{"id":"https://openalex.org/W7214720534","doi":"https://doi.org/10.1016/j.ijregi.2026.101025","title":"Clinical outcomes during the 2025-2026 and 2024-2025 influenza seasons in a US EHR network: an ecological comparison during A(H3N2) subclade K predominance","display_name":"Clinical outcomes during the 2025-2026 and 2024-2025 influenza seasons in a US EHR network: an ecological comparison during A(H3N2) subclade K predominance","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7214720534","doi":"https://doi.org/10.1016/j.ijregi.2026.101025","pmid":"https://pubmed.ncbi.nlm.nih.gov/42921464","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13693347"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijregi.2026.101025","doi":"https://doi.org/10.1016/j.ijregi.2026.101025","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijregi.2026.101025","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2772707626001876/pdf","source":{"id":"https://openalex.org/S4210169834","display_name":"IJID Regions","issn_l":"2772-7076","issn":["2772-7076"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IJID Regions","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2772707626001876/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014114350","display_name":"Taito Kitano","orcid":"https://orcid.org/0000-0003-0623-066X","observed_orcids":["https://orcid.org/0000-0003-0623-066X"]},"institutions":[{"id":"https://openalex.org/I4387153019","display_name":"Nara Prefecture General Medical Center","ror":"https://ror.org/00bhf8j88","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4387153019","https://openalex.org/I4405284808"]},{"id":"https://openalex.org/I4405286871","display_name":"Japan Institute for Health Security","ror":"https://ror.org/03c8bq125","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4405286871"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Taito Kitano","raw_affiliation_strings":["AMR Clinical Reference Center, Japan Institute for Health Security, Tokyo, Japan","Department of Pediatrics, Nara Prefecture General Medical Center, Nara, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0623-066X","affiliations":[{"raw_affiliation_string":"AMR Clinical Reference Center, Japan Institute for Health Security, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286871"]},{"raw_affiliation_string":"Department of Pediatrics, Nara Prefecture General Medical Center, Nara, Japan","institution_ids":["https://openalex.org/I4387153019"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028990375","display_name":"Sayaka Yoshida","orcid":"https://orcid.org/0000-0002-1800-5104","observed_orcids":["https://orcid.org/0000-0002-1800-5104","https://orcid.org/0009-0003-2554-1348"]},"institutions":[{"id":"https://openalex.org/I4387153019","display_name":"Nara Prefecture General Medical Center","ror":"https://ror.org/00bhf8j88","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4387153019","https://openalex.org/I4405284808"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sayaka Yoshida","raw_affiliation_strings":["Department of Pediatrics, Nara Prefecture General Medical Center, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Nara Prefecture General Medical Center, Nara, Japan","institution_ids":["https://openalex.org/I4387153019"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014114350"],"corresponding_institution_ids":["https://openalex.org/I4387153019","https://openalex.org/I4405286871"],"apc_list":{"value":1380,"currency":"USD","value_usd":1380},"apc_paid":{"value":1380,"currency":"USD","value_usd":1380},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6791596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":null,"first_page":"101025","last_page":"101025"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/2024-2025-influenza-season","display_name":"2024-2025 influenza season","score":0.9959999918937683},{"id":"https://openalex.org/keywords/influenza-mortality","display_name":"influenza mortality","score":0.5099999904632568},{"id":"https://openalex.org/keywords/intensive-care-unit-admission","display_name":"intensive care unit admission","score":0.8600000143051147},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.8109999895095825},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vasopressor-use","display_name":"vasopressor use","score":0.9879999756813049},{"id":"https://openalex.org/keywords/seasonal-influenza-comparison","display_name":"seasonal influenza comparison","score":0.39800000190734863},{"id":"https://openalex.org/keywords/children-and-adults","display_name":"children and adults","score":0.6660000085830688},{"id":"https://openalex.org/keywords/electronic-health-records","display_name":"electronic health records","score":0.5099999904632568},{"id":"https://openalex.org/keywords/trinetx","display_name":"TriNetX","score":0.8339999914169312},{"id":"https://openalex.org/keywords/nucleic-acid-detection","display_name":"nucleic acid detection","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C200197925","wikidata":"https://www.wikidata.org/wiki/Q7630927","display_name":"Subclade","level":5,"score":0.9315000176429749},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8027999997138977},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.7700999975204468},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6539999842643738},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5401999950408936},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5109000205993652},{"id":"https://openalex.org/C143095724","wikidata":"https://www.wikidata.org/wiki/Q515895","display_name":"Odds","level":3,"score":0.45210000872612},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4212999939918518},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.398499995470047},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.38190001249313354},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.3813000023365021},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3709999918937683},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.35350000858306885},{"id":"https://openalex.org/C2779954635","wikidata":"https://www.wikidata.org/wiki/Q3508755","display_name":"Influenza-like illness","level":3,"score":0.3319000005722046},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2946000099182129},{"id":"https://openalex.org/C3018751465","wikidata":"https://www.wikidata.org/wiki/Q4120645","display_name":"Seasonal influenza","level":5,"score":0.29280000925064087},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.29269999265670776},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.29120001196861267},{"id":"https://openalex.org/C192805744","wikidata":"https://www.wikidata.org/wiki/Q5937890","display_name":"Human mortality from H5N1","level":5,"score":0.289900004863739},{"id":"https://openalex.org/C3020505244","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral treatment","level":4,"score":0.288100004196167},{"id":"https://openalex.org/C519248777","wikidata":"https://www.wikidata.org/wiki/Q160122","display_name":"Influenza A virus subtype H5N1","level":3,"score":0.2872999906539917},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.28049999475479126},{"id":"https://openalex.org/C2781416681","wikidata":"https://www.wikidata.org/wiki/Q287246","display_name":"Orthomyxoviridae","level":4,"score":0.2799000144004822},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.27239999175071716},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.2653999924659729},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.26080000400543213},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.2556000053882599}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ijregi.2026.101025","doi":"https://doi.org/10.1016/j.ijregi.2026.101025","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijregi.2026.101025","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2772707626001876/pdf","source":{"id":"https://openalex.org/S4210169834","display_name":"IJID Regions","issn_l":"2772-7076","issn":["2772-7076"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IJID Regions","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13693347","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13693347/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13693347/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IJID Reg","raw_type":"Text"},{"id":"pmid:42921464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42921464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IJID regions","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ijregi.2026.101025","doi":"https://doi.org/10.1016/j.ijregi.2026.101025","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijregi.2026.101025","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2772707626001876/pdf","source":{"id":"https://openalex.org/S4210169834","display_name":"IJID Regions","issn_l":"2772-7076","issn":["2772-7076"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IJID Regions","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320331580","display_name":"bioM\u00e9rieux","ror":"https://ror.org/03hf69k85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214720534.pdf","grobid_xml":"https://content.openalex.org/works/W7214720534.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W2774380382","https://openalex.org/W3175814630","https://openalex.org/W4416690950","https://openalex.org/W4417297178","https://openalex.org/W7127929271","https://openalex.org/W7130652850","https://openalex.org/W7162948137"],"related_works":["https://openalex.org/W7132823208","https://openalex.org/W7162948137","https://openalex.org/W7133197755","https://openalex.org/W7167807861","https://openalex.org/W4387026852","https://openalex.org/W4324123516","https://openalex.org/W7126082353","https://openalex.org/W7119501785","https://openalex.org/W7217604815","https://openalex.org/W7136085758"],"abstract_inverted_index":{"Background":[0],"The":[1,41],"influenza":[2,20,45,79,204],"A(H3N2)":[3,80],"subclade":[4,181,207],"K":[5],"virus":[6],"has":[7],"predominated":[8],"in":[9,82,199],"the":[10,16,56,83,94,106,175],"2025\u20132026":[11,22,57,84],"season.":[12],"This":[13],"study":[14,176],"compared":[15,54],"clinical":[17,42,195],"severity":[18,183,198],"of":[19,109,194,201],"between":[21,55],"and":[23,58,69,72,74,85,99,111,123,134,143,150,154,191,197,213],"2024\u20132025":[24,59,86],"seasons.":[25],"Methods":[26],"In":[27,163],"this":[28,164],"retrospective":[29],"cohort":[30],"study,":[31],"a":[32],"multicenter":[33],"electronic":[34],"health":[35],"record":[36],"database":[37],"(TriNetX)":[38],"was":[39],"used.":[40],"outcomes":[43],"following":[44],"infection":[46,81],"confirmed":[47,78],"by":[48],"nucleic":[49],"acid":[50],"detection":[51],"were":[52,67,101,172],"ecologically":[53],"seasons":[60],"with":[61,77],"propensity":[62,91],"score":[63,92],"matching.":[64],"Results":[65],"There":[66],"8,965":[68],"8,937":[70],"children":[71,98],"7,488":[73],"6,947":[75],"adults":[76,100],"seasons,":[87],"respectively.":[88],"Following":[89],"each":[90],"matching,":[93],"odds":[95],"ratios":[96],"for":[97,118,127,138,147,158],"not":[102,178],"assessed":[103],"(due":[104],"to":[105,210],"small":[107],"number":[108],"events)":[110],"0.87":[112],"[95%":[113],"confidence":[114],"interval":[115],"0.71\u20131.05];":[116],"p=0.148":[117],"death,":[119],"1.32":[120],"[1.10\u20131.59];":[121],"p=0.003":[122],"0.91":[124],"[0.82\u20131.02];":[125],"p=0.092":[126],"critical":[128],"care":[129],"admission,":[130],"1.06":[131],"[0.97\u20131.16];":[132],"p=0.191":[133],"1.01":[135],"[0.94\u20131.08];":[136],"p=0.083":[137],"hospitalization,":[139],"0.88":[140],"[0.73\u20131.07];":[141],"p=0.197":[142],"0.93":[144,155],"[0.83\u20131.04];":[145],"p=0.194":[146],"mechanical":[148],"ventilation":[149],"1.10":[151],"[0.91\u20131.32];":[152],"p=0.320":[153],"[0.83\u20131.03];":[156],"p=0.177":[157],"vasopressor":[159],"use,":[160],"respectively..":[161],"Conclusions":[162],"EHR-based":[165],"season-level":[166],"comparison,":[167],"no":[168],"consistent":[169],"adjusted":[170],"differences":[171],"observed;":[173],"however,":[174],"could":[177],"directly":[179],"assess":[180],"K-specific":[182],"or":[184,206],"rule":[185],"out":[186],"clinically":[187],"relevant":[188],"differences.":[189],"Rapid":[190],"timely":[192],"monitoring":[193],"characteristics":[196],"case":[200],"an":[202],"emerging":[203],"strain":[205],"is":[208],"important":[209],"guide":[211],"preventive":[212],"therapeutic":[214],"strategies":[215],"against":[216],"influenza.":[217]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-30T00:00:00"}