{"id":"https://openalex.org/W7214747420","doi":"https://doi.org/10.64898/2026.09.28.754846","title":"The Flame Retardant Triphenyl Phosphate Induces Varying Responses in Genetically Diverse Mouse Induced Pluripotent Stem Cells","display_name":"The Flame Retardant Triphenyl Phosphate Induces Varying Responses in Genetically Diverse Mouse Induced Pluripotent Stem Cells","publication_year":2026,"publication_date":"2026-09-28","ids":{"openalex":"https://openalex.org/W7214747420","doi":"https://doi.org/10.64898/2026.09.28.754846","pmid":"https://pubmed.ncbi.nlm.nih.gov/42856471","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13648596"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.28.754846","doi":"https://doi.org/10.64898/2026.09.28.754846","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.754846","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.28.754846.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.28.754846.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102910779","display_name":"Madison Armstrong","orcid":"https://orcid.org/0000-0002-1805-2752","observed_orcids":["https://orcid.org/0000-0002-1805-2752"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Madison Armstrong","raw_affiliation_strings":["The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine","Tufts University, Graduate School of Biomedical Sciences, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-1805-2752","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"Tufts University, Graduate School of Biomedical Sciences, Boston, Massachusetts","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151634492","display_name":"Kathryn Janeczko","orcid":"https://orcid.org/0009-0007-6133-8426","observed_orcids":["https://orcid.org/0009-0007-6133-8426"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn Janeczko","raw_affiliation_strings":["The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine"],"raw_orcid":"https://orcid.org/0009-0007-6133-8426","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031845290","display_name":"Hannah B. Dewey","orcid":"https://orcid.org/0000-0002-3009-0452","observed_orcids":["https://orcid.org/0000-0002-3009-0452"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah B. Dewey","raw_affiliation_strings":["The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine","Tufts University, Graduate School of Biomedical Sciences, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-3009-0452","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"Tufts University, Graduate School of Biomedical Sciences, Boston, Massachusetts","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080894389","display_name":"Anne Czechanski","orcid":"https://orcid.org/0000-0003-3210-4210","observed_orcids":["https://orcid.org/0000-0003-3210-4210"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne Czechanski","raw_affiliation_strings":["The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine"],"raw_orcid":"https://orcid.org/0000-0003-3210-4210","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028189129","display_name":"Qiongyu Chen","orcid":"https://orcid.org/0000-0001-5283-5614","observed_orcids":["https://orcid.org/0000-0001-5283-5614","https://orcid.org/0009-0001-4153-7432"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiongyu Chen","raw_affiliation_strings":["The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089743440","display_name":"Emily Swanzey","orcid":"https://orcid.org/0000-0003-2581-6498","observed_orcids":["https://orcid.org/0000-0003-2581-6498"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Swanzey","raw_affiliation_strings":["The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine"],"raw_orcid":"https://orcid.org/0000-0003-2581-6498","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089262311","display_name":"Callan O\u2019Connor","orcid":"https://orcid.org/0000-0002-5699-9955","observed_orcids":["https://orcid.org/0000-0002-5699-9955"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Callan O\u2019Connor","raw_affiliation_strings":["The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine","Tufts University, Graduate School of Biomedical Sciences, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-5699-9955","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"Tufts University, Graduate School of Biomedical Sciences, Boston, Massachusetts","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029183644","display_name":"Whitney Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Whitney Martin","raw_affiliation_strings":["The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017451446","display_name":"Selcan Aydin","orcid":"https://orcid.org/0000-0002-0457-9641","observed_orcids":["https://orcid.org/0000-0002-0457-9641"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Selcan B. Aydin","raw_affiliation_strings":["The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine"],"raw_orcid":"https://orcid.org/0000-0002-0457-9641","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067281001","display_name":"Steven C. Munger","orcid":"https://orcid.org/0000-0002-8458-1871","observed_orcids":["https://orcid.org/0000-0002-8458-1871"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven C. Munger","raw_affiliation_strings":["The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine","Tufts University, Graduate School of Biomedical Sciences, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-8458-1871","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"Tufts University, Graduate School of Biomedical Sciences, Boston, Massachusetts","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018279869","display_name":"Laura G. Reinholdt","orcid":"https://orcid.org/0000-0003-4054-4048","observed_orcids":["https://orcid.org/0000-0003-4054-4048"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura G. Reinholdt","raw_affiliation_strings":["The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine","Tufts University, Graduate School of Biomedical Sciences, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0003-4054-4048","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"Tufts University, Graduate School of Biomedical Sciences, Boston, Massachusetts","institution_ids":["https://openalex.org/I121934306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102910779"],"corresponding_institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210115256"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.8223000168800354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.8223000168800354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triphenyl-phosphate","display_name":"triphenyl phosphate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/flame-retardants","display_name":"flame retardants","score":0.8149999976158142},{"id":"https://openalex.org/keywords/organophosphates","display_name":"organophosphates","score":0.8299999833106995},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9300000071525574},{"id":"https://openalex.org/keywords/diversity-outbred-mice","display_name":"Diversity Outbred mice","score":0.8830000162124634},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"expression quantitative trait loci","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.5870000123977661},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.8360000252723694},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.8989999890327454},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7540000081062317},{"id":"https://openalex.org/keywords/steroid-hormone-signaling","display_name":"steroid hormone signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chemical-toxicity","display_name":"chemical toxicity","score":0.5249999761581421},{"id":"https://openalex.org/keywords/developmental-toxicity","display_name":"developmental toxicity","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.713699996471405},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.608299970626831},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5335999727249146},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49149999022483826},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4830000102519989},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4738999903202057},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4681999981403351},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.45010000467300415},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4438000023365021},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.41679999232292175},{"id":"https://openalex.org/C2780447906","wikidata":"https://www.wikidata.org/wiki/Q418573","display_name":"Triphenyl phosphate","level":3,"score":0.39899998903274536},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.3790000081062317},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3783999979496002},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.3440000116825104},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3330000042915344},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.32190001010894775},{"id":"https://openalex.org/C93231420","wikidata":"https://www.wikidata.org/wiki/Q841450","display_name":"Toxicogenomics","level":4,"score":0.3172000050544739},{"id":"https://openalex.org/C2776588719","wikidata":"https://www.wikidata.org/wiki/Q411097","display_name":"Organophosphate","level":3,"score":0.3127000033855438},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.30790001153945923},{"id":"https://openalex.org/C77957584","wikidata":"https://www.wikidata.org/wiki/Q1133550","display_name":"Gene knockout","level":3,"score":0.3073999881744385},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.3041999936103821},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30399999022483826},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.29109999537467957},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.28529998660087585},{"id":"https://openalex.org/C136302470","wikidata":"https://www.wikidata.org/wiki/Q7607299","display_name":"Stem cell marker","level":3,"score":0.2531999945640564}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.28.754846","doi":"https://doi.org/10.64898/2026.09.28.754846","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.754846","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.28.754846.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42856471","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42856471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13648596","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648596/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.28.754846","doi":"https://doi.org/10.64898/2026.09.28.754846","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.754846","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.28.754846.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214747420.pdf","grobid_xml":"https://content.openalex.org/works/W7214747420.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7008490955","https://openalex.org/W7125383871","https://openalex.org/W4392288986","https://openalex.org/W7160061498","https://openalex.org/W6950294775","https://openalex.org/W4297978243","https://openalex.org/W7214272735","https://openalex.org/W2319710637","https://openalex.org/W7221836210","https://openalex.org/W2031056828"],"abstract_inverted_index":{"Genetic":[0],"variation":[1,126,149,172,209],"impacts":[2],"biological":[3],"response":[4,36],"to":[5,11,28,82,108,171],"chemical":[6,71,250],"and":[7,94,158,201,218,241],"environmental":[8],"exposures,":[9],"contributing":[10],"differences":[12],"in":[13,90,150,173,221],"resistance":[14],"or":[15],"susceptibility.":[16],"Forward":[17],"genetic":[18,32,43,56,125,208,247],"screens":[19],"of":[20,70,99,124,137,213,249],"genetically":[21,134,229],"diverse":[22,135,230],"cell":[23,60,88,202,219,231],"populations":[24,45],"can":[25],"be":[26],"used":[27],"identify":[29],"the":[30,47,122,211,234,246],"precise":[31],"variants":[33],"that":[34,169,207,228],"drive":[35],"variation.":[37],"Cell":[38],"lines":[39],"from":[40],"laboratory":[41],"mouse":[42],"reference":[44],"like":[46,73,112,233],"Diversity":[48],"Outbred":[49],"(DO)":[50],"population":[51],"are":[52,62,96],"well":[53],"powered":[54],"for":[55,65,244],"mapping.":[57,164],"Diverse":[58],"stem":[59,91,100,141,222],"panels":[61,232],"especially":[63],"beneficial":[64],"studying":[66],"early":[67],"developmental":[68,84],"effects":[69,212],"exposures":[72],"triphenyl":[74],"phosphate":[75],"(TPHP),":[76],"an":[77],"organophosphate":[78],"flame":[79],"retardant":[80],"linked":[81],"adverse":[83],"effects,":[85],"including":[86,179,195],"altered":[87],"cycle":[89,220],"cells.":[92,223],"Self-renewal":[93],"pluripotency":[95],"defining":[97],"properties":[98],"cells":[101,142],"during":[102],"development;":[103],"therefore,":[104],"it":[105],"is":[106],"important":[107],"understand":[109,121],"how":[110],"chemicals":[111],"TPHP":[113,128,177,194,214],"may":[114],"alter":[115],"these":[116],"critical":[117],"characteristics.":[118],"To":[119],"better":[120],"influence":[123],"on":[127,183,215],"exposure":[129],"response,":[130],"we":[131],"utilized":[132],"a":[133,180,239],"panel":[136],"DO":[138,235],"induced":[139],"pluripotent":[140],"(DO":[143],"iPSCs).":[144],"Our":[145,204],"analyses":[146],"characterize":[147],"interline":[148],"gene":[151,155,174,216],"expression":[152,156,159,175,217],"through":[153],"differential":[154],"analysis":[157],"quantitative":[160],"trait":[161],"locus":[162],"(eQTL)":[163],"We":[165],"identified":[166],"genomic":[167],"loci":[168],"contribute":[170],"following":[176],"exposure,":[178],"regulatory":[181],"hotspot":[182],"chromosome":[184],"15.":[185],"Gene":[186],"set":[187],"enrichment":[188],"highlighted":[189],"several":[190],"pathways":[191],"affected":[192],"by":[193],"lipid":[196],"metabolism,":[197],"steroid":[198],"hormone":[199],"signaling,":[200],"cycle.":[203],"study":[205],"shows":[206],"modulates":[210],"Additionally,":[224],"our":[225],"work":[226],"demonstrates":[227],"iPSC":[236],"resource":[237],"offer":[238],"tractable":[240],"scalable":[242],"approach":[243],"identifying":[245],"determinants":[248],"toxicity.":[251]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-30T00:00:00"}