{"id":"https://openalex.org/W7214701643","doi":"https://doi.org/10.1007/s00431-026-07437-w","title":"Preoperative brain injury and neurodevelopmental outcomes in syndromic and non-syndromic children with complex congenital heart disease: a single-centre cohort study","display_name":"Preoperative brain injury and neurodevelopmental outcomes in syndromic and non-syndromic children with complex congenital heart disease: a single-centre cohort study","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7214701643","doi":"https://doi.org/10.1007/s00431-026-07437-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/42809062"},"language":"en","primary_location":{"id":"doi:10.1007/s00431-026-07437-w","doi":"https://doi.org/10.1007/s00431-026-07437-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00431-026-07437-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00431-026-07437-w.pdf","source":{"id":"https://openalex.org/S48201647","display_name":"European Journal of Pediatrics","issn_l":"0340-6199","issn":["0340-6199","1432-1076"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00431-026-07437-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081398012","display_name":"Chiara Paolin","orcid":"https://orcid.org/0000-0001-5817-5151","observed_orcids":["https://orcid.org/0000-0001-5817-5151"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Chiara Paolin","raw_affiliation_strings":["Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University of Padova, Padua, Italy. chiara.paolin@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University of Padova, Padua, Italy. chiara.paolin@gmail.com","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033664742","display_name":"Alice Pozza","orcid":"https://orcid.org/0009-0003-4799-5551","observed_orcids":["https://orcid.org/0009-0003-4799-5551"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alice Pozza","raw_affiliation_strings":["Paediatric Cardiology Unit, Department of Women's and Children's Health, University of Padova, Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paediatric Cardiology Unit, Department of Women's and Children's Health, University of Padova, Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020253861","display_name":"Claudio Ancona","orcid":"https://orcid.org/0009-0000-5721-5270","observed_orcids":["https://orcid.org/0009-0000-5721-5270"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudio Ancona","raw_affiliation_strings":["Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University of Padova, Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University of Padova, Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090544935","display_name":"Laura Mezzalira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Mezzalira","raw_affiliation_strings":["School of Medicine, University of Ferrara, Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091694136","display_name":"Paola Elisa Cogo","orcid":"https://orcid.org/0000-0002-6235-140X","observed_orcids":["https://orcid.org/0000-0002-6235-140X"]},"institutions":[{"id":"https://openalex.org/I129043915","display_name":"University of Udine","ror":"https://ror.org/05ht0mh31","country_code":"IT","type":"education","lineage":["https://openalex.org/I129043915"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Cogo","raw_affiliation_strings":["Department of Medical Area, DAME - Division of Paediatrics, University of Udine, Udine, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Area, DAME - Division of Paediatrics, University of Udine, Udine, Italy","institution_ids":["https://openalex.org/I129043915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103052611","display_name":"Giovanni Di Salvo","orcid":"https://orcid.org/0000-0002-0305-0113","observed_orcids":["https://orcid.org/0000-0002-0305-0113","https://orcid.org/0000-0002-1979-2787"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Di Salvo","raw_affiliation_strings":["Paediatric Cardiology Unit, Department of Women's and Children's Health, University of Padova, Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paediatric Cardiology Unit, Department of Women's and Children's Health, University of Padova, Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033728789","display_name":"Massimo Antonio Padalino","orcid":"https://orcid.org/0000-0002-7535-9670","observed_orcids":["https://orcid.org/0000-0002-7535-9670"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Padalino","raw_affiliation_strings":["Paediatric and Congenital Cardiovascular Surgery, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari \"Aldo Moro\", Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paediatric and Congenital Cardiovascular Surgery, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari \"Aldo Moro\", Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061749867","display_name":"Fabio Scattolin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Scattolin","raw_affiliation_strings":["Paediatric and Congenital Cardiac Surgery Unit, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paediatric and Congenital Cardiac Surgery Unit, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016274695","display_name":"Vladimiro Lorenzo Vida","orcid":"https://orcid.org/0000-0002-1829-0259","observed_orcids":["https://orcid.org/0000-0002-1829-0259"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vladimiro Vida","raw_affiliation_strings":["Paediatric and Congenital Cardiac Surgery Unit, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paediatric and Congenital Cardiac Surgery Unit, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085838749","display_name":"Stefano Sartori","orcid":"https://orcid.org/0000-0002-0012-6848","observed_orcids":["https://orcid.org/0000-0002-0012-6848"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Sartori","raw_affiliation_strings":["Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University of Padova, Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University of Padova, Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049364247","display_name":"Renzo Manara","orcid":"https://orcid.org/0000-0002-5130-3971","observed_orcids":["https://orcid.org/0000-0002-5130-3971"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Renzo Manara","raw_affiliation_strings":["Neuroradiology, Department of Neurosciences, University of Padova, Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroradiology, Department of Neurosciences, University of Padova, Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5081398012"],"corresponding_institution_ids":["https://openalex.org/I138689650"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.77916584,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"185","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complex-congenital-heart-disease","display_name":"complex congenital heart disease","score":0.9380000233650208},{"id":"https://openalex.org/keywords/neurodevelopmental-outcomes","display_name":"neurodevelopmental outcomes","score":0.8640000224113464},{"id":"https://openalex.org/keywords/syndromic-congenital-heart-disease","display_name":"syndromic congenital heart disease","score":0.9520000219345093},{"id":"https://openalex.org/keywords/non-syndromic-congenital-heart-disease","display_name":"non-syndromic congenital heart disease","score":0.921999990940094},{"id":"https://openalex.org/keywords/arterial-ischemic-stroke","display_name":"arterial ischemic stroke","score":0.878000020980835},{"id":"https://openalex.org/keywords/subdural-hematoma","display_name":"subdural hematoma","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cerebral-venous-thrombosis","display_name":"cerebral venous thrombosis","score":0.925000011920929},{"id":"https://openalex.org/keywords/white-matter-injury","display_name":"white matter injury","score":0.9599999785423279},{"id":"https://openalex.org/keywords/perinatal-brain-lesions","display_name":"perinatal brain lesions","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cardiac-surgery","display_name":"cardiac surgery","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.965399980545044},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.6535000205039978},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.5637999773025513},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.544700026512146},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.5198000073432922},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.4514999985694885},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.44749999046325684},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.3714999854564667},{"id":"https://openalex.org/C2779388368","wikidata":"https://www.wikidata.org/wiki/Q3450985","display_name":"Neurodevelopmental disorder","level":3,"score":0.36410000920295715},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3555999994277954},{"id":"https://openalex.org/C2779546523","wikidata":"https://www.wikidata.org/wiki/Q17143511","display_name":"Pediatric stroke","level":4,"score":0.3465999960899353},{"id":"https://openalex.org/C2781458332","wikidata":"https://www.wikidata.org/wiki/Q720026","display_name":"Brain damage","level":2,"score":0.3327000141143799},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.3037000000476837},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.29350000619888306},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.2842000126838684},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.27790001034736633},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C146638467","wikidata":"https://www.wikidata.org/wiki/Q10529587","display_name":"Hyperintensity","level":3,"score":0.2619999945163727},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.257999986410141},{"id":"https://openalex.org/C2779224077","wikidata":"https://www.wikidata.org/wiki/Q4674782","display_name":"Acquired brain injury","level":3,"score":0.25290000438690186},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.25130000710487366}],"mesh":[{"descriptor_ui":"D000099203","descriptor_name":"Neurodevelopment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099203","descriptor_name":"Neurodevelopment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099203","descriptor_name":"Neurodevelopment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099203","descriptor_name":"Neurodevelopment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057234","descriptor_name":"Preoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057234","descriptor_name":"Preoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057234","descriptor_name":"Preoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057234","descriptor_name":"Preoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065886","descriptor_name":"Neurodevelopmental Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D065886","descriptor_name":"Neurodevelopmental Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D065886","descriptor_name":"Neurodevelopmental Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D065886","descriptor_name":"Neurodevelopmental Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D065886","descriptor_name":"Neurodevelopmental Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D065886","descriptor_name":"Neurodevelopmental Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D065886","descriptor_name":"Neurodevelopmental Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D065886","descriptor_name":"Neurodevelopmental Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00431-026-07437-w","doi":"https://doi.org/10.1007/s00431-026-07437-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00431-026-07437-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00431-026-07437-w.pdf","source":{"id":"https://openalex.org/S48201647","display_name":"European Journal of Pediatrics","issn_l":"0340-6199","issn":["0340-6199","1432-1076"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pediatrics","raw_type":"journal-article"},{"id":"pmid:42809062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42809062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pediatrics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13623767","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13623767/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13623767/pdf/431_2026_Article_7437.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Eur J Pediatr","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s00431-026-07437-w","doi":"https://doi.org/10.1007/s00431-026-07437-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00431-026-07437-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00431-026-07437-w.pdf","source":{"id":"https://openalex.org/S48201647","display_name":"European Journal of Pediatrics","issn_l":"0340-6199","issn":["0340-6199","1432-1076"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pediatrics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321966","display_name":"Universit\u00e0 degli Studi di Padova","ror":"https://ror.org/00240q980"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214701643.pdf","grobid_xml":"https://content.openalex.org/works/W7214701643.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1508597497","https://openalex.org/W1981244369","https://openalex.org/W2024799684","https://openalex.org/W2051120282","https://openalex.org/W2115667727","https://openalex.org/W2116447029","https://openalex.org/W2127510910","https://openalex.org/W2254991357","https://openalex.org/W2408947477","https://openalex.org/W3134491195","https://openalex.org/W3205418166","https://openalex.org/W4221115267","https://openalex.org/W4307425091","https://openalex.org/W4313236537","https://openalex.org/W4361190676","https://openalex.org/W4389037381","https://openalex.org/W4389297331","https://openalex.org/W4391812954","https://openalex.org/W4408482465","https://openalex.org/W4416955114","https://openalex.org/W7119836119","https://openalex.org/W7163015255","https://openalex.org/W7166452326","https://openalex.org/W7167328650"],"related_works":[],"abstract_inverted_index":{"Children":[0,252],"with":[1,48,56,94,223,253,273,304,310],"complex":[2,57,95,254,305],"congenital":[3,255],"heart":[4,256],"disease":[5,257],"(CHD)":[6,258],"are":[7,242,259,275,294],"at":[8,86,134,236,260,329],"high":[9,261],"risk":[10,262],"of":[11,34,89,117,230,299,317],"brain":[12,21,27,43,73,100,153,232,265,286,319],"lesions":[13,44,154,287],"both":[14],"before":[15],"and":[16,25,29,45,51,68,105,125,131,133,136,165,194,210,217,267,301],"after":[17],"cardiac":[18],"surgery.":[19],"Preoperative":[20,152,285],"injury":[22,74,197,233,266,320],"reflects":[23],"foetal":[24],"perinatal":[26,208],"development":[28],"represents":[30],"an":[31],"independent":[32],"predictor":[33],"neurodevelopmental":[35,52,126,212,238,268,279,331],"outcome.":[36],"This":[37],"study":[38,83],"aimed":[39],"to":[40,63,244,322],"characterize":[41],"preoperative":[42,72,99,231,264,318],"their":[46],"correlation":[47],"clinical":[49],"course":[50],"outcomes":[53],"in":[54,75,157,215,296],"children":[55,77,93,159,204,222,272,303,309],"CHD.":[58,306],"The":[59],"secondary":[60],"objective":[61],"was":[62,84,179],"compare":[64],"findings":[65],"between":[66,102],"syndromic":[67,76,168,203,300],"non-syndromic":[69,164,302,323],"patients,":[70,142],"as":[71],"remains":[78],"underreported.":[79],"A":[80],"single-centre":[81],"cohort":[82,298],"performed":[85],"the":[87,113,180],"University":[88],"Padova,":[90],"Italy,":[91],"involving":[92],"CHD":[96,224,274,311],"who":[97],"underwent":[98],"MRI":[101],"January":[103],"2020":[104],"October":[106],"2024.":[107],"Patients":[108],"were":[109,128,155],"categorized":[110],"based":[111],"on":[112],"presence":[114],"or":[115,120,148],"absence":[116],"a":[118,146,327],"known":[119],"suspected":[121,147],"genetic":[122,150],"syndrome.":[123,151],"Neurological":[124],"evaluations":[127],"conducted":[129],"pre-":[130],"postoperatively,":[132],"6-":[135],"18-months":[137],"follow-up.":[138],"Among":[139],"54":[140],"enrolled":[141],"21":[143],"(39%)":[144],"had":[145],"confirmed":[149],"present":[156],"24":[158],"(44%),":[160,288],"including":[161],"16/33":[162],"(48%)":[163],"8/21":[166],"(38%)":[167],"patients":[169],"(OR":[170],"0.65":[171],"[0.21-1.94],":[172],"p":[173],"=":[174],"0.5708).":[175],"Arterial":[176],"ischemic":[177,291],"stroke":[178,292],"most":[181],"common":[182],"lesion":[183,201],"(20%),":[184,293],"followed":[185],"by":[186],"subdural":[187],"haemorrhage":[188],"(11%),":[189],"cerebral":[190],"sinovenous":[191],"thrombosis":[192],"(9%),":[193],"white":[195],"matter":[196],"(6%).":[198],"Despite":[199],"similar":[200],"rates,":[202],"showed":[205],"more":[206],"complicated":[207],"histories":[209],"greater":[211,237],"impairment,":[213],"particularly":[214],"motor":[216],"language":[218],"domains.":[219],"CONCLUSION:":[220],"Syndromic":[221,271,308],"do":[225,312],"not":[226,313],"have":[227],"higher":[228,330],"rates":[229,316],"but":[234,325],"remain":[235,326],"risk.":[239,332],"Further":[240],"studies":[241],"warranted":[243],"confirm":[245],"these":[246],"findings.":[247],"WHAT":[248,281],"IS":[249,282],"KNOWN:":[250],"\u2022":[251,270,284,307],"for":[263],"impairment.":[269],"often":[276],"excluded":[277],"from":[278],"studies.":[280],"NEW:":[283],"mainly":[289],"arterial":[290],"frequent":[295],"our":[297],"show":[314],"increased":[315],"compared":[321],"children,":[324],"population":[328]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2026-09-30T00:00:00"}