{"id":"https://openalex.org/W7214677334","doi":"https://doi.org/10.7150/thno.140697","title":"A dual CEST-fluorescent reporter enables cross-validated tracking of hematopoietic engraftment in deep bone marrow","display_name":"A dual CEST-fluorescent reporter enables cross-validated tracking of hematopoietic engraftment in deep bone marrow","publication_year":2026,"publication_date":"2026-09-24","ids":{"openalex":"https://openalex.org/W7214677334","doi":"https://doi.org/10.7150/thno.140697","pmid":"https://pubmed.ncbi.nlm.nih.gov/42909934","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13684844"},"language":"en","primary_location":{"id":"doi:10.7150/thno.140697","doi":"https://doi.org/10.7150/thno.140697","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.140697","pdf_url":"https://www.thno.org/v16p9416.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.thno.org/v16p9416.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5120661062","display_name":"Tehila Alter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Tehila Alter","raw_affiliation_strings":["Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093776821","display_name":"Narmeen Haj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Narmeen Haj","raw_affiliation_strings":["Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020062659","display_name":"Doaa Ali\u2010Naffaa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Doaa Ali-Naffaa","raw_affiliation_strings":["Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111571838","display_name":"Maya Rom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Maya Rom","raw_affiliation_strings":["Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076185563","display_name":"Ramez Daniel","orcid":"https://orcid.org/0000-0001-8886-3668","observed_orcids":["https://orcid.org/0000-0001-8886-3668"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ramez Daniel","raw_affiliation_strings":["Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122895883","display_name":"Galit Saar","orcid":"https://orcid.org/0000-0002-7930-2102","observed_orcids":["https://orcid.org/0000-0002-7930-2102"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Galit Saar","raw_affiliation_strings":["Biomedical Core Facility, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Core Facility, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083175534","display_name":"Assaf A. Gilad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Assaf A. Gilad","raw_affiliation_strings":["Biomedical Engineering Faculty, Tel Aviv University, Tel Aviv, Israel","Chemical Engineering and Radiology, Michigan State University, East Lansing, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Faculty, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Chemical Engineering and Radiology, Michigan State University, East Lansing, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068255682","display_name":"Katrien Vandoorne","orcid":"https://orcid.org/0000-0002-8132-8280","observed_orcids":["https://orcid.org/0000-0002-8132-8280"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Katrien Vandoorne","raw_affiliation_strings":["Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5068255682"],"corresponding_institution_ids":["https://openalex.org/I174306211"],"apc_list":{"value":2500,"currency":"AUD","value_usd":1671},"apc_paid":{"value":2500,"currency":"AUD","value_usd":1671},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67802315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"16","first_page":"9416","last_page":"9433"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.43290001153945923,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.43290001153945923,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.11110000312328339,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.05959999933838844,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cest-mri","display_name":"CEST MRI","score":0.625},{"id":"https://openalex.org/keywords/fluorescent-reporter","display_name":"fluorescent reporter","score":0.6650000214576721},{"id":"https://openalex.org/keywords/hematopoietic-engraftment","display_name":"hematopoietic engraftment","score":0.9210000038146973},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.7720000147819519},{"id":"https://openalex.org/keywords/dual-reporter-system","display_name":"dual reporter system","score":0.5550000071525574},{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.859000027179718},{"id":"https://openalex.org/keywords/lsk-cells","display_name":"LSK cells","score":0.7020000219345093},{"id":"https://openalex.org/keywords/cell-tracking","display_name":"cell tracking","score":0.5389999747276306},{"id":"https://openalex.org/keywords/whole-body-fluorescence-imaging","display_name":"whole-body fluorescence imaging","score":0.5979999899864197},{"id":"https://openalex.org/keywords/ct26-cells","display_name":"CT26 cells","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.7802000045776367},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.7069000005722046},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6195999979972839},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6158000230789185},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5899999737739563},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.5368000268936157},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.5248000025749207},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.49950000643730164},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.46950000524520874},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.45660001039505005},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37209999561309814},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.37119999527931213},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.3671000003814697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36390000581741333},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.3447999954223633},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.33550000190734863},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3328999876976013},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.3276999890804291},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.32679998874664307},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3091000020503998},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3034000098705292},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.301800012588501},{"id":"https://openalex.org/C2859252","wikidata":"https://www.wikidata.org/wiki/Q1543928","display_name":"Intravital microscopy","level":3,"score":0.2994999885559082},{"id":"https://openalex.org/C136009344","wikidata":"https://www.wikidata.org/wiki/Q336201","display_name":"Confocal","level":2,"score":0.29649999737739563},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.29409998655319214},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.2581000030040741}],"mesh":[{"descriptor_ui":"D000097573","descriptor_name":"Red Fluorescent Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058948","descriptor_name":"Cell Tracking","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.7150/thno.140697","doi":"https://doi.org/10.7150/thno.140697","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.140697","pdf_url":"https://www.thno.org/v16p9416.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13684844","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684844/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684844/pdf/thnov16p9416.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"Text"},{"id":"pmid:42909934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42909934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7150/thno.140697","doi":"https://doi.org/10.7150/thno.140697","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.140697","pdf_url":"https://www.thno.org/v16p9416.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8200864057","display_name":null,"funder_award_id":"31BX21DSKV","funder_id":"https://openalex.org/F4320331008","funder_display_name":"BIRAX"}],"funders":[{"id":"https://openalex.org/F4320331008","display_name":"BIRAX","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214677334.pdf","grobid_xml":"https://content.openalex.org/works/W7214677334.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2125403231","https://openalex.org/W2051901431","https://openalex.org/W2021239135","https://openalex.org/W3030112419","https://openalex.org/W2127405798","https://openalex.org/W3015847059","https://openalex.org/W2111353779","https://openalex.org/W4200066655","https://openalex.org/W2608743511","https://openalex.org/W2915272776"],"abstract_inverted_index":{"Reporter":[0],"gene":[1],"imaging":[2,231,272,321,356],"can":[3],"enable":[4],"detection":[5,36],"of":[6,37,50,313,357,382,395],"engineered":[7,383],"cells":[8,41,80,131,146,211,263,280,299,308,360],"in":[9,45,76,81,84,96,209,221,237,256,325,339,361,389],"vivo,":[10],"but":[11],"tracking":[12],"hematopoietic":[13,40,128,258,337,359,384],"engraftment":[14,156,269],"within":[15,309,333],"deep":[16,362],"bone":[17],"marrow":[18],"(BM)":[19],"remains":[20],"challenging.We":[21],"addressed":[22],"this":[23,371],"challenge":[24],"by":[25,139,162,248],"developing":[26],"a":[27,71,85,348,375],"dual":[28,203,349],"CEST-MRI":[29,66,180,219,366],"and":[30,42,64,83,93,115,132,142,155,177,193,212,217,232,251,273,300,319,327,335,387,391],"fluorescent":[31,60],"reporter":[32,67,136,205,235,244,289,323,351],"system":[33],"for":[34,119,378,398],"cross-validated":[35,355],"reporter-positive":[38,222],"donor-derived":[39],"their":[43],"progeny":[44],"BM,":[46,326],"with":[47,90,135,189,197,225,277,287,291,296,343,367],"fluorescencebased":[48],"assessment":[49,381],"HSPC-enriched":[51],"compartments.Methods:":[52],"A":[53],"lentiviral":[54],"dual-reporter":[55],"cassette":[56],"co-expressing":[57],"the":[58,65,288,310,314,396],"red":[59,215],"protein":[61],"mScarlet-I":[62],"(mScarlet)":[63],"SuperCESTide":[68],"(SC)":[69],"via":[70],"T2A":[72],"linker":[73],"was":[74,122,157,181,246],"evaluated":[75],"CT26":[77,210],"colon":[78],"carcinoma":[79],"vitro":[82],"bilateral":[86],"flank":[87],"tumor":[88,238],"model":[89],"contralateral":[91,226],"reporter-transduced":[92,199,261,278,340],"non-transduced":[94,227,297,344],"tumors":[95,102,223],"BALB/c":[97],"mice":[98,151],"(n":[99],"=":[100],"6":[101],"per":[103],"group).In":[104],"vivo":[105,110,172,229,316,390],"optical":[106,111,175,230,320],"imaging,":[107,112,165,176],"CEST-MRI,":[108,167],"ex":[109,171],"fluorescence":[113,140,164,216,249,271],"microscopy,":[114,170,174],"histology":[116,233],"were":[117,147,264],"used":[118],"validation.The":[120],"platform":[121,352,397],"then":[123],"applied":[124],"to":[125],"primary":[126],"murine":[127,240],"lineage-negative":[129],"(Lin\u207b)":[130],"Lin\u207bSca-1\u207ac-Kit\u207a":[133],"(LSKs),":[134],"expression":[137,208,236,245],"analyzed":[138],"microscopy":[141,250,305,318],"flow":[143,178,252,328],"cytometry.Reporter-transduced":[144],"Lin\u207b":[145,191,200,242,262,279,298,334],"transplanted":[148,188,196,295],"into":[149],"C57BL/6J":[150],"after":[152,268],"half-body":[153],"irradiation,":[154],"assessed":[158],"8":[159],"weeks":[160,267],"later":[161],"whole-body":[163],"femoral":[166,274,283],"intravital":[168,304],"calvarial":[169],"confocal":[173,317],"cytometry.Femoral":[179],"compared":[182,224,290,342],"among":[183],"non-irradiated":[184,301],"controls,":[185],"irradiated":[186,194,293],"recipients":[187,195,276,294,341],"non-reporter-transduced":[190],"cells,":[192,243],"mScarlet-SC":[198],"cells.Results:":[201],"The":[202],"mScarlet-SuperCESTide":[204],"showed":[206,281],"efficient":[207],"generated":[213],"detectable":[214],"increased":[218,282],"contrast":[220,285],"controls.Ex":[228],"confirmed":[234,322,330],"tissue.In":[239],"BM-derived":[241],"detected":[247,265],"cytometry,":[253],"supporting":[254],"feasibility":[255,372],"sensitive":[257],"populations.Following":[259],"transplantation,":[260],"eight":[266],"using":[270],"CEST-MRI.The":[275],"CEST":[284],"associated":[286],"both":[292],"BM":[302,311],"controls.Additionally,":[303],"visualized":[306],"mScarlet\u207a":[307],"niches":[312],"calvarium.Ex":[315],"retention":[324],"cytometry":[329],"mScarlet":[331],"signal":[332],"LSK":[336],"compartments":[338],"controls.Conclusion:":[345],"We":[346],"developed":[347],"CEST-fluorescent":[350],"that":[353],"enables":[354],"reportertransduced":[358],"BM.By":[363],"integrating":[364],"noninvasive":[365,380],"fluorescence-based":[368],"cellular":[369],"validation,":[370],"study":[373],"establishes":[374],"preclinical":[376],"framework":[377],"cross-validated,":[379],"cell":[385],"localization":[386],"persistence":[388],"supports":[392],"future":[393],"evaluation":[394],"serial":[399],"imaging.":[400]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-29T00:00:00"}
