{"id":"https://openalex.org/W7214724798","doi":"https://doi.org/10.64898/2026.09.28.755085","title":"Oxytocin and Vasopressin Immunoreactivity Differs Across Auditory Brainstem Nuclei in Rodents with Distinct Social Systems","display_name":"Oxytocin and Vasopressin Immunoreactivity Differs Across Auditory Brainstem Nuclei in Rodents with Distinct Social Systems","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7214724798","doi":"https://doi.org/10.64898/2026.09.28.755085"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.28.755085","doi":"https://doi.org/10.64898/2026.09.28.755085","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.755085","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.28.755085.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.28.755085.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040689629","display_name":"Luberson Joseph","orcid":"https://orcid.org/0009-0009-3805-2176","observed_orcids":["https://orcid.org/0009-0009-3805-2176"]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]},{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luberson Joseph","raw_affiliation_strings":["Department of Biological Sciences and University Hospitals, NEOMED Hearing Research Center, Northeast Ohio Medical University, Rootstown, Ohio, 44272","Department of Biology, Oklahoma State University, College of Arts and Sciences, Stillwater, Oklahoma, 74078, USA"],"raw_orcid":"https://orcid.org/0009-0009-3805-2176","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences and University Hospitals, NEOMED Hearing Research Center, Northeast Ohio Medical University, Rootstown, Ohio, 44272","institution_ids":["https://openalex.org/I95240055"]},{"raw_affiliation_string":"Department of Biology, Oklahoma State University, College of Arts and Sciences, Stillwater, Oklahoma, 74078, USA","institution_ids":["https://openalex.org/I115475287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153483613","display_name":"Lucas Boren","orcid":"https://orcid.org/0009-0008-1047-5778","observed_orcids":["https://orcid.org/0009-0008-1047-5778"]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucas Boren","raw_affiliation_strings":["Department of Biology, Oklahoma State University, College of Arts and Sciences, Stillwater, Oklahoma, 74078, USA"],"raw_orcid":"https://orcid.org/0009-0008-1047-5778","affiliations":[{"raw_affiliation_string":"Department of Biology, Oklahoma State University, College of Arts and Sciences, Stillwater, Oklahoma, 74078, USA","institution_ids":["https://openalex.org/I115475287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045775417","display_name":"Grace Ingram","orcid":"https://orcid.org/0009-0002-2194-0969","observed_orcids":["https://orcid.org/0009-0002-2194-0969"]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace Ingram","raw_affiliation_strings":["Department of Biology, Oklahoma State University, College of Arts and Sciences, Stillwater, Oklahoma, 74078, USA"],"raw_orcid":"https://orcid.org/0009-0002-2194-0969","affiliations":[{"raw_affiliation_string":"Department of Biology, Oklahoma State University, College of Arts and Sciences, Stillwater, Oklahoma, 74078, USA","institution_ids":["https://openalex.org/I115475287"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022181861","display_name":"Elizabeth A. McCullagh","orcid":"https://orcid.org/0000-0003-3779-0141","observed_orcids":["https://orcid.org/0000-0003-3779-0141"]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth A. McCullagh","raw_affiliation_strings":["Department of Biology, Oklahoma State University, College of Arts and Sciences, Stillwater, Oklahoma, 74078, USA"],"raw_orcid":"https://orcid.org/0000-0003-3779-0141","affiliations":[{"raw_affiliation_string":"Department of Biology, Oklahoma State University, College of Arts and Sciences, Stillwater, Oklahoma, 74078, USA","institution_ids":["https://openalex.org/I115475287"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022181861"],"corresponding_institution_ids":["https://openalex.org/I115475287"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11665","display_name":"Animal Vocal Communication and Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxytocin","display_name":"oxytocin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":1.0},{"id":"https://openalex.org/keywords/auditory-brainstem","display_name":"auditory brainstem","score":0.8429999947547913},{"id":"https://openalex.org/keywords/lateral-superior-olive","display_name":"lateral superior olive","score":0.9570000171661377},{"id":"https://openalex.org/keywords/medial-superior-olive","display_name":"medial superior olive","score":1.0},{"id":"https://openalex.org/keywords/medial-nucleus-of-the-trapezoid-body","display_name":"medial nucleus of the trapezoid body","score":0.996999979019165},{"id":"https://openalex.org/keywords/sociality","display_name":"sociality","score":0.7900000214576721},{"id":"https://openalex.org/keywords/group-living-species","display_name":"group-living species","score":0.640999972820282},{"id":"https://openalex.org/keywords/neuropeptide-immunoreactivity","display_name":"neuropeptide immunoreactivity","score":0.8709999918937683},{"id":"https://openalex.org/keywords/brain-volume","display_name":"brain volume","score":0.7590000033378601},{"id":"https://openalex.org/keywords/rodents","display_name":"rodents","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C2776176026","wikidata":"https://www.wikidata.org/wiki/Q169960","display_name":"Oxytocin","level":2,"score":0.8719000220298767},{"id":"https://openalex.org/C2779715522","wikidata":"https://www.wikidata.org/wiki/Q507027","display_name":"Forebrain","level":3,"score":0.7950000166893005},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.776199996471405},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.745199978351593},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7336999773979187},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.723800003528595},{"id":"https://openalex.org/C93984277","wikidata":"https://www.wikidata.org/wiki/Q24782073","display_name":"Neuropeptide Y receptor","level":4,"score":0.48330000042915344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4580000042915344},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4350999891757965},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41920000314712524},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.39570000767707825},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.3806000053882599},{"id":"https://openalex.org/C2777075493","wikidata":"https://www.wikidata.org/wiki/Q1137072","display_name":"Hindbrain","level":3,"score":0.3671000003814697},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.35350000858306885},{"id":"https://openalex.org/C2778037994","wikidata":"https://www.wikidata.org/wiki/Q3881782","display_name":"Superior olivary complex","level":4,"score":0.3407000005245209},{"id":"https://openalex.org/C2777443451","wikidata":"https://www.wikidata.org/wiki/Q821413","display_name":"Auditory system","level":2,"score":0.2906999886035919},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.289900004863739},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2890999913215637},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.28679999709129333},{"id":"https://openalex.org/C2983704927","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Social communication","level":2,"score":0.28139999508857727},{"id":"https://openalex.org/C2776178378","wikidata":"https://www.wikidata.org/wiki/Q7835580","display_name":"Trapezoid body","level":3,"score":0.25949999690055847},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.25940001010894775},{"id":"https://openalex.org/C90474776","wikidata":"https://www.wikidata.org/wiki/Q24784390","display_name":"Vasopressin receptor","level":4,"score":0.25679999589920044},{"id":"https://openalex.org/C181612422","wikidata":"https://www.wikidata.org/wiki/Q14908140","display_name":"Oxytocin receptor","level":3,"score":0.25529998540878296}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.28.755085","doi":"https://doi.org/10.64898/2026.09.28.755085","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.755085","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.28.755085.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"doi:10.5281/zenodo.23020878","doi":"https://doi.org/10.5281/zenodo.23020878","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23020878","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.5281/zenodo.23020879","doi":"https://doi.org/10.5281/zenodo.23020879","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23020879","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.64898/2026.09.28.755085","doi":"https://doi.org/10.64898/2026.09.28.755085","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.755085","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.28.755085.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214724798.pdf","grobid_xml":"https://content.openalex.org/works/W7214724798.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1963831028","https://openalex.org/W1970239899","https://openalex.org/W1973258858","https://openalex.org/W1975731777","https://openalex.org/W1984047095","https://openalex.org/W1987667709","https://openalex.org/W2003901018","https://openalex.org/W2007529942","https://openalex.org/W2007658601","https://openalex.org/W2013656165","https://openalex.org/W2015806134","https://openalex.org/W2025173240","https://openalex.org/W2025534251","https://openalex.org/W2058623604","https://openalex.org/W2064323175","https://openalex.org/W2064835296","https://openalex.org/W2066094276","https://openalex.org/W2070668857","https://openalex.org/W2075606380","https://openalex.org/W2092225305","https://openalex.org/W2092355779","https://openalex.org/W2100293177","https://openalex.org/W2103327267","https://openalex.org/W2105254791","https://openalex.org/W2111005252","https://openalex.org/W2118287087","https://openalex.org/W2122682494","https://openalex.org/W2127584704","https://openalex.org/W2133101505","https://openalex.org/W2141869204","https://openalex.org/W2149524054","https://openalex.org/W2164651496","https://openalex.org/W2167279371","https://openalex.org/W2171095353","https://openalex.org/W2312678340","https://openalex.org/W2323675262","https://openalex.org/W2500658306","https://openalex.org/W2561946978","https://openalex.org/W2616287985","https://openalex.org/W2749196801","https://openalex.org/W2946362747","https://openalex.org/W2968251151","https://openalex.org/W3016048142","https://openalex.org/W3091710413","https://openalex.org/W3149736664","https://openalex.org/W3196547074","https://openalex.org/W4254960533","https://openalex.org/W4286499612","https://openalex.org/W4291020917","https://openalex.org/W4308766052","https://openalex.org/W4362472633","https://openalex.org/W4366407871","https://openalex.org/W4384470770","https://openalex.org/W4388322344","https://openalex.org/W4389795814","https://openalex.org/W4390584214","https://openalex.org/W4392910323","https://openalex.org/W4394018441","https://openalex.org/W4400261251","https://openalex.org/W4411538191","https://openalex.org/W4413325769","https://openalex.org/W4413515281","https://openalex.org/W4414596220","https://openalex.org/W4415650252","https://openalex.org/W7128957229","https://openalex.org/W7130677153","https://openalex.org/W7154255741","https://openalex.org/W7164501783","https://openalex.org/W7215125252"],"related_works":["https://openalex.org/W7166994223","https://openalex.org/W2070668857","https://openalex.org/W1987667709","https://openalex.org/W2048066331","https://openalex.org/W1654041858","https://openalex.org/W1974051106","https://openalex.org/W2999414092","https://openalex.org/W4396867092","https://openalex.org/W2600095846","https://openalex.org/W2025173240"],"abstract_inverted_index":{"ABSTRACT":[0],"Oxytocin":[1],"(OT)":[2],"and":[3,15,34,51,70,95,104,107,114,122,128,134,159,165,171,198,206,224],"vasopressin":[4],"(AVP)":[5],"are":[6,25],"neuropeptide":[7,209],"hormones":[8],"involved":[9],"in":[10,28,38,79,85,98,131,154,157,196],"regulating":[11],"animal":[12],"social":[13,115,146,179,223],"behavior":[14],"a":[16],"broad":[17],"spectrum":[18],"of":[19,31,74,92,168,222],"physiological":[20],"processes.":[21],"Although":[22],"their":[23,36],"distributions":[24],"well":[26],"documented":[27],"neuroendocrine":[29],"regions":[30],"the":[32,39,60,65,71,75,90,132,137,166,169,219],"forebrain":[33],"midbrain,":[35],"expression":[37],"hindbrain":[40],"remains":[41],"poorly":[42],"understood.":[43],"Here,":[44],"we":[45],"used":[46],"immunohistochemistry":[47],"to":[48,218],"quantify":[49],"OT":[50,106,121,139,197],"AVP":[52,108,123,149,199],"immunoreactive":[53,200],"puncta":[54,109,124,140,150,201],"within":[55,202,211],"three":[56],"auditory":[57,203,213,225],"brainstem":[58,204,214],"nuclei,":[59],"lateral":[61],"superior":[62,67],"olive":[63,68],"(LSO),":[64],"medial":[66,72],"(MSO),":[69],"nucleus":[73],"trapezoid":[76],"body":[77],"(MNTB)":[78],"six":[80],"wild-caught":[81],"rodent":[82],"species":[83,103,113,118,130,188],"differing":[84],"sociality.":[86,105,190],"We":[87],"also":[88],"quantified":[89],"volume":[91,101,164,183],"these":[93],"nuclei":[94],"examined":[96],"variation":[97,195],"total":[99],"brain":[100,163],"across":[102,178],"count":[110],"differed":[111,173],"among":[112,145,174,187],"groups.":[116],"Group-living":[117],"exhibited":[119],"higher":[120,153],"counts":[125,141,151],"than":[126,156],"monogamous":[127,158],"solitary":[129,160],"LSO":[133,182],"MNTB.":[135],"In":[136],"MSO,":[138],"did":[142,184],"not":[143,177,185],"differ":[144,186],"groups,":[147,180],"whereas":[148,181],"were":[152],"group-living":[155],"species.":[161],"Total":[162],"volumes":[167],"MNTB":[170],"MSO":[172],"species,":[175],"but":[176],"or":[189],"These":[191],"findings":[192],"revealed":[193],"sociality-related":[194],"circuits":[205],"suggest":[207],"that":[208],"signaling":[210],"early":[212],"pathways":[215],"may":[216],"contribute":[217],"neural":[220],"integration":[221],"information.":[226]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-30T00:00:00"}
