{"id":"https://openalex.org/W7214668794","doi":"https://doi.org/10.64898/2026.09.25.752224","title":"BLTP3A dysfunction unleashes lysosomal stress\u2013induced antitumor immunity through STING","display_name":"BLTP3A dysfunction unleashes lysosomal stress\u2013induced antitumor immunity through STING","publication_year":2026,"publication_date":"2026-09-28","ids":{"openalex":"https://openalex.org/W7214668794","doi":"https://doi.org/10.64898/2026.09.25.752224","pmid":"https://pubmed.ncbi.nlm.nih.gov/42856194","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13648468"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.25.752224","doi":"https://doi.org/10.64898/2026.09.25.752224","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.752224","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.09.25.752224","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100640020","display_name":"Elaheh Sadat Hosseini","orcid":"https://orcid.org/0000-0002-1420-0842","observed_orcids":["https://orcid.org/0000-0002-1420-0842"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaheh S. Hosseini","raw_affiliation_strings":["Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","Rutgers School of Graduate Studies, Rutgers University, New Brunswick, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I4390039325"]},{"raw_affiliation_string":"Rutgers School of Graduate Studies, Rutgers University, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Steven Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Wang","raw_affiliation_strings":["Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083104902","display_name":"Mona Arabzadeh","orcid":"https://orcid.org/0000-0002-1867-1166","observed_orcids":["https://orcid.org/0000-0002-1867-1166"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mona Arabzadeh","raw_affiliation_strings":["Center for Systems and Computational Biology, Rutgers Cancer Institute, New Brunswick, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems and Computational Biology, Rutgers Cancer Institute, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092032459","display_name":"Kristen E. Warrington","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen E. Warrington","raw_affiliation_strings":["Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057153021","display_name":"Maria T. S\u00f8gaard","orcid":"https://orcid.org/0000-0002-5795-023X","observed_orcids":["https://orcid.org/0000-0002-5795-023X"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria T. S\u00f8gaard","raw_affiliation_strings":["Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","Rutgers School of Graduate Studies, Rutgers University, New Brunswick, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I4390039325"]},{"raw_affiliation_string":"Rutgers School of Graduate Studies, Rutgers University, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072173769","display_name":"Amartya Singh","orcid":"https://orcid.org/0000-0003-2422-3068","observed_orcids":["https://orcid.org/0000-0003-2422-3068"]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amartya Singh","raw_affiliation_strings":["Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144065452","display_name":"Wenjin Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenjin Chen","raw_affiliation_strings":["Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093496362","display_name":"Lomaani Ranasinghe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lomaani Ranasinghe","raw_affiliation_strings":["Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111245283","display_name":"Rinkee Kumari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rinkee Kumari","raw_affiliation_strings":["Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143863221","display_name":"Christopher Alcott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher K. Alcott","raw_affiliation_strings":["Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","Rutgers School of Graduate Studies, Rutgers University, New Brunswick, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I4390039325"]},{"raw_affiliation_string":"Rutgers School of Graduate Studies, Rutgers University, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088448026","display_name":"Adam Robinson","orcid":"https://orcid.org/0000-0002-3970-422X","observed_orcids":["https://orcid.org/0000-0002-3970-422X","https://orcid.org/0009-0004-7196-316X"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Robinson","raw_affiliation_strings":["Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","Rutgers School of Graduate Studies, Rutgers University, New Brunswick, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I4390039325"]},{"raw_affiliation_string":"Rutgers School of Graduate Studies, Rutgers University, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101810031","display_name":"Shreya Yadav","orcid":"https://orcid.org/0000-0002-2951-3024","observed_orcids":["https://orcid.org/0000-0002-2951-3024"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shreya Yadav","raw_affiliation_strings":["Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","Rutgers School of Graduate Studies, Rutgers University, New Brunswick, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I4390039325"]},{"raw_affiliation_string":"Rutgers School of Graduate Studies, Rutgers University, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004917322","display_name":"Wenwei Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenwei Hu","raw_affiliation_strings":["Department of Radiation Oncology, Rutgers Cancer Institute, Rutgers University, Piscataway, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Rutgers Cancer Institute, Rutgers University, Piscataway, New Jersey, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153246924","display_name":"Jian Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Cao","raw_affiliation_strings":["Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey","Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055824335","display_name":"Eugenia Girda","orcid":"https://orcid.org/0000-0002-4787-5475","observed_orcids":["https://orcid.org/0000-0002-4787-5475"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugenia Girda","raw_affiliation_strings":["Department of Obstetrics, Gynecology, and Reproductive Sciences, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, New Jersey","Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Gynecology, and Reproductive Sciences, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074135831","display_name":"Eileen White","orcid":"https://orcid.org/0000-0003-2961-3065","observed_orcids":["https://orcid.org/0000-0003-2961-3065"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I196064397","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05923xh51","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I196064397","https://openalex.org/I4210150094"]},{"id":"https://openalex.org/I4210150094","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05qdwtz81","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150094"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Eileen P. White","raw_affiliation_strings":["Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey","Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","Ludwig Institute for Cancer Research, Princeton Branch, Princeton, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I4390039325"]},{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Princeton Branch, Princeton, New Jersey","institution_ids":["https://openalex.org/I196064397","https://openalex.org/I4210150094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066468457","display_name":"Christian S. Hinrichs","orcid":"https://orcid.org/0000-0001-5597-2841","observed_orcids":["https://orcid.org/0000-0001-5597-2841"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian S. Hinrichs","raw_affiliation_strings":["Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey","Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5153368030","display_name":"Kyle Kristopher Payne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kyle Kristopher Payne","raw_affiliation_strings":["Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey","Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Duncan and Nancy MacMillan Cancer Immunology and Metabolism Center of Excellence, Rutgers Cancer Institute, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I4390039325"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5153368030"],"corresponding_institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4390039325"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.3361999988555908,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.3361999988555908,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.17249999940395355,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.14309999346733093,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sting-signaling","display_name":"STING signaling","score":0.8939999938011169},{"id":"https://openalex.org/keywords/high-grade-serous-ovarian-carcinoma","display_name":"high-grade serous ovarian cancer","score":0.9010000228881836},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7860000133514404},{"id":"https://openalex.org/keywords/interferon-lambda","display_name":"interferon lambda","score":0.7919999957084656},{"id":"https://openalex.org/keywords/atf4","display_name":"ATF4","score":0.7070000171661377},{"id":"https://openalex.org/keywords/casm","display_name":"CASM","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cxcl9","display_name":"CXCL9","score":0.5730000138282776},{"id":"https://openalex.org/keywords/antigen-presenting-macrophages","display_name":"antigen-presenting macrophages","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.7919999957084656},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6104999780654907},{"id":"https://openalex.org/C2779300339","wikidata":"https://www.wikidata.org/wiki/Q7617409","display_name":"Sting","level":2,"score":0.5785999894142151},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5292999744415283},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.49070000648498535},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4433000087738037},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4381999969482422},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.4194999933242798},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4092999994754791},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4052000045776367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39989998936653137},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.37880000472068787},{"id":"https://openalex.org/C2777349159","wikidata":"https://www.wikidata.org/wiki/Q18055374","display_name":"Stimulator of interferon genes","level":4,"score":0.367900013923645},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.3652999997138977},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.36329999566078186},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36160001158714294},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.35830000042915344},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.35440000891685486},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.3441999852657318},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.34369999170303345},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.31839999556541443},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.2955999970436096},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.29499998688697815},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.28459998965263367},{"id":"https://openalex.org/C2780096491","wikidata":"https://www.wikidata.org/wiki/Q60574533","display_name":"Cellular stress response","level":4,"score":0.2808000147342682},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.26899999380111694},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.2678000032901764},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.26159998774528503},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2567000091075897},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2508000135421753}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.25.752224","doi":"https://doi.org/10.64898/2026.09.25.752224","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.752224","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42856194","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42856194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13648468","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42856194/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.25.752224","doi":"https://doi.org/10.64898/2026.09.25.752224","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.752224","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000862921","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA072720","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000864395","display_name":"Interrogating the role of BLTP3A in organizing protective immunity in ovarian cancer","funder_award_id":"1f99ca305528-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000887763","display_name":"Cancer cell-intrinsic mitochondrial stress responses influence protective immunity","funder_award_id":"1r37ca295820-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000905167","display_name":"IMSD at Rutgers - New Brunswick","funder_award_id":"T32GM139804","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1540340473","https://openalex.org/W1670684017","https://openalex.org/W1912428744","https://openalex.org/W1912968665","https://openalex.org/W1975200363","https://openalex.org/W1978449131","https://openalex.org/W2003466425","https://openalex.org/W2077499130","https://openalex.org/W2111900617","https://openalex.org/W2114072930","https://openalex.org/W2137074525","https://openalex.org/W2139948451","https://openalex.org/W2153188271","https://openalex.org/W2438866487","https://openalex.org/W2476403406","https://openalex.org/W2572272477","https://openalex.org/W2903718866","https://openalex.org/W2937887082","https://openalex.org/W2949498852","https://openalex.org/W2985162644","https://openalex.org/W3010184812","https://openalex.org/W3066929737","https://openalex.org/W3097073976","https://openalex.org/W3097756289","https://openalex.org/W3105265817","https://openalex.org/W3128459342","https://openalex.org/W3184911270","https://openalex.org/W3189195217","https://openalex.org/W3203358158","https://openalex.org/W3208430261","https://openalex.org/W3216766978","https://openalex.org/W4225477669","https://openalex.org/W4229024039","https://openalex.org/W4306810376","https://openalex.org/W4307348290","https://openalex.org/W4318224814","https://openalex.org/W4319231564","https://openalex.org/W4321366308","https://openalex.org/W4324311110","https://openalex.org/W4376254188","https://openalex.org/W4385520050","https://openalex.org/W4387357198","https://openalex.org/W4389306110","https://openalex.org/W4390496349","https://openalex.org/W4390706067","https://openalex.org/W4391262110","https://openalex.org/W4391467446","https://openalex.org/W4394581015","https://openalex.org/W4401109604","https://openalex.org/W4401798287","https://openalex.org/W4404754738","https://openalex.org/W4406390197","https://openalex.org/W4409189508","https://openalex.org/W4410189348","https://openalex.org/W4410613879","https://openalex.org/W4412790717","https://openalex.org/W4413877449","https://openalex.org/W4414121537","https://openalex.org/W4414530106","https://openalex.org/W7160861266"],"related_works":["https://openalex.org/W4416449335","https://openalex.org/W4416446900","https://openalex.org/W7214074456","https://openalex.org/W4414659145","https://openalex.org/W2896875037","https://openalex.org/W3184911270","https://openalex.org/W2325806663","https://openalex.org/W7148775627","https://openalex.org/W7134181822","https://openalex.org/W4403299651"],"abstract_inverted_index":{"SUMMARY":[0],"High-grade":[1],"serous":[2],"ovarian":[3,58],"cancer":[4,59],"progresses":[5],"within":[6],"a":[7,53,125,178],"lipid-rich":[8],"ascites":[9],"microenvironment":[10],"that":[11,32,62,182],"engages":[12],"stress-adaptation":[13],"programs":[14],"supporting":[15],"malignant":[16],"growth,":[17],"yet":[18],"how":[19],"failed":[20],"stress":[21,35,123,134,163],"resolution":[22,164],"influences":[23],"tumor":[24,37,41,158],"progression":[25,38,99],"remains":[26],"incompletely":[27],"defined.":[28],"Here,":[29],"we":[30],"show":[31,61],"unresolved":[33],"lysosomal":[34,54,72,122,133,162],"restrains":[36],"by":[39],"sustaining":[40],"cell-intrinsic":[42],"STING":[43,139,149,170],"activity":[44,140],"and":[45,60,81,100,114,141,150,157],"reorganizing":[46],"antitumor":[47,185],"immunity.":[48,186],"We":[49],"identify":[50],"BLTP3A":[51,68,129],"as":[52],"stress-resolution":[55],"factor":[56],"in":[57,117,137],"the":[63,166],"common":[64],"germline":[65],"missense":[66],"variant":[67,96],"M1098T":[69,76],"increases":[70],"stress-induced":[71,169],"damage.":[73],"Patients":[74],"carrying":[75],"had":[77],"longer":[78],"overall":[79],"survival":[80],"tumors":[82,109],"enriched":[83],"for":[84,154],"cytotoxic":[85],"T":[86],"cell\u2013myeloid":[87],"neighborhoods.":[88],"In":[89],"syngeneic":[90],"tumors,":[91],"Bltp3a":[92],"loss":[93],"or":[94],"orthologous":[95],"expression":[97],"delayed":[98],"generated":[101],"Cxcl9":[102],"+":[103],"antigen-presenting":[104],"macrophage":[105],"niches;":[106],"M1098T-expressing":[107],"human":[108],"similarly":[110],"promoted":[111],"interferon-responsive":[112],"myeloid":[113],"T-cell":[115],"enrichment":[116],"humanized":[118],"mice.":[119],"Mechanistically,":[120],"ascites-induced":[121],"activated":[124],"STING\u2013ATF4\u2013BLTP3A":[126],"feedback":[127],"program.":[128],"dysfunction":[130],"disrupted":[131],"CASM-associated":[132],"resolution,":[135],"resulting":[136],"prolonged":[138],"sustained":[142],"tumor-derived":[143],"IFN-\u03bb":[144,151],"without":[145],"increased":[146],"cGAMP.":[147],"Tumor-cell":[148],"were":[152],"required":[153],"immune":[155],"remodeling":[156],"control.":[159],"Thus,":[160],"BLTP3A-dependent":[161],"constrains":[165],"persistence":[167],"of":[168,174],"signaling,":[171],"whereas":[172],"failure":[173],"this":[175],"response":[176],"sustains":[177],"tumor-intrinsic":[179],"inflammatory":[180],"program":[181],"organizes":[183],"protective":[184]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-29T00:00:00"}
