{"id":"https://openalex.org/W7214755653","doi":"https://doi.org/10.1016/j.omta.2026.201853","title":"Calcineurin-mediated regulation of macrophage plasticity drives anti-tumor activity","display_name":"Calcineurin-mediated regulation of macrophage plasticity drives anti-tumor activity","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7214755653","doi":"https://doi.org/10.1016/j.omta.2026.201853","pmid":"https://pubmed.ncbi.nlm.nih.gov/42909396","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13685445"},"language":"en","primary_location":{"id":"doi:10.1016/j.omta.2026.201853","doi":"https://doi.org/10.1016/j.omta.2026.201853","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omta.2026.201853","pdf_url":null,"source":{"id":"https://openalex.org/S5407055139","display_name":"Molecular Therapy Advances","issn_l":"3117-387X","issn":["3117-387X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","oarl"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.omta.2026.201853","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5153432672","display_name":"Ruijie Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141816","display_name":"Central Hospital of Putuo District","ror":"https://ror.org/04nwd2p56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141816"]},{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruijie Yang","raw_affiliation_strings":["East China Normal University-Shanghai Putuo District Central Hospital Collaborative Research Center for Translational Medicine, Shanghai Putuo District Central Hospital, Shanghai 200062, China","Joint Center for Translational Medicine, Fengxian District Central Hospital, Fengxian District, Shanghai 201499, China","Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China Normal University-Shanghai Putuo District Central Hospital Collaborative Research Center for Translational Medicine, Shanghai Putuo District Central Hospital, Shanghai 200062, China","institution_ids":["https://openalex.org/I4210141816","https://openalex.org/I66867065"]},{"raw_affiliation_string":"Joint Center for Translational Medicine, Fengxian District Central Hospital, Fengxian District, Shanghai 201499, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153501230","display_name":"Yuxue Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141816","display_name":"Central Hospital of Putuo District","ror":"https://ror.org/04nwd2p56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141816"]},{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxue Chen","raw_affiliation_strings":["East China Normal University-Shanghai Putuo District Central Hospital Collaborative Research Center for Translational Medicine, Shanghai Putuo District Central Hospital, Shanghai 200062, China","Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China Normal University-Shanghai Putuo District Central Hospital Collaborative Research Center for Translational Medicine, Shanghai Putuo District Central Hospital, Shanghai 200062, China","institution_ids":["https://openalex.org/I4210141816","https://openalex.org/I66867065"]},{"raw_affiliation_string":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153429004","display_name":"Jiannan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiannan Liu","raw_affiliation_strings":["Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153473330","display_name":"Ruitao Hou","orcid":"https://orcid.org/0009-0003-7653-1510","observed_orcids":["https://orcid.org/0009-0003-7653-1510"]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruitao Hou","raw_affiliation_strings":["Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China"],"raw_orcid":"https://orcid.org/0009-0003-7653-1510","affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153460239","display_name":"Yuqing Chao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqing Chao","raw_affiliation_strings":["Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153437157","display_name":"Yiting Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiting Wang","raw_affiliation_strings":["Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153446244","display_name":"Ning Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Wang","raw_affiliation_strings":["Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046052924","display_name":"Binghe Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Binghe Tan","raw_affiliation_strings":["BRL Medicine, Inc., Shanghai 201109, China","Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BRL Medicine, Inc., Shanghai 201109, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153543343","display_name":"Na Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Zhang","raw_affiliation_strings":["BRL Medicine, Inc., Shanghai 201109, China","Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BRL Medicine, Inc., Shanghai 201109, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153503603","display_name":"Mingyao Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingyao Liu","raw_affiliation_strings":["Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102507977","display_name":"Zhu Y","orcid":"https://orcid.org/0000-0002-8387-2300","observed_orcids":["https://orcid.org/0000-0002-8387-2300","https://orcid.org/0000-0002-7384-607X","https://orcid.org/0000-0003-4555-6232","https://orcid.org/0009-0000-1441-6400","https://orcid.org/0009-0004-2046-9030","https://orcid.org/0000-0003-1372-9135"]},"institutions":[{"id":"https://openalex.org/I4210141816","display_name":"Central Hospital of Putuo District","ror":"https://ror.org/04nwd2p56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141816"]},{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongqiang Zhu","raw_affiliation_strings":["East China Normal University-Shanghai Putuo District Central Hospital Collaborative Research Center for Translational Medicine, Shanghai Putuo District Central Hospital, Shanghai 200062, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China Normal University-Shanghai Putuo District Central Hospital Collaborative Research Center for Translational Medicine, Shanghai Putuo District Central Hospital, Shanghai 200062, China","institution_ids":["https://openalex.org/I4210141816","https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153452172","display_name":"Bing Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141816","display_name":"Central Hospital of Putuo District","ror":"https://ror.org/04nwd2p56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141816"]},{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bing Du","raw_affiliation_strings":["East China Normal University-Shanghai Putuo District Central Hospital Collaborative Research Center for Translational Medicine, Shanghai Putuo District Central Hospital, Shanghai 200062, China","Joint Center for Translational Medicine, Fengxian District Central Hospital, Fengxian District, Shanghai 201499, China","Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China Normal University-Shanghai Putuo District Central Hospital Collaborative Research Center for Translational Medicine, Shanghai Putuo District Central Hospital, Shanghai 200062, China","institution_ids":["https://openalex.org/I4210141816","https://openalex.org/I66867065"]},{"raw_affiliation_string":"Joint Center for Translational Medicine, Fengxian District Central Hospital, Fengxian District, Shanghai 201499, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049288652","display_name":"Juliang Qin","orcid":"https://orcid.org/0000-0003-3328-3425","observed_orcids":["https://orcid.org/0000-0003-3328-3425"]},"institutions":[{"id":"https://openalex.org/I4210141816","display_name":"Central Hospital of Putuo District","ror":"https://ror.org/04nwd2p56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141816"]},{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Juliang Qin","raw_affiliation_strings":["East China Normal University-Shanghai Putuo District Central Hospital Collaborative Research Center for Translational Medicine, Shanghai Putuo District Central Hospital, Shanghai 200062, China","Joint Center for Translational Medicine, Fengxian District Central Hospital, Fengxian District, Shanghai 201499, China","Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China"],"raw_orcid":"https://orcid.org/0000-0003-3328-3425","affiliations":[{"raw_affiliation_string":"East China Normal University-Shanghai Putuo District Central Hospital Collaborative Research Center for Translational Medicine, Shanghai Putuo District Central Hospital, Shanghai 200062, China","institution_ids":["https://openalex.org/I4210141816","https://openalex.org/I66867065"]},{"raw_affiliation_string":"Joint Center for Translational Medicine, Fengxian District Central Hospital, Fengxian District, Shanghai 201499, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China","institution_ids":["https://openalex.org/I66867065"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049288652","https://openalex.org/A5102507977","https://openalex.org/A5153452172"],"corresponding_institution_ids":["https://openalex.org/I4210141816","https://openalex.org/I66867065"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.64197716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"4","first_page":"201853","last_page":"201853"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcineurin","display_name":"calcineurin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ppp3ca","display_name":"PPP3CA","score":0.9610000252723694},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8700000047683716},{"id":"https://openalex.org/keywords/macrophage-plasticity","display_name":"macrophage plasticity","score":0.9580000042915344},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9810000061988831},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9599999785423279},{"id":"https://openalex.org/keywords/calcineurin-inhibitors","display_name":"calcineurin inhibitors","score":0.9570000171661377},{"id":"https://openalex.org/keywords/lung-cancer-immunotherapy","display_name":"lung cancer immunotherapy","score":0.8029999732971191},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9649999737739563}],"concepts":[{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.5072000026702881},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5020999908447266},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4505000114440918},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4453999996185303},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38769999146461487},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.24779999256134033},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.24580000340938568},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.23680000007152557},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.19920000433921814},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.19779999554157257}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.omta.2026.201853","doi":"https://doi.org/10.1016/j.omta.2026.201853","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omta.2026.201853","pdf_url":null,"source":{"id":"https://openalex.org/S5407055139","display_name":"Molecular Therapy Advances","issn_l":"3117-387X","issn":["3117-387X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","oarl"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13685445","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13685445/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13685445/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther Adv","raw_type":"Text"},{"id":"pmid:42909396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42909396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy. Advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.omta.2026.201853","doi":"https://doi.org/10.1016/j.omta.2026.201853","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omta.2026.201853","pdf_url":null,"source":{"id":"https://openalex.org/S5407055139","display_name":"Molecular Therapy Advances","issn_l":"3117-387X","issn":["3117-387X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","oarl"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1089262395","display_name":null,"funder_award_id":"32270960","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G135908898","display_name":null,"funder_award_id":"82173099","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1664813219","display_name":null,"funder_award_id":"23XD1430600","funder_id":"https://openalex.org/F4320335796","funder_display_name":"Program of Shanghai Academic Research Leader"},{"id":"https://openalex.org/G2448236424","display_name":null,"funder_award_id":"2024CXJQ01","funder_id":"https://openalex.org/F4320317789","funder_display_name":"Shanghai Municipal Health Commission"},{"id":"https://openalex.org/G2618160277","display_name":null,"funder_award_id":"23XD1430600","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G3065681691","display_name":null,"funder_award_id":"23141903300","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G3342739023","display_name":null,"funder_award_id":"24QA2707300","funder_id":"https://openalex.org/F4320327803","funder_display_name":"Shanghai Rising-Star Program"},{"id":"https://openalex.org/G5161913616","display_name":null,"funder_award_id":"23141901800","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G77778246","display_name":null,"funder_award_id":"82430092","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G9780428","display_name":null,"funder_award_id":"24J22801200","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"}],"funders":[{"id":"https://openalex.org/F4320317789","display_name":"Shanghai Municipal Health Commission","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320322370","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67"},{"id":"https://openalex.org/F4320327803","display_name":"Shanghai Rising-Star Program","ror":null},{"id":"https://openalex.org/F4320335796","display_name":"Program of Shanghai Academic Research Leader","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214755653.pdf","grobid_xml":"https://content.openalex.org/works/W7214755653.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1521598031","https://openalex.org/W1577688300","https://openalex.org/W1964714738","https://openalex.org/W2009992865","https://openalex.org/W2012086375","https://openalex.org/W2078884784","https://openalex.org/W2080565111","https://openalex.org/W2128246500","https://openalex.org/W2128853478","https://openalex.org/W2140823178","https://openalex.org/W2409448100","https://openalex.org/W2810317548","https://openalex.org/W2964274812","https://openalex.org/W3025322808","https://openalex.org/W3049096757","https://openalex.org/W3086847423","https://openalex.org/W3092452680","https://openalex.org/W3106978737","https://openalex.org/W3146706804","https://openalex.org/W3151167688","https://openalex.org/W3206564803","https://openalex.org/W3206841723","https://openalex.org/W4205711062","https://openalex.org/W4310772623","https://openalex.org/W4392343318","https://openalex.org/W4396856688","https://openalex.org/W4400748356","https://openalex.org/W4404403372","https://openalex.org/W4410386140","https://openalex.org/W4412513584","https://openalex.org/W4413114130"],"related_works":["https://openalex.org/W2105724560","https://openalex.org/W4391403444","https://openalex.org/W17527800","https://openalex.org/W2793719662","https://openalex.org/W2167600490","https://openalex.org/W7061718784","https://openalex.org/W2047046851","https://openalex.org/W2109203270","https://openalex.org/W3126678327","https://openalex.org/W4309666029"],"abstract_inverted_index":{"loss":[0],"significantly":[1],"blunted":[2],"NF-\u03baB":[3],"activation.":[4],"Furthermore,":[5],"pharmacological":[6],"inhibition":[7],"of":[8,57],"calcineurin":[9,42],"using":[10],"cyclosporin":[11],"A":[12],"(CsA)":[13],"effectively":[14],"recapitulated":[15],"the":[16,35,50,72],"myeloid-deficient":[17],"phenotype,":[18],"shifting":[19],"TAMs":[20],"toward":[21],"a":[22,54,62],"pro-tumorigenic":[23],"M2":[24],"state":[25],"and":[26,60],"promoting":[27],"tumor":[28],"malignancy,":[29],"providing":[30],"an":[31],"experimental":[32],"explanation":[33],"for":[34,66],"elevated":[36],"cancer":[37,76],"risk":[38],"associated":[39],"with":[40],"clinical":[41],"inhibitor":[43],"(CNI)":[44],"use.":[45],"Collectively,":[46],"our":[47],"findings":[48],"identify":[49],"PPP3CA-NF-\u03baB":[51],"axis":[52],"as":[53],"pivotal":[55],"regulator":[56],"macrophage":[58],"plasticity":[59],"provide":[61],"high-value":[63],"translational":[64],"basis":[65],"targeting":[67],"this":[68],"pathway":[69],"to":[70],"remodel":[71],"TME":[73],"in":[74],"lung":[75],"immunotherapy.":[77]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-30T00:00:00"}