{"id":"https://openalex.org/W7214735000","doi":"https://doi.org/10.3390/ijms27198729","title":"Tamoxifen Promotes Sustained Bifidobacterium Enrichment in the Gut Microbiota of Male and Female Rats After Spinal Cord Injury","display_name":"Tamoxifen Promotes Sustained Bifidobacterium Enrichment in the Gut Microbiota of Male and Female Rats After Spinal Cord Injury","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7214735000","doi":"https://doi.org/10.3390/ijms27198729","pmid":"https://pubmed.ncbi.nlm.nih.gov/42883973","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13664996"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27198729","doi":"https://doi.org/10.3390/ijms27198729","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27198729","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27198729","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093196983","display_name":"Luis H. Pag\u00e1n-Rivera","orcid":"https://orcid.org/0009-0002-7939-6812","observed_orcids":["https://orcid.org/0009-0002-7939-6812"]},"institutions":[{"id":"https://openalex.org/I158818660","display_name":"University of Puerto Rico, Medical Sciences Campus","ror":"https://ror.org/00h25w961","country_code":"PR","type":"education","lineage":["https://openalex.org/I158818660","https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Luis H. Pag\u00e1n-Rivera","raw_affiliation_strings":["Department of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA"],"raw_orcid":"https://orcid.org/0009-0002-7939-6812","affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA","institution_ids":["https://openalex.org/I158818660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002671920","display_name":"Filipa Godoy\u2010Vitorino","orcid":"https://orcid.org/0000-0003-1880-0498","observed_orcids":["https://orcid.org/0000-0003-1880-0498"]},"institutions":[{"id":"https://openalex.org/I158818660","display_name":"University of Puerto Rico, Medical Sciences Campus","ror":"https://ror.org/00h25w961","country_code":"PR","type":"education","lineage":["https://openalex.org/I158818660","https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":true,"raw_author_name":"Filipa Godoy-Vitorino","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA"],"raw_orcid":"https://orcid.org/0000-0003-1880-0498","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA","institution_ids":["https://openalex.org/I158818660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105963289","display_name":"Samuel E. Ocasio-Rivera","orcid":"https://orcid.org/0000-0001-6580-0242","observed_orcids":["https://orcid.org/0000-0001-6580-0242"]},"institutions":[{"id":"https://openalex.org/I158818660","display_name":"University of Puerto Rico, Medical Sciences Campus","ror":"https://ror.org/00h25w961","country_code":"PR","type":"education","lineage":["https://openalex.org/I158818660","https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Samuel E. Ocasio-Rivera","raw_affiliation_strings":["Department of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA"],"raw_orcid":"https://orcid.org/0000-0001-6580-0242","affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA","institution_ids":["https://openalex.org/I158818660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093196984","display_name":"Mar\u00eda E. Santiago-Gascot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158818660","display_name":"University of Puerto Rico, Medical Sciences Campus","ror":"https://ror.org/00h25w961","country_code":"PR","type":"education","lineage":["https://openalex.org/I158818660","https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Maria E. Santiago-Gascot","raw_affiliation_strings":["Department of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA","institution_ids":["https://openalex.org/I158818660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153507048","display_name":"Viviana Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158818660","display_name":"University of Puerto Rico, Medical Sciences Campus","ror":"https://ror.org/00h25w961","country_code":"PR","type":"education","lineage":["https://openalex.org/I158818660","https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Viviana Gonz\u00e1lez","raw_affiliation_strings":["Department of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA","institution_ids":["https://openalex.org/I158818660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003880070","display_name":"Jos\u00e9 M. Santiago","orcid":"https://orcid.org/0000-0002-0615-5033","observed_orcids":["https://orcid.org/0000-0002-0615-5033"]},"institutions":[{"id":"https://openalex.org/I920381996","display_name":"University of Puerto Rico at Carolina","ror":"https://ror.org/05phyf558","country_code":"PR","type":"education","lineage":["https://openalex.org/I200399037","https://openalex.org/I920381996"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 M. Santiago","raw_affiliation_strings":["Department of Natural Sciences, University of Puerto Rico Carolina Campus, Carolina, PR 00984, USA"],"raw_orcid":"https://orcid.org/0000-0002-0615-5033","affiliations":[{"raw_affiliation_string":"Department of Natural Sciences, University of Puerto Rico Carolina Campus, Carolina, PR 00984, USA","institution_ids":["https://openalex.org/I920381996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008463884","display_name":"Iris K. Salgado","orcid":"https://orcid.org/0009-0009-4377-478X","observed_orcids":["https://orcid.org/0009-0009-4377-478X"]},"institutions":[{"id":"https://openalex.org/I201879955","display_name":"Central University of the Caribbean","ror":"https://ror.org/01rpmzy83","country_code":"PR","type":"education","lineage":["https://openalex.org/I201879955"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Iris Salgado","raw_affiliation_strings":["School of Medicine, Universidad Central del Caribe, Bayamon, PR 00956, USA"],"raw_orcid":"https://orcid.org/0009-0009-4377-478X","affiliations":[{"raw_affiliation_string":"School of Medicine, Universidad Central del Caribe, Bayamon, PR 00956, USA","institution_ids":["https://openalex.org/I201879955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006204957","display_name":"Aranza Torrado-Tapias","orcid":"https://orcid.org/0009-0001-3365-1753","observed_orcids":["https://orcid.org/0009-0001-3365-1753"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aranza Torrado-Tapias","raw_affiliation_strings":["National Institutes of Health, National Human Genome Research Institute, Bethesda, MD 20892, USA"],"raw_orcid":"https://orcid.org/0009-0001-3365-1753","affiliations":[{"raw_affiliation_string":"National Institutes of Health, National Human Genome Research Institute, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076990440","display_name":"J Colon","orcid":"https://orcid.org/0000-0002-2912-554X","observed_orcids":["https://orcid.org/0000-0002-2912-554X"]},"institutions":[{"id":"https://openalex.org/I158818660","display_name":"University of Puerto Rico, Medical Sciences Campus","ror":"https://ror.org/00h25w961","country_code":"PR","type":"education","lineage":["https://openalex.org/I158818660","https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Jennifer M. Col\u00f3n-Mercado","raw_affiliation_strings":["Department of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA","institution_ids":["https://openalex.org/I158818660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153507267","display_name":"Carolina Garc\u00eda-Guay","orcid":"https://orcid.org/0009-0004-1066-4537","observed_orcids":["https://orcid.org/0009-0004-1066-4537"]},"institutions":[{"id":"https://openalex.org/I1662191","display_name":"University of Puerto Rico at R\u00edo Piedras","ror":"https://ror.org/0453v4r20","country_code":"PR","type":"education","lineage":["https://openalex.org/I1662191","https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Carolina Garc\u00eda-Guay","raw_affiliation_strings":["Department of Psychology, University of Puerto Rico Rio Piedras Campus, San Juan, PR 00926, USA"],"raw_orcid":"https://orcid.org/0009-0004-1066-4537","affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Puerto Rico Rio Piedras Campus, San Juan, PR 00926, USA","institution_ids":["https://openalex.org/I1662191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030097709","display_name":"Jorge D. Miranda","orcid":"https://orcid.org/0000-0003-0187-6701","observed_orcids":["https://orcid.org/0000-0003-0187-6701"]},"institutions":[{"id":"https://openalex.org/I158818660","display_name":"University of Puerto Rico, Medical Sciences Campus","ror":"https://ror.org/00h25w961","country_code":"PR","type":"education","lineage":["https://openalex.org/I158818660","https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":true,"raw_author_name":"Jorge D. Miranda","raw_affiliation_strings":["Department of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA","institution_ids":["https://openalex.org/I158818660"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5002671920","https://openalex.org/A5030097709"],"corresponding_institution_ids":["https://openalex.org/I158818660"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"19","first_page":"8729","last_page":"8729"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.0982000008225441,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.9309999942779541},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9929999709129333},{"id":"https://openalex.org/keywords/bifidobacterium","display_name":"Bifidobacterium","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9480000138282776},{"id":"https://openalex.org/keywords/selective-estrogen-receptor-modulators","display_name":"selective estrogen receptor modulators","score":0.7300000190734863},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9210000038146973},{"id":"https://openalex.org/keywords/glycogenolysis","display_name":"glycogenolysis","score":0.7110000252723694},{"id":"https://openalex.org/keywords/microbial-community-composition","display_name":"microbial community composition","score":0.593999981880188},{"id":"https://openalex.org/keywords/functional-metagenomics","display_name":"functional metagenomics","score":0.6019999980926514},{"id":"https://openalex.org/keywords/neurological-recovery","display_name":"neurological recovery","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.7106000185012817},{"id":"https://openalex.org/C2780305828","wikidata":"https://www.wikidata.org/wiki/Q132656","display_name":"Bifidobacterium","level":4,"score":0.5795000195503235},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.566100001335144},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.5130000114440918},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5123000144958496},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.4812999963760376},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.47850000858306885},{"id":"https://openalex.org/C2776996202","wikidata":"https://www.wikidata.org/wiki/Q4904768","display_name":"Bifidobacterium longum","level":5,"score":0.4733000099658966},{"id":"https://openalex.org/C2777945686","wikidata":"https://www.wikidata.org/wiki/Q4904767","display_name":"Bifidobacterium animalis","level":5,"score":0.46799999475479126},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.45019999146461487},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41659998893737793},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.3797999918460846},{"id":"https://openalex.org/C2778536940","wikidata":"https://www.wikidata.org/wiki/Q1975869","display_name":"Lactobacillus gasseri","level":4,"score":0.37929999828338623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3781000077724457},{"id":"https://openalex.org/C177857423","wikidata":"https://www.wikidata.org/wiki/Q17077315","display_name":"Gut\u2013brain axis","level":3,"score":0.3741999864578247},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.33059999346733093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3237999975681305},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.319599986076355},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.31869998574256897},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.313400000333786},{"id":"https://openalex.org/C149984733","wikidata":"https://www.wikidata.org/wiki/Q1666254","display_name":"Intermittent fasting","level":2,"score":0.29179999232292175},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.26989999413490295}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001644","descriptor_name":"Bifidobacterium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001644","descriptor_name":"Bifidobacterium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms27198729","doi":"https://doi.org/10.3390/ijms27198729","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27198729","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13664996","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13664996/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13664996/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:42883973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42883973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms27198729","doi":"https://doi.org/10.3390/ijms27198729","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27198729","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3114805938","display_name":"Neuroscience Research Opportunities to Increase Diversity (NeuroID)","funder_award_id":"R25NS080687","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000862256","display_name":"Puerto Rico Center for Microbiome Sciences","funder_award_id":"P20GM156713","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000881770","display_name":"Advancing Competitive Biomedical Research in Puerto Rico","funder_award_id":"P20GM103475","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000882418","display_name":"COBRE PHASE III:  Center for Neuroplasticity at the University of Puerto Rico","funder_award_id":"P30GM149367","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000915302","display_name":"Center for Collaborative Research in Health Disparities","funder_award_id":"U54MD007600","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G9000915561","display_name":"Effects of Tamoxifen in skeletal muscle recovery after spinal cord injury and mechanisms activated by the drug","funder_award_id":"SC1GM144032","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214735000.pdf","grobid_xml":"https://content.openalex.org/works/W7214735000.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1420654867","https://openalex.org/W1965323887","https://openalex.org/W1976122332","https://openalex.org/W1982466660","https://openalex.org/W1991458195","https://openalex.org/W2016017136","https://openalex.org/W2044009322","https://openalex.org/W2054107136","https://openalex.org/W2076582609","https://openalex.org/W2098505104","https://openalex.org/W2123643041","https://openalex.org/W2154649287","https://openalex.org/W2170645579","https://openalex.org/W2302783498","https://openalex.org/W2341520224","https://openalex.org/W2426632426","https://openalex.org/W2491088014","https://openalex.org/W2532739235","https://openalex.org/W2761877935","https://openalex.org/W2789509678","https://openalex.org/W2808824631","https://openalex.org/W2827724867","https://openalex.org/W2892206041","https://openalex.org/W2901568755","https://openalex.org/W2963276645","https://openalex.org/W2990427812","https://openalex.org/W3016016792","https://openalex.org/W3021887052","https://openalex.org/W3030441098","https://openalex.org/W3093434759","https://openalex.org/W3130342129","https://openalex.org/W3144861507","https://openalex.org/W3161501414","https://openalex.org/W3166369231","https://openalex.org/W3171045923","https://openalex.org/W3179122807","https://openalex.org/W3196224073","https://openalex.org/W4200258267","https://openalex.org/W4224067921","https://openalex.org/W4224287165","https://openalex.org/W4224436908","https://openalex.org/W4225523377","https://openalex.org/W4226495128","https://openalex.org/W4245423645","https://openalex.org/W4254687493","https://openalex.org/W4286685569","https://openalex.org/W4293527491","https://openalex.org/W4306730258","https://openalex.org/W4319950426","https://openalex.org/W4321375249","https://openalex.org/W4376132442","https://openalex.org/W4381988718","https://openalex.org/W4385442179","https://openalex.org/W4385758492","https://openalex.org/W4386198893","https://openalex.org/W4386741726","https://openalex.org/W4389365755","https://openalex.org/W4389702682","https://openalex.org/W4400419392","https://openalex.org/W4400696118","https://openalex.org/W4402922669","https://openalex.org/W4403553346","https://openalex.org/W4404641568","https://openalex.org/W4407419615","https://openalex.org/W4407771461","https://openalex.org/W4408028104","https://openalex.org/W4409147792","https://openalex.org/W4412521547","https://openalex.org/W4414896830","https://openalex.org/W7124283611"],"related_works":["https://openalex.org/W4414896830","https://openalex.org/W2761877935","https://openalex.org/W3134124724","https://openalex.org/W4389021434","https://openalex.org/W2765375216","https://openalex.org/W2532739235","https://openalex.org/W2793039445","https://openalex.org/W3018314211","https://openalex.org/W4389702682","https://openalex.org/W2341520224"],"abstract_inverted_index":{"Spinal":[0],"cord":[1],"injury":[2,7],"(SCI)":[3],"triggers":[4],"complex":[5],"secondary":[6],"cascades":[8],"that":[9,131],"limit":[10],"neurological":[11],"recovery.":[12],"Tamoxifen":[13],"(TAM),":[14],"a":[15,60,92,98],"selective":[16],"estrogen":[17],"receptor":[18],"modulator,":[19],"exerts":[20],"neuroprotective":[21],"effects":[22],"in":[23,40,51,136,149,154,172,191,205,218],"experimental":[24],"SCI,":[25,41],"although":[26],"its":[27],"underlying":[28],"mechanisms":[29],"remain":[30],"unknown.":[31],"Given":[32],"the":[33,158,192,233],"emerging":[34,143],"role":[35],"of":[36,64,68,232],"gut":[37,52,234],"microbiota":[38,235],"dysregulation":[39],"we":[42],"investigated":[43],"whether":[44],"TAM-associated":[45,161,203,226],"recovery":[46,171],"is":[47],"accompanied":[48],"by":[49,97,124],"alterations":[50],"microbial":[53,137,207],"composition":[54],"and":[55,106,116,151,176,185,228],"predicted":[56,206,229],"function.":[57],"We":[58],"conducted":[59],"longitudinal,":[61],"sex-inclusive":[62],"analysis":[63,201],"61":[65],"Sprague\u2013Dawley":[66],"rats":[67],"both":[69,219],"sexes":[70],"assigned":[71],"to":[72],"na\u00efve":[73],"(NA\u00cfVE),":[74],"sham-placebo":[75],"(SHAM":[76,79],"PLB),":[77,83],"sham-TAM":[78],"TAM),":[80],"injured-placebo":[81],"(INJ":[82,86],"or":[84,103],"injured-TAM":[85],"TAM)":[87],"groups.":[88],"Injured":[89],"animals":[90,175],"received":[91],"moderate":[93],"T10":[94],"contusion":[95],"followed":[96],"21-day":[99],"TAM":[100,132,181],"(0.71":[101],"mg/day)":[102],"placebo":[104],"pellet,":[105],"fecal":[107],"samples":[108,121],"were":[109,122,188],"collected":[110],"at":[111,144],"0,":[112],"7,":[113],"14,":[114],"21,":[115],"28":[117],"days":[118,146],"post-injury.":[119],"Fecal":[120],"analyzed":[123],"16S":[125],"rRNA":[126],"gene":[127],"sequencing.":[128],"Results":[129],"showed":[130],"induced":[133],"sustained":[134,225],"shifts":[135],"community":[138],"composition,":[139],"with":[140,170,179],"treatment-associated":[141],"divergence":[142],"14":[145,215],"post-injury":[147],"(DPI)":[148],"females":[150],"21":[152],"DPI":[153,216],"males.":[155],"Bifidobacterium":[156,165],"exhibited":[157],"most":[159],"consistent":[160],"enrichment":[162],"across":[163],"sexes.":[164,220],"abundance":[166],"was":[167],"negatively":[168],"associated":[169,178],"INJ":[173,180],"PLB":[174],"positively":[177],"animals;":[182],"because":[183],"behavioral":[184],"microbiome":[186],"measurements":[187],"not":[189],"made":[190],"same":[193],"animals,":[194],"these":[195,222],"associations":[196],"are":[197],"hypothesis-generating":[198],"only.":[199],"PICRUSt2":[200],"revealed":[202],"changes":[204],"function,":[208],"including":[209],"increased":[210],"glycogen":[211],"degradation":[212],"pathways":[213],"from":[214],"onward":[217],"Together,":[221],"findings":[223],"identify":[224],"taxonomic":[227],"functional":[230],"remodeling":[231],"following":[236],"SCI.":[237]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-09-30T00:00:00"}