Tumeur & Ing\u00e9nierie Cellulaire et G\u00e9nique","ror":"https://ror.org/05w3vvc59","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210128919","https://openalex.org/I4405256580","https://openalex.org/I4405257954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vincent Di Martino","raw_affiliation_strings":["Service d\u2019H\u00e9patologie, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","Universit\u00e9 Marie et Louis Pasteur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR) 1098 Regulation of Immunity for therapeutic innovation in Graft, Host, Tumoral and inflammatory-associated diseases (RIGHT)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d\u2019H\u00e9patologie, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","institution_ids":["https://openalex.org/I4210087978"]},{"raw_affiliation_string":"Universit\u00e9 Marie et Louis Pasteur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR) 1098 Regulation of Immunity for therapeutic innovation in Graft, Host, Tumoral and inflammatory-associated diseases (RIGHT)","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405256580","https://openalex.org/I4405257954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023967370","display_name":"Ana\u00efs Pitta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana\u00efs Pitta","raw_affiliation_strings":["Service d\u2019H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Cabrol"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d\u2019H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Cabrol","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022945624","display_name":"Edouard Bardou\u2010Jacquet","orcid":"https://orcid.org/0000-0002-0784-0710","observed_orcids":["https://orcid.org/0000-0002-0784-0710"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210155724","display_name":"Centre Hospitalier Universitaire de Rennes","ror":"https://ror.org/05qec5a53","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210155724"]},{"id":"https://openalex.org/I4387156410","display_name":"Nutrition, m\u00e9tabolismes et cancer","ror":"https://ror.org/03zb6nw87","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210088668","https://openalex.org/I4387156410","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Edouard Bardou-Jacquet","raw_affiliation_strings":["Univ. Rennes, Centre Hospitalier Universitaire (CHU) Rennes, Service des Maladies du Foie, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) 1241 Nutrition, M\u00e9tabolismes et Cancer (NUMECAN)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Rennes, Centre Hospitalier Universitaire (CHU) Rennes, Service des Maladies du Foie, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) 1241 Nutrition, M\u00e9tabolismes et Cancer (NUMECAN)","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210155724","https://openalex.org/I4387156410","https://openalex.org/I56067802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019796034","display_name":"Anne Jolivet\u2010Gougeon","orcid":"https://orcid.org/0000-0002-4057-9876","observed_orcids":["https://orcid.org/0000-0002-4057-9876"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210155724","display_name":"Centre Hospitalier Universitaire de Rennes","ror":"https://ror.org/05qec5a53","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210155724"]},{"id":"https://openalex.org/I4387155446","display_name":"Bacterial RNAs & Medicine","ror":"https://ror.org/031y0x195","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4387155446","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I4387156410","display_name":"Nutrition, m\u00e9tabolismes et cancer","ror":"https://ror.org/03zb6nw87","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210088668","https://openalex.org/I4387156410","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne Jolivet-Gougeon","raw_affiliation_strings":["Department of Bacteriology, Rennes University Hospital","Univ. Rennes, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), INRAE, Unit\u00e9 Mixte de Recherche (UMR) S1230 Bacterial Regulatory RNAs & Medicine (BRM), Institut Nutrition, M\u00e9tabolismes et Cancer (NUMECAN) Unit\u00e9 Mixte de Recherche (UMR) 1241"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology, Rennes University Hospital","institution_ids":["https://openalex.org/I4210155724"]},{"raw_affiliation_string":"Univ. Rennes, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), INRAE, Unit\u00e9 Mixte de Recherche (UMR) S1230 Bacterial Regulatory RNAs & Medicine (BRM), Institut Nutrition, M\u00e9tabolismes et Cancer (NUMECAN) Unit\u00e9 Mixte de Recherche (UMR) 1241","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210088668","https://openalex.org/I4387155446","https://openalex.org/I4387156410","https://openalex.org/I56067802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034688119","display_name":"Maxime Desmarets","orcid":"https://orcid.org/0000-0002-3801-5297","observed_orcids":["https://orcid.org/0000-0002-3801-5297"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210087978","display_name":"Centre Hospitalier Universitaire de Besan\u00e7on","ror":"https://ror.org/0084te143","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210087978"]},{"id":"https://openalex.org/I4405256580","display_name":"Universit\u00e9 Marie et Louis Pasteur","ror":"https://ror.org/04asdee31","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405256580"]},{"id":"https://openalex.org/I4405257954","display_name":"Interactions H\u00f4te-Greffon-Tumeur & Ing\u00e9nierie Cellulaire et G\u00e9nique","ror":"https://ror.org/05w3vvc59","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210128919","https://openalex.org/I4405256580","https://openalex.org/I4405257954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maxime Desmarets","raw_affiliation_strings":["Centre d\u2019Investigation Clinique 1431, unit\u00e9 de METhodologie (uMETh), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","Universit\u00e9 Marie et Louis Pasteur, EFS, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR) 1098 Regulation of Immunity for therapeutic innovation in Graft, Host, Tumoral and inflammatory-associated diseases (RIGHT)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre d\u2019Investigation Clinique 1431, unit\u00e9 de METhodologie (uMETh), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210087978"]},{"raw_affiliation_string":"Universit\u00e9 Marie et Louis Pasteur, EFS, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR) 1098 Regulation of Immunity for therapeutic innovation in Graft, Host, Tumoral and inflammatory-associated diseases (RIGHT)","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405256580","https://openalex.org/I4405257954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053774911","display_name":"Thierry Th\u00e9venot","orcid":"https://orcid.org/0000-0003-3974-2784","observed_orcids":["https://orcid.org/0000-0003-3974-2784"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210087978","display_name":"Centre Hospitalier Universitaire de Besan\u00e7on","ror":"https://ror.org/0084te143","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210087978"]},{"id":"https://openalex.org/I4405256580","display_name":"Universit\u00e9 Marie et Louis Pasteur","ror":"https://ror.org/04asdee31","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405256580"]},{"id":"https://openalex.org/I4405257954","display_name":"Interactions H\u00f4te-Greffon-Tumeur & Ing\u00e9nierie Cellulaire et G\u00e9nique","ror":"https://ror.org/05w3vvc59","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210128919","https://openalex.org/I4405256580","https://openalex.org/I4405257954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thierry Th\u00e9venot","raw_affiliation_strings":["Service d\u2019H\u00e9patologie, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","Universit\u00e9 Marie et Louis Pasteur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR) 1098 Regulation of Immunity for therapeutic innovation in Graft, Host, Tumoral and inflammatory-associated diseases (RIGHT)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d\u2019H\u00e9patologie, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","institution_ids":["https://openalex.org/I4210087978"]},{"raw_affiliation_string":"Universit\u00e9 Marie et Louis Pasteur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche (UMR) 1098 Regulation of Immunity for therapeutic innovation in Graft, Host, Tumoral and inflammatory-associated diseases (RIGHT)","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405256580","https://openalex.org/I4405257954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062562582","display_name":"Didier Hocquet","orcid":"https://orcid.org/0000-0002-4192-7238","observed_orcids":["https://orcid.org/0000-0002-4192-7238"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210087978","display_name":"Centre Hospitalier Universitaire de Besan\u00e7on","ror":"https://ror.org/0084te143","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210087978"]},{"id":"https://openalex.org/I4210104630","display_name":"Laboratoire Chrono-Environnement","ror":"https://ror.org/028cef883","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1314251682","https://openalex.org/I2738703131","https://openalex.org/I2802818602","https://openalex.org/I4210102700","https://openalex.org/I4210104630","https://openalex.org/I4210107625","https://openalex.org/I4210110412","https://openalex.org/I4210139971","https://openalex.org/I4210155116","https://openalex.org/I4405256580"]},{"id":"https://openalex.org/I4405256580","display_name":"Universit\u00e9 Marie et Louis Pasteur","ror":"https://ror.org/04asdee31","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405256580"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Didier Hocquet","raw_affiliation_strings":["Bioinformatique et Big Data Au Service de La Sant\u00e9, Oncobiologie G\u00e9n\u00e9tique Bioinformatique, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","Hygi\u00e8ne Hospitali\u00e8re, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","Universit\u00e9 Marie et Louis Pasteur, Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 6249 Chrono-environnement"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatique et Big Data Au Service de La Sant\u00e9, Oncobiologie G\u00e9n\u00e9tique Bioinformatique, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","institution_ids":["https://openalex.org/I4210087978"]},{"raw_affiliation_string":"Hygi\u00e8ne Hospitali\u00e8re, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","institution_ids":["https://openalex.org/I4210087978"]},{"raw_affiliation_string":"Universit\u00e9 Marie et Louis Pasteur, Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 6249 Chrono-environnement","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210104630","https://openalex.org/I4405256580"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003510298","display_name":"Beno\u0131\u0302t Valot","orcid":"https://orcid.org/0000-0002-3931-0263","observed_orcids":["https://orcid.org/0000-0002-3931-0263"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210087978","display_name":"Centre Hospitalier Universitaire de Besan\u00e7on","ror":"https://ror.org/0084te143","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210087978"]},{"id":"https://openalex.org/I4210104630","display_name":"Laboratoire Chrono-Environnement","ror":"https://ror.org/028cef883","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1314251682","https://openalex.org/I2738703131","https://openalex.org/I2802818602","https://openalex.org/I4210102700","https://openalex.org/I4210104630","https://openalex.org/I4210107625","https://openalex.org/I4210110412","https://openalex.org/I4210139971","https://openalex.org/I4210155116","https://openalex.org/I4405256580"]},{"id":"https://openalex.org/I4405256580","display_name":"Universit\u00e9 Marie et Louis Pasteur","ror":"https://ror.org/04asdee31","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405256580"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Benoit Valot","raw_affiliation_strings":["Bioinformatique et Big Data Au Service de La Sant\u00e9, Oncobiologie G\u00e9n\u00e9tique Bioinformatique, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","Universit\u00e9 Marie et Louis Pasteur, Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 6249 Chrono-environnement"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatique et Big Data Au Service de La Sant\u00e9, Oncobiologie G\u00e9n\u00e9tique Bioinformatique, Centre Hospitalier Universitaire (CHU) Besan\u00e7on Franche-Comt\u00e9","institution_ids":["https://openalex.org/I4210087978"]},{"raw_affiliation_string":"Universit\u00e9 Marie et Louis Pasteur, Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 6249 Chrono-environnement","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210104630","https://openalex.org/I4405256580"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5093215021"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210087978","https://openalex.org/I4210104630","https://openalex.org/I4405256580"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.5973635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"1930709","last_page":"1930709"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.10899999737739563,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rifaximin","display_name":"rifaximin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9020000100135803},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.8190000057220459},{"id":"https://openalex.org/keywords/rifampicin-resistance","display_name":"rifampicin resistance","score":0.9520000219345093},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9890000224113464},{"id":"https://openalex.org/keywords/spontaneous-bacterial-peritonitis","display_name":"spontaneous bacterial peritonitis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/hepatic-encephalopathy","display_name":"hepatic encephalopathy","score":0.8240000009536743},{"id":"https://openalex.org/keywords/lactulose","display_name":"lactulose","score":0.9150000214576721},{"id":"https://openalex.org/keywords/gut-dysbiosis","display_name":"gut dysbiosis","score":0.7519999742507935},{"id":"https://openalex.org/keywords/ruminococcus-bromii","display_name":"Ruminococcus bromii","score":0.875},{"id":"https://openalex.org/keywords/blautia-obeum","display_name":"Blautia obeum","score":1.0},{"id":"https://openalex.org/keywords/child-pugh-score","display_name":"Child-Pugh score","score":0.949999988079071},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C2778889925","wikidata":"https://www.wikidata.org/wiki/Q416073","display_name":"Rifaximin","level":3,"score":0.7347999811172485},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6525999903678894},{"id":"https://openalex.org/C2780027724","wikidata":"https://www.wikidata.org/wiki/Q288892","display_name":"Ruminococcus","level":3,"score":0.6230000257492065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6025000214576721},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5566999912261963},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.5429999828338623},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.4677000045776367},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.45660001039505005},{"id":"https://openalex.org/C189506811","wikidata":"https://www.wikidata.org/wiki/Q5148442","display_name":"Colonisation resistance","level":3,"score":0.4108999967575073},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.39809998869895935},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.376800000667572},{"id":"https://openalex.org/C2778168646","wikidata":"https://www.wikidata.org/wiki/Q133186","display_name":"Bacteroides","level":3,"score":0.30550000071525574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30000001192092896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.298799991607666},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.2849999964237213},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28200000524520874},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.2669999897480011},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.26080000400543213}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000078262","descriptor_name":"Rifaximin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006501","descriptor_name":"Hepatic Encephalopathy","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010538","descriptor_name":"Peritonitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D010538","descriptor_name":"Peritonitis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D012294","descriptor_name":"Rifamycins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3389/fcimb.2026.1930709","doi":"https://doi.org/10.3389/fcimb.2026.1930709","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1930709","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1930709/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13658500","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13658500/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13658500/pdf/fcimb-16-1930709.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Infect Microbiol","raw_type":"Text"},{"id":"pmid:42871147","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42871147","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular and infection microbiology","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:oai:HAL:hal-05771264v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05771264","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular and Infection Microbiology, 2026, 16, pp.1930709. ⟨10.3389/fcimb.2026.1930709⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:bf0853ca1f89494694e4a286225d4bb9","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bf0853ca1f89494694e4a286225d4bb9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular and Infection Microbiology, Vol 16 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcimb.2026.1930709","doi":"https://doi.org/10.3389/fcimb.2026.1930709","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1930709","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1930709/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214770489.pdf","grobid_xml":"https://content.openalex.org/works/W7214770489.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1979519663","https://openalex.org/W2034285706","https://openalex.org/W2125024218","https://openalex.org/W2401404581","https://openalex.org/W2968783145","https://openalex.org/W2980944208","https://openalex.org/W3000311560","https://openalex.org/W3046751398","https://openalex.org/W3089340783","https://openalex.org/W3094521503","https://openalex.org/W3127288224","https://openalex.org/W3130503684","https://openalex.org/W3153009727","https://openalex.org/W3202289966","https://openalex.org/W3215377564","https://openalex.org/W4205392375","https://openalex.org/W4210773546","https://openalex.org/W4214697251","https://openalex.org/W4225984179","https://openalex.org/W4247903468","https://openalex.org/W4289519074","https://openalex.org/W4291465459","https://openalex.org/W4309651008","https://openalex.org/W4313707017","https://openalex.org/W4380610023","https://openalex.org/W4381052683","https://openalex.org/W4387077472","https://openalex.org/W4387375398","https://openalex.org/W4392184777","https://openalex.org/W4392655383","https://openalex.org/W4403633297","https://openalex.org/W4403680351","https://openalex.org/W4406240604","https://openalex.org/W4408536001","https://openalex.org/W4409112645","https://openalex.org/W4409376239","https://openalex.org/W4410429650","https://openalex.org/W4412424549","https://openalex.org/W4417297677","https://openalex.org/W7154446284"],"related_works":["https://openalex.org/W7141775801","https://openalex.org/W4205392375","https://openalex.org/W2183328392","https://openalex.org/W4415104722","https://openalex.org/W3093898008","https://openalex.org/W4412424549","https://openalex.org/W4402648491","https://openalex.org/W7204261038","https://openalex.org/W4390989065","https://openalex.org/W7204240328"],"abstract_inverted_index":{"Introduction":[0],"Increasing":[1],"evidence":[2],"implicates":[3],"gut":[4,74,205],"dysbiosis":[5],"in":[6,34,49,72,129,164,216],"the":[7,18,40,73,123,141],"pathophysiology":[8],"of":[9,17,29,43,76,111,125,143,171,177,196],"advanced":[10,130],"cirrhosis.":[11,38],"This":[12],"is":[13,47],"an":[14],"ancillary":[15],"study":[16],"ProPILA-Rifax":[19],"trial":[20],"(NCT03069131),":[21],"which":[22],"evaluated":[23],"rifaximin":[24],"(RFX)":[25],"as":[26],"primary":[27],"prophylaxis":[28],"spontaneous":[30],"bacterial":[31,100],"peritonitis":[32],"(SBP)":[33],"patients":[35,78],"with":[36,169,188,225],"severe":[37,200],"Although":[39],"combined":[41],"use":[42],"RFX":[44,116,139,202],"and":[45,61,91,102,109,121,180,192],"lactulose":[46],"effective":[48],"preventing":[50],"recurrent":[51],"hepatic":[52],"encephalopathy":[53],"(HE),":[54],"its":[55],"longitudinal":[56,70],"impact":[57],"on":[58],"microbial":[59,119,206],"communities":[60],"antibiotic":[62],"resistance":[63,149,215],"remains":[64],"poorly":[65],"characterized.":[66],"Methods":[67],"We":[68],"characterized":[69],"changes":[71],"microbiome":[75],"42":[77],"(21":[79],"RFX,":[80],"21":[81],"placebo)":[82],"over":[83],"12":[84],"months":[85],"using":[86],"16S":[87],"rRNA":[88],"gene":[89],"sequencing":[90],"culture-based":[92],"phenotypic":[93,148],"susceptibility":[94],"testing.":[95],"Exploratory":[96],"analyses":[97],"between":[98],"patient":[99,233],"profiles":[101],"clinical":[103],"outcomes":[104],"(disease":[105],"severity,":[106],"overall":[107],"survival,":[108],"incidence":[110,195],"SBP)":[112],"were":[113,185,223],"conducted.":[114],"Results":[115],"treatment":[117],"reduced":[118],"richness":[120],"decreased":[122],"abundance":[124,211],"taxa":[126],"typically":[127],"enriched":[128],"cirrhosis":[131],"(e.g.,":[132],"Escherichia":[133,144],",":[134,136],"Streptococcus":[135],"Veillonella":[137],").":[138],"increased":[140],"proportion":[142],"coli":[145,218],"isolates":[146],"exhibiting":[147],"to":[150,155,231],"rifampicin,":[151],"without":[152],"observed":[153],"cross-resistance":[154],"ciprofloxacin":[156],"or":[157],"cefotaxime.":[158],"In":[159,199],"exploratory":[160],"analyses,":[161],"a":[162,193],"decrease":[163],"Child-Pugh":[165,226],"scores":[166],"was":[167],"correlated":[168],"enrichment":[170],"commensal":[172],"taxa.":[173],"Moreover,":[174],"higher":[175],"abundances":[176],"Ruminococcus":[178],"bromii":[179],"Blautia":[181],"obeum":[182],"at":[183],"inclusion":[184],"respectively":[186],"associated":[187,224],"improved":[189],"12-month":[190],"survival":[191],"lower":[194],"SBP.":[197],"Discussion":[198],"cirrhosis,":[201],"profoundly":[203],"alters":[204],"composition":[207],"by":[208],"reducing":[209],"pathobiont":[210],"while":[212],"promoting":[213],"rifampicin":[214],"E.":[217],".":[219],"Furthermore,":[220],"microbiota-derived":[221],"signatures":[222],"scores,":[227],"highlighting":[228],"their":[229],"potential":[230],"improve":[232],"stratification.":[234]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-09-30T00:00:00"}