{"id":"https://openalex.org/W7214768697","doi":"https://doi.org/10.1093/genetics/iyag255","title":"Kr\u00fcppel-like factors regulate lipid homeostasis to modulate SKN-1/Nrf activity, oxidative stress resistance, and longevity","display_name":"Kr\u00fcppel-like factors regulate lipid homeostasis to modulate SKN-1/Nrf activity, oxidative stress resistance, and longevity","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7214768697","doi":"https://doi.org/10.1093/genetics/iyag255","pmid":"https://pubmed.ncbi.nlm.nih.gov/42806811"},"language":"en","primary_location":{"id":"doi:10.1093/genetics/iyag255","doi":"https://doi.org/10.1093/genetics/iyag255","is_oa":true,"landing_page_url":"https://doi.org/10.1093/genetics/iyag255","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GENETICS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/genetics/iyag255","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085337287","display_name":"Jorge Iv\u00e1n Castillo-Quan","orcid":"https://orcid.org/0000-0002-6324-2854","observed_orcids":["https://orcid.org/0000-0002-6324-2854"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge Iv\u00e1n Castillo-Quan","raw_affiliation_strings":["Joslin Diabetes Center, Harvard Medical School;"],"raw_orcid":"https://orcid.org/0000-0002-6324-2854","affiliations":[{"raw_affiliation_string":"Joslin Diabetes Center, Harvard Medical School;","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153507244","display_name":"Aiden McCarty","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aiden McCarty","raw_affiliation_strings":["Department of Biology, Emmanuel College;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Emmanuel College;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052660085","display_name":"Ugne Kurdeikaite","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ugne Kurdeikaite","raw_affiliation_strings":["Joslin Diabetes Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joslin Diabetes Center;","institution_ids":["https://openalex.org/I1293231726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153438917","display_name":"Katherine Gilmore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193478522","display_name":"Emmanuel College - Massachusetts","ror":"https://ror.org/02rdhhs90","country_code":"US","type":"education","lineage":["https://openalex.org/I193478522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Gilmore","raw_affiliation_strings":["Emmanuel College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emmanuel College","institution_ids":["https://openalex.org/I193478522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153482630","display_name":"Arlette Cabral","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193478522","display_name":"Emmanuel College - Massachusetts","ror":"https://ror.org/02rdhhs90","country_code":"US","type":"education","lineage":["https://openalex.org/I193478522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arlette Cabral","raw_affiliation_strings":["Emmanuel College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emmanuel College","institution_ids":["https://openalex.org/I193478522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114196357","display_name":"Justin Mejia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193478522","display_name":"Emmanuel College - Massachusetts","ror":"https://ror.org/02rdhhs90","country_code":"US","type":"education","lineage":["https://openalex.org/I193478522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Mejia","raw_affiliation_strings":["Emmanuel College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emmanuel College","institution_ids":["https://openalex.org/I193478522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074122609","display_name":"Julia Barrett","orcid":"https://orcid.org/0000-0002-5857-3632","observed_orcids":["https://orcid.org/0000-0002-5857-3632"]},"institutions":[{"id":"https://openalex.org/I193478522","display_name":"Emmanuel College - Massachusetts","ror":"https://ror.org/02rdhhs90","country_code":"US","type":"education","lineage":["https://openalex.org/I193478522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Barrett","raw_affiliation_strings":["Emmanuel College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emmanuel College","institution_ids":["https://openalex.org/I193478522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120816109","display_name":"Maria La Terza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193478522","display_name":"Emmanuel College - Massachusetts","ror":"https://ror.org/02rdhhs90","country_code":"US","type":"education","lineage":["https://openalex.org/I193478522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria La Terza","raw_affiliation_strings":["Emmanuel College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emmanuel College","institution_ids":["https://openalex.org/I193478522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153474315","display_name":"Emma Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193478522","display_name":"Emmanuel College - Massachusetts","ror":"https://ror.org/02rdhhs90","country_code":"US","type":"education","lineage":["https://openalex.org/I193478522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma Johnson","raw_affiliation_strings":["Emmanuel College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emmanuel College","institution_ids":["https://openalex.org/I193478522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124863484","display_name":"Allison Carroll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193478522","display_name":"Emmanuel College - Massachusetts","ror":"https://ror.org/02rdhhs90","country_code":"US","type":"education","lineage":["https://openalex.org/I193478522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison Carroll","raw_affiliation_strings":["Emmanuel College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emmanuel College","institution_ids":["https://openalex.org/I193478522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160402361","display_name":"T. Keith Blackwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Keith Blackwell","raw_affiliation_strings":[". Joslin Diabetes Center , Harvard Medical School , Boston , MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Joslin Diabetes Center , Harvard Medical School , Boston , MA","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009582773","display_name":"Jean E. Schaffer","orcid":"https://orcid.org/0000-0002-4954-6659","observed_orcids":["https://orcid.org/0000-0002-4954-6659"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean E. Schaffer","raw_affiliation_strings":["Joslin Diabetes Center, Harvard Medical School;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joslin Diabetes Center, Harvard Medical School;","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013973347","display_name":"Natalie Moroz","orcid":"https://orcid.org/0000-0003-3200-9168","observed_orcids":["https://orcid.org/0000-0003-3200-9168"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Natalie Moroz","raw_affiliation_strings":["Department of Biology, Emmanuel College;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Emmanuel College;","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013973347"],"corresponding_institution_ids":[],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":{"value":4477,"currency":"USD","value_usd":4477},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kruppel-like-factors","display_name":"Kr\u00fcppel-like factors","score":0.9390000104904175},{"id":"https://openalex.org/keywords/nrf1","display_name":"NRF1","score":0.859000027179718},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipid-homeostasis","display_name":"lipid homeostasis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/oxidative-stress-tolerance","display_name":"oxidative stress resistance","score":0.9959999918937683},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.9909999966621399},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9100000262260437},{"id":"https://openalex.org/keywords/lipophagy","display_name":"lipophagy","score":0.7720000147819519},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.6000000238418579},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7480999827384949},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.7210000157356262},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6721000075340271},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.6622999906539917},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6589999794960022},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5996999740600586},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5709999799728394},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.5134999752044678},{"id":"https://openalex.org/C85051948","wikidata":"https://www.wikidata.org/wiki/Q416064","display_name":"Sterol regulatory element-binding protein","level":4,"score":0.4894999861717224},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.40639999508857727},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.3984000086784363},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.38339999318122864},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.38280001282691956},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.3547999858856201},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.33070001006126404},{"id":"https://openalex.org/C2994476132","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid oxidation","level":3,"score":0.32899999618530273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32850000262260437},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.2955000102519989},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.28949999809265137},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2847999930381775},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.28060001134872437}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1093/genetics/iyag255","doi":"https://doi.org/10.1093/genetics/iyag255","is_oa":true,"landing_page_url":"https://doi.org/10.1093/genetics/iyag255","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GENETICS","raw_type":"journal-article"},{"id":"doi:10.1101/2025.11.22.689963","doi":"https://doi.org/10.1101/2025.11.22.689963","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.11.22.689963","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/11/25/2025.11.22.689963.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41394699","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41394699","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42806811","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42806811","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12699417","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12699417/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/genetics/iyag255","doi":"https://doi.org/10.1093/genetics/iyag255","is_oa":true,"landing_page_url":"https://doi.org/10.1093/genetics/iyag255","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GENETICS","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000887409","display_name":"Homeostasis functions of SKN-1A/Nrf1","funder_award_id":"R01AG054215","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9001234858","display_name":null,"funder_award_id":"PD18019","funder_id":"https://openalex.org/F4320306710","funder_display_name":"Glenn Foundation for Medical Research"},{"id":"https://openalex.org/G9001261852","display_name":null,"funder_award_id":"REBOOT21004","funder_id":"https://openalex.org/F4320308417","funder_display_name":"American Foundation for Aging Research"}],"funders":[{"id":"https://openalex.org/F4320306228","display_name":"American Federation for Aging Research","ror":"https://ror.org/000r61a05"},{"id":"https://openalex.org/F4320306710","display_name":"Glenn Foundation for Medical Research","ror":"https://ror.org/02ebg5q27"},{"id":"https://openalex.org/F4320308417","display_name":"American Foundation for Aging Research","ror":"https://ror.org/000r61a05"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214768697.pdf","grobid_xml":"https://content.openalex.org/works/W7214768697.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W952227139","https://openalex.org/W1013361806","https://openalex.org/W1965047336","https://openalex.org/W1966990623","https://openalex.org/W1980815200","https://openalex.org/W2001302985","https://openalex.org/W2001908075","https://openalex.org/W2010181168","https://openalex.org/W2024494094","https://openalex.org/W2025341515","https://openalex.org/W2035676834","https://openalex.org/W2038120788","https://openalex.org/W2041680143","https://openalex.org/W2041986831","https://openalex.org/W2080586434","https://openalex.org/W2080904805","https://openalex.org/W2084043096","https://openalex.org/W2090738979","https://openalex.org/W2095358593","https://openalex.org/W2095785516","https://openalex.org/W2098567793","https://openalex.org/W2102035119","https://openalex.org/W2111822899","https://openalex.org/W2117187041","https://openalex.org/W2130844401","https://openalex.org/W2135550833","https://openalex.org/W2144875446","https://openalex.org/W2148242921","https://openalex.org/W2156322705","https://openalex.org/W2159315155","https://openalex.org/W2159565935","https://openalex.org/W2160395555","https://openalex.org/W2167235559","https://openalex.org/W2189389315","https://openalex.org/W2203651313","https://openalex.org/W2204428530","https://openalex.org/W2253615956","https://openalex.org/W2320556571","https://openalex.org/W2345997946","https://openalex.org/W2401299463","https://openalex.org/W2440050696","https://openalex.org/W2508503153","https://openalex.org/W2525662188","https://openalex.org/W2574665962","https://openalex.org/W2591753874","https://openalex.org/W2757860389","https://openalex.org/W2761655984","https://openalex.org/W2763456538","https://openalex.org/W2891168366","https://openalex.org/W2897859321","https://openalex.org/W2907855283","https://openalex.org/W2937699055","https://openalex.org/W2950758232","https://openalex.org/W2963133454","https://openalex.org/W2981305867","https://openalex.org/W2990697870","https://openalex.org/W2993507558","https://openalex.org/W3086105617","https://openalex.org/W3106696187","https://openalex.org/W3119614560","https://openalex.org/W3120392574","https://openalex.org/W3134421658","https://openalex.org/W4280562370","https://openalex.org/W4281690804","https://openalex.org/W4292283940","https://openalex.org/W4309763228","https://openalex.org/W4313545131","https://openalex.org/W4321085072","https://openalex.org/W4386045959","https://openalex.org/W4389978086","https://openalex.org/W4400803990","https://openalex.org/W4409173603","https://openalex.org/W4409292562","https://openalex.org/W4409312366","https://openalex.org/W4412072840","https://openalex.org/W4414713504","https://openalex.org/W4417284196","https://openalex.org/W7125420761","https://openalex.org/W7125819611","https://openalex.org/W7143330669"],"related_works":["https://openalex.org/W4417361734","https://openalex.org/W2160395555","https://openalex.org/W1581515055","https://openalex.org/W4406894929","https://openalex.org/W4400581608","https://openalex.org/W1569358416","https://openalex.org/W2967726757","https://openalex.org/W4405981098","https://openalex.org/W2625050143","https://openalex.org/W3010958658"],"abstract_inverted_index":{"Maintenance":[0],"of":[1,55,78,93,120,142,163,177,186,194],"lipid":[2,39,56,90,115,137,178,187,198],"and":[3,11,30,41,67,70,76,104,125,129,158,166,204],"redox":[4],"homeostasis":[5,188],"is":[6],"essential":[7],"for":[8,65,71,98],"stress":[9,34,43,74,202],"resistance":[10,75,203],"longevity,":[12],"but":[13,95],"the":[14,26,48,72,89,130,143,161],"transcriptional":[15],"networks":[16],"coordinating":[17],"these":[18,154,181],"processes":[19],"remain":[20],"incompletely":[21],"understood.":[22],"In":[23],"Caenorhabditis":[24],"elegans,":[25],"transcription":[27],"factors":[28],"SKN-1A/Nrf1":[29],"SKN-1C/Nrf2":[31],"mediate":[32],"distinct":[33],"responses":[35],"that":[36,58,109],"promote":[37],"proteostasis,":[38],"homeostasis,":[40],"oxidative":[42,73,201],"resistance.":[44],"Here,":[45],"we":[46],"identify":[47],"Kr\u00fcppel-like":[49],"factor":[50],"KLF-1":[51,62,86,110,128,157],"as":[52,189],"a":[53],"regulator":[54,145],"accumulation":[57,138],"modulates":[59],"SKN-1":[60,195],"activity.":[61],"was":[63,96],"required":[64],"SKN-1A":[66,94,112],"SKN-1C":[68,121],"activation":[69,113],"longevity":[77],"germline-deficient":[79],"animals,":[80],"without":[81],"changing":[82],"skn-1":[83],"transcript":[84],"abundance.":[85],"selectively":[87],"modulated":[88],"homeostatic":[91],"response":[92],"dispensable":[97],"its":[99,118],"proteasome":[100],"recovery":[101],"response.":[102],"Genetic":[103],"supplementation":[105],"experiments":[106],"further":[107],"indicated":[108],"influences":[111],"through":[114],"accumulation,":[116],"while":[117,139],"regulation":[119,176,185],"involves":[122],"both":[123],"lipid-dependent":[124],"lipid-independent":[126],"mechanisms.":[127],"related":[131],"KLF-2":[132,159],"exerted":[133],"opposing":[134,155],"effects":[135],"on":[136],"acting":[140],"independently":[141],"lipogenic":[144],"Sterol":[146],"regulatory":[147],"element-Binding":[148],"Protein":[149],"1":[150],"(SBP-1/SREBP1).":[151],"Consistent":[152],"with":[153,200],"effects,":[156],"regulated":[160],"expression":[162],"unc-51/ULK1,":[164],"atg-9/ATG9A,":[165],"lipl-1/LIPJ/K":[167],"in":[168,174],"opposite":[169],"directions,":[170],"implicating":[171],"lipophagy-associated":[172],"pathways":[173],"their":[175],"homeostasis.":[179],"Together,":[180],"findings":[182],"establish":[183],"KLF-dependent":[184],"an":[190],"upstream":[191],"physiological":[192],"determinant":[193],"activity,":[196],"linking":[197],"metabolism":[199],"longevity.":[205]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-09-30T00:00:00"}