{"id":"https://openalex.org/W7214753395","doi":"https://doi.org/10.1016/j.xcrm.2026.103080","title":"A multi-omics analysis of advanced triple-negative breast cancer identifies predictors to chemo-immunotherapy and on-treatment dynamics","display_name":"A multi-omics analysis of advanced triple-negative breast cancer identifies predictors to chemo-immunotherapy and on-treatment dynamics","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7214753395","doi":"https://doi.org/10.1016/j.xcrm.2026.103080","pmid":"https://pubmed.ncbi.nlm.nih.gov/42810342","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13710547"},"language":"en","primary_location":{"id":"doi:10.1016/j.xcrm.2026.103080","doi":"https://doi.org/10.1016/j.xcrm.2026.103080","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xcrm.2026.103080","pdf_url":null,"source":{"id":"https://openalex.org/S4210207453","display_name":"Cell Reports Medicine","issn_l":"2666-3791","issn":["2666-3791"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.xcrm.2026.103080","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089436970","display_name":"Nicolaas Van Renne","orcid":"https://orcid.org/0000-0002-3053-8835","observed_orcids":["https://orcid.org/0000-0002-3053-8835"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Nicolaas Van Renne","raw_affiliation_strings":["Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082230442","display_name":"Elisa Agostinetto","orcid":"https://orcid.org/0000-0003-0295-7511","observed_orcids":["https://orcid.org/0000-0003-0295-7511"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Elisa Agostinetto","raw_affiliation_strings":["Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium; H\u00f4pital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium; H\u00f4pital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153489804","display_name":"Andrea Joaqu\u00edn Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Andrea Joaqu\u00edn Garc\u00eda","raw_affiliation_strings":["Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065872123","display_name":"Marie Morfouace","orcid":"https://orcid.org/0009-0006-8786-0645","observed_orcids":["https://orcid.org/0009-0006-8786-0645","https://orcid.org/0000-0002-3958-3755"]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210124801","display_name":"European Organisation for Research and Treatment of Cancer","ror":"https://ror.org/034wxcc35","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I4210124801"]}],"countries":["BE","FR"],"is_corresponding":false,"raw_author_name":"Marie Morfouace","raw_affiliation_strings":["EORTC Headquarters, Brussels, Belgium; Institut Gustave Roussy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EORTC Headquarters, Brussels, Belgium; Institut Gustave Roussy, Villejuif, France","institution_ids":["https://openalex.org/I2801843802","https://openalex.org/I4210124801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046415071","display_name":"Marcin Mo\u017cejko","orcid":"https://orcid.org/0000-0002-5631-0046","observed_orcids":["https://orcid.org/0000-0002-5631-0046"]},"institutions":[{"id":"https://openalex.org/I4654613","display_name":"University of Warsaw","ror":"https://ror.org/039bjqg32","country_code":"PL","type":"education","lineage":["https://openalex.org/I4654613"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marcin Mo\u017cejko","raw_affiliation_strings":["Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Warsaw, Poland","institution_ids":["https://openalex.org/I4654613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093428848","display_name":"Zo\u00eb Denis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Zo\u00eb Denis","raw_affiliation_strings":["Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125755675","display_name":"Sophie D\u00e9glise","orcid":"https://orcid.org/0009-0007-7699-1823","observed_orcids":["https://orcid.org/0009-0007-7699-1823"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405257820","display_name":"Institute of Molecular Health Sciences","ror":"https://ror.org/05q2cwx50","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257820"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sophie D\u00e9glise","raw_affiliation_strings":["Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088","https://openalex.org/I4405257820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010642463","display_name":"Bernd Bodenmiller","orcid":"https://orcid.org/0000-0002-6325-7861","observed_orcids":["https://orcid.org/0000-0002-6325-7861"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405257820","display_name":"Institute of Molecular Health Sciences","ror":"https://ror.org/05q2cwx50","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257820"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Bernd Bodenmiller","raw_affiliation_strings":["Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088","https://openalex.org/I4405257820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037867030","display_name":"Henoch Sangjoon Hong","orcid":"https://orcid.org/0000-0002-3367-1738","observed_orcids":["https://orcid.org/0000-0002-3367-1738"]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]},{"id":"https://openalex.org/I4405266695","display_name":"Merck Healthcare KGaA, Darmstadt (Germany)","ror":"https://ror.org/04vpzfb52","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4405266695"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Henoch S. Hong","raw_affiliation_strings":["The Healthcare Business of Merck KGaA, Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Healthcare Business of Merck KGaA, Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964","https://openalex.org/I4405266695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048492884","display_name":"David Venet","orcid":"https://orcid.org/0000-0001-9038-5271","observed_orcids":["https://orcid.org/0000-0001-9038-5271"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"David Venet","raw_affiliation_strings":["Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061986553","display_name":"Marcela Carausu","orcid":"https://orcid.org/0000-0002-2414-2500","observed_orcids":["https://orcid.org/0000-0002-2414-2500"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Marcela Carausu","raw_affiliation_strings":["Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066081150","display_name":"Robin Liechti","orcid":"https://orcid.org/0000-0001-8351-4776","observed_orcids":["https://orcid.org/0000-0001-8351-4776"]},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Robin Liechti","raw_affiliation_strings":["Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109942964","display_name":"St\u00e9phanie Tissot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"St\u00e9phanie Tissot","raw_affiliation_strings":["Center of Experimental Therapeutics, CHUV, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Experimental Therapeutics, CHUV, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013921145","display_name":"Sylvie Rusakiewicz","orcid":"https://orcid.org/0000-0001-5939-5690","observed_orcids":["https://orcid.org/0000-0001-5939-5690"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sylvie Rusakiewicz","raw_affiliation_strings":["Center of Experimental Therapeutics, CHUV, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Experimental Therapeutics, CHUV, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063122523","display_name":"Mattia Rediti","orcid":"https://orcid.org/0000-0002-6713-2599","observed_orcids":["https://orcid.org/0000-0002-6713-2599"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]},{"id":"https://openalex.org/I4210114103","display_name":"IFOM","ror":"https://ror.org/02hcsa680","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210114103"]}],"countries":["BE","IT"],"is_corresponding":false,"raw_author_name":"Mattia Rediti","raw_affiliation_strings":["Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium; IFOM ETS, the AIRC Institute of Molecular Oncology, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium; IFOM ETS, the AIRC Institute of Molecular Oncology, Milan, Italy","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318","https://openalex.org/I4210114103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062265079","display_name":"Xavier Catteau","orcid":"https://orcid.org/0000-0003-3031-5719","observed_orcids":["https://orcid.org/0000-0003-3031-5719"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Xavier Catteau","raw_affiliation_strings":["H\u00f4pital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062772363","display_name":"Daniel Schulz","orcid":"https://orcid.org/0000-0002-0913-1678","observed_orcids":["https://orcid.org/0000-0002-0913-1678"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405257820","display_name":"Institute of Molecular Health Sciences","ror":"https://ror.org/05q2cwx50","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257820"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Daniel Schulz","raw_affiliation_strings":["Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088","https://openalex.org/I4405257820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109782636","display_name":"Delphine Loirat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Delphine Loirat","raw_affiliation_strings":["Medical Oncology Department, Institut Curie, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department, Institut Curie, Paris, France","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093460734","display_name":"Daniel Herrero-Saboya","orcid":"https://orcid.org/0009-0001-9948-1531","observed_orcids":["https://orcid.org/0009-0001-9948-1531"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I70768539","display_name":"\u00c9cole Nationale Sup\u00e9rieure des Mines de Paris","ror":"https://ror.org/04y8cs423","country_code":"FR","type":"education","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I70768539"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daniel Herrero Saboya","raw_affiliation_strings":["Computational and Systems Biology of Cancer, Institut Curie, INSERM U1331, Mines ParisTech, PSL University, Paris, France; Computational Medicine, Servier Research & Development, Saclay, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational and Systems Biology of Cancer, Institut Curie, INSERM U1331, Mines ParisTech, PSL University, Paris, France; Computational Medicine, Servier Research & Development, Saclay, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2746051580","https://openalex.org/I70768539","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078388793","display_name":"Philippe Georges Aftimos","orcid":"https://orcid.org/0000-0001-9946-4726","observed_orcids":["https://orcid.org/0000-0001-9946-4726"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Philippe Aftimos","raw_affiliation_strings":["H\u00f4pital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025403673","display_name":"Matteo Benelli","orcid":"https://orcid.org/0000-0003-1227-356X","observed_orcids":["https://orcid.org/0000-0003-1227-356X"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Benelli","raw_affiliation_strings":["Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043393829","display_name":"\u00c1ngel Guerrero Zotano","orcid":"https://orcid.org/0000-0003-0318-9120","observed_orcids":["https://orcid.org/0000-0003-0318-9120"]},"institutions":[{"id":"https://openalex.org/I4210103093","display_name":"Fundaci\u00f3n Instituto Valenciano de Oncolog\u00eda","ror":"https://ror.org/01fh9k283","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210103093"]},{"id":"https://openalex.org/I4210163263","display_name":"GEICAM \u2013 Spanish Breast Cancer Group","ror":"https://ror.org/05ygm7711","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210163263"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Angel L. Guerrero-Zotano","raw_affiliation_strings":["Medical Oncology Department, Instituto Valenciano de Oncologia, Valencia, Spain; Grupo Espa\u00f1ol de Investigaci\u00f3n C\u00e1ncer de Mama (GEICAM), San Sebasti\u00e1n de los Reyes, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department, Instituto Valenciano de Oncologia, Valencia, Spain; Grupo Espa\u00f1ol de Investigaci\u00f3n C\u00e1ncer de Mama (GEICAM), San Sebasti\u00e1n de los Reyes, Spain","institution_ids":["https://openalex.org/I4210103093","https://openalex.org/I4210163263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073796630","display_name":"Andrea Gombos","orcid":"https://orcid.org/0000-0003-1664-2369","observed_orcids":["https://orcid.org/0000-0003-1664-2369"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Andrea Gombos","raw_affiliation_strings":["H\u00f4pital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008071748","display_name":"Hans Wildiers","orcid":"https://orcid.org/0000-0001-8990-7837","observed_orcids":["https://orcid.org/0000-0001-8990-7837"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Hans Wildiers","raw_affiliation_strings":["Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053018926","display_name":"Jip T. van Dinter","orcid":"https://orcid.org/0000-0002-3749-1531","observed_orcids":["https://orcid.org/0000-0002-3749-1531"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jip Van Dinter","raw_affiliation_strings":["Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-3749-1531","affiliations":[{"raw_affiliation_string":"Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071439381","display_name":"Ariane A. Sickinghe","orcid":"https://orcid.org/0000-0002-0630-9354","observed_orcids":["https://orcid.org/0000-0002-0630-9354"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ariane Sickinghe","raw_affiliation_strings":["Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052242950","display_name":"Nicolas Penel","orcid":"https://orcid.org/0000-0001-5243-1548","observed_orcids":["https://orcid.org/0000-0001-5243-1548"]},"institutions":[{"id":"https://openalex.org/I4210131356","display_name":"Centre Oscar Lambret","ror":"https://ror.org/03xfq7a50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210131356","https://openalex.org/I4210141925"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Penel","raw_affiliation_strings":["Centre Oscar Lambret, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Oscar Lambret, Lille, France","institution_ids":["https://openalex.org/I4210131356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110853958","display_name":"Jean\u2010Charles Goeminne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Charles Goeminne","raw_affiliation_strings":["Centre Hospitalier Universitaire UCL Namur (site Sainte Elisabeth), Namur, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Universitaire UCL Namur (site Sainte Elisabeth), Namur, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153538217","display_name":"J\u00falio Oliveira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"J\u00falio Oliveira","raw_affiliation_strings":["Instituto Portugu\u00eas de Oncologia do Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Portugu\u00eas de Oncologia do Porto, Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009987129","display_name":"Birut\u0117 Brasi\u016bnien\u0117","orcid":"https://orcid.org/0000-0002-7097-1131","observed_orcids":["https://orcid.org/0000-0002-7097-1131"]},"institutions":[{"id":"https://openalex.org/I173212132","display_name":"Vilnius University","ror":"https://ror.org/03nadee84","country_code":"LT","type":"education","lineage":["https://openalex.org/I173212132"]},{"id":"https://openalex.org/I4210161607","display_name":"Vilnius University Hospital Santariskiu Klinikos","ror":"https://ror.org/0590pq693","country_code":"LT","type":"healthcare","lineage":["https://openalex.org/I4210161607"]}],"countries":["LT"],"is_corresponding":false,"raw_author_name":"Birute Brasiuniene","raw_affiliation_strings":["National Cancer Center of Vilnius University Hospital Santaros clinics, Vilnius, Lithuania; Faculty of Medicine, Vilnius University, Vilnius, Lithuania"],"raw_orcid":"https://orcid.org/0000-0002-7097-1131","affiliations":[{"raw_affiliation_string":"National Cancer Center of Vilnius University Hospital Santaros clinics, Vilnius, Lithuania; Faculty of Medicine, Vilnius University, Vilnius, Lithuania","institution_ids":["https://openalex.org/I173212132","https://openalex.org/I4210161607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015546743","display_name":"Emanuela Romano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emanuela Romano","raw_affiliation_strings":["Medical Oncology Department, Institut Curie, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department, Institut Curie, Paris, France","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089113899","display_name":"Justin Micah Balko","orcid":"https://orcid.org/0000-0002-4263-5974","observed_orcids":["https://orcid.org/0000-0002-4263-5974"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin M. Balko","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":"https://orcid.org/0000-0002-4263-5974","affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071056994","display_name":"Marleen Kok","orcid":"https://orcid.org/0000-0001-9043-9815","observed_orcids":["https://orcid.org/0000-0001-9043-9815"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marleen Kok","raw_affiliation_strings":["Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036326710","display_name":"Ewa Szczurek","orcid":"https://orcid.org/0000-0002-1320-6695","observed_orcids":["https://orcid.org/0000-0002-1320-6695"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4654613","display_name":"University of Warsaw","ror":"https://ror.org/039bjqg32","country_code":"PL","type":"education","lineage":["https://openalex.org/I4654613"]}],"countries":["DE","PL"],"is_corresponding":false,"raw_author_name":"Ewa Szczurek","raw_affiliation_strings":["Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Warsaw, Poland; Institute of AI for Health, Helmholtz Munich, Neuherberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Warsaw, Poland; Institute of AI for Health, Helmholtz Munich, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4654613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057269336","display_name":"Christos P. Sotiriou","orcid":"https://orcid.org/0000-0002-5745-9977","observed_orcids":["https://orcid.org/0000-0002-5745-9977"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Christos Sotiriou","raw_affiliation_strings":["Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium; H\u00f4pital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium; H\u00f4pital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034407564","display_name":"Laurence Buisseret","orcid":"https://orcid.org/0000-0002-3751-0819","observed_orcids":["https://orcid.org/0000-0002-3751-0819"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Laurence Buisseret","raw_affiliation_strings":["Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium; H\u00f4pital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium. Electronic address: laurence.buisseret@bordet.be"],"raw_orcid":"https://orcid.org/0000-0002-3751-0819","affiliations":[{"raw_affiliation_string":"Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium; H\u00f4pital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium. Electronic address: laurence.buisseret@bordet.be","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]}],"institutions":[],"countries_distinct_count":11,"institutions_distinct_count":28,"corresponding_author_ids":["https://openalex.org/A5034407564"],"corresponding_institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"],"apc_list":{"value":5620,"currency":"USD","value_usd":5620},"apc_paid":{"value":5620,"currency":"USD","value_usd":5620},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.69572794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"10","first_page":"103080","last_page":"103080"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.05979999899864197,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.890999972820282},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8489999771118164},{"id":"https://openalex.org/keywords/chemoimmunotherapy","display_name":"chemoimmunotherapy","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9399999976158142},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.6639999747276306},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8289999961853027},{"id":"https://openalex.org/keywords/macrophage-proliferation","display_name":"macrophage proliferation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7089999914169312},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.593999981880188},{"id":"https://openalex.org/keywords/tumor-fibrosis","display_name":"tumor fibrosis","score":0.5659999847412109},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7390000224113464},{"id":"https://openalex.org/keywords/multiplex-immunofluorescence","display_name":"multiplex immunofluorescence","score":0.7670000195503235},{"id":"https://openalex.org/keywords/imaging-mass-cytometry","display_name":"imaging mass cytometry","score":0.9010000228881836},{"id":"https://openalex.org/keywords/synergy-trial","display_name":"SYNERGY trial","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6937000155448914},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.65420001745224},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5853000283241272},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5666999816894531},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5015000104904175},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4677000045776367},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4043999910354614},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.39730000495910645},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.39579999446868896},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.38670000433921814},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.36390000581741333},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35589998960494995},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.3538999855518341},{"id":"https://openalex.org/C2994430510","wikidata":"https://www.wikidata.org/wiki/Q3270846","display_name":"Myeloid cells","level":3,"score":0.35249999165534973},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34709998965263367},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.34529998898506165},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3337000012397766},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.31220000982284546},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.31220000982284546},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.29910001158714294},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.298799991607666},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.2718999981880188},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.27160000801086426},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.2517000138759613}],"mesh":[{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1016/j.xcrm.2026.103080","doi":"https://doi.org/10.1016/j.xcrm.2026.103080","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xcrm.2026.103080","pdf_url":null,"source":{"id":"https://openalex.org/S4210207453","display_name":"Cell Reports Medicine","issn_l":"2666-3791","issn":["2666-3791"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Medicine","raw_type":"journal-article"},{"id":"pmid:42810342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42810342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports. Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13710547","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710547/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Rep Med","raw_type":"Text"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/808552","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/808552","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Medicine, 7 (10)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:4c8041ba8156422baae3175ad2a18ef2","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4c8041ba8156422baae3175ad2a18ef2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports Medicine, Vol 7, Iss 10, Pp 103080- (2026)","raw_type":"article"},{"id":"pmh:oai:flore.unifi.it:2158/1499362","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2158/1499362","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unil.ch:iris/285467","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/285467","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"},{"id":"doi:10.3929/ethz-c-000808552","doi":"https://doi.org/10.3929/ethz-c-000808552","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-c-000808552","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"}],"best_oa_location":{"id":"doi:10.1016/j.xcrm.2026.103080","doi":"https://doi.org/10.1016/j.xcrm.2026.103080","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xcrm.2026.103080","pdf_url":null,"source":{"id":"https://openalex.org/S4210207453","display_name":"Cell Reports Medicine","issn_l":"2666-3791","issn":["2666-3791"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323069","display_name":"Stichting Tegen Kanker","ror":"https://ror.org/01h3dr788"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1966327575","https://openalex.org/W1969346276","https://openalex.org/W1988818350","https://openalex.org/W2009671859","https://openalex.org/W2114505219","https://openalex.org/W2115528316","https://openalex.org/W2131271579","https://openalex.org/W2134539328","https://openalex.org/W2151709200","https://openalex.org/W2169456326","https://openalex.org/W2592811885","https://openalex.org/W2604789376","https://openalex.org/W2759118902","https://openalex.org/W2769890142","https://openalex.org/W2794018125","https://openalex.org/W2897422388","https://openalex.org/W2913089258","https://openalex.org/W2921768356","https://openalex.org/W2943363006","https://openalex.org/W2944687997","https://openalex.org/W2945057866","https://openalex.org/W2984472267","https://openalex.org/W3009737061","https://openalex.org/W3139293810","https://openalex.org/W3164692211","https://openalex.org/W3176308859","https://openalex.org/W3205008568","https://openalex.org/W3207557929","https://openalex.org/W3214596602","https://openalex.org/W4285992810","https://openalex.org/W4301159569","https://openalex.org/W4318203454","https://openalex.org/W4320489657","https://openalex.org/W4324046116","https://openalex.org/W4361006372","https://openalex.org/W4366401389","https://openalex.org/W4377822333","https://openalex.org/W4386917560","https://openalex.org/W4387494379","https://openalex.org/W4387948619","https://openalex.org/W4388233301","https://openalex.org/W4389728585","https://openalex.org/W4390661182","https://openalex.org/W4401419197","https://openalex.org/W4402561371","https://openalex.org/W4403156481","https://openalex.org/W4410803512","https://openalex.org/W4415939916","https://openalex.org/W7162519740"],"related_works":["https://openalex.org/W7117315736","https://openalex.org/W4388048207","https://openalex.org/W4280544068","https://openalex.org/W7204153867","https://openalex.org/W7052495947","https://openalex.org/W7214025840","https://openalex.org/W2955262653","https://openalex.org/W6903952341","https://openalex.org/W4410466404","https://openalex.org/W3202723367"],"abstract_inverted_index":{"No":[0],"validated":[1,81],"biomarkers":[2],"beyond":[3],"PD-L1":[4],"currently":[5],"guide":[6],"immune":[7],"checkpoint":[8],"inhibition":[9],"(ICI)":[10],"in":[11,23,43,89,153],"advanced":[12,38],"triple-negative":[13],"breast":[14],"cancer":[15],"(TNBC),":[16],"and":[17,51,66,79,127,137,149],"how":[18],"tumors":[19,98],"remodel":[20],"their":[21],"microenvironment":[22,151],"response":[24],"to":[25,108],"ICI":[26],"remains":[27],"incompletely":[28],"understood.":[29],"We":[30],"perform":[31],"a":[32,141],"temporal":[33],"analysis":[34],"of":[35,129],"patients":[36],"with":[37,41,96,99,112],"TNBC":[39],"treated":[40],"chemo-immunotherapy":[42],"the":[44,52],"SYNERGY":[45],"trial":[46],"(NCT03616886;":[47],"n":[48,56],"=":[49,57],"84)":[50],"EORTC-1553-SPECTA":[53],"initiative":[54],"(NCT02834884;":[55],"38)":[58],"using":[59],"RNA":[60],"sequencing,":[61,63],"whole-exome":[62],"multiplex":[64],"immunofluorescence,":[65],"imaging":[67],"mass":[68],"cytometry.":[69],"A":[70],"transcriptomic":[71],"progression-free":[72],"survival":[73],"(PFS)-based":[74],"risk":[75],"signature":[76],"stratifies":[77],"outcomes":[78,93,105],"is":[80],"across":[82],"ICI-treated":[83],"cohorts,":[84],"while":[85,103],"showing":[86],"context-dependent":[87],"behavior":[88],"non-ICI":[90],"settings.":[91],"Favorable":[92],"are":[94,106],"associated":[95],"immune-enriched":[97],"organized":[100],"lymphoid":[101],"architecture,":[102],"poor":[104],"linked":[107],"fibrotic,":[109],"angiogenic":[110],"microenvironments":[111],"frequent":[113],"PI3K":[114],"alterations.":[115],"Upon":[116],"treatment,":[117],"early":[118],"progression":[119],"was":[120],"characterized":[121],"by":[122],"fibrovascular":[123,136],"remodeling,":[124],"macrophage":[125],"expansion,":[126],"upregulation":[128],"alternative":[130],"immunosuppressive":[131],"mediators.":[132],"These":[133],"findings":[134],"establish":[135],"myeloid":[138],"reprogramming":[139],"as":[140],"coordinated":[142],"resistance":[143],"program,":[144],"identify":[145],"actionable":[146],"therapeutic":[147],"targets,":[148],"support":[150],"stratification":[152],"future":[154],"ICI-based":[155],"trials.":[156]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-09-30T00:00:00"}