{"id":"https://openalex.org/W7214767308","doi":"https://doi.org/10.64898/2026.09.28.754959","title":"Dietary selenium deficiency drives sex-specific circadian disturbance through redox imbalance and causes early systolic dysfunction in mice","display_name":"Dietary selenium deficiency drives sex-specific circadian disturbance through redox imbalance and causes early systolic dysfunction in mice","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7214767308","doi":"https://doi.org/10.64898/2026.09.28.754959"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.28.754959","doi":"https://doi.org/10.64898/2026.09.28.754959","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.754959","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.28.754959.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.28.754959.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5153544286","display_name":"Xuanxuan Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Xuanxuan Guo","raw_affiliation_strings":["Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045681406","display_name":"Ferdy Lambregtse","orcid":"https://orcid.org/0000-0003-2541-3752","observed_orcids":["https://orcid.org/0000-0003-2541-3752"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ferdy Lambregtse","raw_affiliation_strings":["Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078691146","display_name":"Lotte Geerlings","orcid":"https://orcid.org/0000-0001-7180-9542","observed_orcids":["https://orcid.org/0000-0001-7180-9542"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Lotte Geerlings","raw_affiliation_strings":["Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153461743","display_name":"Jumo Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jumo Zhu","raw_affiliation_strings":["Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018005804","display_name":"Sietske N. Zijlstra","orcid":"https://orcid.org/0009-0002-2965-3411","observed_orcids":["https://orcid.org/0009-0002-2965-3411"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sietske N. Zijlstra","raw_affiliation_strings":["Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111127122","display_name":"Anna M. Feringa","orcid":"https://orcid.org/0000-0002-7011-2994","observed_orcids":["https://orcid.org/0000-0002-7011-2994"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anna M. Feringa","raw_affiliation_strings":["Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082476351","display_name":"Elisabeth M. Schouten","orcid":"https://orcid.org/0000-0001-9568-5345","observed_orcids":["https://orcid.org/0000-0001-9568-5345"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Elisabeth M Schouten","raw_affiliation_strings":["Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065012134","display_name":"Herman H.W. Sillj\u00e9","orcid":"https://orcid.org/0000-0003-3292-6302","observed_orcids":["https://orcid.org/0000-0003-3292-6302"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Herman H.W. Sillj\u00e9","raw_affiliation_strings":["Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024940207","display_name":"Lutz Schomburg","orcid":"https://orcid.org/0000-0001-9445-1555","observed_orcids":["https://orcid.org/0000-0001-9445-1555"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lutz Schomburg","raw_affiliation_strings":["Charit\u00e9 Universit\u00e4tsmedizin Berlin, Institut f\u00fcr Experimentelle Endokrinologie, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charit\u00e9 Universit\u00e4tsmedizin Berlin, Institut f\u00fcr Experimentelle Endokrinologie, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105820804","display_name":"Peter van der Meer","orcid":"https://orcid.org/0000-0002-9705-4413","observed_orcids":["https://orcid.org/0000-0002-9705-4413"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Peter van der Meer","raw_affiliation_strings":["Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007013405","display_name":"Nils B\u00f6mer","orcid":"https://orcid.org/0000-0001-5926-6960","observed_orcids":["https://orcid.org/0000-0001-5926-6960"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Nils Bomer","raw_affiliation_strings":["Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-5926-6960","affiliations":[{"raw_affiliation_string":"Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007013405"],"corresponding_institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-selenium-deficiency","display_name":"dietary selenium deficiency","score":0.9240000247955322},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6570000052452087},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.8450000286102295},{"id":"https://openalex.org/keywords/redox-imbalance","display_name":"redox imbalance","score":0.8989999890327454},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9399999976158142},{"id":"https://openalex.org/keywords/systolic-dysfunction","display_name":"systolic dysfunction","score":0.7089999914169312},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.8489999771118164},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.6800000071525574},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.6959999799728394},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.6840000152587891},{"id":"https://openalex.org/keywords/selenium-status","display_name":"selenium status","score":0.6060000061988831},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2779135701","wikidata":"https://www.wikidata.org/wiki/Q1322302","display_name":"Selenium deficiency","level":5,"score":0.8468999862670898},{"id":"https://openalex.org/C553756173","wikidata":"https://www.wikidata.org/wiki/Q876","display_name":"Selenium","level":2,"score":0.7922000288963318},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.767300009727478},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.760200023651123},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7533000111579895},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5831999778747559},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.429500013589859},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4088999927043915},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.40450000762939453},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.39259999990463257},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.3458999991416931},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.3352999985218048},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.29679998755455017},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.2944999933242798},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.28999999165534973},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2678000032901764},{"id":"https://openalex.org/C2993469949","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Cardiac dysfunction","level":3,"score":0.2612999975681305}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.28.754959","doi":"https://doi.org/10.64898/2026.09.28.754959","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.754959","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.28.754959.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.28.754959","doi":"https://doi.org/10.64898/2026.09.28.754959","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.754959","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.28.754959.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3031378702","display_name":"Poor diet and heaRt failurE deVelopmENT: molecular mechanisms of Selenium Deficiency \u2013 PREVENT-SeD","funder_award_id":"OCENW.M.23.184","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320323105","display_name":"Universitair Medisch Centrum Groningen","ror":"https://ror.org/03cv38k47"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214767308.pdf","grobid_xml":"https://content.openalex.org/works/W7214767308.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1685813921","https://openalex.org/W1982882767","https://openalex.org/W1984068025","https://openalex.org/W2001833830","https://openalex.org/W2013131201","https://openalex.org/W2055331130","https://openalex.org/W2074769261","https://openalex.org/W2113868111","https://openalex.org/W2114407212","https://openalex.org/W2118204731","https://openalex.org/W2139318112","https://openalex.org/W2158895600","https://openalex.org/W2171360543","https://openalex.org/W2259520888","https://openalex.org/W2292493149","https://openalex.org/W2314228618","https://openalex.org/W2471362850","https://openalex.org/W2754468938","https://openalex.org/W2787429377","https://openalex.org/W2791848894","https://openalex.org/W2971574869","https://openalex.org/W2979481024","https://openalex.org/W3038198963","https://openalex.org/W3140631703","https://openalex.org/W3202090264","https://openalex.org/W4200278620","https://openalex.org/W4211152088","https://openalex.org/W4213148808","https://openalex.org/W4220946720","https://openalex.org/W4253545088","https://openalex.org/W4315780026","https://openalex.org/W4376867268","https://openalex.org/W4385163757","https://openalex.org/W4388633028","https://openalex.org/W4391257088","https://openalex.org/W4391678782","https://openalex.org/W4402747611","https://openalex.org/W7119490667"],"related_works":["https://openalex.org/W7161140637","https://openalex.org/W3031526733","https://openalex.org/W1998640197","https://openalex.org/W2107607658","https://openalex.org/W2330707037","https://openalex.org/W4200335100","https://openalex.org/W1979754583","https://openalex.org/W7202171786","https://openalex.org/W2897575318","https://openalex.org/W7215864099"],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"Selenium":[2,70,213,266],"is":[3,18,241],"a":[4,38,140,306,310,327],"vital":[5],"trace":[6],"element":[7],"involved":[8],"in":[9,20,106,295],"antioxidant":[10],"defence":[11],"and":[12,26,60,88,125,130,153,166,170,227,232,253,283,287,317,320,335],"cardiovascular":[13,329],"health.":[14],"Although":[15],"selenium":[16,47,74,147,176,191,239,315,324],"deficiency":[17,71,148,192,214,240,267,316],"implicated":[19],"cardiomyopathies,":[21],"its":[22],"early":[23,97,150,194,269],"cardiac":[24,49,79,119,158,179,216,236,256,274,318],"effects":[25,291],"underlying":[27],"mechanisms":[28,300],"remain":[29],"poorly":[30],"defined.":[31],"Methods":[32],"C57BL6/Njr":[33],"mice":[34,246],"were":[35,64,103],"fed":[36],"either":[37],"selenium-deficient":[39],"or":[40,81],"control":[41],"diet":[42],"for":[43],"12":[44],"weeks.":[45],"Systemic":[46],"status,":[48],"function":[50],"by":[51,204,220,277],"echocardiography,":[52],"left":[53],"ventricular":[54,110],"(LV)":[55],"transcriptomic":[56],"profiles,":[57],"redox":[58,121,165,231,286],"balance,":[59],"circadian":[61,126,167,233,251,288],"pathway":[62,168],"markers":[63,102],"assessed,":[65],"including":[66],"sex-specific":[67,134,172,299],"analyses.":[68],"Results":[69],"reduced":[72,92],"plasma":[73],"levels":[75],"without":[76],"inducing":[77],"overt":[78,157,198,273,349],"hypertrophy":[80],"fibrosis.":[82],"Echocardiography":[83],"showed":[84],"preserved":[85,210],"ejection":[86,211],"fraction":[87],"fractional":[89],"shortening":[90],"but":[91],"global":[93,206],"longitudinal":[94,207],"strain,":[95],"indicating":[96],"systolic":[98],"dysfunction.":[99],"Cardiac":[100],"stress":[101,257],"increased":[104],"predominantly":[105],"male":[107,245,296],"mice.":[108],"Left":[109],"RNA":[111],"sequencing":[112],"revealed":[113],"enrichment":[114],"of":[115,222,229,255,279,285,301,323],"pathways":[116,258],"related":[117],"to":[118,178,238,344,347],"remodelling,":[120],"regulation,":[122],"mitochondrial":[123,225],"function,":[124],"rhythm.":[127],"Additional":[128],"protein":[129],"metabolic":[131],"analyses":[132],"supported":[133],"redox\u2013circadian":[135,183,307,338],"alterations,":[136],"with":[137,164,244],"males":[138],"showing":[139],"more":[141,293],"pronounced":[142,294],"stress-response":[143],"profile.":[144],"Conclusions":[145],"Dietary":[146,190],"induces":[149,193,268],"myocardial":[151,195,270],"dysfunction":[152,196,271],"molecular":[154,217],"remodelling":[155,218,319],"before":[156,197,272],"failure.":[159,351],"These":[160,290],"changes":[161],"are":[162,292],"associated":[163],"disruption":[169,228,284],"show":[171],"features,":[173],"suggesting":[174,298],"that":[175],"contributes":[177],"homeostasis":[180],"through":[181],"sex-dependent":[182],"regulation.":[184],"TRANSLATIONAL":[185],"PERSPECTIVES":[186],"What":[187,261],"Is":[188],"New?":[189],"heart":[199,350],"failure":[200],"develops,":[201],"as":[202,309,326],"detected":[203],"impaired":[205],"strain":[208],"despite":[209],"fraction.":[212],"promotes":[215],"characterized":[219],"activation":[221,254,278],"hypertrophic":[223,280],"signalling,":[224],"stress,":[226,250],"interconnected":[230],"pathways.":[234],"The":[235,303],"response":[237],"sexually":[242],"dimorphic,":[243],"exhibiting":[247],"greater":[248],"oxidative":[249],"dysregulation,":[252],"than":[259],"females.":[260],"Are":[262],"the":[263],"Clinical":[264],"Implications?":[265],"failure,":[275],"accompanied":[276],"gene":[281],"programmes":[282],"homeostasis.":[289],"mice,":[297],"susceptibility.":[302],"findings":[304],"identify":[305],"axis":[308],"potential":[311],"mechanistic":[312],"link":[313],"between":[314],"support":[321],"evaluation":[322],"status":[325],"modifiable":[328],"risk":[330],"factor.":[331],"Early":[332],"nutritional":[333],"intervention":[334],"therapies":[336],"targeting":[337],"signalling":[339],"may":[340],"offer":[341],"new":[342],"opportunities":[343],"prevent":[345],"progression":[346],"clinically":[348]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-30T00:00:00"}
