{"id":"https://openalex.org/W7214701907","doi":"https://doi.org/10.64898/2026.09.22.26363432","title":"Gantenerumab reduces brain amyloid-\u03b2 proteoforms: Biochemical evaluation in dominantly inherited Alzheimer disease","display_name":"Gantenerumab reduces brain amyloid-\u03b2 proteoforms: Biochemical evaluation in dominantly inherited Alzheimer disease","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7214701907","doi":"https://doi.org/10.64898/2026.09.22.26363432","pmid":"https://pubmed.ncbi.nlm.nih.gov/42856312","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13648682"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.22.26363432","doi":"https://doi.org/10.64898/2026.09.22.26363432","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.26363432","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/29/2026.09.22.26363432.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/29/2026.09.22.26363432.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084864678","display_name":"Soumya Mukherjee","orcid":"https://orcid.org/0000-0001-5326-4008","observed_orcids":["https://orcid.org/0000-0001-5326-4008"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soumya Mukherjee","raw_affiliation_strings":["The Tracy Family Stable Isotope Labeling Quantitation (SILQ) Center, Washington University in St. Louis, St. Louis, MO, USA","Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0001-5326-4008","affiliations":[{"raw_affiliation_string":"The Tracy Family Stable Isotope Labeling Quantitation (SILQ) Center, Washington University in St. Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068417558","display_name":"Nicolas R. Barth\u00e9lemy","orcid":"https://orcid.org/0000-0003-4937-2860","observed_orcids":["https://orcid.org/0000-0003-4937-2860"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas R. Barth\u00e9lemy","raw_affiliation_strings":["The Tracy Family Stable Isotope Labeling Quantitation (SILQ) Center, Washington University in St. Louis, St. Louis, MO, USA","Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0003-4937-2860","affiliations":[{"raw_affiliation_string":"The Tracy Family Stable Isotope Labeling Quantitation (SILQ) Center, Washington University in St. Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147363401","display_name":"Taraneh E Atri","orcid":"https://orcid.org/0009-0001-4492-2424","observed_orcids":["https://orcid.org/0009-0001-4492-2424"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taraneh Atri","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0009-0001-4492-2424","affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100434806","display_name":"Qing Wang","orcid":"https://orcid.org/0000-0002-1296-7097","observed_orcids":["https://orcid.org/0000-0002-1296-7097"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Li","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0002-1296-7097","affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039519781","display_name":"Daniel P. Yen","orcid":"https://orcid.org/0000-0003-4101-9448","observed_orcids":["https://orcid.org/0000-0003-4101-9448"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Yen","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026669710","display_name":"Yingxin He","orcid":"https://orcid.org/0000-0003-2543-4553","observed_orcids":["https://orcid.org/0000-0003-2543-4553"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yingxin He","raw_affiliation_strings":["The Tracy Family Stable Isotope Labeling Quantitation (SILQ) Center, Washington University in St. Louis, St. Louis, MO, USA","Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0003-2543-4553","affiliations":[{"raw_affiliation_string":"The Tracy Family Stable Isotope Labeling Quantitation (SILQ) Center, Washington University in St. Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039073415","display_name":"Reid A. Coyle","orcid":"https://orcid.org/0009-0007-8888-729X","observed_orcids":["https://orcid.org/0009-0007-8888-729X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reid Coyle","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0009-0007-8888-729X","affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033286093","display_name":"Vitaliy Ovod","orcid":"https://orcid.org/0000-0001-6722-4883","observed_orcids":["https://orcid.org/0000-0001-6722-4883"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vitaliy Ovod","raw_affiliation_strings":["The Tracy Family Stable Isotope Labeling Quantitation (SILQ) Center, Washington University in St. Louis, St. Louis, MO, USA","Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0001-6722-4883","affiliations":[{"raw_affiliation_string":"The Tracy Family Stable Isotope Labeling Quantitation (SILQ) Center, Washington University in St. Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027162729","display_name":"Erin E. Franklin","orcid":"https://orcid.org/0000-0002-6614-4109","observed_orcids":["https://orcid.org/0000-0002-6614-4109"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210123851","display_name":"Hope Center for Neurological Disorders","ror":"https://ror.org/035nzyk88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin E. Franklin","raw_affiliation_strings":["Departments of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA","Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA;","Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA;","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210123851"]},{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114002779","display_name":"Chengjie Xiong","orcid":"https://orcid.org/0000-0001-5092-4306","observed_orcids":["https://orcid.org/0000-0001-5092-4306"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chengjie Xiong","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073392602","display_name":"Guoqiao Wang","orcid":"https://orcid.org/0000-0002-6808-8737","observed_orcids":["https://orcid.org/0000-0002-6808-8737"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guoqiao Wang","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153512018","display_name":"Jinbin Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinbin Xu","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006350013","display_name":"Huifangjie L. Farsad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huifangjie Farsad","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071199467","display_name":"Catherine Jane Mummery","orcid":"https://orcid.org/0000-0002-6739-0803","observed_orcids":["https://orcid.org/0000-0002-6739-0803"]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Catherine J. Mummery","raw_affiliation_strings":["Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047385288","display_name":"Colin Louis Masters","orcid":"https://orcid.org/0000-0003-3072-7940","observed_orcids":["https://orcid.org/0000-0003-3072-7940"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Colin L. Masters","raw_affiliation_strings":["Alzheimer\u2019s Research Australia, University of Western Australia, Perth, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Research Australia, University of Western Australia, Perth, Australia","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047159861","display_name":"Raquel S\u00e1nchez\u2010Valle","orcid":"https://orcid.org/0000-0001-7750-896X","observed_orcids":["https://orcid.org/0000-0001-7750-896X"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raquel Sanchez-Valle","raw_affiliation_strings":["Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Institut d\u2019Investigaci\u00f3ns Biom\u00e8diques August Pi I Sunyer, University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Institut d\u2019Investigaci\u00f3ns Biom\u00e8diques August Pi I Sunyer, University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085497748","display_name":"Mario Masellis","orcid":"https://orcid.org/0000-0002-6244-2096","observed_orcids":["https://orcid.org/0000-0002-6244-2096"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mario Masellis","raw_affiliation_strings":["Division of Neurology, Departments of Medicine and Medical Sciences, University of Toronto, Toronto, Canada","Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurology, Departments of Medicine and Medical Sciences, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, Canada","institution_ids":["https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061279452","display_name":"Ging\u2010Yuek Robin Hsiung","orcid":"https://orcid.org/0000-0002-8017-0856","observed_orcids":["https://orcid.org/0000-0002-8017-0856"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ging-Yuek Robin Hsiung","raw_affiliation_strings":["Division of Neurology, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurology, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153483922","display_name":"Serge Guthier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405276480","display_name":"McGill University Research Centre for Studies in Aging","ror":"https://ror.org/05h8ts335","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4405276480"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Serge Guthier","raw_affiliation_strings":["Department of Neurology and Neurosurgery, McGill University, Montr\u00e9al, QC, H3A 1A1, Canada","McGill University Research Centre for Studies in Aging, McGill University, 6825 Boulevard LaSalle, Verdun, Qu\u00e9bec, H4H 1R3, Canada","Montreal Neurological Institute, McGill University, Montr\u00e9al, QC, H3A 2B4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neurosurgery, McGill University, Montr\u00e9al, QC, H3A 1A1, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"McGill University Research Centre for Studies in Aging, McGill University, 6825 Boulevard LaSalle, Verdun, Qu\u00e9bec, H4H 1R3, Canada","institution_ids":["https://openalex.org/I4405276480","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Montreal Neurological Institute, McGill University, Montr\u00e9al, QC, H3A 2B4, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080612573","display_name":"James J. Lah","orcid":"https://orcid.org/0000-0002-8810-620X","observed_orcids":["https://orcid.org/0000-0002-8810-620X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James J. Lah","raw_affiliation_strings":["Emory University, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023066705","display_name":"Sarah Berman","orcid":"https://orcid.org/0000-0002-5096-4962","observed_orcids":["https://orcid.org/0000-0002-5096-4962"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah B. Berman","raw_affiliation_strings":["Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082433792","display_name":"Erik D. Roberson","orcid":"https://orcid.org/0000-0002-1810-9763","observed_orcids":["https://orcid.org/0000-0002-1810-9763"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik D. Roberson","raw_affiliation_strings":["University of Alabama at Birmingham Alzheimer\u2019s Disease Research Center Birmingham Alabama USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham Alzheimer\u2019s Disease Research Center Birmingham Alabama USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072102337","display_name":"Ghulam Mustafa Surti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ghulam Surti","raw_affiliation_strings":["Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003680013","display_name":"Lawrence S. Honig","orcid":"https://orcid.org/0000-0002-9703-2265","observed_orcids":["https://orcid.org/0000-0002-9703-2265"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence S. Honig","raw_affiliation_strings":["Taub Institute and Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taub Institute and Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065774007","display_name":"Roger Clarnette","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger Clarnette","raw_affiliation_strings":["Taub Institute, Sergievsky Center, and Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taub Institute, Sergievsky Center, and Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015729390","display_name":"Paolo Vitali","orcid":"https://orcid.org/0000-0001-8953-1542","observed_orcids":["https://orcid.org/0000-0001-8953-1542","https://orcid.org/0000-0001-9204-2678"]},"institutions":[{"id":"https://openalex.org/I4405276480","display_name":"McGill University Research Centre for Studies in Aging","ror":"https://ror.org/05h8ts335","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4405276480"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Paolo Vitali","raw_affiliation_strings":["McGill University Research Centre for Studies in Aging, McGill University, 6825 Boulevard LaSalle, Verdun, Qu\u00e9bec, H4H 1R3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University Research Centre for Studies in Aging, McGill University, 6825 Boulevard LaSalle, Verdun, Qu\u00e9bec, H4H 1R3, Canada","institution_ids":["https://openalex.org/I4405276480","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087306024","display_name":"John Matthew Ringman","orcid":"https://orcid.org/0000-0001-5429-0777","observed_orcids":["https://orcid.org/0000-0001-5429-0777"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Ringman","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112371406","display_name":"Thomas D. Bird","orcid":"https://orcid.org/0000-0001-9598-3529","observed_orcids":["https://orcid.org/0000-0001-9598-3529"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2801852214","display_name":"University of Washington Medical Center","ror":"https://ror.org/00wbzw723","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801852214"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas D. Bird","raw_affiliation_strings":["Department of Neurology, University of Washington Medical Center, 1959 NE Pacific Street, Seattle, WA, 98195, USA","Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, 325 9th Ave, Seattle, WA, 98104, USA","Division of Medical Genetics, Department of Medicine, University of Washington, 1705 NE Pacific St, Seattle, WA, 98195, USA","Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA, 98108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Washington Medical Center, 1959 NE Pacific Street, Seattle, WA, 98195, USA","institution_ids":["https://openalex.org/I2801852214"]},{"raw_affiliation_string":"Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, 325 9th Ave, Seattle, WA, 98104, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Division of Medical Genetics, Department of Medicine, University of Washington, 1705 NE Pacific St, Seattle, WA, 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA, 98108, USA","institution_ids":["https://openalex.org/I4210094549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153541152","display_name":"William S. Brook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83657090","display_name":"Neuroscience Research Australia","ror":"https://ror.org/01g7s6g79","country_code":"AU","type":"facility","lineage":["https://openalex.org/I83657090"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"William S. Brooks","raw_affiliation_strings":["Neuroscience Research Australia, Randwick, 2031 NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Australia, Randwick, 2031 NSW, Australia","institution_ids":["https://openalex.org/I83657090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018836358","display_name":"Nick C. Fox","orcid":"https://orcid.org/0000-0002-6660-657X","observed_orcids":["https://orcid.org/0000-0002-6660-657X"]},"institutions":[{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nick C. Fox","raw_affiliation_strings":["Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK","UK Dementia Research Institute at UCL, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"raw_affiliation_string":"UK Dementia Research Institute at UCL, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089040841","display_name":"Kazushi Suzuki","orcid":"https://orcid.org/0009-0008-9772-991X","observed_orcids":["https://orcid.org/0009-0008-9772-991X"]},"institutions":[{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazushi Suzuki","raw_affiliation_strings":["Division of Neurology, Internal Medicine, National Defense Medical College, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurology, Internal Medicine, National Defense Medical College, Saitama, Japan","institution_ids":["https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040635626","display_name":"Sandra E. Black","orcid":"https://orcid.org/0000-0001-7093-8289","observed_orcids":["https://orcid.org/0000-0001-7093-8289"]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sandra E. Black","raw_affiliation_strings":["Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada","Division of Neurology, Departments of Medicine and Medical Sciences, University of Toronto, Toronto, Canada","Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, Canada","L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1323843004"]},{"raw_affiliation_string":"Division of Neurology, Departments of Medicine and Medical Sciences, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, Canada","institution_ids":["https://openalex.org/I4391768120"]},{"raw_affiliation_string":"L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1323843004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035514608","display_name":"Johannes Levin","orcid":"https://orcid.org/0000-0001-5092-4306","observed_orcids":["https://orcid.org/0000-0001-5092-4306"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210113080","display_name":"Munich Cluster for Systems Neurology","ror":"https://ror.org/025z3z560","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210113080","https://openalex.org/I62916508","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes Levin","raw_affiliation_strings":["Department of Neurology, Ludwig-Maximilians Universit\u00e4t M\u00fcnchen, Munich 80539, Germany","German Center for Neurodegenerative Diseases (DZNE), 81377, Munich, Germany","Munich Cluster for Systems Neurology (SyNergy), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Ludwig-Maximilians Universit\u00e4t M\u00fcnchen, Munich 80539, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), 81377, Munich, Germany","institution_ids":["https://openalex.org/I2801533059"]},{"raw_affiliation_string":"Munich Cluster for Systems Neurology (SyNergy), Munich, Germany","institution_ids":["https://openalex.org/I4210113080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071364728","display_name":"Martin Rhys Farlow","orcid":"https://orcid.org/0000-0001-7897-5471","observed_orcids":["https://orcid.org/0000-0001-7897-5471"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin R. Farlow","raw_affiliation_strings":["Department of Neurology, Indiana University School of Medicine, Indianapolis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Indiana University School of Medicine, Indianapolis","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088915384","display_name":"Jasmeer P. Chhatwal","orcid":"https://orcid.org/0000-0002-7792-1698","observed_orcids":["https://orcid.org/0000-0002-7792-1698"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jasmeer Chhatwal","raw_affiliation_strings":["Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000626788","display_name":"Neelum T. Aggarwal","orcid":"https://orcid.org/0000-0002-4341-8023","observed_orcids":["https://orcid.org/0000-0002-4341-8023"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neelum T. Aggarwal","raw_affiliation_strings":["Rush University Medical Center Chicago Illinois USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush University Medical Center Chicago Illinois USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010409175","display_name":"Mathias Jucker","orcid":"https://orcid.org/0000-0001-9045-1072","observed_orcids":["https://orcid.org/0000-0001-9045-1072"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mathias Jucker","raw_affiliation_strings":["German Center for Neurodegenerative Diseases (DZNE), T\u00fcbingen, Germany","Hertie-Institute for Clinical Brain Research, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I2801533059"]},{"raw_affiliation_string":"Hertie-Institute for Clinical Brain Research, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210141865","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005004760","display_name":"Matthew P. Frosch","orcid":"https://orcid.org/0000-0002-3940-9861","observed_orcids":["https://orcid.org/0000-0002-3940-9861"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew P. Frosch","raw_affiliation_strings":["Department of Neurology, Alzheimer\u2019s Disease Research Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Alzheimer\u2019s Disease Research Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000414426","display_name":"Julia Kofler","orcid":"https://orcid.org/0000-0003-4298-7328","observed_orcids":["https://orcid.org/0000-0003-4298-7328"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia K. Kofler","raw_affiliation_strings":["Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150043306","display_name":"Charles White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles White","raw_affiliation_strings":["University of Texas Southwestern, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136084589","display_name":"Dirk Keene","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Dirk Keene","raw_affiliation_strings":["Department of Pathology, University of California, San Diego, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California, San Diego, La Jolla, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100332948","display_name":"Jie Chen","orcid":"https://orcid.org/0000-0002-6808-1076","observed_orcids":["https://orcid.org/0000-0002-6808-1076"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Chen","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108141609","display_name":"Jonathan D. Glass","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Glass","raw_affiliation_strings":["Emory University, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063529297","display_name":"Marla Gearing","orcid":"https://orcid.org/0000-0002-1959-7412","observed_orcids":["https://orcid.org/0000-0002-1959-7412"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marla Gearing","raw_affiliation_strings":["Emory University, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086893120","display_name":"Natalie Sarah Ryan","orcid":"https://orcid.org/0000-0003-0361-7455","observed_orcids":["https://orcid.org/0000-0003-0361-7455"]},"institutions":[{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Natalie S. Ryan","raw_affiliation_strings":["Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK","UK Dementia Research Institute at UCL, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"raw_affiliation_string":"UK Dementia Research Institute at UCL, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035343739","display_name":"David Fernando Aguillon","orcid":"https://orcid.org/0000-0003-2283-536X","observed_orcids":["https://orcid.org/0000-0003-2283-536X"]},"institutions":[{"id":"https://openalex.org/I35961687","display_name":"Universidad de Antioquia","ror":"https://ror.org/03bp5hc83","country_code":"CO","type":"education","lineage":["https://openalex.org/I35961687"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"David Aguill\u00f3n","raw_affiliation_strings":["Group of Neuroscience of Antioquia, GNA, Medical School, University of Antioquia, Medellin, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Group of Neuroscience of Antioquia, GNA, Medical School, University of Antioquia, Medellin, Colombia","institution_ids":["https://openalex.org/I35961687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041542664","display_name":"Charlene B Supnet","orcid":"https://orcid.org/0000-0001-6917-770X","observed_orcids":["https://orcid.org/0000-0001-6917-770X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlene Supnet-Bell","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090741969","display_name":"Brian Andrew Gordon","orcid":"https://orcid.org/0000-0003-2109-2955","observed_orcids":["https://orcid.org/0000-0003-2109-2955"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian A. Gordon","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0003-2109-2955","affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000597778","display_name":"Tammie L.S. Benzinger","orcid":"https://orcid.org/0000-0002-8114-0552","observed_orcids":["https://orcid.org/0000-0002-8114-0552","https://orcid.org/0000-0003-2109-2955"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tammie L.S. Benzinger","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0002-8114-0552","affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110779863","display_name":"John Randall Sims","orcid":"https://orcid.org/0009-0009-5090-7886","observed_orcids":["https://orcid.org/0009-0009-5090-7886"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Sims","raw_affiliation_strings":["Eli Lilly and Company, Indianapolis, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly and Company, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Roy Yaari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy Yaari","raw_affiliation_strings":["Eli Lilly and Company, Indianapolis, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly and Company, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110539556","display_name":"Tobias Bittner","orcid":"https://orcid.org/0000-0001-9256-0360","observed_orcids":["https://orcid.org/0000-0001-9256-0360"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]},{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Tobias Bittner","raw_affiliation_strings":["Genentech, Inc., South San Francisco, CA, USA; F. Hoffmann-La Roche Ltd, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA, USA; F. Hoffmann-La Roche Ltd, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719","https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107632204","display_name":"Gregory Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gregory Klein","raw_affiliation_strings":["Pharma Research and Early Development, F Hoffmann-La Roche Ltd., Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharma Research and Early Development, F Hoffmann-La Roche Ltd., Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037459780","display_name":"Paul Delmar","orcid":"https://orcid.org/0000-0002-2095-6283","observed_orcids":["https://orcid.org/0000-0002-2095-6283"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Paul Delmar","raw_affiliation_strings":["Pharma Research and Early Development, F Hoffmann-La Roche Ltd., Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharma Research and Early Development, F Hoffmann-La Roche Ltd., Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063630764","display_name":"John C. Morris","orcid":"https://orcid.org/0000-0001-9820-5618","observed_orcids":["https://orcid.org/0000-0001-9820-5618","https://orcid.org/0000-0002-6854-5547"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C Morris","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091736410","display_name":"Jorge J. Llibre\u2010Guerra","orcid":"https://orcid.org/0000-0002-2137-7750","observed_orcids":["https://orcid.org/0000-0002-2137-7750"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge Llibre-Guerra","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0002-2137-7750","affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088660280","display_name":"David B. Clifford","orcid":"https://orcid.org/0000-0001-5719-1555","observed_orcids":["https://orcid.org/0000-0001-5719-1555"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David B. Clifford","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010166794","display_name":"Celeste M M. Karch","orcid":"https://orcid.org/0000-0002-6854-5547","observed_orcids":["https://orcid.org/0000-0002-6854-5547"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Celeste M. Karch","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0002-6854-5547","affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068373508","display_name":"Eric McDade","orcid":"https://orcid.org/0000-0002-6764-3866","observed_orcids":["https://orcid.org/0000-0002-6764-3866"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric McDade","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110995863","display_name":"Richard J. Perrin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210123851","display_name":"Hope Center for Neurological Disorders","ror":"https://ror.org/035nzyk88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Perrin","raw_affiliation_strings":["Departments of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA","Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA;","Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA;","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210123851"]},{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022462599","display_name":"Randall John Bateman","orcid":"https://orcid.org/0000-0002-7729-1702","observed_orcids":["https://orcid.org/0000-0002-7729-1702"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Randall J. Bateman","raw_affiliation_strings":["The Tracy Family Stable Isotope Labeling Quantitation (SILQ) Center, Washington University in St. Louis, St. Louis, MO, USA","Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0002-7729-1702","affiliations":[{"raw_affiliation_string":"The Tracy Family Stable Isotope Labeling Quantitation (SILQ) Center, Washington University in St. Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5156338844","display_name":"the Dominantly Inherited Alzheimer Network Observational Study","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"the Dominantly Inherited Alzheimer Network Observational Study","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5133386457","display_name":"Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU)","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dominantly Inherited Alzheimer Network-Trials Unit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":9,"institutions_distinct_count":40,"corresponding_author_ids":["https://openalex.org/A5022462599"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gantenerumab","display_name":"gantenerumab","score":0.9850000143051147},{"id":"https://openalex.org/keywords/solanezumab","display_name":"solanezumab","score":0.9940000176429749},{"id":"https://openalex.org/keywords/anti-amyloid-monoclonal-antibodies","display_name":"anti-amyloid monoclonal antibodies","score":0.9279999732971191},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.7630000114440918},{"id":"https://openalex.org/keywords/tau-phosphorylation","display_name":"tau phosphorylation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/anti-amyloid-therapy","display_name":"anti-amyloid therapy","score":0.6069999933242798},{"id":"https://openalex.org/keywords/postmortem-brain","display_name":"postmortem brain","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.640999972820282},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6202999949455261},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5467000007629395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5065000057220459},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4602000117301941},{"id":"https://openalex.org/C2778512808","wikidata":"https://www.wikidata.org/wiki/Q16943522","display_name":"Diad","level":4,"score":0.45840001106262207},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4496999979019165},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4456000030040741},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4323999881744385},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3472999930381775},{"id":"https://openalex.org/C2986936838","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Brain tissue","level":2,"score":0.34130001068115234},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.31700000166893005},{"id":"https://openalex.org/C3019883945","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Low resolution","level":3,"score":0.3057999908924103},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.2985000014305115},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.2930999994277954},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.2930000126361847},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2847000062465668},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.2799000144004822},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2680000066757202},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C2776429142","wikidata":"https://www.wikidata.org/wiki/Q1620189","display_name":"Brain biopsy","level":3,"score":0.2581999897956848},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.25780001282691956},{"id":"https://openalex.org/C3018877446","wikidata":"https://www.wikidata.org/wiki/Q1421432","display_name":"Disease monitoring","level":3,"score":0.2540999948978424}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.22.26363432","doi":"https://doi.org/10.64898/2026.09.22.26363432","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.26363432","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/29/2026.09.22.26363432.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13648682","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648682/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648682/pdf/nihpp-2026.09.22.26363432v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"medRxiv","raw_type":"Text"},{"id":"pmid:42856312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42856312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"medRxiv : the preprint server for health sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.09.22.26363432","doi":"https://doi.org/10.64898/2026.09.22.26363432","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.26363432","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/29/2026.09.22.26363432.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2738149705","display_name":null,"funder_award_id":"DIAN-TU-001","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G3486421421","display_name":null,"funder_award_id":"P30 AG066511","funder_id":"https://openalex.org/F4320309381","funder_display_name":"Emory University"},{"id":"https://openalex.org/G4061011720","display_name":null,"funder_award_id":"R01AG053267","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G4993545300","display_name":null,"funder_award_id":"R01AG053267-S1","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G6482217519","display_name":"DOMINANTLY INHERITED ALZHEIMER NETWORK TRIAL: AN OPPORTUNITY TO PREVENT DEMENTIA","funder_award_id":"U01AG042791","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6950638934","display_name":"POSTMORTEM VALIDATION OF BIOMARKERS FOR IMAGING PARKINSON DISEASE","funder_award_id":"R01NS092865","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7163257988","display_name":"Healthy Aging and Senile Dementia","funder_award_id":"P01AG003991","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7744436808","display_name":"Dominantly Inherited Alzheimer Network","funder_award_id":"U19AG032438","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7939110024","display_name":"Dominantly Inherited Alzheimer's Network Trials Unit - Adaptive Prevention Trial","funder_award_id":"R01AG046179","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8841389803","display_name":"DIAN-TU: Next Generation Prevention Trial","funder_award_id":"R01AG053267","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000858584","display_name":"Dissect the mechanisms of selective regional vulnerability in Lewy Body Dementias via comparative snRNA-seq analysis","funder_award_id":"R01NS123571","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000883349","display_name":"Alzheimer's Disease Research Center","funder_award_id":"P30AG066444","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000900711","display_name":"University of Washington Alzheimer's Disease Research Center","funder_award_id":"P30AG066509","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000915971","display_name":"Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study","funder_award_id":"P01AG026276","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000918277","display_name":"Goizueta Alzheimer's Disease Research Center","funder_award_id":"P30AG066511","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320309381","display_name":"Emory University","ror":"https://ror.org/03czfpz43"},{"id":"https://openalex.org/F4320315931","display_name":"GHR Foundation","ror":"https://ror.org/05ahavf04"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333592","display_name":"Avid Radiopharmaceuticals","ror":"https://ror.org/00szax507"},{"id":"https://openalex.org/F4320334507","display_name":"Goizueta Business School, Emory University","ror":null},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214701907.pdf","grobid_xml":"https://content.openalex.org/works/W7214701907.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W1552543129","https://openalex.org/W1580355318","https://openalex.org/W1927066019","https://openalex.org/W2032920422","https://openalex.org/W2046847750","https://openalex.org/W2053288220","https://openalex.org/W2053488262","https://openalex.org/W2057682957","https://openalex.org/W2071310220","https://openalex.org/W2075039096","https://openalex.org/W2103440561","https://openalex.org/W2108216694","https://openalex.org/W2118753807","https://openalex.org/W2144021643","https://openalex.org/W2154735761","https://openalex.org/W2159377066","https://openalex.org/W2164765564","https://openalex.org/W2166109990","https://openalex.org/W2171250577","https://openalex.org/W2346833359","https://openalex.org/W2518195265","https://openalex.org/W2604285326","https://openalex.org/W2745586739","https://openalex.org/W2794390181","https://openalex.org/W2892024211","https://openalex.org/W2913321668","https://openalex.org/W2945016564","https://openalex.org/W2945823364","https://openalex.org/W3012272172","https://openalex.org/W3035823399","https://openalex.org/W3082754683","https://openalex.org/W3096454499","https://openalex.org/W3102160053","https://openalex.org/W3111942360","https://openalex.org/W3137826907","https://openalex.org/W3138745875","https://openalex.org/W3176983361","https://openalex.org/W3186377521","https://openalex.org/W3200284920","https://openalex.org/W4225741213","https://openalex.org/W4280495704","https://openalex.org/W4289783434","https://openalex.org/W4296982306","https://openalex.org/W4312086960","https://openalex.org/W4322500140","https://openalex.org/W4324032790","https://openalex.org/W4360591479","https://openalex.org/W4362601668","https://openalex.org/W4367318835","https://openalex.org/W4384206832","https://openalex.org/W4387671247","https://openalex.org/W4388688059","https://openalex.org/W4389617681","https://openalex.org/W4396217735","https://openalex.org/W4401055811","https://openalex.org/W4406996424","https://openalex.org/W4408201841","https://openalex.org/W4408598466","https://openalex.org/W4408988700","https://openalex.org/W4410302183","https://openalex.org/W4410701496","https://openalex.org/W4412416720","https://openalex.org/W4414420350","https://openalex.org/W4414601717","https://openalex.org/W4415215633","https://openalex.org/W4415916120","https://openalex.org/W7117511775","https://openalex.org/W7126091256","https://openalex.org/W7129099488","https://openalex.org/W7164891918","https://openalex.org/W7168081369","https://openalex.org/W7169729491"],"related_works":["https://openalex.org/W4406223465","https://openalex.org/W4410997410","https://openalex.org/W4312086888","https://openalex.org/W4414420350","https://openalex.org/W2171051792","https://openalex.org/W4396808269","https://openalex.org/W2118753807","https://openalex.org/W4406197171","https://openalex.org/W6903528755","https://openalex.org/W4396217735"],"abstract_inverted_index":{"Abstract":[0],"Therapeutic":[1],"strategies":[2],"targeting":[3,292,328,394],"amyloid-\u03b2":[4,19,342,375],"(A\u03b2)":[5,20,376],"in":[6,84,103,159,180,202,220,250,269,279,346,387,402,407,482,512,603,619,640,675,700],"Alzheimer":[7,110,333],"disease":[8,64,111,334],"(AD)":[9],"include":[10],"antibodies":[11,99,127,395,540],"directed":[12],"against":[13,373],"fibrillar":[14,301,720],"amyloid":[15,291,327,351,470],"plaques":[16,352,471,596],"or":[17,101,130,149,271,536,588,692],"soluble":[18,207,270,339,505,546,691],"species,":[21],"yet":[22],"how":[23],"these":[24,413,453],"approaches":[25],"reshape":[26],"brain":[27,86,257,310,336,484,515,567,729],"pathology":[28,152,474],"remains":[29],"poorly":[30],"understood.":[31],"Postmortem":[32],"neuropathological":[33],"assessment":[34],"is":[35],"crucial":[36],"for":[37,67,120,529],"evaluating":[38],"the":[39,91,160,181,204,217,308,332,358,365,381,447,504,513,576,604,620,630,637,641,690,727],"degree":[40],"of":[41,61,93,107,170,195,232,274,338,362,380,384,399,435,452,469,486,575,593,654,695],"A\u03b2":[42,80,172,177,198,200,275,306,478,508,595,611,615,657,696,725],"removal,":[43],"providing":[44],"information":[45],"and":[46,51,58,81,142,206,240,276,311,316,340,343,353,370,405,455,472,476,479,488,506,509,525,545,553,580,661,670,697,730,735],"context":[47],"that":[48,290,299,541,712,718],"fluid":[49],"biomarkers":[50,428],"positron":[52],"emission":[53,423],"tomography":[54,424],"(PET)":[55,425],"alone":[56],"cannot,":[57],"guiding":[59],"development":[60],"more":[62,438],"effective":[63],"modifying":[65],"therapies":[66],"AD.":[68,321,363,388,740],"In":[69,255,412,494,680],"this":[70,495],"study,":[71,496],"using":[72,392,497],"high":[73,498],"resolution":[74,499],"mass":[75,500],"spectrometry":[76,501],"we":[77,502],"quantitatively":[78],"measured":[79,503],"tau":[82,235,242,253,277,344,473,480,510,666,678,698],"proteoforms":[83,173,278,345,443,511,618,699],"postmortem":[85,347,483,514,566],"tissue":[87,258,485,516,568],"homogenates":[88,517],"to":[89,210,281,432,457,543,559,629,702],"evaluate":[90,458],"impact":[92],"long-term":[94],"treatment":[95,293,450,551,683],"with":[96,124,135,143,147,155,295,320,533,565,587,599,714,739],"anti-A\u03b2":[97,125,393],"monoclonal":[98,126],"gantenerumab":[100,534,607,646],"solanezumab":[102,537,682],"a":[104],"clinical":[105,161,414,605],"trial":[106,520],"dominantly":[108,408],"inherited":[109,409],"(DIAD).":[112,411],"Symptomatic":[113],"DIAD":[114,138,212,285,309,573,632,706,728],"participants":[115,226,262,521,574,648],"who":[116,522],"had":[117,526],"been":[118,419,527],"treated":[119,487,528,647],"\u223c":[121,530],"4":[122,531],"years":[123,532],"(gantenerumab,":[128],"n=4":[129],"solanezumab,":[131],"n=4)":[132],"were":[133,523,563],"compared":[134,209,628],"untreated,":[136,571],"symptomatic":[137,524,572],"mutation":[139],"carriers":[140],"(n=40)":[141,579],"age-relevant":[144],"non-DIAD":[145,221,585,642],"controls":[146,586],"modest":[148,591],"no":[150],"plaque":[151,183,622],"(n=18).":[153,597],"Consistent":[154,598],"antemortem":[156,600],"A\u03b2-PET":[157,601],"findings":[158,288,602,710],"trial,":[162,606],"gantenerumab-treated":[163,225],"participant":[164],"samples":[165,259,569,703],"showed":[166,192,228,650],"significantly":[167,608,651],"lower":[168,193,230,652,663],"levels":[169,194,218,273,638,694],"specific":[171,610],"(A\u03b2":[174,612,658],"42":[175,613],",":[176,614],"40":[178,616],")":[179,617,660],"insoluble":[182,205,233,251,272,305,477,507,544,621,664,676,693,724],"associated":[184,319,623,738],"pool":[185,624],"(range:":[186,625],"60-80":[187],"%":[188],"reduction);":[189],"they":[190],"also":[191,227,312,649,731],"post-translationally":[196,655],"modified":[197,656],"proteoform":[199],"3pGlu":[201,659],"both":[203],"pool,":[208],"untreated":[211,489,631],"participants,":[213,633],"but":[214,634],"without":[215,247,589,635,672],"reaching":[216,636],"found":[219,639],"controls.":[222,643],"Samples":[223,644],"from":[224,260,283,307,421,518,556,570,581,645,704,726],"regionally":[229,662],"amounts":[231],"phosphorylated":[234,665],"species":[236,243,667],"(pT181,":[237,668],"pT205,":[238],"pT208)":[239],"MTBR":[241],"(354-369,":[244],"306-317,":[245],"299-317)":[246],"apparent":[248,673],"differences":[249,267,674],"total":[252,677],"levels.":[254,679],"contrast,":[256,681],"solanezumab-treated":[261],"did":[263,684],"not":[264,685],"show":[265,686],"significant":[266,687],"overall":[268],"comparison":[280,701],"those":[282],"non-treated":[284,705],"individuals.":[286,707],"These":[287,709],"support":[289,711],"(ATT)":[294,330],"gantenerumab,":[296,715],"an":[297,716],"antibody":[298,717],"targets":[300,719],"A\u03b2,":[302,547,721],"can":[303,722],"remove":[304,723],"mitigate":[313,732],"\u201cdownstream\u201d":[314,733],"biochemical":[315,467,734],"pathophysiological":[317,736],"changes":[318,737],"Key":[322],"Summary":[323],"Question":[324],"How":[325],"do":[326],"treatments":[329],"affect":[331],"(AD)-related":[335],"pathologies":[337],"aggregated":[341],"tissue?":[348],"Background":[349],"Extracellular":[350],"neurofibrillary":[354],"tangles":[355],"(NFTs)":[356],"are":[357,444,491],"primary":[359,382],"pathological":[360,442],"hallmarks":[361],"For":[364],"past":[366],"three":[367],"decades,":[368],"active":[369],"passive":[371,390],"immunization":[372],"cerebral":[374],"has":[377,418],"constituted":[378],"one":[379],"avenues":[383],"disease-modifying":[385],"intervention":[386],"Recently,":[389],"immunizations":[391],"have":[396],"demonstrated":[397],"slowing":[398],"cognitive":[400],"decline":[401],"sporadic":[403],"AD":[404,410,464,490],"possibly":[406],"trials,":[415],"target":[416,436],"engagement":[417,437],"inferred":[420],"A\u03b2-positron":[422],"and/or":[426],"biofluid":[427],"during":[429],"life.":[430],"However,":[431],"confirm":[433],"evidence":[434],"directly,":[439],"identify":[440],"which":[441],"affected,":[445],"quantify":[446],"dose":[448],"dependent":[449],"effects":[451,462],"treatments,":[454],"begin":[456],"their":[459],"putative":[460],"downstream":[461],"on":[463,689],"pathophysiology,":[465],"quantitative":[466],"comparisons":[468],"(soluble":[475],"species)":[481],"needed.":[492],"Findings":[493],"DIAN-TU-001":[519],"(n=4)":[535],"(n=4),":[538],"two":[539],"bind":[542],"respectively.":[548],"Intervals":[549],"between":[550],"discontinuation":[552],"death":[554],"ranged":[555],"5":[557],"months":[558],"3":[560],"years.":[561],"Comparisons":[562],"made":[564],"DIAN-Obs":[577],"study":[578],"age-relevant,":[582],"cognitively":[583],"normal,":[584],"only":[590],"burdens":[592],"diffuse":[594],"decreased":[609],"60-80%":[626],"reduction)":[627],"amount":[653],"pT205":[669],"pT208),":[671],"effect":[688],"Significance":[708],"ATT":[713]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-30T00:00:00"}