{"id":"https://openalex.org/W7214720604","doi":"https://doi.org/10.64898/2026.10.02.756222","title":"Protein response to deleterious episodes of GC-biased gene conversion in mammals of different Ne","display_name":"Protein response to deleterious episodes of GC-biased gene conversion in mammals of different Ne","publication_year":2026,"publication_date":"2026-10-08","ids":{"openalex":"https://openalex.org/W7214720604","doi":"https://doi.org/10.64898/2026.10.02.756222"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.02.756222","doi":"https://doi.org/10.64898/2026.10.02.756222","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.756222","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/08/2026.10.02.756222.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/08/2026.10.02.756222.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115841593","display_name":"Marie Riffis","orcid":"https://orcid.org/0009-0009-8450-6386","observed_orcids":["https://orcid.org/0009-0009-8450-6386"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I22248866","display_name":"AgroParisTech","ror":"https://ror.org/02kbmgc12","country_code":"FR","type":"education","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210098344","display_name":"G\u00e9n\u00e9tique Quantitative et \u00c9volution Le Moulon","ror":"https://ror.org/012fqzm33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210098344"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Marie Riffis","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, INRAE, CNRS, AgroParisTech, GQE - Le Moulon, 12 route 128, Gif-sur-Yvette, France"],"raw_orcid":"https://orcid.org/0009-0009-8450-6386","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, INRAE, CNRS, AgroParisTech, GQE - Le Moulon, 12 route 128, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210098344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101397003","display_name":"Maxime Locatelli","orcid":"https://orcid.org/0000-0003-2235-6457","observed_orcids":["https://orcid.org/0000-0003-2235-6457"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210135640","display_name":"Laboratoire de Biom\u00e9trie et Biologie Evolutive","ror":"https://ror.org/03skt0t88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210104684","https://openalex.org/I4210107625","https://openalex.org/I4210135640"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maxime Locatelli","raw_affiliation_strings":["Universit\u00e9 Lyon 1, CNRS, Laboratoire de Biom\u00e9trie et Biologie Evolutive - UMR5558, Villeurbanne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Lyon 1, CNRS, Laboratoire de Biom\u00e9trie et Biologie Evolutive - UMR5558, Villeurbanne, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I4210135640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068161771","display_name":"Nathana\u00eblle Saclier","orcid":"https://orcid.org/0000-0003-1522-9644","observed_orcids":["https://orcid.org/0000-0003-1522-9644"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210105943","display_name":"Institut des Sciences de l'Evolution de Montpellier","ror":"https://ror.org/01cah1n37","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I131077856","https://openalex.org/I159885104","https://openalex.org/I19894307","https://openalex.org/I2746051580","https://openalex.org/I2802818602","https://openalex.org/I4210090127","https://openalex.org/I4210105943","https://openalex.org/I4210107625","https://openalex.org/I4210131494","https://openalex.org/I4210166444"]},{"id":"https://openalex.org/I4210166444","display_name":"Institut de Recherche pour le D\u00e9veloppement","ror":"https://ror.org/05q3vnk25","country_code":"FR","type":"government","lineage":["https://openalex.org/I2802818602","https://openalex.org/I4210090127","https://openalex.org/I4210131494","https://openalex.org/I4210166444"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nathana\u00eblle Saclier","raw_affiliation_strings":["ISEM, Univ Montpellier, CNRS, IRD, Montpellier, France"],"raw_orcid":"https://orcid.org/0000-0003-1522-9644","affiliations":[{"raw_affiliation_string":"ISEM, Univ Montpellier, CNRS, IRD, Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210105943","https://openalex.org/I4210166444"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082545455","display_name":"Nicolas Galtier","orcid":"https://orcid.org/0000-0002-0479-4878","observed_orcids":["https://orcid.org/0000-0002-0479-4878"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210105943","display_name":"Institut des Sciences de l'Evolution de Montpellier","ror":"https://ror.org/01cah1n37","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I131077856","https://openalex.org/I159885104","https://openalex.org/I19894307","https://openalex.org/I2746051580","https://openalex.org/I2802818602","https://openalex.org/I4210090127","https://openalex.org/I4210105943","https://openalex.org/I4210107625","https://openalex.org/I4210131494","https://openalex.org/I4210166444"]},{"id":"https://openalex.org/I4210166444","display_name":"Institut de Recherche pour le D\u00e9veloppement","ror":"https://ror.org/05q3vnk25","country_code":"FR","type":"government","lineage":["https://openalex.org/I2802818602","https://openalex.org/I4210090127","https://openalex.org/I4210131494","https://openalex.org/I4210166444"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Galtier","raw_affiliation_strings":["ISEM, Univ Montpellier, CNRS, IRD, Montpellier, France"],"raw_orcid":"https://orcid.org/0000-0002-0479-4878","affiliations":[{"raw_affiliation_string":"ISEM, Univ Montpellier, CNRS, IRD, Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210105943","https://openalex.org/I4210166444"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5115841593"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210098344"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.7681000232696533,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.7681000232696533,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.052400000393390656,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gc-biased-gene-conversion","display_name":"GC-biased gene conversion","score":0.9789999723434448},{"id":"https://openalex.org/keywords/deleterious-mutations","display_name":"deleterious mutations","score":0.7649999856948853},{"id":"https://openalex.org/keywords/protein-evolution","display_name":"protein evolution","score":0.7400000095367432},{"id":"https://openalex.org/keywords/effective-population-size","display_name":"effective population size","score":0.7979999780654907},{"id":"https://openalex.org/keywords/mammalian-genomes","display_name":"mammalian genomes","score":0.5329999923706055},{"id":"https://openalex.org/keywords/recombination","display_name":"recombination","score":0.4480000138282776},{"id":"https://openalex.org/keywords/purifying-selection","display_name":"purifying selection","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C112212490","wikidata":"https://www.wikidata.org/wiki/Q471134","display_name":"Gene conversion","level":4,"score":0.6543999910354614},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6078000068664551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5436000227928162},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.4925000071525574},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4821000099182129},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3952000141143799},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3515999913215637},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33410000801086426},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.31459999084472656},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.2957000136375427},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2948000133037567},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29350000619888306},{"id":"https://openalex.org/C29906990","wikidata":"https://www.wikidata.org/wiki/Q1440688","display_name":"Frameshift mutation","level":4,"score":0.288100004196167},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.26159998774528503}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.10.02.756222","doi":"https://doi.org/10.64898/2026.10.02.756222","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.756222","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/08/2026.10.02.756222.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"doi:10.5281/zenodo.17401938","doi":"https://doi.org/10.5281/zenodo.17401938","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.17401938","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.5281/zenodo.17401939","doi":"https://doi.org/10.5281/zenodo.17401939","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.17401939","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.64898/2026.10.02.756222","doi":"https://doi.org/10.64898/2026.10.02.756222","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.756222","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/08/2026.10.02.756222.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214720604.pdf","grobid_xml":"https://content.openalex.org/works/W7214720604.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1963756058","https://openalex.org/W1966621093","https://openalex.org/W1970283686","https://openalex.org/W1980484686","https://openalex.org/W1992733095","https://openalex.org/W2000063205","https://openalex.org/W2001805109","https://openalex.org/W2004391041","https://openalex.org/W2010341755","https://openalex.org/W2011164389","https://openalex.org/W2014342923","https://openalex.org/W2035225116","https://openalex.org/W2035761714","https://openalex.org/W2046588537","https://openalex.org/W2047657819","https://openalex.org/W2091835941","https://openalex.org/W2095856324","https://openalex.org/W2102507175","https://openalex.org/W2103906623","https://openalex.org/W2105817668","https://openalex.org/W2106335192","https://openalex.org/W2108795433","https://openalex.org/W2116640594","https://openalex.org/W2122544432","https://openalex.org/W2124691860","https://openalex.org/W2126419817","https://openalex.org/W2128546985","https://openalex.org/W2134542215","https://openalex.org/W2142781472","https://openalex.org/W2143699138","https://openalex.org/W2144934389","https://openalex.org/W2147333062","https://openalex.org/W2147641903","https://openalex.org/W2157009009","https://openalex.org/W2163884997","https://openalex.org/W2169957736","https://openalex.org/W2170296971","https://openalex.org/W2239591911","https://openalex.org/W2590803980","https://openalex.org/W2767501586","https://openalex.org/W2888308804","https://openalex.org/W2889542049","https://openalex.org/W2906684375","https://openalex.org/W2953071745","https://openalex.org/W2981705970","https://openalex.org/W3005235420","https://openalex.org/W3012521282","https://openalex.org/W3015097627","https://openalex.org/W3162148509","https://openalex.org/W4378977815","https://openalex.org/W4389132733","https://openalex.org/W4399280689","https://openalex.org/W4405837012","https://openalex.org/W4411255345","https://openalex.org/W4412123854"],"related_works":["https://openalex.org/W4412123854","https://openalex.org/W7166256558","https://openalex.org/W7165666698","https://openalex.org/W1986196866","https://openalex.org/W1976720438","https://openalex.org/W4225756494","https://openalex.org/W2906684375","https://openalex.org/W4402623657","https://openalex.org/W3203587289","https://openalex.org/W7151972136"],"abstract_inverted_index":{"Abstract":[0],"GC-biased":[1],"gene":[2],"conversion":[3],"(gBGC)":[4],"is":[5,53,141,148],"a":[6,101,108,151,166,209],"widespread":[7,142],"recombination-associated":[8],"process":[9],"that":[10,100,111],"favours":[11],"the":[12,31,48,60,83,87,91,216,226,233],"fixation":[13],"of":[14,18,33,51,63,68,86,168,186,194,211,218,229],"GC":[15,37,198],"alleles":[16],"independently":[17],"their":[19],"fitness.":[20],"In":[21],"coding":[22,159],"regions,":[23],"it":[24],"can":[25],"oppose":[26],"purifying":[27],"selection":[28],"and":[29,80,180,208,232],"favour":[30],"accumulation":[32],"deleterious":[34,49,66],"AT":[35,196],"to":[36,55,59,115,135,197],"mutations.In":[38],"mammals":[39,144],"where":[40],"recombination":[41],"hotspots":[42],"are":[43],"predominantly":[44],"determined":[45],"by":[46,190],"PRDM9,":[47],"effect":[50],"gBGC":[52,69,104,127,147,187],"expected":[54],"be":[56,116],"episodic":[57],"due":[58],"rapid":[61],"turnover":[62],"hotspots.":[64],"The":[65],"impact":[67],"episodes":[70,92,128],"on":[71],"proteins":[72,89],"has":[73,94],"been":[74,95],"well":[75],"documented,":[76],"particularly":[77],"in":[78,103,129,145,158,205,213,236],"rodents":[79],"primates.":[81],"However,":[82],"evolutionary":[84,227],"response":[85,110],"affected":[88],"after":[90],"end":[93],"scarcely":[96],"investigated.":[97],"Theory":[98],"predicts":[99],"decline":[102],"intensity":[105],"should":[106],"trigger":[107],"compensatory":[109,124,203],"enables":[112],"previous":[113],"damage":[114],"repaired.":[117],"Recently,":[118],"we":[119,133,154],"reported":[120],"evidence":[121,201],"for":[122,202],"pervasive":[123],"evolution":[125,204],"following":[126],"Hydromyini":[130],"rodents.":[131],"Here,":[132],"aimed":[134],"investigate":[136],"whether":[137],"this":[138],"post-gBGC":[139,230],"compensation":[140,231],"among":[143],"which":[146],"episodic.":[149],"Using":[150],"phylogenetic":[152],"approach,":[153],"analysed":[155],"substitution":[156],"patterns":[157],"exons":[160],"from":[161],"five":[162],"mammalian":[163],"taxa":[164],"spanning":[165],"range":[167],"effective":[169],"population":[170],"size":[171],"(Ne):":[172],"Murini":[173],",":[174,176,178],"Rattini":[175],"Cetacea":[177],"Cercopithecidae":[179],"Hominoidae":[181],".":[182],"We":[183],"detected":[184],"thousands":[185],"episodes,":[188],"characterised":[189],"an":[191],"increased":[192],"rate":[193],"non-synonymous":[195],"substitutions.We":[199],"found":[200],"non-primate":[206],"taxa,":[207],"lack":[210],"signal":[212],"Primates.":[214],"Although":[215],"influence":[217],"Ne":[219],"remains":[220],"unclear,":[221],"our":[222],"study":[223],"highlights":[224],"both":[225],"significance":[228],"methodological":[234],"challenges":[235],"detecting":[237],"it.":[238]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-30T00:00:00"}