{"id":"https://openalex.org/W7214767640","doi":"https://doi.org/10.64898/2026.09.23.753952","title":"An FEV-Associated Metastasis-Initiating-Like State Linked to Tumor Cell Plasticity and Immune Niche Remodeling in Prostate Cancer","display_name":"An FEV-Associated Metastasis-Initiating-Like State Linked to Tumor Cell Plasticity and Immune Niche Remodeling in Prostate Cancer","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7214767640","doi":"https://doi.org/10.64898/2026.09.23.753952"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.23.753952","doi":"https://doi.org/10.64898/2026.09.23.753952","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.23.753952","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.23.753952.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.23.753952.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048858126","display_name":"Sijia Wu","orcid":"https://orcid.org/0000-0002-2863-6065","observed_orcids":["https://orcid.org/0000-0002-2863-6065","https://orcid.org/0009-0001-9394-2536"]},"institutions":[{"id":"https://openalex.org/I149594827","display_name":"Xidian University","ror":"https://ror.org/05s92vm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I149594827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sijia Wu","raw_affiliation_strings":["School of Life Science and Technology, Xidian University, Xi\u2019an, Shaanxi, 710126, PR China"],"raw_orcid":"https://orcid.org/0000-0002-2863-6065","affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Xidian University, Xi\u2019an, Shaanxi, 710126, PR China","institution_ids":["https://openalex.org/I149594827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134109602","display_name":"Jiangpeng Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiangpeng Wei","raw_affiliation_strings":["State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and-National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth\u00b7Military Medical University, Xi\u2019an, Shaanxi, 710032, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and-National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth\u00b7Military Medical University, Xi\u2019an, Shaanxi, 710032, PR China","institution_ids":["https://openalex.org/I4210089514","https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054329538","display_name":"Xiaorui Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149594827","display_name":"Xidian University","ror":"https://ror.org/05s92vm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I149594827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaorui Shi","raw_affiliation_strings":["School of Life Science and Technology, Xidian University, Xi\u2019an, Shaanxi, 710126, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Xidian University, Xi\u2019an, Shaanxi, 710126, PR China","institution_ids":["https://openalex.org/I149594827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153447752","display_name":"Xin Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Liu","raw_affiliation_strings":["State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and-National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth\u00b7Military Medical University, Xi\u2019an, Shaanxi, 710032, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and-National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth\u00b7Military Medical University, Xi\u2019an, Shaanxi, 710032, PR China","institution_ids":["https://openalex.org/I4210089514","https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153413224","display_name":"Xiaobo zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaobo Zhou","raw_affiliation_strings":["School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, Texas, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, Texas, 77030, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5125364175","display_name":"Liyu Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149594827","display_name":"Xidian University","ror":"https://ror.org/05s92vm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I149594827"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liyu Huang","raw_affiliation_strings":["School of Life Science and Technology, Xidian University, Xi\u2019an, Shaanxi, 710126, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Xidian University, Xi\u2019an, Shaanxi, 710126, PR China","institution_ids":["https://openalex.org/I149594827"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5125364175"],"corresponding_institution_ids":["https://openalex.org/I149594827"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fev","display_name":"FEV","score":0.8050000071525574},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7129999995231628},{"id":"https://openalex.org/keywords/tumor-plasticity","display_name":"tumor plasticity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7120000123977661},{"id":"https://openalex.org/keywords/androgen-signaling","display_name":"androgen signaling","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.7080000042915344},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.7129999995231628},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8043000102043152},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6554999947547913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6297000050544739},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5361999869346619},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5113000273704529},{"id":"https://openalex.org/C62361671","wikidata":"https://www.wikidata.org/wiki/Q1754612","display_name":"Regulon","level":4,"score":0.5022000074386597},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4936999976634979},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4650999903678894},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4336000084877014},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42410001158714294},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4212000072002411},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.4196000099182129},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.39100000262260437},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3425999879837036},{"id":"https://openalex.org/C2780480104","wikidata":"https://www.wikidata.org/wiki/Q18351145","display_name":"Immunoediting","level":4,"score":0.33660000562667847},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.33180001378059387},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33180001378059387},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3246000111103058},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.32429999113082886},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.32089999318122864},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3142000138759613},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.30309998989105225},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.29829999804496765},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.2854999899864197},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.2849000096321106},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2662999927997589},{"id":"https://openalex.org/C2779118045","wikidata":"https://www.wikidata.org/wiki/Q21114021","display_name":"TIGIT","level":4,"score":0.2612000107765198},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.2599000036716461},{"id":"https://openalex.org/C2777899217","wikidata":"https://www.wikidata.org/wiki/Q4759439","display_name":"Androgen deprivation therapy","level":4,"score":0.2581999897956848},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25760000944137573},{"id":"https://openalex.org/C2776438761","wikidata":"https://www.wikidata.org/wiki/Q5206280","display_name":"DU145","level":5,"score":0.2547000050544739},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.25279998779296875},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.25130000710487366}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.23.753952","doi":"https://doi.org/10.64898/2026.09.23.753952","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.23.753952","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.23.753952.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.23.753952","doi":"https://doi.org/10.64898/2026.09.23.753952","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.23.753952","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.23.753952.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214767640.pdf","grobid_xml":"https://content.openalex.org/works/W7214767640.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2177796249","https://openalex.org/W98336268","https://openalex.org/W4403921034","https://openalex.org/W2001166951","https://openalex.org/W7098696175","https://openalex.org/W1502590907","https://openalex.org/W2122768590","https://openalex.org/W4405205568","https://openalex.org/W4403051003","https://openalex.org/W2976283076"],"abstract_inverted_index":{"Abstract":[0],"Prostate":[1],"cancer":[2,134],"progression":[3],"is":[4,71,109,144],"accompanied":[5,122],"by":[6,123],"dynamic":[7],"remodeling":[8],"of":[9,160],"malignant":[10,35,85],"cell":[11,36,86,135,171],"states,":[12],"whose":[13],"metastatic":[14,45,67],"potential":[15,167,194],"and":[16,30,39,57,70,80,103,116,126,137,150,173,184],"regulatory":[17],"programs":[18],"remain":[19],"poorly":[20],"defined.":[21],"Here,":[22],"we":[23],"integrated":[24],"single-cell,":[25],"spatial,":[26],"bulk":[27],"transcriptomic,":[28],"epigenomic,":[29],"experimental":[31],"data":[32],"to":[33,66,165],"characterize":[34],"state":[37,50,87],"transitions":[38],"identify":[40],"candidate":[41,94],"regulators":[42],"associated":[43,95,110,146],"with":[44,61,96,100,111,147,181],"progression.":[46],"A":[47],"distinct":[48,185],"intermediate":[49],"exhibits":[51],"increased":[52],"copy-number":[53],"alterations,":[54],"stemness,":[55],"proliferation,":[56],"MYC":[58],"activity,":[59],"together":[60],"the":[62,84,97,154],"highest":[63],"transcriptional":[64],"similarity":[65],"tumor":[68,155,170],"cells,":[69],"therefore":[72],"designated":[73],"as":[74,91,129,131],"a":[75,92,112,178],"metastasis-initiating-like":[76],"(MIC-like)":[77],"state.":[78],"Transcriptional":[79],"regulon":[81,104],"dynamics":[82],"along":[83],"trajectory":[88],"highlight":[89],"FEV":[90,108,143,176],"prominent":[93],"MIC-like":[98],"state,":[99],"concordant":[101],"expression":[102,186],"activity":[105],"patterns.":[106],"Functionally,":[107],"hybrid":[113],"epithelial-mesenchymal":[114],"phenotype,":[115,121],"its":[117,158,166,193],"perturbation":[118],"disrupts":[119],"this":[120,140],"reduced":[124,148],"epithelial":[125],"mesenchymal":[127],"features":[128],"well":[130],"impaired":[132],"prostate":[133],"migration":[136],"invasion.":[138],"Beyond":[139],"tumor-intrinsic":[141],"feature,":[142],"also":[145],"cytotoxicity":[149],"interferon":[151],"responses":[152],"in":[153,169,196],"microenvironment":[156],"through":[157],"regulation":[159],"MIF-family":[161],"genes.":[162],"In":[163],"addition":[164],"roles":[168],"plasticity":[172],"immune":[174],"remodeling,":[175],"shows":[177],"reciprocal":[179],"association":[180],"androgen":[182],"signaling":[183],"patterns":[187],"across":[188],"treatment":[189],"response":[190],"groups,":[191],"highlighting":[192],"relevance":[195],"therapeutic":[197],"contexts.":[198]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-30T00:00:00"}