{"id":"https://openalex.org/W7214668317","doi":"https://doi.org/10.7150/ijbs.134874","title":"ZIP1-dependent lymphatic adaptations facilitate lymph node metastasis of pancreatic cancer","display_name":"ZIP1-dependent lymphatic adaptations facilitate lymph node metastasis of pancreatic cancer","publication_year":2026,"publication_date":"2026-09-10","ids":{"openalex":"https://openalex.org/W7214668317","doi":"https://doi.org/10.7150/ijbs.134874","pmid":"https://pubmed.ncbi.nlm.nih.gov/42807947"},"language":"en","primary_location":{"id":"doi:10.7150/ijbs.134874","doi":"https://doi.org/10.7150/ijbs.134874","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijbs.134874","pdf_url":"https://www.ijbs.com/v22p8119.pdf","source":{"id":"https://openalex.org/S26312460","display_name":"International Journal of Biological Sciences","issn_l":"1449-2288","issn":["1449-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.ijbs.com/v22p8119.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040438616","display_name":"Ruoyang Chen","orcid":"https://orcid.org/0000-0002-1424-7528","observed_orcids":["https://orcid.org/0000-0002-1424-7528"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruoyang Chen","raw_affiliation_strings":["Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100679700","display_name":"Kaili Zhang","orcid":"https://orcid.org/0000-0002-0339-6173","observed_orcids":["https://orcid.org/0000-0002-0339-6173"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaili Zhang","raw_affiliation_strings":["Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100316693","display_name":"Jiajia Wan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajia Wan","raw_affiliation_strings":["Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153253280","display_name":"Yuanyuan Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Yang","raw_affiliation_strings":["Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153375198","display_name":"Linlin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linlin Wang","raw_affiliation_strings":["Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153373462","display_name":"Xiangjing Miao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangjing Miao","raw_affiliation_strings":["Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153282870","display_name":"Qingqing Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingqing Fang","raw_affiliation_strings":["Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149645547","display_name":"Yu Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Hu","raw_affiliation_strings":["Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072565585","display_name":"Xixi Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xixi Duan","raw_affiliation_strings":["Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016649841","display_name":"Xiaohan Lou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohan Lou","raw_affiliation_strings":["Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153334160","display_name":"Xiaohan Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohan Yao","raw_affiliation_strings":["Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108854596","display_name":"Anqi Li","orcid":"https://orcid.org/0009-0000-9660-1246","observed_orcids":["https://orcid.org/0009-0000-9660-1246","https://orcid.org/0000-0003-3812-8803","https://orcid.org/0009-0008-3948-6307"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anqi Li","raw_affiliation_strings":["Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112879468","display_name":"Linyu Zhu","orcid":"https://orcid.org/0009-0004-4092-9655","observed_orcids":["https://orcid.org/0009-0004-4092-9655"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linyu Zhu","raw_affiliation_strings":["Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064144163","display_name":"Zhihai Qin","orcid":"https://orcid.org/0000-0001-9793-7964","observed_orcids":["https://orcid.org/0000-0001-9793-7964"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihai Qin","raw_affiliation_strings":["Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5120979739","display_name":"Chen Ni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Ni","raw_affiliation_strings":["Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"R. Chen, K. Zhang, J. Wan and C. Ni contributed equally to this article","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210156804"],"apc_list":{"value":2000,"currency":"AUD","value_usd":1337},"apc_paid":{"value":2000,"currency":"AUD","value_usd":1337},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.79219977,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"14","first_page":"8119","last_page":"8138"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12426","display_name":"Lymphatic Disorders and Treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zip1","display_name":"ZIP1","score":0.9190000295639038},{"id":"https://openalex.org/keywords/zinc-transporters","display_name":"zinc transporters","score":0.7129999995231628},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9259999990463257},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/claudin-5","display_name":"claudin-5","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.9819999933242798},{"id":"https://openalex.org/keywords/transendothelial-migration","display_name":"transendothelial migration","score":0.8569999933242798},{"id":"https://openalex.org/keywords/zinc-dyshomeostasis","display_name":"zinc dyshomeostasis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.8572999835014343},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.8016999959945679},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5684999823570251},{"id":"https://openalex.org/C2776636583","wikidata":"https://www.wikidata.org/wiki/Q6708231","display_name":"Lymphangiogenesis","level":4,"score":0.555899977684021},{"id":"https://openalex.org/C2910366181","wikidata":"https://www.wikidata.org/wiki/Q6708239","display_name":"Lymphatic Endothelium","level":3,"score":0.478300005197525},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4672999978065491},{"id":"https://openalex.org/C2780965494","wikidata":"https://www.wikidata.org/wiki/Q11238641","display_name":"Lymphatic vessel","level":4,"score":0.4672999978065491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4023999869823456},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.39640000462532043},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3822000026702881},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.3797999918460846},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.366100013256073},{"id":"https://openalex.org/C2777996000","wikidata":"https://www.wikidata.org/wiki/Q7130412","display_name":"Pancreatic tumor","level":4,"score":0.3476000130176544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32919999957084656},{"id":"https://openalex.org/C103041312","wikidata":"https://www.wikidata.org/wiki/Q7916457","display_name":"Vascular endothelial growth factor C","level":5,"score":0.32829999923706055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30469998717308044},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2727999985218048},{"id":"https://openalex.org/C2778740770","wikidata":"https://www.wikidata.org/wiki/Q6708283","display_name":"Lymphovascular invasion","level":4,"score":0.26330000162124634},{"id":"https://openalex.org/C2992571226","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node metastasis","level":4,"score":0.25049999356269836}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042601","descriptor_name":"Lymphatic Vessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042601","descriptor_name":"Lymphatic Vessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042601","descriptor_name":"Lymphatic Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D042601","descriptor_name":"Lymphatic Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062507","descriptor_name":"Claudin-5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062507","descriptor_name":"Claudin-5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.7150/ijbs.134874","doi":"https://doi.org/10.7150/ijbs.134874","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijbs.134874","pdf_url":"https://www.ijbs.com/v22p8119.pdf","source":{"id":"https://openalex.org/S26312460","display_name":"International Journal of Biological Sciences","issn_l":"1449-2288","issn":["1449-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Sciences","raw_type":"journal-article"},{"id":"pmid:42807947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42807947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of biological sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13618232","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13618232/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13618232/pdf/ijbsv22p8119.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Biol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7150/ijbs.134874","doi":"https://doi.org/10.7150/ijbs.134874","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijbs.134874","pdf_url":"https://www.ijbs.com/v22p8119.pdf","source":{"id":"https://openalex.org/S26312460","display_name":"International Journal of Biological Sciences","issn_l":"1449-2288","issn":["1449-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6589034795761108,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2916448402","display_name":null,"funder_award_id":"82372911","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3296949546","display_name":null,"funder_award_id":"SBGJ202302037","funder_id":"https://openalex.org/F4320318564","funder_display_name":"Health Commission of Henan Province"},{"id":"https://openalex.org/G4003023663","display_name":null,"funder_award_id":"YQRC2023005","funder_id":"https://openalex.org/F4320318564","funder_display_name":"Health Commission of Henan Province"},{"id":"https://openalex.org/G7534475375","display_name":null,"funder_award_id":"32370973","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G991287329","display_name":null,"funder_award_id":"82073231","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320318564","display_name":"Health Commission of Henan Province","ror":"https://ror.org/04nne1357"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214668317.pdf","grobid_xml":"https://content.openalex.org/works/W7214668317.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Tumor":[0],"disseminates":[1],"through":[2],"lymphatic":[3,13,20,44,53,75,92,116,126,141],"vessels":[4,21,45],"to":[5,23,48,128],"form":[6],"lymph":[7],"node":[8],"(LN)":[9],"metastasis,":[10],"which":[11,132],"requires":[12],"adaptations.However,":[14],"it":[15],"remains":[16],"largely":[17],"unknown":[18],"how":[19],"adapt":[22,47],"the":[24,89],"stimuli":[25],"causing":[26],"LN":[27,56,82,95,146,157,176],"metastasis":[28,57,83,96,158,177],"of":[29,58,84,91,97,103,159,178],"pancreatic":[30,40,60,85,98,161,179,186],"cancer.Zinc":[31],"dyshomeostasis":[32],"has":[33],"been":[34],"observed":[35],"in":[36,62,115,136,173],"various":[37],"tumors,":[38],"including":[39],"cancer.We":[41],"hypothesize":[42],"that":[43,70,80,167],"actively":[46],"zinc":[49,63],"imbalance,":[50],"and":[51,55,77,94,109,145,170],"examine":[52],"functions":[54],"transplanted":[59],"cancer":[61,99,187],"transporter":[64],"ZIP1":[65,71,104,124,150],"deficient":[66],"mice.The":[67],"results":[68],"show":[69],"is":[72,143],"required":[73],"for":[74,185],"glycolysis":[76,127],"junctional":[78,171],"adaptations":[79,172],"facilitate":[81],"cancer.In":[86],"Zip1":[87,138],"-/-mice,":[88],"opening":[90],"barrier":[93,142],"are":[100,148,153],"both":[101],"mitigated.Inhibition":[102],"decreases":[105],"Zn":[106],"2+":[107],"influx":[108],"increases":[110],"tight":[111],"junction":[112],"protein":[113],"Claudin-5":[114,134],"endothelial":[117],"cells,":[118],"thereby":[119],"suppressing":[120],"tumor":[121],"trans-endothelial":[122],"migration.Mechanistically,":[123],"promotes":[125],"produce":[129],"lactic":[130],"acids":[131],"impair":[133],"expression.Furthermore,":[135],"lymphatic-specific":[137],"knockout":[139],"mice,":[140],"tightened":[144],"metastases":[147],"reduced.Importantly,":[149],"+":[151],"lymphatics":[152,174],"positively":[154],"associated":[155],"with":[156],"human":[160],"cancer.Taken":[162],"together,":[163],"these":[164],"findings":[165],"suggest":[166],"ZIP1-dependent":[168],"metabolic":[169],"accelerate":[175],"cancer,":[180],"providing":[181],"potential":[182],"therapeutic":[183],"targets":[184],"metastasis.":[188]},"counts_by_year":[],"updated_date":"2026-10-07T09:51:55.459714","created_date":"2026-09-29T00:00:00"}