{"id":"https://openalex.org/W7214708477","doi":"https://doi.org/10.64898/2026.09.28.755146","title":"A biological-response compound representation allows chemical perturbation prediction across cell lines","display_name":"A biological-response compound representation allows chemical perturbation prediction across cell lines","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7214708477","doi":"https://doi.org/10.64898/2026.09.28.755146"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.28.755146","doi":"https://doi.org/10.64898/2026.09.28.755146","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.755146","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.28.755146.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.28.755146.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5153428208","display_name":"L\u00e9a Kaufmann","orcid":"https://orcid.org/0000-0001-6466-6811","observed_orcids":["https://orcid.org/0000-0001-6466-6811"]},"institutions":[{"id":"https://openalex.org/I4210096154","display_name":"Institute for Research in Immunology and Cancer","ror":"https://ror.org/00wj6x496","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096154"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"L\u00e9a Kaufmann","raw_affiliation_strings":["Department of biochemistry and molecular medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3T 1J4, Canada","Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3T 1J4, Canada"],"raw_orcid":"https://orcid.org/0000-0001-6466-6811","affiliations":[{"raw_affiliation_string":"Department of biochemistry and molecular medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3T 1J4, Canada","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3T 1J4, Canada","institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120493958","display_name":"Lola Le Breton","orcid":"https://orcid.org/0009-0004-2119-0795","observed_orcids":["https://orcid.org/0009-0004-2119-0795"]},"institutions":[{"id":"https://openalex.org/I4210164802","display_name":"Mila - Quebec Artificial Intelligence Institute","ror":"https://ror.org/05c22rx21","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210164802"]},{"id":"https://openalex.org/I45683168","display_name":"Polytechnique Montr\u00e9al","ror":"https://ror.org/05f8d4e86","country_code":"CA","type":"education","lineage":["https://openalex.org/I45683168"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lola Le Breton","raw_affiliation_strings":["Mila \u2013 Quebec AI Institute, Montr\u00e9al, QC H2S 3H1, Canada","Polytechnique Montr\u00e9al, Montr\u00e9al, QC H3T 0A3, Canada"],"raw_orcid":"https://orcid.org/0009-0004-2119-0795","affiliations":[{"raw_affiliation_string":"Mila \u2013 Quebec AI Institute, Montr\u00e9al, QC H2S 3H1, Canada","institution_ids":["https://openalex.org/I4210164802"]},{"raw_affiliation_string":"Polytechnique Montr\u00e9al, Montr\u00e9al, QC H3T 0A3, Canada","institution_ids":["https://openalex.org/I45683168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093126011","display_name":"Elise Carraz-Billat","orcid":"https://orcid.org/0009-0007-9047-3918","observed_orcids":["https://orcid.org/0009-0007-9047-3918"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4405253846","display_name":"Dynamique des Cellules Tumorales","ror":"https://ror.org/0152wf839","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405253846"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elise Carraz-Billat","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, Gustave Roussy, Inserm, UMR 1279 Tumor Cell Dynamics 94805 Villejuif, France"],"raw_orcid":"https://orcid.org/0009-0007-9047-3918","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, Gustave Roussy, Inserm, UMR 1279 Tumor Cell Dynamics 94805 Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405253846"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Quentin Fournier","orcid":"https://orcid.org/0000-0002-1036-0777","observed_orcids":["https://orcid.org/0000-0002-1036-0777"]},"institutions":[{"id":"https://openalex.org/I4210164802","display_name":"Mila - Quebec Artificial Intelligence Institute","ror":"https://ror.org/05c22rx21","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210164802"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Quentin Fournier","raw_affiliation_strings":["Department of computer science and operations research, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3T 1N8, Canada","Mila \u2013 Quebec AI Institute, Montr\u00e9al, QC H2S 3H1, Canada"],"raw_orcid":"https://orcid.org/0000-0002-1036-0777","affiliations":[{"raw_affiliation_string":"Department of computer science and operations research, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3T 1N8, Canada","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Mila \u2013 Quebec AI Institute, Montr\u00e9al, QC H2S 3H1, Canada","institution_ids":["https://openalex.org/I4210164802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086458708","display_name":"S\u00e9bastien Lemieux","orcid":"https://orcid.org/0000-0001-5477-1386","observed_orcids":["https://orcid.org/0000-0001-5477-1386"]},"institutions":[{"id":"https://openalex.org/I4210096154","display_name":"Institute for Research in Immunology and Cancer","ror":"https://ror.org/00wj6x496","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096154"]},{"id":"https://openalex.org/I4210164802","display_name":"Mila - Quebec Artificial Intelligence Institute","ror":"https://ror.org/05c22rx21","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210164802"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"S\u00e9bastien Lemieux","raw_affiliation_strings":["Department of biochemistry and molecular medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3T 1J4, Canada","Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3T 1J4, Canada","Mila \u2013 Quebec AI Institute, Montr\u00e9al, QC H2S 3H1, Canada"],"raw_orcid":"https://orcid.org/0000-0001-5477-1386","affiliations":[{"raw_affiliation_string":"Department of biochemistry and molecular medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3T 1J4, Canada","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3T 1J4, Canada","institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"]},{"raw_affiliation_string":"Mila \u2013 Quebec AI Institute, Montr\u00e9al, QC H2S 3H1, Canada","institution_ids":["https://openalex.org/I4210164802"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5086458708"],"corresponding_institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I4210164802","https://openalex.org/I70931966"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-expression-response","display_name":"gene expression response","score":0.5170000195503235},{"id":"https://openalex.org/keywords/drug-response-prediction","display_name":"drug response prediction","score":0.5989999771118164},{"id":"https://openalex.org/keywords/lincs-l1000","display_name":"LINCS L1000","score":0.9670000076293945},{"id":"https://openalex.org/keywords/batch-effects","display_name":"batch effects","score":0.8090000152587891},{"id":"https://openalex.org/keywords/phenotypic-screening","display_name":"phenotypic screening","score":0.796999990940094},{"id":"https://openalex.org/keywords/cobimetinib","display_name":"cobimetinib","score":0.8830000162124634},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.3059999942779541}],"concepts":[{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5644999742507935},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5371000170707703},{"id":"https://openalex.org/C177918212","wikidata":"https://www.wikidata.org/wiki/Q803623","display_name":"Perturbation (astronomy)","level":2,"score":0.4717000126838684},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.46309998631477356},{"id":"https://openalex.org/C55037315","wikidata":"https://www.wikidata.org/wiki/Q5421151","display_name":"Experimental data","level":2,"score":0.4307999908924103},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.374099999666214},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3720000088214874},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.35989999771118164},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.34459999203681946},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.33329999446868896},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.3109999895095825},{"id":"https://openalex.org/C2983013280","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Biological cell","level":2,"score":0.30320000648498535},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2962999939918518},{"id":"https://openalex.org/C2777735758","wikidata":"https://www.wikidata.org/wiki/Q817765","display_name":"Path (computing)","level":2,"score":0.295199990272522},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.2937999963760376},{"id":"https://openalex.org/C2993684226","wikidata":"https://www.wikidata.org/wiki/Q2662727","display_name":"Human cell","level":3,"score":0.28209999203681946},{"id":"https://openalex.org/C124223222","wikidata":"https://www.wikidata.org/wiki/Q2281940","display_name":"Chemical process","level":2,"score":0.2791000008583069},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.27070000767707825},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.2648000121116638}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.28.755146","doi":"https://doi.org/10.64898/2026.09.28.755146","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.755146","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.28.755146.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.28.755146","doi":"https://doi.org/10.64898/2026.09.28.755146","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.755146","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/29/2026.09.28.755146.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326644","display_name":"Canada First Research Excellence Fund","ror":"https://ror.org/01ktx4s83"},{"id":"https://openalex.org/F4320330273","display_name":"Institut de Valorisation des Donn\u00e9es","ror":"https://ror.org/05a3srq89"},{"id":"https://openalex.org/F4320331257","display_name":"Alliance de recherche num\u00e9rique du Canada","ror":"https://ror.org/010r6td27"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214708477.pdf","grobid_xml":"https://content.openalex.org/works/W7214708477.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1966174785","https://openalex.org/W1975147762","https://openalex.org/W1984994707","https://openalex.org/W1988037271","https://openalex.org/W2033708806","https://openalex.org/W2038683568","https://openalex.org/W2044433744","https://openalex.org/W2044834685","https://openalex.org/W2070050178","https://openalex.org/W2080686146","https://openalex.org/W2102838769","https://openalex.org/W2116478324","https://openalex.org/W2125408763","https://openalex.org/W2130410032","https://openalex.org/W2214074259","https://openalex.org/W2346079527","https://openalex.org/W2474854223","https://openalex.org/W2547418417","https://openalex.org/W2612467560","https://openalex.org/W2801128564","https://openalex.org/W2952240264","https://openalex.org/W2965552103","https://openalex.org/W3047366767","https://openalex.org/W3203480730","https://openalex.org/W4205644221","https://openalex.org/W4309944312","https://openalex.org/W4313485929","https://openalex.org/W4323304388","https://openalex.org/W4375955255","https://openalex.org/W4385955324","https://openalex.org/W4387130479","https://openalex.org/W4403405969","https://openalex.org/W4403784877","https://openalex.org/W4406016362","https://openalex.org/W4407896879","https://openalex.org/W4412160990","https://openalex.org/W4413495491","https://openalex.org/W4416308796","https://openalex.org/W4416919031","https://openalex.org/W7125686081","https://openalex.org/W7127099979","https://openalex.org/W7129499852","https://openalex.org/W7133242378"],"related_works":["https://openalex.org/W4302304569","https://openalex.org/W4403784877","https://openalex.org/W7172384247","https://openalex.org/W4417447689","https://openalex.org/W7165657532","https://openalex.org/W7168180750","https://openalex.org/W7214770393","https://openalex.org/W7204223536","https://openalex.org/W4412673344","https://openalex.org/W4414158134"],"abstract_inverted_index":{"Abstract":[0],"Accurately":[1],"predicting":[2],"cellular":[3],"responses":[4,77,178],"to":[5,13,73,116],"drugs":[6],"remains":[7],"a":[8,48,69,163,183],"challenge":[9],"with":[10,68,129],"the":[11,85,122,130,134,138,151,170,174,194],"potential":[12],"reduce":[14,193],"experimental":[15,131],"screening":[16],"costs":[17],"and":[18,87,95,176,190],"accelerate":[19],"drug":[20],"discovery.":[21],"Current":[22],"computational":[23],"approaches":[24],"represent":[25],"compounds":[26],"through":[27],"chemical":[28,59,99,187],"structures,":[29],"which":[30,101],"carry":[31],"little":[32],"information":[33],"regarding":[34],"their":[35],"activity":[36],"within":[37],"biological":[38,66],"systems.":[39],"We":[40],"show":[41],"that":[42,155],"gene":[43],"expression":[44],"responses,":[45],"measured":[46],"in":[47,78],"reference":[49,152,175],"cell":[50,79],"line,":[51],"can":[52],"instead":[53],"serve":[54],"as":[55],"transferable":[56],"representations":[57,67],"of":[58,81,119,133,140,162,169,196],"perturbations.":[60],"The":[61],"proposed":[62],"framework,":[63],"BioPert,":[64],"uses":[65],"small":[70],"neural":[71],"network":[72],"predict":[74],"transcriptional":[75],"delta":[76],"lines":[80],"different":[82],"lineages.":[83],"Across":[84],"Tahoe-100M":[86],"LINCS":[88],"L1000":[89],"datasets,":[90],"BioPert":[91,144],"outperforms":[92],"molecular":[93],"fingerprints":[94],"embeddings":[96],"learned":[97],"from":[98],"structure,":[100],"provide":[102],"limited":[103],"improvements":[104],"over":[105,121],"random":[106],"controls.":[107],"BioPert\u2019s":[108],"prediction":[109,189],"correlations":[110],"reach":[111],"0.79":[112],"on":[113],"Tahoe-100M,":[114],"corresponding":[115],"an":[117],"improvement":[118],"0.34":[120],"next-best":[123],"representation.":[124],"On":[125],"LINCS,":[126],"performance":[127],"varies":[128],"reproducibility":[132],"test":[135],"conditions,":[136],"highlighting":[137],"impact":[139],"batch":[141],"effects.":[142,159],"Notably,":[143],"considerably":[145],"surpasses":[146],"predictions":[147],"obtained":[148],"by":[149],"copying":[150],"response,":[153],"demonstrating":[154],"it":[156],"captures":[157],"context-dependent":[158],"Further":[160],"analysis":[161],"C32-cobimetinib":[164],"case":[165],"shows":[166],"pathway-level":[167],"accuracy":[168],"predictions,":[171],"including":[172],"when":[173],"target":[177],"differ.":[179],"These":[180],"results":[181],"open":[182],"new":[184],"path":[185],"for":[186],"perturbation":[188],"could":[191],"ultimately":[192],"burden":[195],"phenotypic":[197],"screening.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-30T00:00:00"}